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List of works by Kanneboyina Nagaraju

"Of Mice and Measures": A Project to Improve How We Advance Duchenne Muscular Dystrophy Therapies to the Clinic

scientific article published on 01 January 2018

"Watching time tick by…": Decision making for Duchenne muscular dystrophy trials

scientific article published on 3 November 2015

A Promising Future for Stem-Cell-Based Therapies in Muscular Dystrophies-In Vitro and In Vivo Treatments to Boost Cellular Engraftment ⬇️

scientific article published on 31 October 2019

A longitudinal, integrated, clinical, histological and mRNA profiling study of resistance exercise in myositis

scientific article

A mouse model of inherited choline kinase β-deficiency presents with specific cardiac abnormalities and a predisposition to arrhythmia

scientific article published on 11 February 2022

A robust in vitro screening assay to identify NF-kappaB inhibitors for inflammatory muscle diseases

scientific article published on 21 July 2009

AMP-activated protein kinase signaling regulated expression of urea cycle enzymes in response to changes in dietary protein intake

scientific article published on 01 August 2019

Accurate Quantitation of Dystrophin Protein in Human Skeletal Muscle Using Mass Spectrometry

scientific article published on December 2012

Activation of the endoplasmic reticulum stress response in autoimmune myositis: Potential role in muscle fiber damage and dysfunction

scientific article published on 01 June 2005

Activation of the ubiquitin proteasome pathway in a mouse model of inflammatory myopathy: a potential therapeutic target

scientific article

An update on pathogenic mechanisms of inflammatory myopathies.

scientific article

Animal models of myositis

scientific article

Annexin A1 Deficiency does not Affect Myofiber Repair but Delays Regeneration of Injured Muscles

scientific article

Annexin A2 links poor myofiber repair with inflammation and adipogenic replacement of the injured muscle

scientific article published on 21 February 2017

Asynchronous remodeling is a driver of failed regeneration in Duchenne muscular dystrophy

scientific article

Author Correction: Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle

scientific article published on 15 January 2018

Author Correction: Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle.

scientific article

Behavioral and locomotor measurements using an open field activity monitoring system for skeletal muscle diseases

scientific article

Best Practices and Standard Protocols as a Tool to Enhance Translation for Neuromuscular Disorders

scientific article published on May 2015

Bodywide skipping of exons 45-55 in dystrophic mdx52 mice by systemic antisense delivery

scientific article

Characterization of dysferlin deficient SJL/J mice to assess preclinical drug efficacy: fasudil exacerbates muscle disease phenotype

scientific article

Conditional over-expression of PITX1 causes skeletal muscle dystrophy in mice ⬇️

scientific article published on May 25, 2012

Correction: Functional and Molecular Effects of Arginine Butyrate and Prednisone on Muscle and Heart in the Dystrophin Deficient mice

Correction: Functional and Molecular Effects of Arginine Butyrate and Prednisone on Muscle and Heart in the Dystrophin Deficient mdx mice

scientific article

Correction: Functional and Molecular Effects of Arginine Butyrate and Prednisone on Muscle and Heart in the Dystrophin Deficient mdx mice.

scientific article published on 31 August 2010

Daily Supplementation of D-ribose Shows No Therapeutic Benefits in the MHC-I Transgenic Mouse Model of Inflammatory Myositis ⬇️

scientific article published on June 13, 2013

Deconstructing Pompe disease by analyzing single muscle fibers: to see a world in a grain of sand...

scientific article

Developing standard procedures for murine and canine efficacy studies of DMD therapeutics: report of two expert workshops on "Pre-clinical testing for Duchenne dystrophy": Washington DC, October 27th-28th 2007 and Zürich, June 30th-July 1st 2008.

scientific article published on 26 June 2009

Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies.

scientific article

Discovery of potential urine-accessible metabolite biomarkers associated with muscle disease and corticosteroid response in the mdx mouse model for Duchenne

scientific article published on 16 July 2019

Discovery of serum protein biomarkers in the mdx mouse model and cross-species comparison to Duchenne muscular dystrophy patients

scientific article

Disruption of a key ligand-H-bond network drives dissociative properties in vamorolone for Duchenne muscular dystrophy treatment

scientific article published on 11 September 2020

Dysferlin deficiency enhances monocyte phagocytosis: a model for the inflammatory onset of limb-girdle muscular dystrophy 2B.

scientific article

Dysferlin deficiency shows compensatory induction of Rab27A/Slp2a that may contribute to inflammatory onset.

scientific article published on 02 October 2008

Dystrophin-deficient cardiomyopathy in mouse: expression of Nox4 and Lox are associated with fibrosis and altered functional parameters in the heart

scientific article published on 25 April 2008

Effect of endurance exercise on microRNAs in myositis skeletal muscle-A randomized controlled study.

scientific article published on 22 August 2017

Effect of genetic background on the dystrophic phenotype in mdx mice.

scientific article

Effect of the IL-1 Receptor Antagonist Kineret® on Disease Phenotype in mdx Mice

scientific article

Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer

scholarly article

Effects of Chronic, Maximal Phosphorodiamidate Morpholino Oligomer (PMO) Dosing on Muscle Function and Dystrophin Restoration in a Mouse Model of Duchenne Muscular Dystrophy

scientific article published on 21 September 2021

Effects on muscle tissue remodeling and lipid metabolism in muscle tissue from adult patients with polymyositis or dermatomyositis treated with immunosuppressive agents

scientific article published on 10 June 2016

Elevation of proinflammatory cytokines in patients with Aicardi-Goutières syndrome

scientific article published on 13 February 2013

Elusive sources of variability of dystrophin rescue by exon skipping

scientific article

Endoplasmic Reticulum Stress in Skeletal Muscle Homeostasis and Disease ⬇️

scientific article published on June 1, 2012

Endothelial cell activation and neovascularization are prominent in dermatomyositis

scientific article

Endurance Exercise Improves Molecular Pathways of Aerobic Metabolism in Patients With Myositis

scientific article

Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy

scientific article

Enhancing translation: guidelines for standard pre-clinical experiments in mdx mice

scientific article published on 6 July 2011

Evaluation of skeletal and cardiac muscle function after chronic administration of thymosin beta-4 in the dystrophin deficient mouse

scientific article

Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B

scientific article published on 03 June 2019

Functional and molecular effects of arginine butyrate and prednisone on muscle and heart in the mdx mouse model of Duchenne Muscular Dystrophy

scientific article

GREG cells, a dysferlin-deficient myogenic mouse cell line ⬇️

scientific article published on October 12, 2011

Glucocorticoid Analogues: Potential Therapeutic Alternatives for Treating Inflammatory Muscle Diseases ⬇️

scientific article published on March 1, 2012

Glucocorticoid efficacy in asthma: is improved tissue remodeling upstream of anti-inflammation

scientific article published in January 2010

Glucocorticoid-treated mice are an inappropriate positive control for long-term preclinical studies in the mdx mouse

scientific article

Glycogen stored in skeletal but not in cardiac muscle in acid alpha-glucosidase mutant (Pompe) mice is highly resistant to transgene-encoded human enzyme

scientific journal article

Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells

scientific article

IL-6 signaling blockade increases inflammation but does not affect muscle function in the mdx mouse

scientific article

Identification of disease specific pathways using in vivo SILAC proteomics in dystrophin deficient mdx mouse.

scientific article published on 7 January 2013

Idiopathic inflammatory myopathies: pathogenic mechanisms of muscle weakness ⬇️

scientific article published on 07 June 2013

Immune-mediated pathology in Duchenne muscular dystrophy

scientific article published on August 2015

Immunoblotting of single cell types isolated from frozen sections by laser microdissection

scientific article

Immunopathogenic pathways in canine inflammatory myopathies resemble human myositis

scientific article published on 23 June 2006

Improving Reproducibility of Phenotypic Assessments in the DyW Mouse Model of Laminin-α2 Related Congenital Muscular Dystrophy

scientific article

Improving translatability of preclinical studies for neuromuscular disorders: lessons from the TREAT-NMD Advisory Committee for Therapeutics (TACT)

scientific article published on 07 February 2020

Induction of tolerance to a recombinant human enzyme, acid alpha-glucosidase, in enzyme deficient knockout mice

scientific article published on April 1, 2003

Infection-induced expansion of a MHC Class Ib-dependent intestinal intraepithelial gammadelta T cell subset

scientific article published in June 2004

Inflammasome up-regulation and activation in dysferlin-deficient skeletal muscle

scientific article

Inhibition of inflammation with celastrol fails to improve muscle function in dysferlin-deficient A/J mice

scientific article

Long-term efficacy of systemic multiexon skipping targeting dystrophin exons 45-55 with a cocktail of vivo-morpholinos in mdx52 mice

scientific article

Long-term treatment with naproxcinod significantly improves skeletal and cardiac disease phenotype in the mdx mouse model of dystrophy

scientific article

Losartan decreases cardiac muscle fibrosis and improves cardiac function in dystrophin-deficient mdx mice

scientific article

Measurement of activation of the endoplasmic reticulum stress response in autoimmune myositis

scientific article published on 01 January 2011

Membrane Stabilization by Modified Steroid Offers a Potential Therapy for Muscular Dystrophy Due to Dysferlin Deficit

scientific article published on 27 August 2018

Membrane sealant Poloxamer P188 protects against isoproterenol induced cardiomyopathy in dystrophin deficient mice

scientific article

Metabolic remodeling agents show beneficial effects in the dystrophin-deficient mdx mouse model

scientific article

Mitochondria mediate cell membrane repair and contribute to Duchenne muscular dystrophy

scientific article

Mitochondrial dysfunction and consequences in calpain-3-deficient muscle

scientific article published on 11 December 2020

Mitochondrial dysfunction and role of harakiri in the pathogenesis of myositis

scientific article published on 18 July 2019

Mitotic asynchrony induces transforming growth factor-β1 secretion from airway epithelium

scientific article

Morpholino-induced exon skipping stimulates cell-mediated and humoral responses to dystrophin in mdx mice

scientific article published on 16 April 2019

Muscle miRNAome shows suppression of chronic inflammatory miRNAs with both prednisone and vamorolone

scientific article published on 08 June 2018

Muscle myeloid type I interferon gene expression may predict therapeutic responses to rituximab in myositis patients

scientific article

Muscle weakness in myositis: microRNAs mediate dystrophin reduction in MHC class I transgenic mouse model and human muscle biopsies

scientific article published on 03 February 2020

Muscular dystrophy in the mdx mouse is a severe myopathy compounded by hypotrophy, hypertrophy and hyperplasia.

scientific article published on May 2015

Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle

scientific article published on 16 October 2017

NKG2A inhibits TH2 cell effector function in vitro

scientific article

Non-invasive MRI and spectroscopy of mdx mice reveal temporal changes in dystrophic muscle imaging and in energy deficits

scientific article

Non-invasive optical imaging of muscle pathology in mdx mice using cathepsin caged near-infrared imaging

scientific article

Nonimmune mechanisms of muscle damage in myositis: role of the endoplasmic reticulum stress response and autophagy in the disease pathogenesis

scientific article

Novel approaches to corticosteroid treatment in Duchenne muscular dystrophy

scientific article published on November 2012

OPN-a induces muscle inflammation by increasing recruitment and activation of pro-inflammatory macrophages.

scientific article published on 25 July 2016

Omigapil treatment decreases fibrosis and improves respiratory rate in dy(2J) mouse model of congenital muscular dystrophy

scientific article

One-year treatment of morpholino antisense oligomer improves skeletal and cardiac muscle functions in dystrophic mdx mice

scientific article

Orthogonal analysis of dystrophin protein and mRNA as a surrogate outcome for drug development

scientific article published on 05 August 2019

Overexpression of MHC class I heavy chain protein in young skeletal muscle leads to severe myositis: implications for juvenile myositis

scientific article published on 21 August 2009

Pharmacologic management of Duchenne muscular dystrophy: target identification and preclinical trials

scientific article

Phase 1 trial of vamorolone, a first-in-class steroid, shows improvements in side effects via biomarkers bridged to clinical outcomes

scientific article published on 7 March 2018

Phase IIa trial in Duchenne muscular dystrophy shows vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug

scientific article published on 13 September 2018

Platelets induce apoptosis during sepsis in a contact-dependent manner that is inhibited by GPIIb/IIIa blockade

scientific article

Polymyositis and dermatomyositis: pathophysiology

scientific article

Population Pharmacokinetics of Vamorolone (VBP15) in Healthy Men and Boys With Duchenne Muscular Dystrophy

scientific article published on 11 February 2019

Potential of oligonucleotide-mediated exon-skipping therapy for Duchenne muscular dystrophy.

scientific article

Preclinical drug trials in the mdx mouse: assessment of reliable and sensitive outcome measures

scientific article

Quantitative Antisense Screening and Optimization for Exon 51 Skipping in Duchenne Muscular Dystrophy.

scientific article published on 28 July 2017

Replacing acid alpha-glucosidase in Pompe disease: recombinant and transgenic enzymes are equipotent, but neither completely clears glycogen from type II muscle fibers.

scientific article

Report on the Myomatrix Conference April 22-24, 2012, University of Nevada, Reno, Nevada, USA

scientific article published on 15 July 2012

Risk factors and disease mechanisms in myositis.

scientific article published in April 2018

Role of Toll-like receptors in the pathogenesis of dystrophin-deficient skeletal and heart muscle

scientific article published on 23 December 2013

Role of major histocompatibility complex class I molecules in autoimmune myositis

scientific article

Role of non-immune mechanisms of muscle damage in idiopathic inflammatory myopathies

scientific article

Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy

scientific article

Selective modulation through the glucocorticoid receptor ameliorates muscle pathology in mdx mice

scientific article

Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and juvenile dermatomyositis

scientific article published on 21 October 2018

Serum pharmacodynamic biomarkers for chronic corticosteroid treatment of children

scientific article published on 17 August 2016

Sexual dimorphism in immune response genes as a function of puberty

scientific article

Skeletal, cardiac, and respiratory muscle function and histopathology in the P448Lneo- mouse model of FKRP-deficient muscular dystrophy.

scientific article published on 6 April 2018

Sources of variability and effect of experimental approach on expression profiling data interpretation

scientific article

Suppression of autophagy permits successful enzyme replacement therapy in a lysosomal storage disorder--murine Pompe disease

scientific article

Synthesis, Characterization, and Function of an RNA-Based Transfection Reagent

scientific article published on 01 March 2018

TNF-α-Induced microRNAs Control Dystrophin Expression in Becker Muscular Dystrophy

scientific article published on 26 August 2015

The TREAT-NMD advisory committee for therapeutics (TACT): an innovative de-risking model to foster orphan drug development

scientific article

The effects of MyD88 deficiency on disease phenotype in dysferlin-deficient A/J mice: role of endogenous TLR ligands.

scientific article

The molecular basis of skeletal muscle weakness in a mouse model of inflammatory myopathy ⬇️

scientific article published on November 1, 2012

The protein phosphatase 2A B56γ regulatory subunit is required for heart development

scientific article published on 18 February 2014

The proton pump inhibitor lansoprazole improves the skeletal phenotype in dystrophin deficient mdx mice

scientific article

The role of TRAIL in mediating autophagy in myositis skeletal muscle: a potential nonimmune mechanism of muscle damage

scientific article

The role of nitrite in muscle function, susceptibility to contraction injury, and fatigability in sickle cell mice

scientific article published on 14 August 2018

The use of proteomic analysis to study trafficking defects in axons

scientific article published on 2 September 2015

The use of urinary and kidney SILAM proteomics to monitor kidney response to high dose morpholino oligonucleotides in the mdx mouse

scientific article published in January 2015

Time series proteome profiling to study endoplasmic reticulum stress response.

scientific article

Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy

scientific article published on 9 April 2008

Understanding the origin of non-immune cell-mediated weakness in the idiopathic inflammatory myopathies - potential role of ER stress pathways

scientific article published on September 2015

Update on Standard Operating Procedures in Preclinical Research for DMD and SMA Report of TREAT-NMD Alliance Workshop, Schiphol Airport, 26 April 2015, The Netherlands.

scientific article

Upregulation of MHC class I in transgenic mice results in reduced force-generating capacity in slow-twitch muscle.

scientific article published on May 2009

VBP15, a glucocorticoid analogue, is effective at reducing allergic lung inflammation in mice

scientific article

VBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects

scientific article

VBP15, a novel anti-inflammatory, is effective at reducing the severity of murine experimental autoimmune encephalomyelitis.

scientific article published on 13 November 2014

VBP15: preclinical characterization of a novel anti-inflammatory delta 9,11 steroid

scientific article

Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy

scientific article published on 11 February 2019

Vamorolone trial in Duchenne muscular dystrophy shows dose-related improvement of muscle function

scientific article published on 26 August 2019

Vamorolone, a dissociative steroidal compound, reduces collagen antibody-induced joint damage and inflammation when administered after disease onset

scientific article published on 24 August 2019

Δ-9,11 modification of glucocorticoids dissociates nuclear factor-κB inhibitory efficacy from glucocorticoid response element-associated side effects.

scientific article

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