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List of works by Jeffrey Trent

8q24 risk alleles and prostate cancer in African-Barbadian men.

scientific article

A BAP1 mutation in a Danish family predisposes to uveal melanoma and other cancers

scientific article

A Genome-wide Association Study Reveals that Variants within the HLA Region Are Associated with Risk for Nonobstructive Azoospermia ⬇️

scientific article published on April 26, 2012

A Pharmacological Chaperone Molecule Induces Cancer Cell Death by Restoring Tertiary DNA Structures in Mutant hTERT Promoters

scientific article published on 19 September 2016

A common intronic variant of PARP1 confers melanoma risk and mediates melanocyte growth via regulation of MITF. ⬇️

scientific article

A cryptic BAP1 splice mutation in a family with uveal and cutaneous melanoma, and paraganglioma

scientific article published in October 2012

A genome scan for eye color in 502 twin families: most variation is due to a QTL on chromosome 15q.

scientific article

A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population

scientific article published on 14 December 2011

A major locus for hereditary prostate cancer in Finland: localization by linkage disequilibrium of a haplotype in the HPCX region

scientific article published on 20 May 2005

A major locus for hereditary prostate cancer in Finland: localization by linkage disequilibrium of a haplotype in the HPCX region

scholarly article by Agnes B. Baffoe-Bonnie et al published 22 October 2005 in Human Genetics

A novel missense mutation in ACTG1 causes dominant deafness in a Norwegian DFNA20/26 family, but ACTG1 mutations are not frequent among families with hereditary hearing impairment.

scientific article published on 14 June 2006

A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

scientific article published on 13 November 2011

A recurrent germline BAP1 mutation and extension of the BAP1 tumor predisposition spectrum to include basal cell carcinoma

scientific article

Abstract 3417: The genomic landscape of canine melanoma reveals broad mutational heterogeneity and recurrent patterns of structural variation

Abstract 4487: An INDEL variant confers melanoma risk through PARP1 expression regulation

Adrenocortical carcinoma survival rates correlated to genomic copy number variants

scientific article published in February 2008

Advancing a clinically relevant perspective of the clonal nature of cancer

scientific article

Alpha-methylacyl-CoA racemase: a new molecular marker for prostate cancer.

scientific article

An integrated framework for reporting clinically relevant biomarkers from paired tumor/normal genomic and transcriptomic sequencing data in support of clinical trials in personalized medicine

scientific article

Analysis of variability in high throughput screening data: applications to melanoma cell lines and drug responses

scientific article

Arginine depletion therapy with ADI-PEG20 limits tumor growth in argininosuccinate synthase deficient ovarian cancer, including small cell carcinoma of the ovary, hypercalcemic type

scientific article published on 14 May 2020

Assessing Combinational Drug Efficacy in Cancer Cells by Using Image-based Dynamic Response Analysis.

scientific article published on January 2015

Assessment of PALB2 as a candidate melanoma susceptibility gene

scientific article

Association of prostate cancer risk with snps in regions containing androgen receptor binding sites captured by ChIP‐On‐chip analyses ⬇️

scientific article published on June 10, 2011

Cancer of the ampulla of Vater: analysis of the whole genome sequence exposes a potential therapeutic vulnerability ⬇️

scientific article published on July 4, 2012

Canine osteosarcoma genome sequencing identifies recurrent mutations in DMD and the histone methyltransferase gene SETD2

scientific article published on 19 July 2019

Characterization of X chromosome inactivation using integrated analysis of whole-exome and mRNA sequencing

scientific article published in 2014

Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region.

scientific article

Common sequence variants on 20q11.22 confer melanoma susceptibility

scientific article published on 18 May 2008

Conditioning-based modeling of contextual genomic regulation

scientific article published on April 2009

Contribution of HPC1 (RNASEL) and HPCX variants to prostate cancer in a founder population

scientific article

Correlates of clinical benefit from immunotherapy and targeted therapy in metastatic renal cell carcinoma: comprehensive genomic and transcriptomic analysis

scientific article published on 01 July 2020

Deletion mapping suggests that the 1p22 melanoma susceptibility gene is a tumor suppressor localized to a 9-mb interval

article

Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib

scientific article

Differential responses of stress genes to low dose-rate gamma irradiation ⬇️

scientific article published on April 1, 2003

Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type.

scientific article published on 10 September 2015

Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27

scientific article

E6201, an intravenous MEK1 inhibitor, achieves an exceptional response in BRAF V600E-mutated metastatic malignant melanoma with brain metastases

scientific article published on 28 September 2018

Effects of HIV-1 Nef on cellular gene expression profiles

scientific article

Effects of HIV-1 nef on cellular gene expression profiles

scientific article (publication date: 2002)

Effects of RNase L mutations associated with prostate cancer on apoptosis induced by 2',5'-oligoadenylates ⬇️

scientific article published on October 15, 2003

Epigenetic transdifferentiation of normal melanocytes by a metastatic melanoma microenvironment

scientific article published on November 2005

Erratum: Genome-wide linkage scan for atypical nevi in p16-Leiden melanoma families

scholarly article published in European Journal of Human Genetics

Erratum: Genome-wide scanning for linkage in Finnish breast cancer families

scholarly article published in European Journal of Human Genetics

Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing

scientific article published on 09 September 2021

Evaluation of DLC1 as a prostate cancer susceptibility gene: mutation screen and association study

scientific article

Evaluation of pre-analytical factors affecting plasma DNA analysis.

scientific article

Evidence for a general cancer susceptibility locus at 3p24 in families with hereditary prostate cancer

scientific article published on 01 March 2005

Evidence for a prostate cancer susceptibility locus on the X chromosome.

article

Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12

scientific article

Feasibility of circulating tumor DNA analysis in dogs with naturally occurring malignant and benign splenic lesions

scientific article published on 15 April 2022

Fine-mapping the putative chromosome 17q21–22 prostate cancer susceptibility gene to a 10 cM region based on linkage analysis

article

Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing

scientific article published on 25 December 2011

From GWAS to genome sequencing: complementary approaches to identify melanoma predisposition genes

scientific article

Functional evidence implicating S100P in prostate cancer progression

scientific article

Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease

scientific article published on 08 July 2003

Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis

scientific article (publication date: 15 May 2002)

Gene-expression profiling in human cutaneous melanoma

scientific article

GeneLink: a database to facilitate genetic studies of complex traits

scientific article

Generation and analysis of melanoma SAGE libraries: SAGE advice on the melanoma transcriptome

scientific article

Genome and Transcriptome Sequencing in Prospective Metastatic Triple-Negative Breast Cancer Uncovers Therapeutic Vulnerabilities ⬇️

scientific article published on November 19, 2012

Genome-Wide Association Study for Serum Complement C3 and C4 Levels in Healthy Chinese Subjects ⬇️

scientific article published on September 13, 2012

Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3

scientific journal article

Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men

scientific article published on 24 February 2012

Genome-wide homozygosity mapping localizes a gene for autosomal recessive non-progressive infantile ataxia to 20q11-q13

article

Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer Study (AAHPC)

scientific article published on 01 January 2007

Genome-wide linkage scan for atypical nevi in p16-Leiden melanoma families

article published in 2008

Genome-wide linkage scan for prostate cancer susceptibility genes in men with aggressive disease: significant evidence for linkage at chromosome 15q12.

scientific article published in March 2006

Genome-wide scan for linkage in finnish hereditary prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26.

scientific article

Genome-wide scan for prostate cancer susceptibility genes using families from the University of Michigan prostate cancer genetics project finds evidence for linkage on chromosome 17 near BRCA1.

scientific article published on December 2003

Genome-wide scanning for linkage in Finnish breast cancer families

article

Genome-wide screen for prostate cancer susceptibility genes in men with clinically significant disease

scientific article

Genome‐wide scan for prostate cancer susceptibility genes in the Johns Hopkins hereditary prostate cancer families ⬇️

scientific article published on December 1, 2003

Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer

scientific article published on 8 April 2002

Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk

scientific article (publication date: October 2002)

HACE1 prevents lung carcinogenesis via inhibition of RAC-family GTPases

scientific article published on 04 May 2020

Hereditary prostate cancer in Finland: fine-mapping validates 3p26 as a major predisposition locus

scholarly article by Annika R�kman et al published 11 November 2004 in Human Genetics

High frequency of BRAF mutations in nevi

scientific article

High-throughput RNAi Screening Identifies a Role for TNK1 in Growth and Survival of Pancreatic Cancer Cells ⬇️

scientific article published on May 2, 2011

Histone Deacetylase Inhibitors Synergize with Catalytic Inhibitors of EZH2 to Exhibit Antitumor Activity in Small Cell Carcinoma of the Ovary, Hypercalcemic Type

scientific article published on 19 September 2018

Identification and characterization of mouse Rab32 by mRNA and protein expression analysis

scientific article published on September 2003

Identification of Recurrent Activating HER2 Mutations in Primary Canine Pulmonary Adenocarcinoma

scientific article published on 20 August 2019

Identification of a prostate cancer susceptibility locus on chromosome 7q11-21 in Jewish families

scholarly article

Identification of combination gene sets for glioma classification.

scientific article

Identifying treatment options for BRAFV600 wild-type metastatic melanoma: A SU2C/MRA genomics-enabled clinical trial

scientific article published on 07 April 2021

Improved methods for RNAseq-based alternative splicing analysis

scientific article published on 24 May 2021

Inference from clustering with application to gene-expression microarrays

scientific article

Inherited genetic variant predisposes to aggressive but not indolent prostate cancer

scientific article

Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma

scientific article published on April 2017

Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen

scientific article published on January 2008

Integration of genomic technologies for accelerated cancer drug development

scientific article published on September 2003

Interaction effect of PTEN and CDKN1B chromosomal regions on prostate cancer linkage

scientific article published on 5 June 2004

Joint effect of HSD3B1 and HSD3B2 genes is associated with hereditary and sporadic prostate cancer susceptibility

scientific article published on 01 March 2002

Localization of a novel melanoma susceptibility locus to 1p22

scientific article

Looking beyond morphology: cancer gene expression profiling using DNA microarrays

scientific article published on January 2003

Loss of Inositol Polyphosphate 5-Phosphatase Is an Early Event in Development of Cutaneous Squamous Cell Carcinoma ⬇️

scientific article published on September 28, 2010

Loss of the tumor suppressor SMARCA4 in small cell carcinoma of the ovary, hypercalcemic type (SCCOHT).

scientific article published on 3 November 2014

Loss-of-function fibroblast growth factor receptor-2 mutations in melanoma

scientific article

Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia

scientific article published in May 2003

Molecular classification of familial non-BRCA1/BRCA2 breast cancer

scholarly article

Molecular determinants of human uveal melanoma invasion and metastasis

scientific article published in January 2002

Network Rewiring in Cancer: Applications to Melanoma Cell Lines and the Cancer Genome Atlas Patients

scientific article published on 10 July 2018

Noise factor analysis for cDNA microarrays

scientific article published in July 2004

Nonlinear mixed effects dose response modeling in high throughput drug screens: application to melanoma cell line analysis

scientific article published on 15 December 2017

Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma

scientific article

Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer

scientific article published on 8 August 2004

Notch and NOXA-related pathways in melanoma cells.

scientific article

Personalized treatment of Sézary syndrome by targeting a novel CTLA4:CD28 fusion.

scientific article

Perspectives from man's best friend: National Academy of Medicine's Workshop on Comparative Oncology.

scientific article published on February 2016

Physical and transcript map of the hereditary prostate cancer region at xq27.

scientific article

Pilot Trial of Selecting Molecularly Guided Therapy for Patients with Non-V600 BRAF-Mutant Metastatic Melanoma: Experience of the SU2C/MRA Melanoma Dream Team.

scientific article published on 10 June 2015

Polymorphic GGC repeats in the androgen receptor gene are associated with hereditary and sporadic prostate cancer risk

scientific article published on 23 January 2002

Ponatinib shows potent antitumor activity in small cell carcinoma of the ovary hypercalcemic type (SCCOHT) through multi-kinase inhibition

scientific article published on 9 February 2018

Precision medicine: an opportunity for a paradigm shift in veterinary medicine

scientific article published on January 2016

Prospective feasibility trial for genomics-informed treatment in recurrent and progressive glioblastoma.

scientific article published on 26 October 2017

Prospective molecular profiling of canine cancers provides a clinically relevant comparative model for evaluating personalized medicine (PMed) trials

scientific article (publication date: 2014)

Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells

scientific article published on July 2005

RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases

scientific article published on 4 November 2002

Random DNA fragmentation allows detection of single-copy, single-exon alterations of copy number by oligonucleotide array CGH in clinical FFPE samples

scientific article

Randomized trial assessing impact of probiotic supplementation on gut microbiome and clinical outcome from targeted therapy in metastatic renal cell carcinoma

scientific article published on 01 November 2020

Re-assigning the histologic identities of COV434 and TOV-112D ovarian cancer cell lines

scientific article published on 13 December 2020

SDHD Promoter Mutations Ablate GABP Transcription Factor Binding in Melanoma.

scientific article published on 20 January 2017

Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4

scientific article

Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines

scientific article published on 10 March 2020

Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis

scientific article published on 06 September 2018

Stool Microbiome Profiling of Patients with Metastatic Renal Cell Carcinoma Receiving Anti-PD-1 Immune Checkpoint Inhibitors

scientific article published on 02 August 2020

Strategies for testing intervention matching schemes in cancer

scientific article published on 14 June 2020

Stress-gene induction by low-dose gamma irradiation

scientific article published on February 2002

Stress-specific signatures: expression profiling of p53 wild-type and -null human cells

scientific article

Strong feature sets from small samples

scientific article published in January 2002

Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer

scientific article

Temporospatial genomic profiling in glioblastoma identifies commonly altered core pathways underlying tumor progression

scientific article published on 01 January 2020

The BioIntelligence Framework: a new computational platform for biomedical knowledge computing ⬇️

scientific article published on August 2, 2012

The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition.

scientific article

The histone methyltransferase EZH2 is a therapeutic target in small cell carcinoma of the ovary, hypercalcaemic type.

scientific article

The identification of trans-associations between prostate cancer GWAS SNPs and RNA expression differences in tumor-adjacent stroma

scientific article published on January 2015

The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type.

scientific article

The interaction of four genes in the inflammation pathway significantly predicts prostate cancer risk

scientific article

The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer

scientific article published on 10 July 2020

Toward a drug development path that targets metastatic progression in osteosarcoma.

scientific article

Toward precision medicine in glioblastoma: the promise and the challenges

scientific article published on May 2015

Tracking transcriptional activities with high-content epifluorescent imaging ⬇️

scientific article published on April 1, 2012

Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibility

scientific article published on 18 March 2019

Two-locus genome-wide linkage scan for prostate cancer susceptibility genes with an interaction effect

article

Which is better for cDNA-microarray-based classification: ratios or direct intensities

scientific article published on 28 September 2004

Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma

scientific article

p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas

scientific article

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