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List of works by Laurent Meijer

1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta

scientific article published in January 2004

10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.

scientific article published on 23 March 2015

3'-Substituted 7-halogenoindirubins, a new class of cell death inducing agents.

scientific article published on July 2006

3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3

scientific article

5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms

scientific article

6-Br-5methylindirubin-3'oxime (5-Me-6-BIO) targeting the leishmanial glycogen synthase kinase-3 (GSK-3) short form affects cell-cycle progression and induces apoptosis-like death: exploitation of GSK-3 for treating leishmaniasis

scientific article published on 13 May 2009

9- and 11-Substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma

scientific article

9-cyano-1-azapaullone (cazpaullone), a glycogen synthase kinase-3 (GSK-3) inhibitor activating pancreatic beta cell protection and replication

scientific article

A Collection of Bioactive Nitrogen-Containing Molecules from the Marine Sponge Acanthostrongylophora ingens

scientific article published on 15 August 2019

A Pd(0) based cross-coupling approach to the synthesis of 2-amidopurines and their evaluation as CDK inhibitors

scientific article published on 06 October 2006

A Simple Isomerization of the Purine Scaffold of a Kinase Inhibitor, Roscovitine, Affords a Four- to Seven-Fold Enhancement of Its Affinity for Four CDKs. Could This Be Traced Back to Conjugation-Induced Stiffenings/Loosenings of Rotational Barriers?

scientific article published on 12 July 2017

A facile consensus ranking approach enhances virtual screening robustness and identifies a cell-active DYRK1α inhibitor

scientific article published on 16 October 2018

A one-pot synthesis and biological activity of ageladine A and analogues.

scientific article published on 17 March 2011

A western blot assay to measure cyclin dependent kinase activity in cells or in vitro without the use of radioisotopes ⬇️

scientific article published on August 15, 2013

Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease?

scientific article

Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects

scientific article published in January 2003

An Integrated Computational Approach to the Phenomenon of Potent and Selective Inhibition of Aurora Kinases B and C by a Series of 7-Substituted Indirubins

scientific article published on 01 August 2007

An Overview of In Vivo and In Vitro Models for Autosomal Dominant Polycystic Kidney Disease: A Journey from 3D-Cysts to Mini-Pigs

scientific article published on 25 June 2020

Anticancer alkaloid lamellarins inhibit protein kinases

scientific article published on 7 October 2008

Antimalarial drug discovery: targeting protein kinases

scientific article published on March 2007

Antimalarial potential of xestoquinone, a protein kinase inhibitor isolated from a Vanuatu marine sponge Xestospongia sp.

scientific article

Antitumoral effects of cyclin-dependent kinases inhibitors CR8 and MR4 on chronic myeloid leukemia cell lines

scientific article published on 17 July 2015

Autophagy: a novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model.

scientific article published on October 2008

Biosynthesis of new indigoid inhibitors of protein kinases using recombinant cytochrome P450 2A6.

scientific article published in January 2005

Butyrolactone I derivatives from Aspergillus terreus carrying an unusual sulfate moiety

scientific article

CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells

scientific article

CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD.

scientific article published on 3 October 2012

CDK1-inhibitory activity of paullones depends on electronic properties of 9-substituents

scientific article published in September 2004

CDK1/cyclin B regulation during oocyte maturation in two closely related lugworm species, Arenicola marina and Arenicola defodiens

scientific article published in February 2004

CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome

scientific journal article

Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8.

scientific article published on 14 March 2018

Catalyst-free synthesis of quinazolin-4-ones from (hetero)aryl-guanidines: application to the synthesis of pyrazolo[4,3-f]quinazolin-9-ones, a new family of DYRK1A inhibitors ⬇️

scientific article published on September 19, 2012

Cdk2 is required for breast cancer mediated by the low-molecular-weight isoform of cyclin E

scientific article

Characterisation of the anti-migratory activity of the 6-bromoindirubin-3’oxime (BIO) derivative VTIND42 in patient-derived GBM subpopulations

scientific article published in 2019

Chemical synthesis and biological validation of immobilized protein kinase inhibitory Leucettines

scientific article published on 6 February 2013

Chloromethylhalicyclamine B, a Marine-Derived Protein Kinase CK1δ/ε Inhibitor

scientific article

Combined Virtual and Experimental Screening for CK1 Inhibitors Identifies a Modulator of p53 and Reveals Important Aspects of in Silico Screening Performance

scientific article published on 6 October 2017

Concise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullones.

scientific article published on 15 June 2010

Constitutive TLR4 signalling in intestinal epithelium reduces tumor load by increasing apoptosis in APCMin/+ mice ⬇️

scientific article published on January 14, 2013

Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A

scientific article published on 27 September 2018

Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin

scientific article published in February 2005

Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives

scientific article published on 28 June 2005

Cyclin-dependent kinase inhibitor indirubin-3'-oxime selectively inhibits human papillomavirus type 16 E7-induced numerical centrosome anomalies

scientific article published on October 2004

Cyclin-dependent kinase inhibitors closer to market launch?

scientific article published on 22 April 2013

Cyclin-dependent kinase inhibitors: a survey of recent patent literature

scientific article published on March 2010

Decrease in p3-Alcβ37 and p3-Alcβ40, products of Alcadein β generated by γ-secretase cleavages, in aged monkeys and patients with Alzheimer's disease

scientific article published on 07 November 2019

Degradation of Hof1 by SCF(Grr1) is important for actomyosin contraction during cytokinesis in yeast.

scientific article

Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models

scientific article

Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25.

scientific article

Development of 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters as selective inhibitors of mitochondrial malate dehydrogenase (mMDH).

scientific article

Development of Kinase Inhibitors via Metal-Catalyzed C⁻H Arylation of 8-Alkyl-thiazolo[5,4-]-quinazolin-9-ones Designed by Fragment-Growing Studies

article

Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with Roscovitine, a novel cyclin-dependent kinase antagonist ⬇️

scientific article published on November 15, 1997

Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure

scientific article

Dispacamide E and other bioactive bromopyrrole alkaloids from two Indonesian marine sponges of the genus Stylissa

scientific article

Editorial: Role of cyclin-dependent kinase-5 (Cdk5) in the central nervous system

scientific article published on 01 August 2007

Epoxide-containing side chains enhance antiproliferative activity of paullones

scientific article published on 7 April 2005

Erratum to: microRNA machinery is an integral component of drug-induced transcription inhibition in HIV-1 infection ⬇️

scientific article published on July 12, 2010

Evaluation and comparison of 3D-QSAR CoMSIA models for CDK1, CDK5, and GSK-3 inhibition by paullones

scientific article published in January 2004

Evaluation of the first cytostatically active 1-aza-9-oxafluorenes as novel selective CDK1 inhibitors with P-glycoprotein modulating properties

scientific article published on 01 February 2003

Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors ⬇️

scientific article published on July 24, 1998

Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor

scientific article published on 22 September 2016

Exploring Kinase Inhibition Properties of 9H-pyrimido[5,4-b]- and [4,5-b]indol-4-amine Derivatives

scientific article published on 09 May 2020

Expression and activity of cyclin-dependent kinases and glycogen synthase kinase-3 during NT2 neuronal differentiation

scientific article published on May 2004

From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity

scientific article

Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors.

scientific article published on 31 August 2016

GSK-3-selective inhibitors derived from Tyrian purple indirubins

scientific article

Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis

scientific article published in June 2004

Harnessing Neutrophil Survival Mechanisms during Chronic Infection by Pseudomonas aeruginosa: Novel Therapeutic Targets to Dampen Inflammation in Cystic Fibrosis

scientific article

Human cells enter mitosis with damaged DNA after treatment with pharmacological concentrations of genotoxic agents ⬇️

scientific article published on September 15, 2012

Identification and structure-activity relationship of 8-hydroxy-quinoline-7-carboxylic acid derivatives as inhibitors of Pim-1 kinase

scientific article published on 15 March 2010

Identification of CLK1 Inhibitors by a Fragment-linking Based Virtual Screening

scientific article

Identification of intracellular targets of small molecular weight chemical compounds using affinity chromatography

scientific article published in January 2007

Identification of potential cellular targets of aloisine A by affinity chromatography

scientific article published on 18 June 2009

Imidazo[2,1 -b]thiazolylmethylene- and indolylmethylene-2-indolinones: a new class of cyclin-dependent kinase inhibitors. Design, synthesis, and CDK1/cyclin B inhibition

scientific article published on December 1, 2000

Impact of meriolins, a new class of cyclin-dependent kinase inhibitors, on malignant glioma proliferation and neo-angiogenesis.

scientific article

Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor

scientific article published in November 2006

Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins

scientific article published on May 2004

Indirubins deplete striatal monoamines in the intact and MPTP-treated mouse brain and block kainate-induced striatal astrogliosis

journal article published in 2010

Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design.

scientific article published on 24 January 2018

Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides

scientific article published on 28 February 2018

Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice

scientific article published on 18 March 2019

Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes prosurvival stimuli to induce apoptosis in chronic lymphocytic leukemia cells

scientific article published on 26 March 2013

Inhibition of Tat-mediated HIV-1 replication and neurotoxicity by novel GSK3-beta inhibitors

scientific article published on 22 April 2011

Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity

scientific article

Intracellular Targets of Paullones. Identification following affinity purification on immobilized inhibitor

scientific article published on 18 April 2002

Isolation of drugs active against mammalian prions using a yeast-based screening assay

scientific article published on 10 August 2003

Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.

scientific article published on 26 May 2011

Long-Term Fipronil Treatment Induces Hyperactivity in Female Mice

scientific article published on 29 February 2020

Low molecular weight cyclin E is specific in breast cancer and is associated with mechanisms of tumor progression

scientific article published on 10 April 2009

Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases.

scientific article

Mechanism of CDK5/p25 binding by CDK inhibitors

scientific article

Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum.

scientific article

Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex.

scientific article published on 31 January 2008

Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases

scientific article

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

scientific article published on 18 March 2016

Molecular cloning and characterisation of p15(CDK-BP), a novel CDK-binding protein

scientific article (publication date: 3 April 2002)

Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype.

scientific article

N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine

scientific article

Non-Linear Pharmacokinetics of Oral Roscovitine (Seliciclib) in Cystic Fibrosis Patients Chronically Infected with Pseudomonas aeruginosa: A Study on Population Pharmacokinetics with Monte Carlo Simulations

scientific article published on 12 November 2020

Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp.

scientific article published on 28 April 2015

Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes

scientific article published in February 2005

Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases

scientific article published on November 2012

Novel Mouse Tauopathy Model for Repetitive Mild Traumatic Brain Injury: Evaluation of Long-Term Effects on Cognition and Biomarker Levels After Therapeutic Inhibition of Tau Phosphorylation

scientific article published on 11 March 2019

Olomoucine, an inhibitor of the cdc2/cdk2 kinases activity, blocks plant cells at the G1 to S and G2 to M cell cycle transitions ⬇️

scientific article published on October 17, 1994

Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice

scientific article

Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection

scientific article published on 23 December 2013

Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type 1 by targeting cellular, not viral, proteins

scientific article

Pharmacological inhibitors of cyclin-dependent kinases

scientific article

Pharmacological inhibitors of glycogen synthase kinase 3.

scientific article

Photoreactivity of indirubin derivatives.

scientific article

Plasmodium falciparum NIMA-related kinase Pfnek-1: sex specificity and assessment of essentiality for the erythrocytic asexual cycle

scientific article

Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors

scientific article (publication date: 11 March 2004)

Polyprenyl-hydroquinones and -furans from three marine sponges inhibit the cell cycle regulating phosphatase CDC25A.

scientific article published in February 2004

Potent inhibitors of CDK5 derived from roscovitine: synthesis, biological evaluation and molecular modelling

scientific article published on 10 November 2012

Protein kinases as drug targets in parasitic protozoa

scientific article

Purification of CK1 by affinity chromatography on immobilised axin

scientific article published on 12 March 2007

Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase

scientific article published on September 2002

Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue.

scientific article published on February 2009

Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases

scientific article published on November 2005

Rebeccamycin derivatives as dual DNA-damaging agents and potent checkpoint kinase 1 inhibitors.

scientific article

Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis.

scientific article published on 5 April 2016

Roscovitine targets, protein kinases and pyridoxal kinase

scientific journal article

Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1.

scientific article

Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B

scientific article

Several human cyclin-dependent kinase inhibitors, structurally related to roscovitine, are new anti-malarial agents.

scientific article published on 23 September 2014

Small-molecule inducers of Aβ-42 peptide production share a common mechanism of action

scientific article

Soluble 3',6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period

scientific article published on 25 September 2008

Specific Triazine Herbicides Induce Amyloid-β42 Production

scientific article

Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models

scientific article published on 30 April 2019

Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases

scientific article published in February 2004

Structure-aided optimization of kinase inhibitors derived from alsterpaullone.

scientific article published on March 2005

Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics

scientific article published in April 2002

Suzuki-type Pd(0) coupling reactions in the synthesis of 2-arylpurines as Cdk inhibitors

scientific article published on 17 April 2006

Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins.

scientific article published on 12 May 2009

Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents

scientific article published on 2 November 2012

Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors.

scientific article published on 3 July 2009

Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors

scientific article

Synthesis and biological evaluation of analogs of the marine alkaloids granulatimide and isogranulatimide

scientific article

Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indoles as PI3Kα inhibitors ⬇️

scientific article published on September 10, 2012

Synthesis and biological evaluation of new penta- and heptacyclic indolo- and quinolinocarbazole ring systems obtained via Pd(0) catalysed reductive N-heteroannulation

scientific article published on 24 August 2010

Synthesis and biological evaluation of novel phenylcarbazoles as potential anticancer agents

scientific article published on January 2006

Synthesis and biological evaluation of selective and potent cyclin-dependent kinase inhibitors

scientific article

Synthesis and biological evaluation of tetrahydro[1,4]diazepino[1,2-a]indol-1-ones as cyclin-dependent kinase inhibitors.

scientific article

Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors

scientific article published on December 2005

Synthesis and molecular modelling studies of 8-arylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amines as multitarget Ser/Thr kinases inhibitors

scientific article published on 23 December 2014

Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives

scientific article published on 16 July 2016

Synthesis and target identification of hymenialdisine analogs

scientific article

Synthesis of 3,5-bis(2-indolyl)pyridine and 3-[(2-indolyl)-5-phenyl]pyridine derivatives as CDK inhibitors and cytotoxic agents

scientific article

Synthesis of 3-substituted-2-oxoindole analogues and their evaluation as kinase inhibitors, anticancer and antiangiogenic agents

scientific article published on 21 February 2006

Synthesis of acridinyl-thiazolino derivatives and their evaluation for anti-inflammatory, analgesic and kinase inhibition activities.

scientific article published in July 2005

Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: a novel DYRK1A inhibitor class.

scientific article

Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors

scientific article published on 16 September 2014

Synthesis of paullones with aminoalkyl side chains

scientific article published on 01 July 2002

Synthesis, anti-inflammatory, analgesic and kinase (CDK-1, CDK-5 and GSK-3) inhibition activity evaluation of benzimidazole/benzoxazole derivatives and some Schiff's bases

scientific article published on 9 February 2006

Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives.

scientific article published on 10 June 2011

Synthesis, resolution, and biological evaluation of atropisomeric (aR)- and (aS)-16-methyllamellarins N: unique effects of the axial chirality on the selectivity of protein kinases inhibition

scientific article published on 13 September 2013

TRPC6 channel translocation into phagosomal membrane augments phagosomal function

scientific article

Targeting low molecular weight cyclin E (LMW-E) in breast cancer.

scientific article published on 22 June 2011

The Effect of the Cyclin-Dependent Kinase Inhibitor Olomoucine on Cell Cycle Kinetics ⬇️

scientific article published on October 10, 1997

The cyclin-dependent kinase (cdk) inhibitors, olomoucine and roscovitine, alter the expression of a molluscan circadian pacemaker ⬇️

scientific article published on 01 October 1997

The inhibition of cyclin-dependent kinases induces differentiation of supernumerary hair cells and Deiters' cells in the developing organ of Corti.

scientific article published on 4 September 2003

Use of ATP analogs to inhibit HIV-1 transcription

scientific article

[b]-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors

scientific article published on 13 November 2019

cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease.

scientific article published on 23 December 2013

microRNA machinery is an integral component of drug-induced transcription inhibition in HIV-1 infection

scientific article

p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol

scientific article

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