List of works - Olavi Pelkonen

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*.

scientific article published on January 2012

A simple method for differentiation of monoisotopic drug metabolites with hydrogen-deuterium exchange liquid chromatography/electrospray mass spectrometry

scientific article published in May 2005

Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.

scientific article

An evaluation of the cytochrome P450 inhibition potential of selected pesticides in human hepatic microsomes.

scientific article published in August 2009

Analysis of nine drugs and their cytochrome P450-specific probe metabolites from urine by liquid chromatography-tandem mass spectrometry utilizing sub 2 microm particle size column

scientific article published on 7 November 2008

Analysis of reproductive toxicity and classification of glufosinate-ammonium

scientific article

Analytical challenges for conducting rapid metabolism characterization for QIVIVE.

scientific article published on 28 August 2013

Aryl hydrocarbon receptor nuclear translocator and upstream stimulatory factor regulate Cytochrome P450 2a5 transcription through a common E-box site

scientific article published on April 2007

Biotransformation in vitro: An essential consideration in the quantitative in vitro-to-in vivo extrapolation (QIVIVE) of toxicity data

scientific article

CYP-associated drug-drug interactions: A mission accomplished?

scientific article published on 06 October 2020

Characterization of Diuron N-Demethylation by Mammalian Hepatic Microsomes and cDNA-Expressed Human Cytochrome P450 Enzymes

scientific article published on 18 June 2007

Characterization of human cytochrome P450 induction by pesticides.

scientific article published on 28 January 2012

Chemical exposure and infant leukaemia: development of an adverse outcome pathway (AOP) for aetiology and risk assessment research

scientific article published on 23 May 2017

Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes.

scientific article published on 17 June 2008

Comparative metabolism of benfuracarb in in vitro mammalian hepatic microsomes model and its implications for chemical risk assessment

scientific article published on 16 August 2013

Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems

scientific article published in September 2003

Comparison of metabolic stability and metabolite identification of 55 ECVAM/ICCVAM validation compounds between human and rat liver homogenates and microsomes - a preliminary analysis.

scientific article published in January 2009

Contaminant exposure and effects in Baltic ringed and grey seals as assessed by biomarkers

scientific article published in February 2003

Corrigendum to “Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay” [Eur. J. Pharm. Sci. 24 (2005) 123–132]

scholarly article published in European Journal of Pharmaceutical Sciences

Cytochrome P450 (CYP) inhibition screening: comparison of three tests

scientific article published on 27 June 2006

Cytochrome P450 Induction and Xeno-Sensing Receptors Pregnane X Receptor, Constitutive Androstane Receptor, Aryl Hydrocarbon Receptor and Peroxisome Proliferator-Activated Receptor α at the Crossroads of Toxicokinetics and Toxicodynamics.

scientific article published on 12 March 2018

Cytochrome P450 enzyme activity in five herbivorous, non-passerine bird species

scientific article published on 01 January 2003

Diabetes and elimination of antipyrine in man: an analysis of 298 patients classified by type of diabetes, age, sex, duration of disease and liver involvement

scientific article

Differentiation-Promoting Medium Additives for Hepatocyte Cultivation and Cryopreservation

scientific article published on January 2015

Drug Metabolism - From In Vitro to In Vivo, From Simple to Complex: Reflections of the BCPT Nordic Prize 2014 Awardee

scientific article

Dual action of oestrogens on the mouse constitutive androstane receptor

scientific article published on December 2003

Editorial

scientific article published in December 2013

Editorial

Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation

scientific article published in June 2005

Effect of renal impairment on the pharmacokinetics of bupropion and its metabolites

scientific article

Effects of cytochrome P450 inhibitors and inducers on the metabolism and pharmacokinetics of ospemifene.

scientific article published on 15 August 2013

Effects of ospemifene on drug metabolism mediated by cytochrome P450 enzymes in humans in vitro and in vivo

scientific article published on 05 July 2013

Effects of pharmaceuticals and other active chemicals at biological targets: mechanisms, interactions, and integration into PB-PK/PD models.

scientific article published on July 2009

Effects of selective serotonin reuptake inhibitors on timolol metabolism in human liver microsomes and cryo-preserved hepatocytes

scientific article published on 11 November 2009

Establishing a systematic framework to characterise in vitro methods for human hepatic metabolic clearance

scientific article published on 09 August 2018

Estimation of health risk by using toxicokinetic modelling: a case study of polychlorinated biphenyl PCB153.

scientific article published on 13 July 2013

Estrogen receptor alpha genotype confers interindividual variability of response to estrogen and testosterone in mesenchymal-stem-cell-derived osteoblasts

scientific article

Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung

scientific article

Expression of CYP3A4 in human breast tumour and non-tumour tissues

scientific article

Expression of cytochrome P450 (CYP) enzymes in human nonpigmented ciliary epithelial cells: induction of CYP1B1 expression by TCDD.

scientific article published on 25 March 2009

Formation of GSH-trapped reactive metabolites in human liver microsomes, S9 fraction, HepaRG-cells, and human hepatocytes

article

From known knowns to known unknowns: predicting in vivo drug metabolites

scientific article published on May 2009

Functional expression, inhibition and induction of CYP enzymes in HepaRG cells

scientific article published on 26 March 2009

Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?

scientific article published on 16 April 2020

Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?

scientific article published on 19 April 2020

Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?

scientific article published on 28 April 2020

Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?

scientific article published on 11 April 2020

Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?

scientific article published on 29 April 2020

Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?

scientific article published on 18 June 2020

Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to evaluate the risk of the S-EDCs?

scientific article published on 08 June 2020

Human variation and CYP enzyme contribution in benfuracarb metabolism in human in vitro hepatic models

scientific article published on 7 September 2013

Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone

scientific article

Immunohistochemical demonstration of the expression of CYP2E1 in human breast tumour and non-tumour tissues

scientific article published on 01 July 2003

In silico prediction of ADME and pharmacokinetics. Report of an expert meeting organised by COST B15.

scientific article published on December 2002

In vitro interaction cocktail assay for nine major cytochrome P450 enzymes with 13 probe reactions and a single LC/MSMS run: analytical validation and testing with monoclonal anti-CYP antibodies

scientific article published on 01 July 2007

In vitro metabolism and interactions of the fungicide metalaxyl in human liver preparations.

scientific article published on 17 June 2006

In vitro methods in the prediction of kinetics of drugs: focus on drug metabolism.

scientific article

In vitro screening of drug metabolism during drug development: can we trust the predictions?

scientific article published on June 2005

In vivo-in vitro-in silico pharmacokinetic modelling in drug development: current status and future directions

scientific article

Inhibition and induction of CYP enzymes in humans: an update

scientific article published on 27 October 2020

Inhibition and induction of human cytochrome P450 enzymes: current status

scientific article published on 11 July 2008

Inhibition of cytochrome P450 2B6 activity by hormone replacement therapy and oral contraceptive as measured by bupropion hydroxylation

scientific article published on October 1, 2003

Integration of epidemiological findings with mechanistic evidence in regulatory pesticide risk assessment: EFSA experiences

scientific article published on 03 May 2019

Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia†

scientific article published in March 2017

Issues in the design and interpretation of chronic toxicity and carcinogenicity studies in rodents: approaches to dose selection.

scientific article published on January 2007

Lack of association between CYP2A5 induction and apoptosis in mouse primary hepatocytes

scientific article published in February 2002

Liquid chromatography-mass spectrometry in in vitro drug metabolite screening.

scientific article published on 26 December 2008

Local kinetics and dynamics of xenobiotics

scientific article published on 01 January 2008

Marked effect of liver and kidney function on the pharmacokinetics of selegiline

scientific article published in January 2005

Metabolic and Efflux Properties of Caco-2 Cells Stably Transfected with Nuclear Receptors

scientific article published on 09 August 2006

Metabolism and metabolite profiles in vitro and in vivo of ospemifene in humans and preclinical species

scientific article published on 18 November 2015

Metabolism and pharmacokinetics in children and the elderly

scientific article published on 01 April 2007

Metabolism of carbosulfan II. Human interindividual variability in its in vitro hepatic biotransformation and the identification of the cytochrome P450 isoforms involved.

scientific article published on 20 March 2010

Metabolism of carbosulfan. I. Species differences in the in vitro biotransformation by mammalian hepatic microsomes including human.

scientific article

Metabolism of ophthalmic timolol: new aspects of an old drug

scientific article published on May 2011

Metabolism of α-thujone in human hepatic preparationsin vitro ⬇️

scientific article published on November 18, 2010

Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54

scientific article published on 01 February 2006

Molecular approaches to the identification of biomarkers of exposure and effect--report of an expert meeting organized by COST Action B15. November 28, 2003.

scientific article

Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay

scientific article published in January 2005

Obfuscating transparency?

scientific article published on 11 July 2018

Omics and its potential impact on R&D and regulation of complex herbal products

scientific article published on February 2012

Open letter to the European Commission: scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science, and risk assessment principles

scientific article published on 27 August 2013

Ospemifene metabolism in humans in vitro and in vivo: metabolite identification, quantitation, and CYP assignment of major hydroxylations

scientific article published on January 2013

Pharmacokinetics of thiamine in female Baltic salmon (Salmo salar L.) broodfish

scientific article published on January 2005

Placental transfer and DNA binding of benzo(a)pyrene in human placental perfusion

scientific article

Polycyclic aromatic hydrocarbon (PAH) metabolizing enzyme activities in human lung, and their inducibility by exposure to naphthalene, phenanthrene, pyrene, chrysene, and benzo(a)pyrene as shown in the rat lung and liver

scientific article published on 12 August 2006

Prediction of drug metabolism and interactions on the basis of in vitro investigations.

scientific article

Predictive toxicity: grand challenges

scientific article published on 23 April 2010

Preservation, induction or incorporation of metabolism into the in vitro cellular system − Views to current opportunities and limitations

scientific article published on 19 June 2012

Principles of Pharmacology and Toxicology Also Govern Effects of Chemicals on the Endocrine System.

scientific article published on 30 May 2015

Rapid detection and characterization of reactive drug metabolites in vitro using several isotope-labeled trapping agents and ultra-performance liquid chromatography/time-of-flight mass spectrometry

scientific article

Reactive metabolites in early drug development: predictive in vitro tools

scientific article

Regulation of CYP3A genes in the human respiratory tract

scientific article

Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells.

scientific article published on February 2003

Regulation of Cyp2a5 transcription in mouse primary hepatocytes: roles of hepatocyte nuclear factor 4 and nuclear factor I.

scientific article published on August 2004

Regulation of the Cyp2a5 gene involves an aryl hydrocarbon receptor-dependent pathway

scientific article published on 18 January 2005

Reproductive and developmental toxicity.

scientific article published in July 2005

Response to “The Path Forward on Endocrine Disruptors Requires Focus”.

scientific article published in February 2016

Review of current and "omics" methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms

scientific article published on 22 February 2012

Scientific Opinion about the Guidance of the Chemical Regulation Directorate (UK) on how aged sorption studies for pesticides should be conducted, analysed and used in regulatory assessments

scientific article published on 27 August 2018

Scientific Opinion addressing the state of the science on risk assessment of plant protection products for in‐soil organisms

scientific article published in February 2017

Scientific Opinion of the PPR Panel on the follow‐up of the findings of the External Scientific Report ‘Literature review of epidemiological studies linking exposure to pesticides and health effects’

scientific article published in October 2017

Scientific Opinion of the Scientific Panel on Plant Protection Products and their Residues (PPR Panel) on the genotoxic potential of triazine amine (metabolite common to several sulfonylurea active substances)

scientific article published on 09 March 2020

Scientific Opinion on the setting of health-based reference values for metabolites of the active substance terbuthylazine

scientific article published on 04 June 2019

Scientific Opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for regulatory risk assessment of pesticides for aquatic organisms

scientific article published on 23 August 2018

Scientific Opinion on the state of the science on pesticide risk assessment for amphibians and reptiles

scientific article published on 23 February 2018

Scientific opinion on pesticides in foods for infants and young children

scientific article published on 28 June 2018

Scientific statement on the coverage of bats by the current pesticide risk assessment for birds and mammals

scientific article published on 29 July 2019

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

scientific article published on 5 July 2013

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

scientific article published in December 2013

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

scientific article

Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles

scientific article published in September 2013

Selective inhibition of CYP2B6-catalyzed bupropion hydroxylation in human liver microsomes in vitro

scientific article

Selegiline Metabolism and Cytochrome P450 Enzymes:In vitro Study in Human Liver Microsomes*

Significant interspecies differences in induction profiles of hepatic CYP enzymes by TCDD in bank and field voles

scientific article

Stability of sufentanil and levobupivacaine solutions and a mixture in a 0.9% sodium chloride infusion stored in polypropylene syringes

scientific article published in May 2003

Tandem mass spectrometric analysis of S- and N-linked glutathione conjugates of pulegone and menthofuran and identification of P450 enzymes mediating their formation

scientific article published in April 2016

The functional role of CYP2B6 in human drug metabolism: substrates and inhibitors in vitro, in vivo and in silico.

scientific article published on October 2006

The inhibition of major human hepatic cytochrome P450 enzymes by 18 pesticides: comparison of the N-in-one and single substrate approaches

scientific article published on 23 May 2012

Thujone and thujone-containing herbal medicinal and botanical products: toxicological assessment.

scientific article

Timolol Metabolism in Human Liver Microsomes Is Mediated Principally by CYP2D6

scientific article published on 12 April 2007

Toxicokinetics and metabolism

scientific article published on 01 July 2005

Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches

scientific article published on 04 July 2012

Toxicology Meets Pharmacodynamics and Pharmacokinetics - New Concepts, Models and In Vitro Approaches and Tools

scientific article published on 22 August 2018

Upholding science in health, safety and environmental risk assessments and regulations

scientific article

Validation of in vitro methods for human cytochrome P450 enzyme induction: Outcome of a multi-laboratory study

scientific article published on 31 May 2019

Why is Research on Herbal Medicinal Products Important and How Can We Improve Its Quality?

scientific article

Xenobiotic metabolism of bank vole (Myodes glareolus) exposed to PCDDs

scientific article

List of works by Olavi Pelkonen

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*.

A simple method for differentiation of monoisotopic drug metabolites with hydrogen-deuterium exchange liquid chromatography/electrospray mass spectrometry

Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.

An evaluation of the cytochrome P450 inhibition potential of selected pesticides in human hepatic microsomes.

Analysis of nine drugs and their cytochrome P450-specific probe metabolites from urine by liquid chromatography-tandem mass spectrometry utilizing sub 2 microm particle size column

Analysis of reproductive toxicity and classification of glufosinate-ammonium

Analytical challenges for conducting rapid metabolism characterization for QIVIVE.

Aryl hydrocarbon receptor nuclear translocator and upstream stimulatory factor regulate Cytochrome P450 2a5 transcription through a common E-box site

Biotransformation in vitro: An essential consideration in the quantitative in vitro-to-in vivo extrapolation (QIVIVE) of toxicity data

CYP-associated drug-drug interactions: A mission accomplished?

Characterization of Diuron N-Demethylation by Mammalian Hepatic Microsomes and cDNA-Expressed Human Cytochrome P450 Enzymes

Characterization of human cytochrome P450 induction by pesticides.

Chemical exposure and infant leukaemia: development of an adverse outcome pathway (AOP) for aetiology and risk assessment research

Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes.

Comparative metabolism of benfuracarb in in vitro mammalian hepatic microsomes model and its implications for chemical risk assessment

Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems

Comparison of metabolic stability and metabolite identification of 55 ECVAM/ICCVAM validation compounds between human and rat liver homogenates and microsomes - a preliminary analysis.

Contaminant exposure and effects in Baltic ringed and grey seals as assessed by biomarkers

Corrigendum to “Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay” [Eur. J. Pharm. Sci. 24 (2005) 123–132]

Cytochrome P450 (CYP) inhibition screening: comparison of three tests

Cytochrome P450 Induction and Xeno-Sensing Receptors Pregnane X Receptor, Constitutive Androstane Receptor, Aryl Hydrocarbon Receptor and Peroxisome Proliferator-Activated Receptor α at the Crossroads of Toxicokinetics and Toxicodynamics.

Cytochrome P450 enzyme activity in five herbivorous, non-passerine bird species

Diabetes and elimination of antipyrine in man: an analysis of 298 patients classified by type of diabetes, age, sex, duration of disease and liver involvement

Differentiation-Promoting Medium Additives for Hepatocyte Cultivation and Cryopreservation

Drug Metabolism - From In Vitro to In Vivo, From Simple to Complex: Reflections of the BCPT Nordic Prize 2014 Awardee

Dual action of oestrogens on the mouse constitutive androstane receptor

Editorial

Editorial

Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation

Effect of renal impairment on the pharmacokinetics of bupropion and its metabolites

Effects of cytochrome P450 inhibitors and inducers on the metabolism and pharmacokinetics of ospemifene.

Effects of ospemifene on drug metabolism mediated by cytochrome P450 enzymes in humans in vitro and in vivo

Effects of pharmaceuticals and other active chemicals at biological targets: mechanisms, interactions, and integration into PB-PK/PD models.

Effects of selective serotonin reuptake inhibitors on timolol metabolism in human liver microsomes and cryo-preserved hepatocytes

Establishing a systematic framework to characterise in vitro methods for human hepatic metabolic clearance

Estimation of health risk by using toxicokinetic modelling: a case study of polychlorinated biphenyl PCB153.

Estrogen receptor alpha genotype confers interindividual variability of response to estrogen and testosterone in mesenchymal-stem-cell-derived osteoblasts

Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung

Expression of CYP3A4 in human breast tumour and non-tumour tissues

Expression of cytochrome P450 (CYP) enzymes in human nonpigmented ciliary epithelial cells: induction of CYP1B1 expression by TCDD.

Formation of GSH-trapped reactive metabolites in human liver microsomes, S9 fraction, HepaRG-cells, and human hepatocytes

From known knowns to known unknowns: predicting in vivo drug metabolites

Functional expression, inhibition and induction of CYP enzymes in HepaRG cells

Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?

Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?

Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?

Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?

Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?

Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?

Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to evaluate the risk of the S-EDCs?

Human variation and CYP enzyme contribution in benfuracarb metabolism in human in vitro hepatic models

Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone

Immunohistochemical demonstration of the expression of CYP2E1 in human breast tumour and non-tumour tissues

In silico prediction of ADME and pharmacokinetics. Report of an expert meeting organised by COST B15.

In vitro interaction cocktail assay for nine major cytochrome P450 enzymes with 13 probe reactions and a single LC/MSMS run: analytical validation and testing with monoclonal anti-CYP antibodies

In vitro metabolism and interactions of the fungicide metalaxyl in human liver preparations.

In vitro methods in the prediction of kinetics of drugs: focus on drug metabolism.

In vitro screening of drug metabolism during drug development: can we trust the predictions?

In vivo-in vitro-in silico pharmacokinetic modelling in drug development: current status and future directions

Inhibition and induction of CYP enzymes in humans: an update

Inhibition and induction of human cytochrome P450 enzymes: current status

Inhibition of cytochrome P450 2B6 activity by hormone replacement therapy and oral contraceptive as measured by bupropion hydroxylation

Integration of epidemiological findings with mechanistic evidence in regulatory pesticide risk assessment: EFSA experiences

Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia†

Issues in the design and interpretation of chronic toxicity and carcinogenicity studies in rodents: approaches to dose selection.

Lack of association between CYP2A5 induction and apoptosis in mouse primary hepatocytes

Liquid chromatography-mass spectrometry in in vitro drug metabolite screening.

Local kinetics and dynamics of xenobiotics

Marked effect of liver and kidney function on the pharmacokinetics of selegiline

Metabolic and Efflux Properties of Caco-2 Cells Stably Transfected with Nuclear Receptors

Metabolism and metabolite profiles in vitro and in vivo of ospemifene in humans and preclinical species

Metabolism and pharmacokinetics in children and the elderly

Metabolism of carbosulfan II. Human interindividual variability in its in vitro hepatic biotransformation and the identification of the cytochrome P450 isoforms involved.

Metabolism of carbosulfan. I. Species differences in the in vitro biotransformation by mammalian hepatic microsomes including human.

Metabolism of ophthalmic timolol: new aspects of an old drug

Metabolism of α-thujone in human hepatic preparationsin vitro ⬇️

Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54

Molecular approaches to the identification of biomarkers of exposure and effect--report of an expert meeting organized by COST Action B15. November 28, 2003.

Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay