Search filters

List of works by Umesh Varshney

A distinct physiological role of MutY in mutation prevention in mycobacteria.

scientific article published on 24 September 2009

A distinct role of formamidopyrimidine DNA glycosylase (MutM) in down-regulation of accumulation of G, C mutations and protection against oxidative stress in mycobacteria

scientific article published on 16 August 2007

A genetic analysis of the functional interactions within Mycobacterium tuberculosis single-stranded DNA binding protein

scientific article

A mutation in the ribosomal protein uS12 reveals novel functions of its universally conserved PNSA loop

scientific article published on 23 December 2020

A physiological connection between tmRNA and peptidyl-tRNA hydrolase functions in Escherichia coli.

scientific article published on 16 November 2004

A single mammalian mitochondrial translation initiation factor functionally replaces two bacterial factors

scientific article published on February 2008

A unique uracil-DNA binding protein of the uracil DNA glycosylase superfamily

scientific article

Acquisition of a stable mutation in metY allows efficient initiation from an amber codon in Escherichia coli.

scientific article

An evolutionarily conserved element in initiator tRNAs prompts ultimate steps in ribosome maturation

scientific article published on 03 October 2016

An extended Shine-Dalgarno sequence in mRNA functionally bypasses a vital defect in initiator tRNA.

scientific article

An unexpected absence of queuosine modification in the tRNAs of an Escherichia coli B strain

scientific article published in December 2002

Analysis of the fusA2 locus encoding EFG2 in Mycobacterium smegmatis.

scientific article published in November 2009

Analysis of the impact of a uracil DNA glycosylase attenuated in AP-DNA binding in maintenance of the genomic integrity in Escherichia coli

scientific article

Analysis of the initiator tRNA genes from a slow- and a fast-growing Mycobacterium

scientific article published on 24 July 2002

Antimicrobial activity of fusidic acid in Escherichia coli is dependent on the relative levels of ribosome recycling factor and elongation factor G

scientific article published on 01 July 2018

Avoiding acidic region streaking in two-dimensional gel electrophoresis: case study with two bacterial whole cell protein extracts

scientific article published on 01 September 2014

Base excision and nucleotide excision repair pathways in mycobacteria ⬇️

scientific article published on July 18, 2011

Base excision repair pathways of bacteria: new promise for an old problem

scientific article published on 07 February 2020

Biochemical properties of MutT2 proteins from Mycobacterium tuberculosis and M. smegmatis and their contrasting antimutator roles in Escherichia coli

scientific article published on 25 January 2013

Biochemical properties of single-stranded DNA-binding protein from Mycobacterium smegmatis, a fast-growing mycobacterium and its physical and functional interaction with uracil DNA glycosylases

scientific article published in May 2002

Characterization of Mycobacterium tuberculosis ribosome recycling factor (RRF) and a mutant lacking six amino acids from the C-terminal end reveals that the C-terminal residues are important for its occupancy on the ribosome

scientific article published on 01 December 2002

Chimeras of Escherichia coli and Mycobacterium tuberculosis single-stranded DNA binding proteins: characterization and function in Escherichia coli

scientific article

Cloning, expression, purification, crystallization and preliminary X-ray analysis of peptidyl-tRNA hydrolase from Mycobacterium tuberculosis.

scientific article published on 26 August 2006

Coevolution of the translational machinery optimizes initiation with unusual initiator tRNAs and initiation codons in mycoplasmas

scientific article published on 13 September 2017

Common location of determinants in initiator transfer RNAs for initiator-elongator discrimination in bacteria and in eukaryotes

scientific article published on 13 March 2003

Complexes of the uracil-DNA glycosylase inhibitor protein, Ugi, with Mycobacterium smegmatis and Mycobacterium tuberculosis uracil-DNA glycosylases

scientific article (publication date: July 2003)

Compromised base excision repair pathway in Mycobacterium tuberculosis imparts superior adaptability in the host

scientific article published on 19 March 2021

Contrasting effects of mutating active site residues, aspartic acid 64 and histidine 187 of Escherichia coli uracil-DNA glycosylase on uracil excision and interaction with an inhibitor protein

scientific article published on October 1, 2002

Contributions of the N- and C-Terminal Domains of Initiation Factor 3 to Its Functions in the Fidelity of Initiation and Antiassociation of the Ribosomal Subunits.

scientific article published on 20 March 2017

Correction for Kapoor et al., "Functional Significance of an Evolutionarily Conserved Alanine (GCA) Resume Codon in tmRNA in Escherichia coli"

scientific article published on 10 July 2019

Covalent binding of uracil DNA glycosylase UdgX to abasic DNA upon uracil excision

scientific article published on 17 May 2019

Crowding, molecular volume and plasticity: an assessment involving crystallography, NMR and simulations

scientific article published on 01 December 2012

Crucial contribution of the multiple copies of the initiator tRNA genes in the fidelity of tRNA fMet selection on the ribosomal P-site in Escherichia coli ⬇️

scientific article published on August 26, 2010

Detrimental effects of hypoxia-specific expression of uracil DNA glycosylase (Ung) in Mycobacterium smegmatis.

scientific article published on 22 October 2010

Development of Assay Systems for Amber Codon Decoding at the Steps of Initiation and Elongation in Mycobacteria

scientific article published on 15 November 2018

Development of a new generation of vectors for gene expression, gene replacement, and protein-protein interaction studies in mycobacteria

scientific article published on 11 January 2013

Development of mCherry tagged UdgX as a highly sensitive molecular probe for specific detection of uracils in DNA

scientific article published on 09 August 2019

Diagnostic validation of IgM and IgG ELISA and real-time PCR in detecting scrub typhus infection in endemic regions

scientific article published on 01 April 2018

Diet-dependent depletion of queuosine in tRNAs in Caenorhabditis elegans does not lead to a developmental block

scientific article published in June 2007

Distinct mechanisms of DNA repair in mycobacteria and their implications in attenuation of the pathogen growth.

scientific article published on October 2011

Distinct properties of a hypoxia specific paralog of single stranded DNA binding (SSB) protein in mycobacteria

scientific article published on 03 October 2017

Distinctive contributions of the ribosomal P-site elements m2G966, m5C967 and the C-terminal tail of the S9 protein in the fidelity of initiation of translation in Escherichia coli

scientific article published on 25 March 2013

Diverse roles of nucleoside diphosphate kinase in genome stability and growth fitness

scientific article published on 05 April 2020

Effects of mutations at tyrosine 66 and asparagine 123 in the active site pocket of Escherichia coli uracil DNA glycosylase on uracil excision from synthetic DNA oligomers: evidence for the occurrence of long-range interactions between the enzyme an

scientific article

Epidemiological, clinical and laboratory profile of scrub typhus cases detected by serology and RT-PCR in Kumaon, Uttarakhand: a hospital-based study

scientific article published in January 2017

Evolution of initiator tRNAs and selection of methionine as the initiating amino acid

scientific article published on 20 June 2016

Fidelity of translation in the presence of mammalian mitochondrial initiation factor 3.

scientific article published on 10 August 2017

Functional significance of an evolutionarily conserved alanine (GCA) resume codon in tmRNA in Escherichia coli

scientific article published on 20 May 2011

Genetic analysis identifies a function for the queC (ybaX) gene product at an initial step in the queuosine biosynthetic pathway in Escherichia coli

scientific article

Hijacking Translation Initiation for Synthetic Biology

scientific article published on 05 February 2020

How many initiator tRNA genes does Escherichia coli need?

scientific article published on 9 May 2014

Hypersensitivity of hypoxia grown Mycobacterium smegmatis to DNA damaging agents: implications of the DNA repair deficiencies in attenuation of mycobacteria

scientific article published on 4 September 2013

Impact of Mutating the Key Residues of a Bifunctional 5,10-Methylenetetrahydrofolate Dehydrogenase-Cyclohydrolase from Escherichia coli on Its Activities.

scientific article

Impact of rRNA methylations on ribosome recycling and fidelity of initiation in Escherichia coli

scientific article published in May 2009

Importance of uracil DNA glycosylase in Pseudomonas aeruginosa and Mycobacterium smegmatis, G+C-rich bacteria, in mutation prevention, tolerance to acidified nitrite, and endurance in mouse macrophages

scientific article published on 5 April 2003

Important role of the nucleotide excision repair pathway in Mycobacterium smegmatis in conferring protection against commonly encountered DNA-damaging agents

scientific article published in September 2008

Initiation with elongator tRNAs.

scientific article published on 12 July 2013

Is the cellular initiation of translation an exclusive property of the initiator tRNAs?

scientific article published on July 2015

MIC and Upper Limit of Wild-Type Distribution for 13 Antifungal Agents against a Trichophyton mentagrophytes-Trichophyton interdigitale Complex of Indian Origin

scientific article published on 24 March 2020

Mechanism of recycling of post-termination ribosomal complexes in eubacteria: a new role of initiation factor 3.

scientific article published on June 2006

Monomeric NADH-oxidizing methylenetetrahydrofolate reductases from Mycobacterium smegmatis lack flavin coenzyme

scientific article published on 06 April 2020

Mutational analysis of the uracil DNA glycosylase inhibitor protein and its interaction with Escherichia coli uracil DNA glycosylase

scientific article

Mutations that alter the regulation of the chb operon of Escherichia coli allow utilization of cellobiose

scientific article published on 19 November 2007

Mycobacterium tuberculosis MutT1 (Rv2985) and ADPRase (Rv1700) proteins constitute a two-stage mechanism of 8-oxo-dGTP and 8-oxo-GTP detoxification and adenosine to cytidine mutation avoidance.

scientific article

Mycobacterium tuberculosis and Escherichia coli nucleoside diphosphate kinases lack multifunctional activities to process uracil containing DNA

scientific journal article

Novel insertion and deletion mutants of RpoB that render Mycobacterium smegmatis RNA polymerase resistant to rifampicin-mediated inhibition of transcription

scientific article published on 11 February 2010

Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli

scientific article published on 06 December 2019

Nudix hydrolases with Coenzyme A (CoA) and acyl-CoA pyrophosphatase activities confer growth advantage to Mycobacterium smegmatis

scientific article published on 05 September 2019

One-carbon metabolic pathway rewiring in Escherichia coli reveals an evolutionary advantage of 10-formyltetrahydrofolate synthetase (Fhs) in survival under hypoxia

scientific article published on December 2014

Overexpression, purification, crystallization and preliminary X-ray analysis of uracil N-glycosylase from Mycobacterium tuberculosis in complex with a proteinaceous inhibitor

scientific article published on 30 November 2006

Paralogous cAMP receptor proteins in Mycobacterium smegmatis show biochemical and functional divergence

scientific article published on 01 December 2014

Peptidyl-tRNA hydrolase and its critical role in protein biosynthesis

scientific article published on August 2006

Physiological role of FolD (methylenetetrahydrofolate dehydrogenase), FchA (methenyltetrahydrofolate cyclohydrolase) and Fhs (formyltetrahydrofolate synthetase) from Clostridium perfringens in a heterologous model of Escherichia coli

scientific article published on 3 November 2015

Plasticity, ligand conformation and enzyme action of Mycobacterium smegmatis MutT1

scientific article published on 16 September 2020

Rapid and reliable site-directed mutagenesis using Kunkel's approach

scientific article published on 01 January 2002

Rapid formylation of the cellular initiator tRNA population makes a crucial contribution to its exclusive participation at the step of initiation

scientific article published on 01 February 2019

Recycling of ribosomal complexes stalled at the step of elongation in Escherichia coli

scientific article published on 21 May 2008

Recycling of the posttermination complexes of Mycobacterium smegmatis and Escherichia coli ribosomes using heterologous factors

scientific article published on 16 June 2010

Regulation of translation by one-carbon metabolism in bacteria and the eukaryotic organelles

scientific article published on 16 November 2020

Rewiring of one carbon metabolism in Salmonella serves as an excellent live vaccine against systemic salmonellosis

scientific article published on 29 October 2018

Role of 16S ribosomal RNA methylations in translation initiation in Escherichia coli

scientific article

Role of the Ribosomal P-Site Elements of m 2 G966, m 5 C967, and the S9 C-Terminal Tail in Maintenance of the Reading Frame during Translational Elongation in Escherichia coli ⬇️

scientific article published on May 31, 2013

SIRT6 transcriptionally regulates global protein synthesis through transcription factor Sp1 independent of its deacetylase activity

scientific article published on 01 September 2019

Simultaneous presence of fhs and purT genes is disadvantageous for the fitness of Escherichia coli growth

scientific article published on 22 June 2015

Species specific interactions of Arr with RplK mediate stringent response in bacteria

scientific article published on 8 January 2018

Structural basis for poor uracil excision from hairpin DNA. An NMR study

scientific article

Structural insights into the specificity and catalytic mechanism of mycobacterial nucleotide pool sanitizing enzyme MutT2

scientific article published on 09 October 2018

Structural plasticity and enzyme action: crystal structures of mycobacterium tuberculosis peptidyl-tRNA hydrolase

scientific article

Structure of the second Single Stranded DNA Binding protein (SSBb) from Mycobacterium smegmatis

scientific article

Structure of uracil-DNA glycosylase from Mycobacterium tuberculosis: insights into interactions with ligands ⬇️

scientific article published on July 27, 2010

Structures of new crystal forms ofMycobacterium tuberculosispeptidyl-tRNA hydrolase and functionally important plasticity of the molecule

scientific article

Substitutions at tyrosine 66 of Escherichia coli uracil DNA glycosylase lead to characterization of an efficient enzyme that is recalcitrant to product inhibition

scientific article published on December 2003

Substrate specificities and functional characterization of a thermo-tolerant uracil DNA glycosylase (UdgB) from Mycobacterium tuberculosis

scientific journal article

Sustenance of Escherichia coli on a single tRNAMet

scientific article published on 01 November 2018

Synergistic effects of UdgB and Ung in mutation prevention and protection against commonly encountered DNA damaging agents in Mycobacterium smegmatis.

scientific article published on 26 November 2009

The IDL of E. coli SSB links ssDNA and protein binding by mediating protein-protein interactions

scientific article published on 26 January 2017

The Termination Phase in Protein Synthesis is not Obligatorily Followed by the RRF/EF-G-Dependent Recycling Phase

scientific article published on 31 May 2016

The initiation factor 3 (IF3) residues interacting with initiator tRNA elbow modulate the fidelity of translation initiation and growth fitness in <i>Escherichia coli</i>

scientific article published in 2022

Translation initiation in mammalian mitochondria- a prokaryotic perspective

scientific article published on 14 November 2019

Two highly conserved features of bacterial initiator tRNAs license them to pass through distinct checkpoints in translation initiation.

scientific article published in February 2017

Unconventional initiator tRNAs sustain Escherichia coli.

scientific article

Unique features of the structure and interactions of mycobacterial uracil-DNA glycosylase: structure of a complex of the Mycobacterium tuberculosis enzyme in comparison with those from other sources

scientific article

Uracil excision repair in Mycobacterium tuberculosis cell-free extracts ⬇️

scientific article published on 02 March 2011

Use of Mycobacterium smegmatis deficient in ADP-ribosyltransferase as surrogate for Mycobacterium tuberculosis in drug testing and mutation analysis

scientific article

Use of sequence microdivergence in mycobacterial ortholog to analyze contributions of the water-activating loop histidine of Escherichia coli uracil-DNA glycosylase in reactant binding and catalysis

scientific article published in July 2004

Utilisation of 10-formyldihydrofolate as substrate by dihydrofolate reductase (DHFR) and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) tranformylase/IMP cyclohydrolase (PurH) in Escherichia coli

scientific article published on 01 July 2018

Paulina is supported by:

About Paulina

Help