Search filters

List of works by Kalappa Muniyappa

Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae ⬇️

scientific article published on 01 July 1997

Binding and regulatory properties of phosphofructokinase from swine kidney ⬇️

scientific article published on 01 August 1984

Binding of gemini bisbenzimidazole drugs with human telomeric G-quadruplex dimers: effect of the spacer in the design of potent telomerase inhibitors

scientific article

Characterization and comparison of the soluble and membrane-bound cyclic AMP-dependent protein kinase from swine kidney ⬇️

scientific article published on 01 January 1983

Characterization of Mycobacterium leprae RecA intein, a LAGLIDADG homing endonuclease, reveals a unique mode of DNA binding, helical distortion, and cleavage compared with a canonical LAGLIDADG homing endonuclease

scientific article published on 15 July 2009

Cloning, overexpression and purification of functionally active Saccharomyces cerevisiae Hop1 protein from Escherichia coli.

scientific article

Correction for Sharadamma et al., "Defining the Functionally Important Domain and Amino Acid Residues in Mycobacterium tuberculosis Integration Host Factor for Genome Stability, DNA Binding, and Integrative Recombination".

scientific article

Crystal Structures of Mycobacterium smegmatis RecA and Its Nucleotide Complexes

scientific article

Crystal structures of Mycobacterium tuberculosis RecA and its complex with ADP-AlF(4): implications for decreased ATPase activity and molecular aggregation ⬇️

scientific article

Crystallization and preliminary X-ray studies of the C-terminal domain of Mycobacterium tuberculosis LexA ⬇️

scientific article published on August 28, 2010

Crystallographic and modelling studies on Mycobacterium tuberculosis RuvA Additional role of RuvB-binding domain and inter species variability

scientific article

Crystallographic identification of an ordered C-terminal domain and a second nucleotide-binding site in RecA: new insights into allostery.

scientific article published on 28 April 2006

DNA Binding, Coprotease, and Strand Exchange Activities of Mycobacterial RecA Proteins: Implications for Functional Diversity among RecA Nucleoprotein Filaments ⬇️

scientific article published on December 16, 2010

DNA-Binding Activities of Hop1 Protein, a Synaptonemal Complex Component from Saccharomyces cerevisiae ⬇️

scientific article published on March 1, 1998

Deciphering the essentiality and function of SxSx motif in Mycobacterium tuberculosis UvrB

scientific article published on 08 January 2020

Defining the Functionally Important Domain and Amino Acid Residues in Mycobacterium tuberculosis Integration Host Factor for Genome Stability, DNA Binding, and Integrative Recombination

scientific article published on 10 July 2017

Design and synthesis of new benzimidazole-carbazole conjugates for the stabilization of human telomeric DNA, telomerase inhibition, and their selective action on cancer cells

scientific article

Differential regulation of MRN (Mre11–Rad50–Nbs1) complex subunits and telomerase activity in cancer cells ⬇️

scientific article published on August 2, 2010

Dimeric 1,3-phenylene-bis(piperazinyl benzimidazole)s: synthesis and structure-activity investigations on their binding with human telomeric G-quadruplex DNA and telomerase inhibition properties

scientific article

Discovery and Structural Characterization of G-quadruplex DNA in Human Acetyl-CoA Carboxylase Gene Promoters: Its Role in Transcriptional Regulation and as a Therapeutic Target for Human Disease

scientific article published on 20 April 2016

Dual targeting of Saccharomyces cerevisiae Pso2 to mitochondria and the nucleus, and its functional relevance in the repair of DNA interstrand crosslinks

scientific article published on 01 May 2022

Enhanced G-Quadruplex DNA Stabilization and Telomerase Inhibition by Novel Fluorescein Derived Salen and Salphen Based Ni(II) and Pd(II) Complexes

scientific article published on 6 February 2017

Evidence for a specific phosphoryl binding site in swine kidney phosphofructokinase ⬇️

scientific article published on April 1, 1984

Force and ATP hydrolysis dependent regulation of RecA nucleoprotein filament by single-stranded DNA binding protein.

scientific article published on 4 December 2012

Functional Analysis of DNA Replication Fork Reversal Catalyzed by Mycobacterium tuberculosis RuvAB Proteins ⬇️

scientific article published on November 17, 2011

Functionally important movements in RecA molecules and filaments: studies involving mutation and environmental changes

scientific article

Genetic and biochemical evidences reveal novel insights into the mechanism underlying Saccharomyces cerevisiae Sae2-mediated abrogation of DNA replication stress

scientific article published on December 2016

Meiosis-specific yeast Hop1 protein promotes pairing of double-stranded DNA helices via G/C isochores

scientific article

Molecular Dissection of Mycobacterium tuberculosis Integration Host Factor Reveals Novel Insights into the Mode of DNA Binding and Nucleoid Compaction.

scientific article

Molecular Mechanism Underlying ATP-Induced Conformational Changes in the Nucleoprotein Filament of Mycobacterium smegmatis RecA.

scientific article

Molecular dissection of Mycobacterium tuberculosis integration host factor reveals novel insights into the mode of DNA binding and nucleoid compaction

scientific article

Mutational analysis of active-site residues in the Mycobacterium leprae RecA intein, a LAGLIDADG homing endonuclease: Asp(122) and Asp(193) are crucial to the double-stranded DNA cleavage activity whereas Asp(218) is not.

scientific article published on January 2010

Mycobacterium leprae RecA is structurally analogous but functionally distinct from Mycobacterium tuberculosis RecA protein

scientific article published on 06 October 2011

Mycobacterium tuberculosis RecA intein possesses a novel ATP-dependent site-specific double-stranded DNA endonuclease activity

scientific journal article

Mycobacterium tuberculosis RecA intein, a LAGLIDADG homing endonuclease, displays Mn(2+) and DNA-dependent ATPase activity

scientific journal article

Mycobacterium tuberculosis RecG protein but not RuvAB or RecA protein is efficient at remodeling the stalled replication forks: implications for multiple mechanisms of replication restart in mycobacteria

scientific article published on 14 August 2015

Mycobacterium tuberculosis RuvA induces two distinct types of structural distortions between the homologous and heterologous Holliday junctions

scientific journal article

Mycobacterium tuberculosis RuvX is a Holliday junction resolvase formed by dimerisation of the monomeric YqgF nuclease domain

scientific article published on 28 January 2016

Mycobacterium tuberculosis UvrB Is a Robust DNA-Stimulated ATPase That Also Possesses Structure-Specific ATP-Dependent DNA Helicase Activity

scientific article published on 12 September 2016

Mycobacterium tuberculosis UvrD1 and UvrA proteins suppress DNA strand exchange promoted by cognate and noncognate RecA proteins

scientific journal article

Mycobacterium tuberculosis nucleoid-associated DNA-binding protein H-NS binds with high-affinity to the Holliday junction and inhibits strand exchange promoted by RecA protein

scientific article

N-terminal disordered domain of Saccharomyces cerevisiae Hop1 protein is dispensable for DNA binding, bridging, and synapsis of double-stranded DNA molecules but is necessary for spore formation.

scientific article

New dimeric carbazole-benzimidazole mixed ligands for the stabilization of human telomeric G-quadruplex DNA and as telomerase inhibitors. A remarkable influence of the spacer.

scientific article published on July 2015

Novel Oligopyrrole Carboxamide based Nickel(II) and Palladium(II) Salens, Their Targeting of Human G-Quadruplex DNA, and Selective Cancer Cell Toxicity

scientific article

Novel derivatives of spirohydantoin induce growth inhibition followed by apoptosis in leukemia cells

scientific article published on 30 October 2008

Novel ruthenium azo-quinoline complexes with enhanced photonuclease activity in human cancer cells

scientific article

Phosphoprotein phosphatase from swine kidney

scientific article published on 01 January 1982

Probing the Potential Role of Non-B DNA Structures at Yeast Meiosis-Specific DNA Double-Strand Breaks

scientific article published in May 2017

Processing of DNA double-stranded breaks and intermediates of recombination and repair by Saccharomyces cerevisiae Mre11 and its stimulation by Rad50, Xrs2, and Sae2 proteins

scientific article published on 26 February 2013

Purification and properties of swine kidney phosphoprotein phosphatase ⬇️

scientific article published on 01 January 1983

Reciprocal regulation of fructose 1,6-bisphosphatase and phosphofructokinase by fructose 2,6-bisphosphate in swine kidney

scientific article published on 01 January 1983

Saccharomyces cerevisiae Hop1 protein zinc finger motif binds to the Holliday junction and distorts the DNA structure: implications for holliday junction migration.

scientific article published on 13 October 2007

Saccharomyces cerevisiae Mre11 is a high-affinity G4 DNA-binding protein and a G-rich DNA-specific endonuclease: implications for replication of telomeric DNA

scientific article

Saccharomyces cerevisiae Red1 protein exhibits nonhomologous DNA end-joining activity and potentiates Hop1-promoted pairing of double-stranded DNA.

scientific article published on 22 June 2017

Selective binding of meiosis-specific yeast Hop1 protein to the holliday junctions distorts the DNA structure and its implications for junction migration and resolution

scientific article

Single-molecule DNA analysis reveals that yeast Hop1 protein promotes DNA folding and synapsis: implications for condensation of meiotic chromosomes

scientific article published on 09 November 2012

Snapshots of RecA protein involving movement of the C-domain and different conformations of the DNA-binding loops: crystallographic and comparative analysis of 11 structures of Mycobacterium smegmatis RecA

scientific article

Stabilization and structural alteration of the G-quadruplex DNA made from the human telomeric repeat mediated by Tröger's base based novel benzimidazole derivatives.

scientific article

Structural Characterization of i-Motif Structure in the Human Acetyl-CoA Carboxylase 1 Gene Promoters and Their Role in the Regulation of Gene Expression

scientific article published on 25 April 2018

Structural studies on MtRecA-nucleotide complexes: insights into DNA and nucleotide binding and the structural signature of NTP recognition

scientific article (publication date: 15 February 2003)

Structural studies on Mycobacterium tuberculosis RecA: molecular plasticity and interspecies variability

scientific article

Structure of Mycobacterium smegmatis single-stranded DNA-binding protein and a comparative study involving homologus SSBs: biological implications of structural plasticity and variability in quaternary association

scientific article

Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination

scientific article

Suramin is a potent and selective inhibitor of Mycobacterium tuberculosis RecA protein and the SOS response: RecA as a potential target for antibacterial drug discovery.

scientific article published on 9 April 2014

Synergy between the N-terminal and C-terminal domains of Mycobacterium tuberculosis HupB is essential for high-affinity binding, DNA supercoiling and inhibition of RecA-promoted strand exchange.

scientific article

Targeting G-quadruplex DNA structures in the telomere and oncogene promoter regions by benzimidazole‒carbazole ligands.

scientific article published on 5 February 2018

The Anionic Phospholipids in the Plasma Membrane Play an Important Role in Regulating the Biochemical Properties and Biological Functions of RecA Proteins

scientific article published on 19 February 2019

The RecA intein of Mycobacterium tuberculosis promotes cleavage of ectopic DNA sites. Implications for the dispersal of inteins in natural populations

scientific journal article

The biological and structural characterization of Mycobacterium tuberculosis UvrA provides novel insights into its mechanism of action ⬇️

scientific article published on May 27, 2011

The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity

scientific article

The intrinsic ATPase activity of Mycobacterium tuberculosis UvrC is crucial for its damage-specific DNA incision function

scientific article published on 29 June 2020

UvrA and UvrC subunits of the Mycobacterium tuberculosis UvrABC excinuclease interact independently of UvrB and DNA

scientific article published on 24 November 2019

X-ray and molecular-dynamics studies on Mycobacterium leprae single-stranded DNA-binding protein and comparison with other eubacterial SSB structures ⬇️

scientific article published on September 18, 2010

Yeast meiosis-specific protein Hop1 binds to G4 DNA and promotes its formation

scientific article published on February 2000

Paulina is supported by:

About Paulina

Help