Search filters

List of works by J. Keith Joung

A Code of Ethics for Gene Drive Research

scientific article published on 11 February 2021

A combined yeast/bacteria two-hybrid system: development and evaluation

scientific article

A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing

scientific article published on 01 June 2020

A synthetic biology framework for programming eukaryotic transcription functions.

scientific article

A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing.

scientific article

Accelerating research through reagent repositories: the genome editing example

scientific article

Activities and specificities of CRISPR/Cas9 and Cas12a nucleases for targeted mutagenesis in maize

scientific article published on 22 July 2018

Adopt a moratorium on heritable genome editing

scientific article published on 01 March 2019

Allele-Specific CRISPR-Cas9 Genome Editing of the Single-Base P23H Mutation for Rhodopsin-Associated Dominant Retinitis Pigmentosa

scientific article published on 01 February 2018

Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss

scientific article published on 03 July 2019

Allosteric inhibition of zinc-finger binding in the major groove of DNA by minor-groove binding ligands

scientific article published in April 2004

An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities

scientific article published on 30 July 2018

An affinity-based scoring scheme for predicting DNA-binding activities of modularly assembled zinc-finger proteins.

scientific article published on 04 December 2008

An improved predictive recognition model for Cys(2)-His(2) zinc finger proteins

scientific article published on 12 February 2014

An improved strategy for constructing "designer" Cys2His2 zinc finger proteins

scientific article

Augmenting and directing long-range CRISPR-mediated activation in human cells

scientific article published on 05 August 2021

Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion.

scientific article

Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity

scientific article

Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition

scientific article

Building with biological LEGO. Interview by Kristie Nybo

scientific article published in June 2012

CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants

scientific article published on 23 September 2015

CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR-Cas9 nuclease off-targets

scientific article

CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells

scientific article published on 20 July 2020

CRISPR DNA base editors with reduced RNA off-target and self-editing activities

scientific article published on 02 September 2019

CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data

scientific article published on 01 December 2018

CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease.

scientific article

CRISPResso2 provides accurate and rapid genome editing sequence analysis

scientific article published on 01 March 2019

Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway.

scientific article published on 18 March 2017

Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

scientific article

Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources

scientific article published on 01 September 2020

Chromatin regulation at the frontier of synthetic biology

scientific article

Comparison of zinc finger nucleases for use in gene targeting in mammalian cells

scientific article

Context influences on TALE-DNA binding revealed by quantitative profiling

scientific article published on 11 June 2015

Continuous directed evolution of DNA-binding proteins to improve TALEN specificity.

scientific article

Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair.

scientific article published on 20 January 2014

Counter-selectable marker for bacterial-based interaction trap systems

scientific article

DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases

scientific article published on 20 November 2007

Defining CRISPR-Cas9 genome-wide nuclease activities with CIRCLE-seq

scientific article published in November 2018

Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases

scientific article published on April 2016

Dimeric CRISPR RNA-Guided FokI-dCas9 Nucleases Directed by Truncated gRNAs for Highly Specific Genome Editing

scientific article

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

scientific article

Discovery of widespread type I and type V CRISPR-Cas inhibitors

scientific article published in Science

Disruption of asxl1 results in myeloproliferative neoplasms in zebrafish.

scientific article

Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish

scientific article published on 04 March 2020

Efficient CRISPR/Cas9-mediated editing of trinucleotide repeat expansion in myotonic dystrophy patient-derived iPS and myogenic cells

scientific article published in September 2018

Efficient genome editing in zebrafish using a CRISPR-Cas system

scientific article

Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing

article

Engineered CRISPR-Cas9 nucleases with altered PAM specificities

scientific article

Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects

scientific article

Engineering Customized TALE Nucleases (TALENs) and TALE Transcription Factors by Fast Ligation‐Based Automatable Solid‐Phase High‐Throughput (FLASH) Assembly ⬇️

scientific article published on July 1, 2013

Engineering Cys2His2 zinc finger domains using a bacterial cell-based two-hybrid selection system

scientific article

Engineering Designer Nucleases with Customized Cleavage Specificities ⬇️

scientific article published on October 1, 2011

Engineering Designer Transcription Activator‐‐Like Effector Nucleases (TALENs) by REAL or REAL‐Fast Assembly ⬇️

scientific article published on October 1, 2012

Engineering Single Cys2His2 Zinc Finger Domains Using a Bacterial Cell-Based Two-Hybrid Selection System ⬇️

scientific article published on January 1, 2010

Engineering zinc finger nucleases for targeted mutagenesis of zebrafish

scientific article published on January 1, 2011

Enhanced proofreading governs CRISPR-Cas9 targeting accuracy

scientific article published on 20 September 2017

Evaluation of OPEN zinc finger nucleases for direct gene targeting of the ROSA26 locus in mouse embryos

scientific article

FLASH assembly of TALENs for high-throughput genome editing ⬇️

scientific article published on May 1, 2012

Fanconi anemia gene editing by the CRISPR/Cas9 system

scientific article

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

scientific article

Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells

scientific article published on 18 June 2009

Gene therapy comes of age.

scientific article published in January 2018

Genome Editing in Human Cells Using CRISPR/Cas Nucleases

scientific article published on October 2015

Genome editing of factor X in zebrafish reveals unexpected tolerance of severe defects in the common pathway.

scientific article published on 2 June 2017

Genome editing technologies: defining a path to clinic

scientific article published on May 2015

Genome editing: a tool for research and therapy: towards a functional understanding of variants for molecular diagnostics using genome editing

scientific article published in October 2014

Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells.

scientific article published on 27 June 2016

Heritable and Precise Zebrafish Genome Editing Using a CRISPR-Cas System ⬇️

scientific article published on July 9, 2013

High frequency targeted mutagenesis in Arabidopsis thaliana using zinc finger nucleases

scientific article

High levels of AAV vector integration into CRISPR-induced DNA breaks

scientific article published on 30 September 2019

High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects.

scientific article

High-frequency modification of plant genes using engineered zinc-finger nucleases

scientific article

High-throughput beta-galactosidase assay for bacterial cell-based reporter systems

scientific article published in March 2004

Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs ⬇️

scientific article published on June 7, 2012

Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection ⬇️

scientific article published on October 3, 2003

Hypoxia drives transient site-specific copy gain and drug-resistant gene expression.

scientific article published on May 2015

Identification of promoter targets of enhancers by epigenetic knockdown using TAL DNA binding proteins.

scientific article published on 18 March 2013

Impact of Genetic Variation on CRISPR-Cas Targeting

scientific article published on 01 April 2018

Improved Somatic Mutagenesis in Zebrafish Using Transcription Activator-Like Effector Nucleases (TALENs) ⬇️

scientific article published on May 24, 2012

In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites ⬇️

scientific article published on August 14, 2013

In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases ⬇️

scientific article published on November 1, 2011

In vivo CRISPR editing with no detectable genome-wide off-target mutations

scientific article published in Nature

Inducible and multiplex gene regulation using CRISPR-Cpf1-based transcription factors.

scientific article

Induction of stable drug resistance in human breast cancer cells using a combinatorial zinc finger transcription factor library

scientific article

Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation.

scientific article published on December 2013

Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma

scientific article

IκB kinase β (IKBKB) mutations in lymphomas that constitutively activate canonical nuclear factor κB (NFκB) signaling.

scientific article

Locus-specific editing of histone modifications at endogenous enhancers

scientific article

Multidimensional control of therapeutic human cell function with synthetic gene circuits

scientific article published on 16 December 2022

Mutant Allele-Specific CRISPR Disruption in DYT1 Dystonia Fibroblasts Restores Cell Function

scientific article published on 15 May 2020

Nodal patterning without Lefty inhibitory feedback is functional but fragile

scientific article published on 7 December 2017

Oligomerized pool engineering (OPEN): an 'open-source' protocol for making customized zinc-finger arrays

scientific article

Open-source guideseq software for analysis of GUIDE-seq data.

scientific article

Optimization of AsCas12a for combinatorial genetic screens in human cells

scientific article published on 13 July 2020

Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.

scientific article

Plant science. DNA binding made easy.

scientific article

Predicting success of oligomerized pool engineering (OPEN) for zinc finger target site sequences ⬇️

scientific article published on November 2, 2010

Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs

scientific article published on 10 January 2018

PrimeDesign software for rapid and simplified design of prime editing guide RNAs

scientific article published on 15 February 2021

Profiling the DNA-binding specificities of engineered Cys2His2 zinc finger domains using a rapid cell-based method

scientific article

Publisher Correction: Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing

scientific article published on 15 June 2020

Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification

scientific article

Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN).

scientific article

Reply to "Genome editing with modularly assembled zinc-finger nucleases"

academic article

Repression of phase-variable cup gene expression by H-NS-like proteins in Pseudomonas aeruginosa

scientific article

Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model.

scientific article published on 22 May 2015

Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo"

Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection

scientific article (publication date: 7 August 2011)

Robust, synergistic regulation of human gene expression using TALE activators ⬇️

scientific article published on February 10, 2013

Scalable characterization of the PAM requirements of CRISPR-Cas enzymes using HT-PAMDA

scientific article published on 05 February 2021

Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA)

scientific article

Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly.

scientific article

Standards needed for gene-editing errors

scientific article published in Nature

Synthetic protein-protein interaction domains created by shuffling Cys2His2 zinc-fingers

scientific article published on 21 March 2006

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage

scientific article

TALEN-based gene correction for epidermolysis bullosa.

scientific article published on 2 April 2013

TALENs: a widely applicable technology for targeted genome editing ⬇️

scientific article published on November 21, 2012

Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins

scientific article

Targeted Mutagenesis in Zebrafish Using CRISPR RNA-Guided Nucleases

scientific article published on January 2015

Targeted deletion and inversion of tandemly arrayed genes in Arabidopsis thaliana using zinc finger nucleases

scientific article published on 03 October 2013

Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells

scientific article published on 30 March 2015

Targeted gene disruption in somatic zebrafish cells using engineered TALENs ⬇️

scientific article published on August 5, 2011

Targeted genome editing in human cells using CRISPR/Cas nucleases and truncated guide RNAs

scientific article

Targeted mutagenesis in zebrafish using customized zinc-finger nucleases

scientific article published on January 2009

Targeted mutagenesis of duplicated genes in soybean with zinc-finger nucleases

scientific article

Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function.

scientific article

Technologies and Computational Analysis Strategies for CRISPR Applications

scientific article published on 01 July 2020

Temporal and Spatial Post-Transcriptional Regulation of Zebrafish Tie1 mRNA by Long Noncoding RNA During Brain Vascular Assembly.

scientific article

The Bacterial Two-Hybrid System as a Reporter System for Analyzing Protein-Protein Interactions ⬇️

scientific article published on 01 March 2007

Therapeutic base editing of human hematopoietic stem cells

scientific article published on 16 March 2020

Toddler: an embryonic signal that promotes cell movement via Apelin receptors

scientific article

Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors

scientific article published on 17 April 2019

Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases

scientific article published in February 2013

Unexpected failure rates for modular assembly of engineered zinc fingers

scientific article

What's changed with genome editing?

scientific article published on 01 July 2014

ZFNGenome: a comprehensive resource for locating zinc finger nuclease target sites in model organisms.

scientific article

Zebrafish dscaml1 Deficiency Impairs Retinal Patterning and Oculomotor Function

scientific article published on 04 November 2019

ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool

scientific article

Zinc Finger Database (ZiFDB): a repository for information on C2H2 zinc fingers and engineered zinc-finger arrays

scientific article published on 23 September 2008

Zinc Finger Targeter (ZiFiT): an engineered zinc finger/target site design tool.

scientific article

Zinc-finger Nucleases: The Next Generation Emerges

Zinc-finger nucleases for somatic gene therapy: the next frontier

scientific article

Zinc-finger nucleases: the next generation emerges

scientific article

piggyBac transposase tools for genome engineering

scientific article published on 30 May 2013

Paulina is supported by:

About Paulina

Help