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List of works by William Pao

'Targeting' the epidermal growth factor receptor tyrosine kinase with gefitinib (Iressa) in non-small cell lung cancer (NSCLC).

scientific article published on February 2004

2011 Focused Update of 2009 American Society of Clinical Oncology Clinical Practice Guideline Update on Chemotherapy for Stage IV Non-Small-Cell Lung Cancer

scientific article

A Platform for Rapid Detection of Multiple Oncogenic Mutations With Relevance to Targeted Therapy in Non–Small-Cell Lung Cancer ⬇️

scientific article published on December 23, 2010

A bioinformatics workflow for variant peptide detection in shotgun proteomics

scientific article

A meta-analysis of somatic mutations from next generation sequencing of 241 melanomas: a road map for the study of genes with potential clinical relevance

scientific article

A new target for therapy in squamous cell carcinoma of the lung

scientific article

A phase I/II study of weekly high-dose erlotinib in previously treated patients with nonsmall cell lung cancer

scientific article

A phase II trial of Salirasib in patients with lung adenocarcinomas with KRAS mutations

scientific article

A pilot study of volume measurement as a method of tumor response evaluation to aid biomarker development

scientific article

A protein knockdown strategy to study the function of beta-catenin in tumorigenesis ⬇️

scientific article published on September 29, 2003

ALK mutations conferring differential resistance to structurally diverse ALK inhibitors.

scientific article

AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer

scientific article

Abstract 1784: Erlotinib at a dose of 25 mg daily for non-small cell lung cancers withEGFRmutations

scientific article published on 15 April 2010

Acquired Resistance to the Mutant-Selective EGFR Inhibitor AZD9291 Is Associated with Increased Dependence on RAS Signaling in Preclinical Models

scientific article

Acquired resistance of EGFR-mutant lung adenocarcinomas to afatinib plus cetuximab is associated with activation of mTORC1.

scientific article

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

scientific article

Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer: distinct natural history of patients with tumors harboring the T790M mutation

scientific article

Acquired resistance to TKIs in solid tumours: learning from lung cancer

scientific article published on July 2014

Acquired resistance to epidermal growth factor receptor kinase inhibitors associated with a novel T854A mutation in a patient with EGFR-mutant lung adenocarcinoma

scientific article

Afatinib plus Cetuximab Delays Resistance Compared to Single-Agent Erlotinib or Afatinib in Mouse Models of TKI-Naïve EGFR L858R-Induced Lung Adenocarcinoma

scientific article

Analysis of genetic variants in never-smokers with lung cancer facilitated by an Internet-based blood collection protocol: a preliminary report

scientific article

Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types

journal article published in 2015

Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers

scientific article

Anchored multiplex PCR for targeted next-generation sequencing

scientific article published on 10 November 2014

Application of next generation sequencing to human gene fusion detection: computational tools, features and perspectives

scientific article published on 09 August 2012

Association of KRAS and EGFR mutations with survival in patients with advanced lung adenocarcinomas

scientific article

BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition

scientific article

BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors

scientific article

Beyond histology: translating tumor genotypes into clinically effective targeted therapies

scientific article

CFD Method for Predicting Annular Pressure Losses and Cuttings Concentration in Eccentric Horizontal Wells

article

CUSTOM-SEQ: a prototype for oncology rapid learning in a comprehensive EHR environment

scientific article published on 23 March 2016

Catalyzing the field of precision oncology, one basket at a time

scientific article published in April 2018

Characterization of breast cancers with PI3K mutations in an academic practice setting using SNaPshot profiling

scientific article

Characterizing the cancer genome in lung adenocarcinoma

scientific article

Chipping away at the lung cancer genome ⬇️

scientific article published on March 6, 2012

Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib

scientific article published in February 2006

Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer

scientific article published on 30 November 2009

Combining EGFR targeted therapy with chemotherapy in pancreatic cancer: is timing important?

scientific article published on 18 October 2005

Comparable rate of EGFR kinase domain mutation in lung adenocarcinomas from Chinese male and female never-smokers

scientific article published on 26 April 2010

Complications of Targeted Drug Therapies for Solid Malignancies: Manifestations and Mechanisms ⬇️

scientific article published on March 1, 2013

Comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes

scientific article published on 29 September 2014

Comprehensive histologic assessment helps to differentiate multiple lung primary nonsmall cell carcinomas from metastases

scientific article published on December 2009

Consensus rules in variant detection from next-generation sequencing data

scientific article

Constitutive activation of Raf-1 induces glioma formation in mice

scientific article published on May 2008

Continued use of afatinib with the addition of cetuximab after progression on afatinib in patients with EGFR mutation-positive non-small-cell lung cancer and acquired resistance to gefitinib or erlotinib

scientific article published on 31 August 2017

Core needle lung biopsy specimens: adequacy for EGFR and KRAS mutational analysis

scientific article published on January 2010

Coupled thermo-hydro-mechanical model with consideration of thermal-osmosis based on modified mixture theory

scientific article published in March 2013

DNA-Mutation Inventory to Refine and Enhance Cancer Treatment (DIRECT): A Catalog of Clinically Relevant Cancer Mutations to Enable Genome-Directed Anticancer Therapy ⬇️

scientific article published on January 23, 2013

Defining clinically relevant molecular subsets of lung cancer

scientific article published on November 2006

Design of Helical Capacitance Sensor for Holdup Measurement in Two-Phase Stratified Flow: A Sinusoidal Function Approach.

scientific article published on 4 July 2016

Detecting somatic point mutations in cancer genome sequencing data: a comparison of mutation callers

scientific article

Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors

scientific article

Differential protein stability and ALK inhibitor sensitivity of EML4-ALK fusion variants.

scientific article

Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC.

scientific article

Disparities by Race, Age, and Sex in the Improvement of Survival for Major Cancers: Results From the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) Program in the United States, 1990 to 2010.

scientific article

Dose-Dependent Mutation Rates Determine Optimum Erlotinib Dosing Strategies for EGFR Mutant Non-Small Cell Lung Cancer Patients

scientific article

Driver mutations among never smoking female lung cancer tissues in China identify unique EGFR and KRAS mutation pattern associated with household coal burning

scientific article published on 03 September 2013

Dual inhibition of EGFR with afatinib and cetuximab in kinase inhibitor-resistant EGFR-mutant lung cancer with and without T790M mutations

scientific article

Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer

scientific article published on 14 September 2009

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

scientific article

EGFR mutant lung cancer

scientific article published on January 1, 2012

EGFR mutations in lung adenocarcinomas: clinical testing experience and relationship to EGFR gene copy number and immunohistochemical expression

scientific article published on 10 April 2008

EGFR-mutant lung adenocarcinomas treated first-line with the novel EGFR inhibitor, XL647, can subsequently retain moderate sensitivity to erlotinib

scientific article

EML4-ALK: honing in on a new target in non-small-cell lung cancer.

scientific article

EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer

scientific article published on 7 January 2016

ERBB activation modulates sensitivity to MEK1/2 inhibition in a subset of driver-negative melanoma

scientific article

Effect of Sand Fines Concentration on the Erosion-Corrosion Mechanism of Carbon Steel 90° Elbow Pipe in Slug Flow

scientific article published on 16 October 2020

Effects of erlotinib in EGFR mutated non-small cell lung cancers with resistance to gefitinib

scientific article

Effects of pharmacokinetic processes and varied dosing schedules on the dynamics of acquired resistance to erlotinib in EGFR-mutant lung cancer

scientific article published on October 2012

Enabling a genetically informed approach to cancer medicine: a retrospective evaluation of the impact of comprehensive tumor profiling using a targeted next-generation sequencing panel

scientific article

Encouragement to submit data of clinical response to EGFR-TKIs in patients with uncommon EGFR mutations

scientific article published in May 2012

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor–Resistant Disease ⬇️

scientific article published on February 11, 2013

Epidermal growth factor receptor as a novel molecular target for aggressive papillary tumors in the middle ear and temporal bone

scientific article published on May 2015

Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: current knowledge and future directions

scientific article

Erlotinib at a dose of 25 mg daily for non-small cell lung cancers with EGFR mutations

scientific article

Erratum: Syk tyrosine kinase required for mouse viability and B-cell development

scientific article published in Nature

Escaping ALK inhibition: mechanisms of and strategies to overcome resistance.

scientific article published in February 2012

Evolutionary modeling of combination treatment strategies to overcome resistance to tyrosine kinase inhibitors in non-small cell lung cancer

scientific article published on 25 October 2011

FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer

scientific article published on 21 May 2014

Facilitating a culture of responsible and effective sharing of cancer genome data

scientific article

Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma

scientific article

Frequency of Driver Mutations in Lung Adenocarcinoma from Female Never-Smokers Varies with Histologic Subtypes and Age at Diagnosis ⬇️

scientific article published on February 8, 2012

Functional KRAS mutations and a potential role for PI3K/AKT activation in Wilms tumors

scientific article published on 11 February 2017

Further Advances in Genetically Informed Lung Cancer Medicine ⬇️

scientific article published on May 1, 2013

Genetic predictors of MEK dependence in non-small cell lung cancer

scientific article

Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia

scientific article published on 29 December 2014

Genetically informed lung cancer medicine

scientific article published on 25 October 2010

Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia

scientific journal article

Genomic analysis of 63,220 tumors reveals insights into tumor uniqueness and targeted cancer immunotherapy strategies

scientific article

Genomic and mutational profiling to assess clonal relationships between multiple non-small cell lung cancers

scientific article

HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation

scientific article published on 5 September 2012

Heterogeneous mechanisms of primary and acquired resistance to third-generation EGFR inhibitors

scientific article published on June 2016

High dose weekly erlotinib achieves therapeutic concentrations in CSF and is effective in leptomeningeal metastases from epidermal growth factor receptor mutant lung cancer

scientific article published on 10 February 2010

High expression levels of total IGF-1R and sensitivity of NSCLC cells in vitro to an anti-IGF-1R antibody (R1507)

scientific article

Highly Active Antitumor Therapy (HAATT) for Epidermal Growth Factor Receptor–Mutant Lung Cancer ⬇️

scientific article published on November 9, 2010

How Genetically Engineered Mouse Tumor Models Provide Insights Into Human Cancers ⬇️

scientific article published on January 24, 2011

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer

scientific article published on 05 October 2009

Impact on disease-free survival of adjuvant erlotinib or gefitinib in patients with resected lung adenocarcinomas that harbor EGFR mutations

scientific article published on March 2011

Inconsistency and features of single nucleotide variants detected in whole exome sequencing versus transcriptome sequencing: A case study in lung cancer

scientific article published on 23 April 2015

Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas

scientific article

Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases

scientific article

Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors

scientific article

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

scientific article

JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors

scientific article published on 29 March 2016

KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib

scientific article

Lung Adenocarcinoma From East Asian Never-Smokers Is a Disease Largely Defined by Targetable Oncogenic Mutant Kinases ⬇️

scientific article published on September 20, 2010

Lung adenocarcinoma: guiding EGFR-targeted therapy and beyond

scientific article published on May 2008

Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors

scientific article

Lung cancer in never smokers: molecular profiles and therapeutic implications

scientific article

Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.

scientific article

MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib

scientific article

MSEA: detection and quantification of mutation hotspots through mutation set enrichment analysis

scientific article

Maintained sensitivity to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer recurring after adjuvant erlotinib or gefitinib

scientific article published on 10 August 2011

Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing

scientific article

Mathematical model of coupled dual chemical osmosis based on mixture-coupling theory ⬇️

article published in 2018

Maximizing the Benefits of Off-Target Kinase Inhibitor Activity ⬇️

scientific article published on February 1, 2013

Mechanism for activation of mutated epidermal growth factor receptors in lung cancer

scientific article

Melanoma BRAF fusions--response

scientific article published in December 2014

Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women

scientific article

Molecular Predictors of Response to Chemotherapy in Non-Small Cell Lung Cancer ⬇️

scientific article published on March 1, 2011

Molecular characteristics of bronchioloalveolar carcinoma and adenocarcinoma, bronchioloalveolar carcinoma subtype, predict response to erlotinib

scientific article

Molecular characteristics predict clinical outcomes: prospective trial correlating response to the EGFR tyrosine kinase inhibitor gefitinib with the presence of sensitizing mutations in the tyrosine binding domain of the EGFR gene

scientific article published on 10 May 2011

Molecular on/off switch

scientific article published in October 2006

Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01.

scientific article published in November 2005

Molecularly tailored adjuvant chemotherapy for resected non-small cell lung cancer: a time for excitement and equipoise

scientific article published on January 2008

Morphologic features of adenocarcinoma of the lung predictive of response to the epidermal growth factor receptor kinase inhibitors erlotinib and gefitinib

scientific article

Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4

scientific article

Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas

scientific article

NCCN Task Force Report: Evaluating the Clinical Utility of Tumor Markers in Oncology ⬇️

scientific article published on November 1, 2011

NF-κB drives acquired resistance to a novel mutant-selective EGFR inhibitor

scientific article published on 29 April 2015

NGS catalog: A database of next generation sequencing studies in humans

scientific article published on 19 April 2012

New Approaches to Targeted Therapy in Lung Cancer ⬇️

scientific article published on May 1, 2012

New driver mutations in non-small-cell lung cancer ⬇️

scientific article published on February 1, 2011

New strategies in overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer

scientific article

Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance

scientific article published on 03 June 2013

Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors

scientific article

Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma

scientific article published on July 2008

Numerical analyses for improved terminal velocity of deep water torpedo anchor

article

Old Habits Die Hard: Addiction of BRAF-Mutant Cancer Cells to MAP Kinase Signaling

scientific article published on April 2015

Optimization of Insulation Padding for Directional Solidification

scientific article published in February 2013

Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling

scientific article

Optimizing the sequence of anti-EGFR-targeted therapy in EGFR-mutant lung cancer

scientific article

PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR

scientific article (publication date: 15 April 2009)

Patterns and processes of somatic mutations in nine major cancers

scientific article

Phase 1 trial of everolimus and gefitinib in patients with advanced nonsmall-cell lung cancer

scientific article

Phase I/II trial of cetuximab and erlotinib in patients with lung adenocarcinoma and acquired resistance to erlotinib.

scientific article

Phase II trial of dasatinib for patients with acquired resistance to treatment with the epidermal growth factor receptor tyrosine kinase inhibitors erlotinib or gefitinib

scientific article published on June 2011

Phase II trial of gefitinib and everolimus in advanced non-small cell lung cancer

scientific article

Practical management of patients with non-small-cell lung cancer treated with gefitinib

scientific article published on 22 November 2004

Predicting sensitivity of non-small-cell lung cancer to gefitinib: is there a role for P-Akt?

scientific article

Prospective assessment of discontinuation and reinitiation of erlotinib or gefitinib in patients with acquired resistance to erlotinib or gefitinib followed by the addition of everolimus

scientific article published in September 2007

RET Fusions Define a Unique Molecular and Clinicopathologic Subtype of Non–Small-Cell Lung Cancer ⬇️

scientific article published on November 13, 2012

ROS1 rearrangements define a unique molecular class of lung cancers

scientific article

Rapamycin prevents the development and progression of mutant epidermal growth factor receptor lung tumors with the acquired resistance mutation T790M.

scientific article

Rapid polymerase chain reaction-based detection of epidermal growth factor receptor gene mutations in lung adenocarcinomas

scientific article published on August 2005

Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer

scientific article

Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer

scientific article

Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay

scientific article

Routine multiplex mutational profiling of melanomas enables enrollment in genotype-driven therapeutic trials

scientific article (publication date: 2012)

SFK/FAK Signaling Attenuates Osimertinib Efficacy in Both Drug-Sensitive and Drug-Resistant Models of EGFR-Mutant Lung Cancer

scientific article published on 17 April 2017

Screening for germline EGFR T790M mutations through lung cancer genotyping

scientific article

Serum levels of surfactant protein D are increased in mice with lung tumors

scientific article published in September 2003

Somatic mutations affect key pathways in lung adenocarcinoma

scientific article

Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies

scientific article published on 29 November 2009

Specific EGFR mutations predict treatment outcome of stage IIIB/IV patients with chemotherapy-naive non-small-cell lung cancer receiving first-line gefitinib monotherapy

scientific article

Spectrum of LKB1, EGFR, and KRAS mutations in chinese lung adenocarcinomas

scientific article

Spectrum of Oncogenic Driver Mutations in Lung Adenocarcinomas from East Asian Never Smokers ⬇️

scientific article published on November 30, 2011

Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm

scientific article published on 21 September 2011

T4 or MI? ⬇️

scientific article published on March 1, 2011

Targeted next-generation sequencing of DNA regions proximal to a conserved GXGXXG signaling motif enables systematic discovery of tyrosine kinase fusions in cancer

scientific article

Targeted therapies: Afatinib--new therapy option for EGFR-mutant lung cancer

scientific article published on 20 August 2013

The Impact of Microenvironmental Heterogeneity on the Evolution of Drug Resistance in Cancer Cells

scientific article published on 15 July 2015

The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers

scientific journal article

Tissue-Specific Immunoregulation: A Call for Better Understanding of the "Immunostat" in the Context of Cancer

scientific article published on 15 March 2018

Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase ⬇️

scientific article published on March 8, 2011

Translating genomic information into clinical medicine: lung cancer as a paradigm

scientific article

Tumor progression stage and anatomical site regulate tumor-associated macrophage and bone marrow-derived monocyte polarization

scientific article

Twice weekly pulse and daily continuous-dose erlotinib as initial treatment for patients with epidermal growth factor receptor-mutant lung cancers and brain metastases

scientific article

Two co-existing germline mutations P53 V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome

scientific article published on 24 August 2013

Unsaturated hydro-mechanical–chemical constitutive coupled model based on mixture coupling theory: Hydration swelling and chemical osmosis ⬇️

article

Update on epidermal growth factor receptor mutations in non-small cell lung cancer

scientific article

Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance

scientific article

Use of cigarette-smoking history to estimate the likelihood of mutations in epidermal growth factor receptor gene exons 19 and 21 in lung adenocarcinomas

scientific article published on 27 February 2006

Use of epidermal growth factor receptor/Kirsten rat sarcoma 2 viral oncogene homolog mutation testing to define clonal relationships among multiple lung adenocarcinomas: comparison with clinical guidelines

scientific article published on 17 April 2009

Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs

scientific article

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