Search filters

List of works by Ilpo Huhtaniemi

15th European Workshop on Molecular and Cellular Endocrinology of the Testis. Introduction

scientific article published on 06 April 2009

A Novel mutation in the FSH receptor inhibiting signal transduction and causing primary ovarian failure.

scientific article

A common polymorphism in the human relaxin-like factor (RLF) gene: no relationship with cryptorchidism

scientific article (publication date: April 2000)

A hormonal contraceptive for men: how close are we?

scientific article published on January 2010

A multicenter phase IIb study of a novel combination of intramuscular androgen (testosterone decanoate) and oral progestogen (etonogestrel) for male hormonal contraception.

scientific article

A new FSHbeta mutation in a 29-year-old woman with primary amenorrhea and isolated FSH deficiency: functional characterization and ovarian response to human recombinant FSH.

scientific article

A novel Ala(-3)Thr mutation in the signal peptide of human luteinizing hormone beta-subunit: potentiation of the inositol phosphate signalling pathway and attenuation of the adenylate cyclase pathway by recombinant variant hormone

scientific article published on March 2002

A novel approach of targeted ablation of mammary carcinoma cells through luteinizing hormone receptors using Hecate-CGbeta conjugate.

scientific article published on May 2003

A novel inactivating mutation of the LH/chorionic gonadotrophin receptor with impaired membrane trafficking leading to Leydig cell hypoplasia type 1.

scientific article

A novel targeted therapy of Leydig and granulosa cell tumors through the luteinizing hormone receptor using a hecate-chorionic gonadotropin beta conjugate in transgenic mice.

scientific article

A novel treatment strategy for ovarian cancer based on immunization against zona pellucida protein (ZP) 3 ⬇️

scientific article published on October 5, 2011

A short evolutionary history of FSH-stimulated spermatogenesis

scientific article

A vital region for human glycoprotein hormone trafficking revealed by an LHB mutation.

scientific article published on 21 September 2016

Absence of the genetic variant Val79Met in human chorionic gonadotropin-beta gene 5 in five European populations

scientific article

Adaptation to acute coronary syndrome-induced stress with lowering of testosterone: a possible survival factor

scientific article

Adenosine triphosphate induces Ca2+ signal in epithelial cells of the mouse caput epididymis through activation of P2X and P2Y purinergic receptors

scientific article published on 30 October 2002

Adrenal hyperplasia and tumours in mice in connection with aberrant pituitary-gonadal function.

scientific article published on 19 October 2008

Adrenocortical tumorigenesis in transgenic mice expressing the inhibin alpha-subunit promoter/simian virus 40 T-antigen transgene: relationship between ectopic expression of luteinizing hormone receptor and transcription factor GATA-4.

scientific article

Advances in the Molecular Pathophysiology, Genetics, and Treatment of Primary Ovarian Insufficiency.

scientific article published on 26 April 2018

Age-related changes in general and sexual health in middle-aged and older men: results from the European Male Ageing Study (EMAS).

scientific article published on 19 November 2009

Aging and the Male Reproductive System

scientific article published on 01 August 2019

Aging of the human ovary and testis

scientific article

Androgen Replacement Therapy in Late-Onset Hypogonadism: Current Concepts and Controversies – A Mini-Review ⬇️

scientific article published on 02 August 2010

Angiogenic activity of human chorionic gonadotropin through LH receptor activation on endothelial and epithelial cells of the endometrium.

scientific article

Are gonadotrophins tumorigenic--a critical review of clinical and experimental data

scientific article

Assisted large fragment insertion by Red/ET-recombination (ALFIRE)--an alternative and enhanced method for large fragment recombineering.

scientific article published on 21 May 2007

Association between cognitive performance and the metabolic syndrome in middle-aged and older European men

Bfk, a novel member of the bcl2 gene family, is highly expressed in principal cells of the mouse epididymis and demonstrates a predominant nuclear localization

scientific journal article

Both testosterone and follicle-stimulating hormone independently inhibit spermatogonial differentiation in irradiated rats.

scientific article published on 6 October 2005

CANDLES, an assay for monitoring GPCR induced cAMP generation in cell cultures.

scientific article

Cell-based evidence regarding the role of FSH in prostate cancer

scientific article published on 02 January 2019

Comparisons of immunoassay and mass spectrometry measurements of serum estradiol levels and their influence on clinical association studies in men.

scientific article published on 30 April 2013

Complete Sertoli cell proliferation induced by follicle-stimulating hormone (FSH) independently of luteinizing hormone activity: evidence from genetic models of isolated FSH action.

scientific article published on 15 January 2004

Compound heterozygous mutations in the luteinizing hormone receptor signal peptide causing 46,XY disorder of sex development

scientific article published on 01 August 2019

Constitutive activity in gonadotropin receptors

scientific article

Delay of postnatal maturation sensitizes the mouse prostate to testosterone-induced pronounced hyperplasia: protective role of estrogen receptor-beta

scientific article

Di/Oligomerization of GPCRs—Mechanisms and Functional Significance

scientific article published on January 1, 2013

Dicer1 ablation in the mouse epididymis causes dedifferentiation of the epithelium and imbalance in sex steroid signaling

scientific journal article

Differential effects of estrogen/androgen on the prevention of nonalcoholic fatty liver disease in the male rat ⬇️

scientific article published on November 21, 2012

Discovery and characterization of new epididymis-specific beta-defensins in mice

scientific article published in July 2005

Discovery in Silico and Characterization in Vitro of Novel Genes Exclusively Expressed in the Mouse Epididymis

article

Does the andropause exist?

scientific article published on 28 August 2007

Does variant luteinizing hormone (V-LH) predispose to improper testicular position in late pregnancy?

scientific article published on 01 September 2005

EVALUATION OF 25-HYDROXYVITAMIN D AND 1,25-DIHYDROXYVITAMIN D AND COGNITIVE DECLINE IN THE EUROPEAN MALE AGEING STUDY

scientific article published in July 2016

Editorial

Editorial: Follicle-Stimulating Hormone: Fertility and Beyond

scientific article published on 06 September 2019

Effects of follicle-stimulating hormone (FSH) and human chorionic gonadotropin in individuals with an inactivating mutation of the FSH receptor

scientific article published in July 2002

Effects of medroxyprogesterone and estradiol on the recovery of spermatogenesis in irradiated rats

scientific article

Effects of resistance training on testosterone metabolism in younger and older men

scientific article published on 14 June 2015

Electroacupuncture mimics exercise in affecting gene expression of skeletal muscle

scientific article published on 19 May 2020

Elevated steroidogenesis, defective reproductive organs, and infertility in transgenic male mice overexpressing human chorionic gonadotropin

scientific article published on 31 July 2003

Endogenous testosterone and brachial artery endothelial function in middle-aged men with symptoms of late-onset hypogonadism ⬇️

scientific article published on August 11, 2011

Endogenous testosterone and serum lipids in middle-aged men

scientific article published on 22 June 2007

Enhanced LH action in transgenic female mice expressing hCGbeta-subunit induces pituitary prolactinomas; the role of high progesterone levels

scientific article

Epididymal dysfunction initiated by the expression of simian virus 40 T-antigen leads to angulated sperm flagella and infertility in transgenic mice

scientific article published in November 2002

Epididymal protein Rnase10 is required for post‐testicular sperm maturation and male fertility ⬇️

scientific article published on June 29, 2012

Epididymis-specific promoter-driven gene targeting: a new approach to control epididymal function?

scientific article published on March 2004

Estrogen enhances recovery from radiation-induced spermatogonial arrest in rat testes

scientific article published on 8 January 2009

Estrogen-regulated genes in rat testes and their relationship to recovery of spermatogenesis after irradiation.

scientific article

European Academy of Andrology (EAA) guidelines* on investigation, treatment and monitoring of functional hypogonadism in males

scientific article published on 05 February 2020

Extragonadal FSHR Expression and Function-Is It Real?

scientific article published on 04 February 2019

Extragonadal LH/hCG action--not yet time to rewrite textbooks

scientific article published on 7 February 2007

Fertility in luteinizing hormone receptor-knockout mice after wild-type ovary transplantation demonstrates redundancy of extragonadal luteinizing hormone action

scientific article

Fetal Leydig Cells Persist as an Androgen-Independent Subpopulation in the Postnatal Testis

scientific article

Focus on gonadotrophin signalling

scientific article published on 01 September 2005

Functional Expression of FSH Receptor in Endometriotic Lesions.

scientific article published on 25 May 2016

Functional Implications of LH/hCG Receptors in Pregnancy-Induced Cushing Syndrome.

scientific article published on 12 January 2017

Functional characterization of the human FSH receptor with an inactivating Ala189Val mutation

scientific article published in April 2002

Functional study of a recombinant form of human LHbeta-subunit variant carrying the Gly(102)Ser mutation found in Asian populations

scientific article published in October 2002

GATA-4 regulates Bcl-2 expression in ovarian granulosa cell tumors

scientific article published on 24 July 2008

Genetic Determinants of Circulating Estrogen Levels, and Evidence of a Causal Effect of Estradiol on Bone Density in Men.

scientific article published on 9 January 2018

Genetic determinants of serum testosterone concentrations in men.

scientific article

Genetically modified mouse models in studies of luteinising hormone action

scientific article

GnRH antagonist treatment of malignant adrenocortical tumors

scholarly article by Milena Doroszko et al published 1 January 2019 in Endocrine-related cancer

Gonadotrophin actions on the testis--genotypes and phenotypes of gonadotrophin and gonadotrophin receptor mutations

scientific article

Gonadotrophin resistance

scientific article published on December 2006

Hecate-CGbeta conjugate and gonadotropin suppression shows two distinct mechanisms of action in the treatment of adrenocortical tumors in transgenic mice expressing Simian Virus 40 T antigen under inhibin-alpha promoter

scientific article published on 4 March 2009

High levels of luteinizing hormone analog stimulate gonadal and adrenal tumorigenesis in mice transgenic for the mouse inhibin-alpha-subunit promoter/Simian virus 40 T-antigen fusion gene

scientific article published in May 2003

Human FSH beta subunit gene is highly conserved

scientific article published on 12 August 2005

Human chorionic gonadotropin (hCG) up-regulates wnt5b and wnt7b in the mammary gland, and hCGbeta transgenic female mice present with mammary Gland tumors exhibiting characteristics of the Wnt/beta-catenin pathway activation

scientific article

Human homologs of the putative G protein-coupled membrane progestin receptors (mPRalpha, beta, and gamma) localize to the endoplasmic reticulum and are not activated by progesterone.

scientific article published on 7 September 2006

Hyperglycosylated human chorionic gonadotropin stimulates angiogenesis through TGF-β receptor activation

scientific article published on 11 December 2012

Identification of novel epididymal genes by expression profiling and in silico gene discovery

scientific article published on 18 January 2006

Imbalanced lipid homeostasis in the conditional Dicer1 knockout mouse epididymis causes instability of the sperm membrane

scientific article published on 3 November 2014

Immortalization by large T-antigen of the adult epididymal duct epithelium.

scientific article published on March 2004

Increased carotid atherosclerosis in andropausal middle-aged men.

scientific article published in May 2005

Indirect Sertoli cell-mediated ablation of germ cells in mice expressing the inhibin-alpha promoter/herpes simplex virus thymidine kinase transgene

scientific article published on 7 July 2004

Influence of mutations affecting gonadotropin production or responsiveness on expression of inhibin subunit mRNA and protein in the mouse ovary

scientific article

Inhibition of recovery of spermatogenesis in irradiated rats by different androgens.

scientific article published in September 2002

Inhibition of small ubiquitin-related modifier-1 expression by luteinizing hormone receptor stimulation is linked to induction of progesterone receptor during ovulation in mouse granulosa cells

scientific article published on 18 September 2003

Interactions of the GnRH receptor with heterotrimeric G proteins ⬇️

scientific article published on November 27, 2012

Is the adrenal cortex a target for gonadotropins?

scientific article published on 06 August 2008

Knockout of luteinizing hormone receptor abolishes the effects of follicle-stimulating hormone on preovulatory maturation and ovulation of mouse graafian follicles

scientific article published on 7 June 2005

Late-onset hypogonadism in men. Experience from the Turku Male Ageing Study (TuMAS).

scientific article published on January 2008

Late-onset hypogonadism: current concepts and controversies of pathogenesis, diagnosis and treatment

scientific article

Leydig cell-specific expression of DAX1 improves fertility of the Dax1-deficient mouse.

scientific article published on 19 February 2003

Life expectancy of humans is increasing

scientific article published in August 2013

Loss of Bmyc results in increased apoptosis associated with upregulation of Myc expression in juvenile murine testis

scientific article published on 6 August 2012

Loss of cysteine-rich secretory protein 4 (Crisp4) leads to deficiency in sperm-zona pellucida interaction in mice

scientific journal article

Low free testosterone is associated with hypogonadal signs and symptoms in men with normal total testosterone levels: results from the European Male Ageing Study.

scientific article

Low prolactin is associated with sexual dysfunction and psychological or metabolic disturbances in middle-aged and elderly men: the European Male Aging Study (EMAS).

scientific article published on 29 October 2013

Luteinizing Hormone and GATA4 Action in the Adrenocortical Tumorigenesis of Gonadectomized Female Mice

scientific article published on 4 October 2017

MECHANISMS IN ENDOCRINOLOGY: Hormonal regulation of spermatogenesis: mutant mice challenging old paradigms

scientific article published on 29 June 2018

Male contraception--quo vadis?

scientific article published on February 2004

Male hormonal contraception: a double-blind, placebo-controlled study

scientific article published on 15 April 2008

Male late-onset hypogonadism: pathogenesis, diagnosis and treatment ⬇️

scientific article published on April 19, 2011

Male pheromone-stimulated neurogenesis in the adult female brain: possible role in mating behavior

scientific article published in July 2007

Male reproductive endocrinology. Preface

scientific article published on 01 April 2011

Measurements of salivary progesterone throughout the menstrual cycle in women suffering from unexplained infertility reveal high frequency of luteal phase defects**Supported by research contracts from The Finnish Life and Pension Insurance Companies

article

Mechanisms of action of hormone-sensitive lipase in mouse Leydig cells: its role in the regulation of the steroidogenic acute regulatory protein

scientific article published on 29 January 2013

Members of the murine Pate family are predominantly expressed in the epididymis in a segment-specific fashion and regulated by androgens and other testicular factors

scientific article

Molecular Mechanisms of Bladder Outlet Obstruction in Transgenic Male Mice Overexpressing Aromatase (Cyp19a1) ⬇️

scientific article published on March 1, 2011

Molecular characterization of postnatal development of testicular steroidogenesis in luteinizing hormone receptor knockout mice

scientific article

Mouse cysteine-rich secretory protein 4 (CRISP4): a member of the Crisp family exclusively expressed in the epididymis in an androgen-dependent manner

scientific article published on 26 January 2005

Mouse models of infertility due to swollen spermatozoa

scientific article published on March 2004

Multiple sites of tumorigenesis in transgenic mice overproducing hCG.

scientific article

Multiple structural and functional abnormalities in the p450 aromatase expressing transgenic male mice are ameliorated by a p450 aromatase inhibitor.

scientific article

Murine relaxin-like factor promoter: functional characterization and regulation by transcription factors steroidogenic factor 1 and DAX-1.

scientific article published in March 2002

Mutations affecting gonadotropin secretion and action

scientific article published on January 2003

Mutations along the hypothalamic-pituitary-gonadal axis affecting male reproduction

scientific article published on December 2007

Mutations along the pituitary-gonadal axis affecting sexual maturation: novel information from transgenic and knockout mice

scientific article

Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells

scientific article

Novel concepts of human chorionic gonadotropin: reproductive system interactions and potential in the management of infertility

scientific article

Novel epididymal protease inhibitors with Kazal or WAP family domain

scientific journal article

Novel genes involved in pathophysiology of gonadotropin-dependent adrenal tumors in mice

scientific article published on 25 January 2017

Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool.

scientific article published in February 2008

PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles.

scientific article published on 7 May 2009

Pharmacogenetics of FSH Action in the Female

scientific article published on 26 June 2019

Phenotypic characterisation of mice with exaggerated and missing LH/hCG action

scientific article published on 9 October 2006

Pituitary hormones are not required for sexual differentiation of male mice: phenotype of the T/ebp/Nkx2.1 null mutant mice

scientific journal article

Polymorphisms in androgen and estrogen receptor genes: effects on male aging

scientific article

REPLACR-mutagenesis, a one-step method for site-directed mutagenesis by recombineering

scientific article published on 11 January 2016

Regional expression of androgen receptor coregulators and androgen action in the mouse epididymis

scientific article published on 15 July 2011

Reproductive disturbances, pituitary lactotrope adenomas, and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropin

scientific article published in October 2002

Rescue of defective G protein-coupled receptor function in vivo by intermolecular cooperation.

scientific article

Restoration of Spermatogenesis in Dibromochloropropane (DBCP)-Treated Rats by Hormone Suppression ⬇️

scientific article published on September 26, 2003

Revisiting the expression and function of follicle-stimulation hormone receptor in human umbilical vein endothelial cells

scientific article

Role of central nervous system and ovarian insulin receptor substrate 2 signaling in female reproductive function in the mouse

scientific article published on 28 February 2007

SUN-213 Hsd17b3 Knockout Mice Serve As A Model To Define Mechanisms Behind The Altered Endocrine Phenotype Of Patients With Hsd17b3 Mutations

Sequestration of connexin43 in the early endosomes: An early event of Leydig cell tumor progression

scholarly article by Dominique Segretain published in November 2003

Serum testosterone but not leptin predicts mortality in elderly men.

scientific article

Sex differences in the development of prolactinoma in mice overexpressing hCGβ: role of TGFβ1.

scientific article published on 17 January 2017

Sexual dimorphism in superantigen shock involves elevated TNF-alpha and TNF-alpha induced hepatic apoptosis

scientific article published on 15 June 2007

Sexual symptoms in aging men indicate poor life satisfaction and increased health service consumption

scientific article published in December 2007

Single-molecule resolution of G protein-coupled receptor (GPCR) complexes.

scientific article published on 24 December 2015

Smoking and low serum testosterone associates with high concentration of oxidized LDL.

scientific article published in January 2008

Spatiotemporal expression of androgen receptors in the female rat brain during the oestrous cycle and the impact of exogenous androgen administration: a comparison with gonadally intact males

scientific article published in March 2010

Sperm volume regulation: maturational changes in fertile and infertile transgenic mice and association with kinematics and tail angulation

scientific article

Structure-function relationships of glycoprotein hormones; lessons from mutations and polymorphisms of the thyrotrophin and gonadotrophin subunit genes

scientific article published on October 2002

Synergistic Activation of Innate and Adaptive Immune Mechanisms in the Treatment of Gonadotropin-Sensitive Tumors ⬇️

scientific article published on April 8, 2013

TGF-beta1 system in Leydig cells. Part I: effect of hCG and progesterone

scientific article published on 21 April 2010

Targeted ablation of prostate carcinoma cells through LH receptor using Hecate-CGbeta conjugate: functional characteristic and molecular mechanism of cell death pathway.

scientific article published on June 2005

Targeted expression of human FSH receptor Asp567Gly mutant mRNA in testis of transgenic mice: role of human FSH receptor promoter

scientific article published in December 2003

Targeted inactivation of the androgen receptor gene in murine proximal epididymis causes epithelial hypotrophy and obstructive azoospermia ⬇️

scientific journal article

Targeted inactivation of the mouse epididymal beta-defensin 41 alters sperm flagellar beat pattern and zona pellucida binding

scientific article published on 14 March 2016

Targeted therapy for adrenocortical tumors in transgenic mice through their LH receptor by Hecate-human chorionic gonadotropin beta conjugate

scientific article published in June 2008

Testosterone replacement therapy induces spermatogenesis and partially restores fertility in luteinizing hormone receptor knockout mice

scientific article published on 28 October 2004

The adrenal gland may be a target of LH action in postmenopausal women

scientific article published in June 2006

The effects of chemicals on mammalian fertility. The report and recommendations of ECVAM Workshop 53--the first strategic workshop of the EU ReProTect Project.

scientific article published on August 2005

The gonadotropin receptors FSH-R and LH-R of Atlantic halibut (Hippoglossus hippoglossus)--2. Differential follicle expression and asynchronous oogenesis

scientific article published on 29 February 2008

The low gonadotropin-independent constitutive production of testicular testosterone is sufficient to maintain spermatogenesis ⬇️

scientific article published on October 29, 2003

The permissive role of prolactin as a regulator of luteinizing hormone action in the female mouse ovary and extragonadal tumorigenesis ⬇️

scientific article published on August 6, 2013

The polymorphic androgen receptor gene CAG repeat, pituitary-testicular function and andropausal symptoms in ageing men.

scientific article published in June 2003

The transgenic expression of the β-subunit of human chorionic gonadotropin influences the growth of implanted tumor cells

Trafficking of the follitropin receptor

scientific article published in January 2013

Transgenesis-mediated reproductive dysfunction and tumorigenesis: effects of immunological neutralization ⬇️

scientific article published on November 30, 2012

Transgenic GATA-4 expression induces adrenocortical tumorigenesis in C57Bl/6 mice ⬇️

scientific article published on February 26, 2013

Transgenic and knockout mouse models for aberrant pituitary-testicular function: relevance to the pathogenesis of cryptorchidism

scientific article published on 01 January 2004

Transgenic and knockout mouse models for the study of luteinizing hormone and luteinizing hormone receptor function.

scientific article

Transgenic mice expressing inhibin α-subunit promoter (inhα)/Simian Virus 40 T-antigen (Tag) transgene as a model for the therapy of granulosa cell-derived ovarian cancer.

scientific article published on 11 December 2013

Transgenic mice expressing p450 aromatase as a model for male infertility associated with chronic inflammation in the testis

scientific article published on 23 November 2005

Transgenic mice harboring murine luteinizing hormone receptor promoter/beta-galactosidase fusion genes: different structural and hormonal requirements of expression in the testis, ovary, and adrenal gland.

scientific article

Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles

scientific article

Up-regulation of steroid biosynthesis by retinoid signaling: Implications for aging.

scientific article

What have gonadotrophin overexpressing transgenic mice taught us about gonadal function?

scientific article

Will GnRH antagonists improve prostate cancer treatment?

scientific article

Zika virus infection-do they also endanger male fertility?

scientific article published on 17 January 2017

[Diagnosis and therapy of male hormonal changes related to aging].

scientific article published in January 2009

Paulina is supported by:

About Paulina

Help