List of works - Brett Finlay

A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system

scientific article

A novel secretion pathway of Salmonella enterica acts as an antivirulence modulator during salmonellosis

scientific article

Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase

scientific article

Anti-immunology: evasion of the host immune system by bacterial and viral pathogens

scientific article

Antibiotic-induced perturbations of the intestinal microbiota alter host susceptibility to enteric infection

scientific article

Bacterial effector binding to ribosomal protein s3 subverts NF-kappaB function

scientific article

Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infection

scientific article

Cheminformatics-Driven Discovery of Selective, Nanomolar Inhibitors for Staphylococcal Pyruvate Kinase ⬇️

scientific article published on November 21, 2011

Cohabitation in the Intestine: Interactions among Helminth Parasites, Bacterial Microbiota, and Host Immunity

scientific article

Cross-feeding between intestinal pathobionts promotes their overgrowth during undernutrition

scientific article published on 25 November 2021

Crossing the line: selection and evolution of virulence traits

scientific article

Cryo-EM structure of the EspA filament from enteropathogenic Escherichia coli: Revealing the mechanism of effector translocation in the T3SS

scientific article published in 2021

Dietary Intervention Reverses Fatty Liver and Altered Gut Microbiota during Early-Life Undernutrition

scientific article published on 08 September 2020

Direct measurement of oxidative and nitrosative stress dynamics in Salmonella inside macrophages

scientific article

Early infancy microbial and metabolic alterations affect risk of childhood asthma

scientific article (publication date: 30 September 2015)

Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by Salmonella

scientific article published in October 2002

Evidence of a large novel gene pool associated with prokaryotic genomic islands

scientific article

Evidence that plant-like genes in Chlamydia species reflect an ancestral relationship between Chlamydiaceae, cyanobacteria, and the chloroplast

scientific article

From ingestion to colonization: the influence of the host environment on regulation of the LEE encoded type III secretion system in enterohaemorrhagic Escherichia coli

scientific article

Gastric acid and escape to systemic circulation represent major bottlenecks to host infection by Citrobacter rodentium

scientific article published on 24 September 2022

Global Profiling of Proteolysis from the Mitochondrial Amino Terminome during Early Intrinsic Apoptosis Prior to Caspase-3 Activation

scientific article published on 29 October 2018

Gut microbes shape microglia and cognitive function during malnutrition

scientific article published on 12 January 2022

Here, there, and everywhere: How pathogenic Escherichia coli sense and respond to gastrointestinal biogeography

scientific article published on 31 October 2019

Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae

scientific article

Host-microbe interactions: fulfilling a niche

scientific article

Immunoglobulin recognition of fecal bacteria in stunted and non-stunted children: findings from the Afribiota study

scientific article published on 27 July 2020

Invasive and adherent bacterial pathogens co-Opt host clathrin for infection

scientific article

Master Sculptor at Work: Enteropathogenic Escherichia coli Infection Uniquely Modifies Mitochondrial Proteolysis during Its Control of Human Cell Death

scientific article published on 02 June 2020

Metabonomics reveals drastic changes in anti-inflammatory/pro-resolving polyunsaturated fatty acids-derived lipid mediators in leprosy disease

scientific article (publication date: 2013)

Methicillin-resistant Staphylococcus aureus (MRSA) Pyruvate Kinase as a Target for Bis-indole Alkaloids with Antibacterial Activities ⬇️

scientific article

Molecular analysis as an aid to assess the public health risk of non-O157 Shiga toxin-producing Escherichia coli strains

scientific article

Multiple Salmonella-pathogenicity island 2 effectors are required to facilitate bacterial establishment of its intracellular niche and virulence

scientific article published on 25 June 2020

NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion

scientific journal article

Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain

scientific article

Oxysterol-binding protein (OSBP) enhances replication of intracellular Salmonella and binds the Salmonella SPI-2 effector SseL via its N-terminus ⬇️

scientific article published on September 28, 2011

Proceedings of the Canadian society of allergy and clinical immunology annual scientific meeting 2015

scientific article (publication date: May 2016)

Quantitative Mass Spectrometry Identifies Novel Host Binding Partners for Pathogenic Escherichia coli Type III Secretion System Effectors.

scientific article

Quantitative mass spectrometry catalogues Salmonella pathogenicity island-2 effectors and identifies their cognate host binding partners

scientific article

Salmonella effectors within a single pathogenicity island are differentially expressed and translocated by separate type III secretion systems

scientific journal article

Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine

scientific article

Selectively reduced intracellular proliferation of Salmonella enterica serovar typhimurium within APCs limits antigen presentation and development of a rapid CD8 T cell response

scientific article

SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34

scientific article published on August 2008

SopD acts cooperatively with SopB during Salmonella enterica serovar Typhimurium invasion

scientific journal article

SopD2 is a novel type III secreted effector of Salmonella typhimurium that targets late endocytic compartments upon delivery into host cells

scientific journal article

Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine

scientific article

Structural analysis of a prototypical ATPase from the type III secretion system

scientific article

Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS

scientific article

Structural and cellular insights into the L,D-transpeptidase YcbB as a therapeutic target in C. rodentium, S. Typhimurium, and S. Typhi infections

scientific article published on 02 November 2020

Structural characterization of the molecular platform for type III secretion system assembly.

scientific article published in June 2005

The Salmonella type III effector SspH2 specifically exploits the NLR co-chaperone activity of SGT1 to subvert immunity

scientific article

The Zinc Regulated Antivirulence Pathway of Salmonella Is a Multiprotein Immunoglobulin Adhesion System

scientific article

The enemy within us: lessons from the 2011 European Escherichia coli O104:H4 outbreak

scientific article

The gut microbiome in human neurological disease: A review

scientific article

The intestinal microbiome in early life: health and disease

scientific article

The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling

scientific article

The related effector proteins SopD and SopD2 from Salmonella enterica serovar Typhimurium contribute to virulence during systemic infection of mice

scientific journal article

Transcriptional inhibitor of virulence factors in enteropathogenic Escherichia coli.

scientific article published in October 2005

Two enteropathogenic Escherichia coli type III secreted proteins, EspA and EspB, are virulence factors

scientific article

List of works by Brett Finlay

A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system

A novel secretion pathway of Salmonella enterica acts as an antivirulence modulator during salmonellosis

Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase

Anti-immunology: evasion of the host immune system by bacterial and viral pathogens

Antibiotic-induced perturbations of the intestinal microbiota alter host susceptibility to enteric infection

Bacterial effector binding to ribosomal protein s3 subverts NF-kappaB function

Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infection

Cheminformatics-Driven Discovery of Selective, Nanomolar Inhibitors for Staphylococcal Pyruvate Kinase ⬇️

Cohabitation in the Intestine: Interactions among Helminth Parasites, Bacterial Microbiota, and Host Immunity

Cross-feeding between intestinal pathobionts promotes their overgrowth during undernutrition

Crossing the line: selection and evolution of virulence traits

Cryo-EM structure of the EspA filament from enteropathogenic Escherichia coli: Revealing the mechanism of effector translocation in the T3SS

Dietary Intervention Reverses Fatty Liver and Altered Gut Microbiota during Early-Life Undernutrition

Direct measurement of oxidative and nitrosative stress dynamics in Salmonella inside macrophages

Early infancy microbial and metabolic alterations affect risk of childhood asthma

Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by Salmonella

Evidence of a large novel gene pool associated with prokaryotic genomic islands

Evidence that plant-like genes in Chlamydia species reflect an ancestral relationship between Chlamydiaceae, cyanobacteria, and the chloroplast

From ingestion to colonization: the influence of the host environment on regulation of the LEE encoded type III secretion system in enterohaemorrhagic Escherichia coli

Gastric acid and escape to systemic circulation represent major bottlenecks to host infection by Citrobacter rodentium

Global Profiling of Proteolysis from the Mitochondrial Amino Terminome during Early Intrinsic Apoptosis Prior to Caspase-3 Activation

Gut microbes shape microglia and cognitive function during malnutrition

Here, there, and everywhere: How pathogenic Escherichia coli sense and respond to gastrointestinal biogeography

Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae

Host-microbe interactions: fulfilling a niche

Immunoglobulin recognition of fecal bacteria in stunted and non-stunted children: findings from the Afribiota study

Invasive and adherent bacterial pathogens co-Opt host clathrin for infection

Master Sculptor at Work: Enteropathogenic Escherichia coli Infection Uniquely Modifies Mitochondrial Proteolysis during Its Control of Human Cell Death

Metabonomics reveals drastic changes in anti-inflammatory/pro-resolving polyunsaturated fatty acids-derived lipid mediators in leprosy disease

Methicillin-resistant Staphylococcus aureus (MRSA) Pyruvate Kinase as a Target for Bis-indole Alkaloids with Antibacterial Activities ⬇️

Molecular analysis as an aid to assess the public health risk of non-O157 Shiga toxin-producing Escherichia coli strains

Multiple Salmonella-pathogenicity island 2 effectors are required to facilitate bacterial establishment of its intracellular niche and virulence

NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion

Oral infection of mice with Salmonella enterica serovar Typhimurium causes meningitis and infection of the brain

Oxysterol-binding protein (OSBP) enhances replication of intracellular Salmonella and binds the Salmonella SPI-2 effector SseL via its N-terminus ⬇️

Proceedings of the Canadian society of allergy and clinical immunology annual scientific meeting 2015

Quantitative Mass Spectrometry Identifies Novel Host Binding Partners for Pathogenic Escherichia coli Type III Secretion System Effectors.

Quantitative mass spectrometry catalogues Salmonella pathogenicity island-2 effectors and identifies their cognate host binding partners

Salmonella effectors within a single pathogenicity island are differentially expressed and translocated by separate type III secretion systems

Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine

Selectively reduced intracellular proliferation of Salmonella enterica serovar typhimurium within APCs limits antigen presentation and development of a rapid CD8 T cell response

SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34

SopD acts cooperatively with SopB during Salmonella enterica serovar Typhimurium invasion

SopD2 is a novel type III secreted effector of Salmonella typhimurium that targets late endocytic compartments upon delivery into host cells

Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine

Structural analysis of a prototypical ATPase from the type III secretion system

Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS

Structural and cellular insights into the L,D-transpeptidase YcbB as a therapeutic target in C. rodentium, S. Typhimurium, and S. Typhi infections

Structural characterization of the molecular platform for type III secretion system assembly.

The Salmonella type III effector SspH2 specifically exploits the NLR co-chaperone activity of SGT1 to subvert immunity

The Zinc Regulated Antivirulence Pathway of Salmonella Is a Multiprotein Immunoglobulin Adhesion System

The enemy within us: lessons from the 2011 European Escherichia coli O104:H4 outbreak

The gut microbiome in human neurological disease: A review

The intestinal microbiome in early life: health and disease

The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling

The related effector proteins SopD and SopD2 from Salmonella enterica serovar Typhimurium contribute to virulence during systemic infection of mice

Transcriptional inhibitor of virulence factors in enteropathogenic Escherichia coli.

Two enteropathogenic Escherichia coli type III secreted proteins, EspA and EspB, are virulence factors