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List of works by J. Keith Joung

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Efficient genome editing in zebrafish using a CRISPR-Cas system

scientific article
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

scientific article
High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects.

scientific article
TALENs: a widely applicable technology for targeted genome editing

scientific article published on November 21, 2012
FLASH assembly of TALENs for high-throughput genome editing

scientific article published on May 1, 2012
Engineered CRISPR-Cas9 nucleases with altered PAM specificities

scientific article
Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

scientific article published on April 25, 2014
Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

scientific article published on October 30, 2014
Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification

scientific article
Targeted gene disruption in somatic zebrafish cells using engineered TALENs

scientific article published on August 5, 2011
Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells

scientific article published on 18 June 2009
High-frequency modification of plant genes using engineered zinc-finger nucleases

scientific article
Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA)

scientific article
Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins

scientific article published on October 9, 2013
Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection

scientific article (publication date: 7 August 2011)
A synthetic biology framework for programming eukaryotic transcription functions.

scientific article
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy

scientific article published on 20 September 2017
Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells.

scientific article published on 27 June 2016
Unexpected failure rates for modular assembly of engineered zinc fingers

scientific article
Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.

scientific article
In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases

scientific article published on November 1, 2011
Toddler: an embryonic signal that promotes cell movement via Apelin receptors

scientific article
Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition

scientific article
Heritable and Precise Zebrafish Genome Editing Using a CRISPR-Cas System

scientific article published on July 9, 2013
Locus-specific editing of histone modifications at endogenous enhancers

scientific article
ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool

scientific article
Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation.

scientific article published on December 2013
Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells

scientific article published on 30 March 2015
Zinc-finger nucleases: the next generation emerges

scientific article
High frequency targeted mutagenesis in Arabidopsis thaliana using zinc finger nucleases

scientific article
Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs

scientific article published on June 7, 2012
Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN).

scientific article
Defining and improving the genome-wide specificities of CRISPR–Cas9 nucleases

scientific article published on May 1, 2016
Oligomerized pool engineering (OPEN): an 'open-source' protocol for making customized zinc-finger arrays

scientific article
CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR-Cas9 nuclease off-targets

scientific article
Zinc Finger Targeter (ZiFiT): an engineered zinc finger/target site design tool.

scientific article published on 25 May 2007
DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases

scientific article published on 20 November 2007
Gene therapy comes of age.

scientific article published in January 2018
TALEN-based gene correction for epidermolysis bullosa.

scientific article published on 2 April 2013
Robust, synergistic regulation of human gene expression using TALE activators

scientific article published on February 10, 2013
Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity

scientific article published on February 16, 2014
Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects

scientific article
Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly.

scientific article
Improved Somatic Mutagenesis in Zebrafish Using Transcription Activator-Like Effector Nucleases (TALENs)

scientific article published on May 24, 2012
Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection

scientific article published on October 3, 2003
Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors

scientific article published on 17 April 2019
Targeted mutagenesis of duplicated genes in soybean with zinc-finger nucleases

scientific article
Comparison of zinc finger nucleases for use in gene targeting in mammalian cells

scientific article
Repression of phase-variable cup gene expression by H-NS-like proteins in Pseudomonas aeruginosa

scientific article
An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities

scientific article published on 30 July 2018

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