List of works - Leif Groop

Biological, clinical and population relevance of 95 loci for blood lipids

scientific article

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

scientific article (publication date: June 2007)

Genetic studies of body mass index yield new insights for obesity biology

scientific article

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article

Cardiovascular morbidity and mortality associated with the metabolic syndrome

scientific article published on April 2001

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

scientific article published on 6 October 2011

Hundreds of variants clustered in genomic loci and biological pathways affect human height

scientific article

Discovery and refinement of loci associated with lipid levels

scientific article

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

scientific article

Age-related clonal hematopoiesis associated with adverse outcomes

scientific article

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

scientific article

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

scientific article

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

scientific article

Common variants at 30 loci contribute to polygenic dyslipidemia

scientific article

Large-scale association analysis identifies new risk loci for coronary artery disease

scientific article published on 02 December 2012

Common variants near MC4R are associated with fat mass, weight and risk of obesity

scientific article

Genome-wide association study identifies eight loci associated with blood pressure

scientific article (publication date: June 2009)

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

scientific article

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

scientific journal article

A reference panel of 64,976 haplotypes for genotype imputation

scientific article

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

Clinical risk factors, DNA variants, and the development of type 2 diabetes

scientific article

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

scientific article published in September 2008

Variants in MTNR1B influence fasting glucose levels

scientific article

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

scientific article published on 13 May 2012

Polymorphisms associated with cholesterol and risk of cardiovascular events

scientific article

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

scientific article published in August 2007

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

scientific article

The genetic architecture of type 2 diabetes

scientific article (publication date: 11 July 2016)

Identification of ten loci associated with height highlights new biological pathways in human growth

scientific article

Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus

scientific article

Common variants associated with plasma triglycerides and risk for coronary artery disease

scientific article

Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits

scientific article

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies

scientific article

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

scientific article published in June 2009

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

scientific journal article

Epigenetics: a molecular link between environmental factors and type 2 diabetes

scientific article

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

scientific article

Demonstrating stratification in a European American population

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways

scientific article

A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue

scientific article

Discerning the ancestry of European Americans in genetic association studies

scientific article

Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors

scientific article published on 12 June 2009

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children

scientific article

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

scientific article

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion

scientific article

FTO genotype is associated with phenotypic variability of body mass index

scientific article published on 16 September 2012

List of works by Leif Groop

Biological, clinical and population relevance of 95 loci for blood lipids

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

Genetic studies of body mass index yield new insights for obesity biology

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Cardiovascular morbidity and mortality associated with the metabolic syndrome

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Hundreds of variants clustered in genomic loci and biological pathways affect human height

Discovery and refinement of loci associated with lipid levels

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Age-related clonal hematopoiesis associated with adverse outcomes

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Defining the role of common variation in the genomic and biological architecture of adult human height

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

Common variants at 30 loci contribute to polygenic dyslipidemia

Large-scale association analysis identifies new risk loci for coronary artery disease

Common variants near MC4R are associated with fat mass, weight and risk of obesity

Genome-wide association study identifies eight loci associated with blood pressure

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

A reference panel of 64,976 haplotypes for genotype imputation

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

New genetic loci link adipose and insulin biology to body fat distribution

Clinical risk factors, DNA variants, and the development of type 2 diabetes

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

Variants in MTNR1B influence fasting glucose levels

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Polymorphisms associated with cholesterol and risk of cardiovascular events

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

The genetic architecture of type 2 diabetes

Identification of ten loci associated with height highlights new biological pathways in human growth

Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus

Common variants associated with plasma triglycerides and risk for coronary artery disease

Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Epigenetics: a molecular link between environmental factors and type 2 diabetes

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Demonstrating stratification in a European American population

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways

A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue

Discerning the ancestry of European Americans in genetic association studies

Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion

FTO genotype is associated with phenotypic variability of body mass index