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List of works by Osamu Nureki

A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase

scientific article

ATP binding by glutamyl-tRNA synthetase is switched to the productive mode by tRNA binding

scientific article

Activation mechanism of endothelin ETB receptor by endothelin-1

scientific article

Alternative Tertiary Structure of tRNA for Recognition by a Posttranscriptional Modification Enzyme ⬇️

scientific article (publication date: 2 May 2003)

An enzyme with a deep trefoil knot for the active-site architecture

scientific article

Asymmetric coiled-coil structure with Guanine nucleotide exchange activity

scientific article

Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase

scientific article

Base editors for simultaneous introduction of C-to-T and A-to-G mutations

scientific article published on 01 June 2020

Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets

scientific article

C-terminal domain of archaeal O -phosphoseryl-tRNA kinase displays large-scale motion to bind the 7-bp D-stem of archaeal tRNA Sec ⬇️

scientific article published on September 24, 2010

Cap-specific terminal N 6-methylation of RNA by an RNA polymerase II-associated methyltransferase

scientific article published on 22 November 2018

Conformational transition of Sec machinery inferred from bacterial SecYE structures

scientific article

Consensus mutagenesis approach improves the thermal stability of system xc - transporter, xCT, and enables cryo-EM analyses

scientific article published on 05 October 2020

Conserved cysteine residues of GidA are essential for biogenesis of 5-carboxymethylaminomethyluridine at tRNA anticodon

scientific article

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

scientific article published on 03 June 2019

Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein

scientific article published on 09 March 2020

Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation

scientific article published on 15 May 2020

Cryo-EM structures capture the transport cycle of the P4-ATPase flippase

scientific article published on 15 August 2019

Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies

scientific article published on 17 July 2020

Cryo-EM structures of the human volume-regulated anion channel LRRC8

scientific article published on 20 August 2018

Crystal Structure and Activity of the Endoribonuclease Domain of the piRNA Pathway Factor Maelstrom

scientific article

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

scientific article

Crystal Structure of Silkworm PIWI-Clade Argonaute Siwi Bound to piRNA

scientific article

Crystal structure of Cex1p reveals the mechanism of tRNA trafficking between nucleus and cytoplasm ⬇️

scientific article published on February 8, 2013

Crystal structure of Drosophila Piwi

scientific article published on 12 February 2020

Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling

scientific article

Crystal structure of Saccharomyces cerevisiae mitochondrial GatFAB reveals a novel subunit assembly in tRNA-dependent amidotransferases

scientific article

Crystal structure of a claudin provides insight into the architecture of tight junctions

scientific article

Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification ⬇️

scientific article published on October 23, 2010

Crystal structure of archaeosine tRNA-guanine transglycosylase

scientific article

Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

scientific article

Crystal structure of human DAAM1 formin homology 2 domain

scientific article

Crystal structure of human endothelin ETB receptor in complex with peptide inverse agonist IRL2500

scientific article published on 21 June 2019

Crystal structure of plant vacuolar iron transporter VIT1

scientific article published on 11 February 2019

Crystal structure of the MgtE Mg2+ transporter

scientific article

Crystal structure of the Pyrococcus horikoshii DNA primase-UTP complex: implications for the mechanism of primer synthesis

scientific article

Crystal structure of the Sec4p⋅Sec2p complex in the nucleotide exchanging intermediate state

scientific article

Crystal structure of the channelrhodopsin light-gated cation channel

scientific article

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

scientific article

Crystal structure of the cytosolic domain of the cation diffusion facilitator family protein

scientific article

Crystal structure of the homologous-pairing domain from the human Rad52 recombinase in the undecameric form

scientific article

Crystal structure of the human centromere protein B (CENP-B) dimerization domain at 1.65-A resolution

scientific article

Crystal structure of the radical SAM enzyme catalyzing tricyclic modified base formation in tRNA

scientific article

Crystal structure of the red light-activated channelrhodopsin Chrimson

scientific article published in Nature Communications

Crystal structure of the tRNA processing enzyme RNase PH from Aquifex aeolicus

scientific article (publication date: 22 August 2003)

Crystal structures of human ET receptor provide mechanistic insight into receptor activation and partial activation

scientific article published in Nature Communications

Crystal structures of the CP1 domain from Thermus thermophilus isoleucyl-tRNA synthetase and its complex with L-valine

scientific article

DUSP10 constrains innate IL-33-mediated cytokine production in ST2 memory-type pathogenic Th2 cells

scientific article published in Nature Communications

Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure

scientific article

Expanding Role of the Jumonji C Domain as an RNA Hydroxylase ⬇️

scientific article published on August 25, 2010

Functional convergence of two lysyl-tRNA synthetases with unrelated topologies

scientific article

Functional roles of Mg2+ binding sites in ion-dependent gating of a Mg2+ channel, MgtE, revealed by solution NMR.

scientific article published on 3 April 2018

Mg2+-dependent gating of bacterial MgtE channel underlies Mg2+ homeostasis

scientific article

Mg2+-sensing mechanism of Mg2+ transporter MgtE probed by molecular dynamics study

scientific article

Molecular insights into atypical modes of β-arrestin interaction with seven transmembrane receptors

scientific article published on 04 January 2024

Omnipotent role of archaeal elongation factor 1 alpha (EF1α) in translational elongation and termination, and quality control of protein synthesis ⬇️

scientific article published on October 25, 2010

Outward- and inward-facing structures of a putative bacterial transition-metal transporter with homology to ferroportin

scientific article

Publisher Correction: Base editors for simultaneous introduction of C-to-T and A-to-G mutations

scientific article published on 05 June 2020

Pyrrolysyl-tRNA synthetase-tRNA(Pyl) structure reveals the molecular basis of orthogonality

scientific article

Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopy.

scientific article published on 10 November 2017

Real-time observation of flexible domain movements in CRISPR-Cas9.

scientific article published on 12 April 2018

Salicylic acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity

scientific article

Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe

scientific article

Simplification of the genetic code: restricted diversity of genetically encoded amino acids

scientific article

Structural Basis for the Altered PAM Specificities of Engineered CRISPR-Cas9

scientific article

Structural Basis for the Catalytic Mechanism of DncV, Bacterial Homolog of Cyclic GMP-AMP Synthase

scientific article

Structural Basis for the Counter-Transport Mechanism of a H + /Ca 2+ Exchanger ⬇️

scientific article published on May 23, 2013

Structural Insights into Divalent Cation Modulations of ATP-Gated P2X Receptor Channels

scientific article

Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS

scientific article

Structural and biochemical analyses of hemimethylated DNA binding by the SeqA protein

scientific article

Structural basis for Na(+) transport mechanism by a light-driven Na(+) pump

scientific article

Structural basis for amino acid export by DMT superfamily transporter YddG

scientific article

Structural basis for dynamic mechanism of nitrate/nitrite antiport by NarK

scientific article

Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain

scientific article

Structural basis for mRNA surveillance by archaeal Pelota and GTP-bound EF1α complex

scientific article

Structural basis for nonribosomal peptide synthesis by an aminoacyl-tRNA synthetase paralog ⬇️

scientific article published on February 15, 2011

Structural basis for oligomerization of the prokaryotic peptide transporter PepT

scientific article published on 24 April 2019

Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion

scientific article (publication date: June 2003)

Structural basis for potent inhibition of SIRT2 deacetylase by a macrocyclic peptide inducing dynamic structural change

scientific article

Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains

scientific article

Structural basis for specific inhibition of Autotaxin by a DNA aptamer

scientific article

Structural basis for the drug extrusion mechanism by a MATE multidrug transporter ⬇️

scientific article published on March 27, 2013

Structural basis for the promiscuous PAM recognition by Corynebacterium diphtheriae Cas9

scientific article published on 29 April 2019

Structural basis for translation termination by archaeal RF1 and GTP-bound EF1  complex

scientific article

Structural basis for translational fidelity ensured by transfer RNA lysidine synthetase

scientific article

Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2

scientific article

Structural basis of novel interactions between the small-GTPase and GDI-like domains in prokaryotic FeoB iron transporter

scientific article

Structural basis of replication origin recognition by the DnaA protein

scientific article (publication date: 15 April 2003)

Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4

scientific article

Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2

scientific article published on 15 November 2021

Structural insights into RNA-dependent eukaryal and archaeal selenocysteine formation

scientific article

Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1

scientific article published in Nature Communications

Structural insights into tetraspanin CD9 function

scientific article published on 30 March 2020

Structural insights into the mechanism of rhodopsin phosphodiesterase

scientific article published on 05 November 2020

Structure and function of Zucchini endoribonuclease in piRNA biogenesis

scientific article

Structure and function of a membrane component SecDF that enhances protein export

scientific article

Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition

scientific article

Structure of a tRNA-dependent kinase essential for selenocysteine decoding

scientific article

Structure of an archaeal non-discriminating glutamyl-tRNA synthetase: a missing link in the evolution of Gln-tRNAGln formation

scientific article

Structure of the triose-phosphate/phosphate translocator reveals the basis of substrate specificity.

scientific article

Structure ofSaccharomyces cerevisiaemitochondrial Qri7 in complex with AMP

scientific article

Structures and mechanisms of CRISPR RNA-guided effector nucleases

scientific article

Taste transduction and channel synapses in taste buds

scientific article published on 16 September 2020

The structure of alanyl-tRNA synthetase with editing domain

scientific article published on 7 July 2009

The structure of lipid nanodisc-reconstituted TRPV3 reveals the gating mechanism

scientific article published on 22 June 2020

Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases

scientific article

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