Search filters

List of works by Roosmarijn Vandenbroucke

A Hidden Epithelial Barrier in the Brain with a Central Role in Regulating Brain Homeostasis. Implications for Aging

scientific article published in December 2016

A New Venue of TNF Targeting

scientific article published on 2 April 2018

A New Venue of TNF Targeting.

scientific article published on 11 May 2018

A Study of Cecal Ligation and Puncture-Induced Sepsis in Tissue-Specific Tumor Necrosis Factor Receptor 1-Deficient Mice

scientific article published on 08 November 2019

A new angle on blood-CNS interfaces: a role for connexins?

scientific article published on 12 March 2014

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

scientific article published on 06 May 2019

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation.

scientific article published on 23 May 2018

Amyloid β Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases.

scientific article published on September 2015

An acute phase protein ready to go therapeutic for sepsis

scientific article published on January 2014

An inflammatory triangle in psoriasis: TNF, type I IFNs and IL-17.

scientific article published on 31 October 2014

Antisense oligonucleotides against TNFR1 prevent toxicity of TNF/IFNγ treatment in mouse tumor models

scientific article

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

scientific article published on 26 May 2022

Biodegradable Dextran Nanogels for RNA Interference: Focusing on Endosomal Escape and Intracellular siRNA Delivery

scientific article published on 8 May 2009

Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop

scientific article published on 08 November 2019

Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock

scientific article published on 12 November 2019

Caloric restriction: beneficial effects on brain aging and Alzheimer's disease

scientific article published on 30 May 2016

Can ultrasound solve the transport barrier of the neural retina?

scientific article published on 23 July 2008

Cellular entry pathway and gene transfer capacity of TAT-modified lipoplexes

scientific article

Choose your models wisely: how different murine bone marrow-derived dendritic cell protocols influence the success of nanoparticulate vaccines in vitro.

scientific article published on 21 June 2014

Choroid plexus tumor necrosis factor receptor 1: A new neuroinflammatory piece of the complex Alzheimer's disease puzzle

scientific article published on 01 July 2019

Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain

scientific article published on 15 July 2019

Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders

scientific article published on 13 May 2015

Comment on 'Tumour necrosis factor-α plays a significant role in the Aldara-induced skin inflammation in mice'.

scientific article published on 6 February 2016

Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs

scientific article published on 09 April 2016

Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death

scientific article published on 4 December 2009

Correction to: Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017.

scientific article published on 12 January 2018

Corrigendum: Transient Hepatic Overexpression of Insulin-Like Growth Factor 2 Induces Free Cholesterol and Lipid Droplet Formation.

scientific article published on 29 July 2016

Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease.

scientific article published on 22 February 2018

Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017.

scientific article published on 7 November 2017

Decreased TNF Levels and Improved Retinal Ganglion Cell Survival in MMP-2 Null Mice Suggest a Role for MMP-2 as TNF Sheddase

scientific article published on 15 September 2015

Determining differentially expressed miRNAs and validating miRNA--target relationships using the SPRET/Ei mouse strain

scientific article published on 10 December 2014

Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8.

scientific article published on 18 January 2016

Dextran Microgels for Time-Controlled Delivery of siRNA

scientific article published on 11 April 2008

Dual Inhibition of TNFR1 and IFNAR1 in Imiquimod-Induced Psoriasiform Skin Inflammation in Mice

scientific article published on 24 April 2015

E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion

scientific article

Efficient analysis of mouse genome sequences reveal many nonsense variants

scientific article published on 04 May 2016

Endothelial LRP1 transports amyloid-β(1-42) across the blood-brain barrier

scientific article

Evaluation of Digitally Encoded Layer-by-layer Coated Microparticles as Cell Carriers

scientific article published on 23 September 2008

Extracellular Vesicles in Alzheimer's and Parkinson's Disease: Small Entities with Large Consequences

scientific article published on 15 November 2020

Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases

scientific article

GTRV Summer School--Oligonucleotide-Based Strategies to Control Gene Expression: Delivery Issues. 6-8 September 2007, La Grande Motte, France.

scientific article published in November 2007

Gastric Infection Partially Protects against Neurotoxicity in A 6-OHDA Parkinson's Disease Mouse Model

Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1.

scientific article

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice

scientific article published on 25 June 2018

Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1.

scientific article

Hematopoietic plakophilin-3 regulates acute tissue-specific and systemic inflammation in mice

scientific article

High-precision isotopic analysis of Mg and Ca in biological samples using multi-collector ICP-mass spectrometry after their sequential chromatographic isolation - Application to the characterization of the body distribution of Mg and Ca isotopes in

scientific article published on 28 July 2020

Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles.

scientific article published on 05 September 2016

Immunogenicity and Protection Efficacy of a Naked Self-Replicating mRNA-Based Zika Virus Vaccine

scientific article published on 23 August 2019

Importance of extracellular vesicle secretion at the blood-cerebrospinal fluid interface in the pathogenesis of Alzheimer's disease

scientific article published on 23 August 2021

Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer's disease

scientific article published in 2024

Into rather unexplored terrain-transcellular transport across the blood-brain barrier

scientific article published on 8 February 2016

Intracellular drug delivery in Leishmania-infected macrophages: Evaluation of saponin-loaded PLGA nanoparticles

scientific article

Is there new hope for therapeutic matrix metalloproteinase inhibition?

scientific article

Line FRAP with the confocal laser scanning microscope for diffusion measurements in small regions of 3-D samples

scientific article

Low-grade peripheral inflammation affects brain pathology in the App<sup>NL-G-F</sup>mouse model of Alzheimer's disease

scientific article published on 07 October 2021

MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation in the Posterior Eye Segment

scientific article

Magnetic layer-by-layer coated particles for efficient MRI of dendritic cells and mesenchymal stem cells

scientific article published on 9 October 2013

Maintaining the silence: reflections on long-term RNAi

scientific article published on 07 August 2008

Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases

scientific article published in July 2012

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF.

scientific article published on 30 May 2013

Matrix metalloproteinase8 has a central role in inflammatory disorders and cancer progression.

scientific article published on 08 March 2011

Matrix metalloproteinases as drug targets in ischemia/reperfusion injury.

scientific article published on 02 July 2011

Mice overexpressing β-1,4-Galactosyltransferase I are resistant to TNF-induced inflammation and DSS-induced colitis

scientific article

Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model

scientific article published on 10 January 2020

Modulation of Dendritic Cells by Lipid Grafted Polyelectrolyte Microcapsules

scientific article published on 14 June 2012

Monitoring ALS1 and ALS3 gene expression during in vitro Candida albicans biofilm formation under continuous flow conditions

scientific article published on 6 August 2008

Mouse models of ageing and their relevance to disease

scientific article

Nanobodies as therapeutics: big opportunities for small antibodies

scientific article published on 11 April 2016

New strategies for nucleic acid delivery to conquer cellular and nuclear membranes

scientific article

Nuclear accumulation of plasmid DNA can be enhanced by non-selective gating of the nuclear pore

scientific article

Overexpression of Gilz Protects Mice Against Lethal Septic Peritonitis

scientific article published on 01 August 2019

Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice.

scientific article

Polyelectrolyte LbL microcapsules versus PLGA microparticles for immunization with a protein antigen

scientific article published on 29 October 2011

Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation

scientific article published on 16 October 2013

Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(beta-amino esters).

scientific article

Quantifying the Average Number of Nucleic Acid Therapeutics per Nanocarrier by Single Particle Tracking Microscopy

scientific article published on 12 February 2018

Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium

scientific article

Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis.

scientific article published on 31 October 2017

Sizing nanomaterials in bio-fluids by cFRAP enables protein aggregation measurements and diagnosis of bio-barrier permeability

scientific article

Synthesis and Validation of a Hydroxypyrone-Based, Potent, and Specific Matrix Metalloproteinase-12 Inhibitor with Anti-Inflammatory Activity In Vitro and In Vivo.

scientific article

TNFR1 inhibition with a Nanobody protects against EAE development in mice

scientific article

TNFR1-induced lethal inflammation is mediated by goblet and Paneth cell dysfunction

scientific article published on 26 November 2014

Targeting gliovascular connexins prevents inflammatory blood-brain barrier leakage and astrogliosis

scientific article published in 2022

Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death

scientific article published on 13 October 2014

The N-terminal p.(Ser38Cys) TIMP3 mutation underlying Sorsby fundus dystrophy is a founder mutation disrupting an intramolecular disulfide bond

scientific article published on 06 February 2019

The choroid plexus epithelium as a novel player in the stomach-brain axis during Helicobacter infection.

scientific article published on 16 December 2017

The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease: more than just a barrier

scientific article

The effect of aging on brain barriers and the consequences for Alzheimer's disease development

scientific article published on 3 May 2016

The first MMP in sepsis

scientific article published on 18 May 2011

The internalization route resulting in successful gene expression depends on both cell line and polyethylenimine polyplex type

scientific article published on 15 September 2006

The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls

scientific article published on 15 December 2009

Therapeutic implications of the choroid plexus-cerebrospinal fluid interface in neuropsychiatric disorders

scientific article published on 23 June 2015

Tightening the retinal glia limitans attenuates neuroinflammation after optic nerve injury

scientific article published on 09 July 2020

Topical imiquimod yields systemic effects due to unintended oral uptake.

scientific article published on 28 January 2016

Transient Hepatic Overexpression of Insulin-Like Growth Factor 2 Induces Free Cholesterol and Lipid Droplet Formation.

scientific article published on 25 April 2016

Treatment of Intestinal Fibrosis in Experimental Inflammatory Bowel Disease by the Pleiotropic Actions of a Local Rho Kinase Inhibitor

scientific article published on 19 June 2017

Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1.

scientific article published on October 2011

Ultrasound assisted siRNA delivery using PEG-siPlex loaded microbubbles.

scientific article published on 14 December 2007

Ultrasound exposure of lipoplex loaded microbubbles facilitates direct cytoplasmic entry of the lipoplexes.

scientific article published in March 2009

Ultrasound-responsive polymer-coated microbubbles that bind and protect DNA.

scientific article published in August 2006

With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions

scientific article

mRNA-Lipoplex loaded microbubble contrast agents for ultrasound-assisted transfection of dendritic cells

scientific article published on 25 August 2011

Paulina is supported by:

About Paulina

Help