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List of works by Joseph L. Goldstein

19 Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

scientific article published on 01 January 1983

3-Hydroxy-3-methylglutaryl-CoA reductase: a transmembrane glycoprotein of the endoplasmic reticulum with N-linked "high-mannose" oligosaccharides

scientific article published on December 1983

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor ⬇️

scientific article published on November 5, 1991

42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter

scientific article

5' end of HMG CoA reductase gene contains sequences responsible for cholesterol-mediated inhibition of transcription

scientific article

60 years of winged victories for biomedical research

scientific article

A 25-hydroxycholesterol-resistant cell line deficient in acyl-CoA: cholesterol acyltransferase ⬇️

scientific article published on July 5, 1991

A Well-Hung Horse: Sired by Knowledge and Imagination

scientific article

A conversation with Robert Lefkowitz, Joseph Goldstein, and Michael Brown. Interview by Ushma S. Neil and Howard A. Rockman

scientific article published in May 2012

A mutation that impairs the ability of lipoprotein receptors to localise in coated pits on the cell surface of human fibroblasts ⬇️

scientific article published on December 22, 1977

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

scientific article

A tribute to Akira Endo, discoverer of a “Penicillin” for cholesterol

article

Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

scientific article (publication date: 2003)

Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL/J mice

scientific article published on 06 July 2009

Acceptance remarks of Joseph L Goldstein and Michael S. Brown on the occasion of the presentation of the Kober Medal, 2002.

scientific article

Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region

scientific article

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

scientific article published on June 1998

Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. Comparison with the rate of cholesterol synthesis in different physiological states ⬇️

scientific article published on June 25, 1979

Akira Endo, who discovered a “penicillin” for heart attacks (1933 to 2024) ⬇️

scholarly article published in 2024

Alu-Alu recombination deletes splice acceptor sites and produces secreted low density lipoprotein receptor in a subject with familial hypercholesterolemia

scientific article published in March 1987

Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice

scientific article

Amplification of the gene for 3-hydroxy-3-methylglutaryl coenzyme A reductase, but not for the 53-kDa protein, in UT-1 cells.

scientific article

Analysis of a mutant strain of human fibroblasts with a defect in the internalization of receptor-bound low density lipoprotein ⬇️

scientific article published on December 1, 1976

Antibody against low density lipoprotein receptor blocks uptake of low density lipoprotein (but not high density lipoprotein) by the adrenal gland of the mouse in vivo ⬇️

scientific article published on May 25, 1981

Apolipoprotein C-I modulates the interaction of apolipoprotein E with beta-migrating very low density lipoproteins (beta-VLDL) and inhibits binding of beta-VLDL to low density lipoprotein receptor-related protein

scientific article published on December 1990

Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase

scientific article

Artists Create Puzzles, Scientists Solve Them

scientific article published on 23 August 2017

Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease

scientific article

Assays for inhibitors of CAAX farnesyltransferase in vitro and in intact cells

scientific article published on January 1995

Assignment of the human gene for the low density lipoprotein receptor to chromosome 19: synteny of a receptor, a ligand, and a genetic disease ⬇️

scientific article published on May 1, 1984

Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1)

scientific article (publication date: 24 June 1994)

Atherosclerosis and its complications: contributions from the Association of American Physicians, 1886-1986

scientific article published on 01 January 1986

Atherosclerosis. Scavenging for receptors

scientific article published in February 1990

Atherosclerosis: The low-density lipoprotein receptor hypothesis ⬇️

scientific article published on November 1, 1977

BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver.

scientific article

Balzac's Unknown Masterpiece: spotting the next big thing in art and science

scientific article

Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells.

scientific article published on November 1994

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

scientific article

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

scientific article

Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia.

scientific article

Binding and internalization of 125I-LDL in normal and mutant human fibroblasts. A quantitative autoradiographic study

scientific article published on June 1979

Biochemical and genetic studies of the apoprotein E secreted by mouse macrophages and human monocytes

scientific article published on 01 August 1982

Biologically active low density lipoprotein in human peripheral lymph ⬇️

scientific article published on January 1, 1978

Biomedicine. Lowering LDL--not only how low, but how long?

scientific article

Biosynthesis of N- and O-linked oligosaccharides of the low density lipoprotein receptor ⬇️

scientific article published on December 25, 1983

Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).

scientific article published on December 1998

CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB

scientific article

Cassette of eight exons shared by genes for LDL receptor and EGF precursor

scientific article

Cellular pathology of progressive atherosclerosis in the WHHL rabbit. An animal model of familial hypercholesterolemia

scientific article published on 01 January 1983

Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.

scholarly article

Characterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteins

scientific article

Characterization of the low density lipoprotein receptor in membranes prepared from human fibroblasts ⬇️

scientific article published on June 10, 1978

Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism

scientific article published on August 2002

Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs

scientific article published on 27 September 2004

Cholesterol ester formation in cultured human fibroblasts. Stimulation by oxygenated sterols ⬇️

scientific article published on May 25, 1975

Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL

scientific article

Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver

scientific article published on November 1997

Cholesterol synthesis in vivo and in vitro in the WHHL rabbit, an animal with defective low density lipoprotein receptors ⬇️

scientific article published on 01 April 1983

Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles

scientific article

Cholesterol-induced conformational changes in the sterol-sensing domain of the Scap protein suggest feedback mechanism to control cholesterol synthesis

scientific article published on 3 April 2017

Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine beta-very low density lipoproteins

scientific article published on 01 March 1980

Cholesteryl ester synthesis in macrophages: stimulation by beta-very low density lipoproteins from cholesterol-fed animals of several species

scientific article published on 01 November 1980

Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis

scientific article

Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2.

scientific article

Co-localization of 125I-epidermal growth factor and ferritin-low density lipoprotein in coated pits: a quantitative electron microscopic study in normal and mutant human fibroblasts ⬇️

scientific article published on October 1, 1982

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

scientific article

Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver

scientific journal article

Complementation of mutation in acyl-CoA:cholesterol acyltransferase (ACAT) fails to restore sterol regulation in ACAT-defective sterol-resistant hamster cells

scientific article

Concentration and composition of lipoproteins in blood plasma of the WHHL rabbit. An animal model of human familial hypercholesterolemia

scientific article published on 01 November 1982

Creation and revelation: two different routes to advancement in the biomedical sciences

scientific article

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

scientific article

Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells

scientific article

Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. I. Isolation and sequencing of a full-length cDNA.

scientific article published in March 1986

Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. II. Isolation of the gene and characterization of the 5' flanking region

scientific article published in March 1986

Cytoplasmic sequence required for basolateral targeting of LDL receptor in livers of transgenic mice

scientific article published on April 1992

Defective lipoprotein receptors and atherosclerosis. Lessons from an animal counterpart of familial hypercholesterolemia

scientific article published on August 1983

Deficiency of low density lipoprotein receptors in liver and adrenal gland of the WHHL rabbit, an animal model of familial hypercholesterolemia ⬇️

scientific article published on April 1, 1981

Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts ⬇️

scientific article published on September 1, 1976

Degradation of low density lipoprotein . dextran sulfate complexes associated with deposition of cholesteryl esters in mouse macrophages ⬇️

scientific article published on August 10, 1979

Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits

scientific article

Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit

scientific article published in June 1986

Deletion in the gene for the low-density-lipoprotein receptor in a majority of French Canadians with familial hypercholesterolemia

scientific article published on 01 September 1987

Deletion of clustered O-linked carbohydrates does not impair function of low density lipoprotein receptor in transfected fibroblasts

scientific article published on February 1986

Deletion of exon encoding cysteine-rich repeat of low density lipoprotein receptor alters its binding specificity in a subject with familial hypercholesterolemia

scientific article published on October 1986

Demonstration of low density lipoprotein receptors in mouse teratocarcinoma stem cells and description of a method for producing receptor-deficient mutant mice ⬇️

scientific article published on June 1, 1979

Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts ⬇️

scientific article published on May 1, 1983

Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors

scientific article

Different combinations of cysteine-rich repeats mediate binding of low density lipoprotein receptor to two different proteins

scientific article published on December 1989

Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

scientific article published on 8 January 2002

Direct Demonstration That Loop1 of Scap Binds to Loop7: A CRUCIAL EVENT IN CHOLESTEROL HOMEOSTASIS.

scientific article published on 11 April 2016

Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain

scientific article

Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL

scientific article

Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation

scientific article

Divalent cation and prenyl pyrophosphate specificities of the protein farnesyltransferase from rat brain, a zinc metalloenzyme.

scientific article published in March 1992

Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor ⬇️

scientific article published on June 1, 1984

Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum

scientific article published on 01 January 1985

Duplication of seven exons in LDL receptor gene caused by Alu-Alu recombination in a subject with familial hypercholesterolemia

scientific article

Esterification of low density lipoprotein cholesterol in human fibroblasts and its absence in homozygous familial hypercholesterolemia

scientific article

Evidence for a dominant gene that suppresses hypercholesterolemia in a family with defective low density lipoprotein receptors

scientific article

Evidence for regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in nonhepatic tissues of rat ⬇️

scientific article published on August 1, 1976

Evolution of the LDL receptor concept-from cultured cells to intact animals

scientific article published on January 1980

Exon-Alu recombination deletes 5 kilobases from the low density lipoprotein receptor gene, producing a null phenotype in familial hypercholesterolemia

scientific article published on June 1986

Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands

scientific article

Expression of the familial hypercholesterolemia gene in heterozygotes: mechanism for a dominant disorder in man.

scientific article

Expression of the familial hypercholesterolemia gene in heterozygotes: model for a dominant disorder in man

scientific article published on 01 January 1974

Exuberant unpredictability: sine qua non for priceless and prizeworthy biomedical research

scientific article

Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.

scientific article published in October 1999

Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows ⬇️

scientific article published on October 1, 1981

Familial hypercholesterolemia. A genetic regulatory defect in cholesterol metabolism

scientific article

Familial hypercholesterolemia: A genetic defect in the low-density lipoprotein receptor

scientific article

Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity

scientific article

Familial hypercholesterolemia: genetic, biochemical and pathophysiologic considerations

scientific article published on January 1, 1975

Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol

scientific article

Familial hypercholesterolemia: model for genetic receptor disease

scientific article published on January 1, 1979

Familial hypercholesterolemia: pathogenesis of a receptor disease

scientific article published on July 1, 1978

Familial hypercholesterolemia: unraveling a genetic receptor disease

scientific article published on January 1, 1977

Familial pseudomembranous colitis and its relation to lincomycin therapy

scientific article published on 01 September 1975

Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase

scientific article

First cysteine-rich repeat in ligand-binding domain of low density lipoprotein receptor binds Ca2+ and monoclonal antibodies, but not lipoproteins.

scientific article published in December 1987

Fluorescence Visualization of Receptor-Bound Low Density Lipoprotein in Human Fibroblasts ⬇️

scientific article published on 01 January 1980

From fatty streak to fatty liver: 33 years of joint publications in the JCI

scientific article published on April 2008

Gene therapy for cholesterol

scientific article published in July 1994

Genetic distinction between sterol-mediated transcriptional and posttranscriptional control of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

scientific article published on May 1991

Genetic heterogeneity in familial hypercholesterolemia: evidence for two different mutations affecting functions of low-density lipoprotein receptor ⬇️

scientific article published on March 1, 1975

Genetics of the LDL receptor: Evidence that the mutations affecting binding and internalization are allelic ⬇️

scientific article published on November 1, 1977

Genetics of the low density lipoprotein receptor. Diminished receptor activity in lymphocytes from heterozygotes with familial hypercholesterolemia ⬇️

scientific article published on March 1, 1978

Geranylgeranylated Rab proteins terminating in Cys-Ala-Cys, but not Cys-Cys, are carboxyl-methylated by bovine brain membranes in vitro

scientific article published in October 1994

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice.

scientific article

Ghrelin secretion stimulated by {beta}1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice

scientific article

Growth hormone acts on liver to stimulate autophagy, support glucose production, and preserve blood glucose in chronically starved mice

scientific article published on 25 March 2019

HMG CoA reductase: a negatively regulated gene with unusual promoter and 5' untranslated regions

scientific article

Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin

scientific article

Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection

scientific article published on December 1995

Heart attacks: gone with the century?

scientific article published on 01 May 1996

Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor

scientific article

Heterozygous familial hypercholesterolemia: Failure of normal allele to compensate for mutant allele at a regulated genetic locus ⬇️

scientific article published on October 1, 1976

High levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in the ovary of the pregnant rabbit

scientific article published on 01 July 1978

History of science. A golden era of Nobel laureates

scientific article published in November 2012

Homozygous familial hypercholesterolemia (receptor-negative type). Repository identification No. GM-361.

scientific article

Homozygous familial hypercholesterolemia: specificity of the biochemical defect in cultured cells and feasibility of prenatal detection

scientific article published on March 1974

How LDL receptors influence cholesterol and atherosclerosis

scientific article

How a jolt and a bolt in a dentist's chair revolutionized cataract surgery

scientific article published in October 2004

How to win a Lasker? Take a close look at Bathers and Bulls ⬇️

scientific article published on October 1, 2010

Human low density lipoprotein receptor expressed in Xenopus oocytes. Conserved signals for O-linked glycosylation and receptor-mediated endocytosis ⬇️

scientific article published on 01 June 1988

Human mutations affecting the low density lipoprotein pathway ⬇️

scientific article published on June 1, 1977

Hydrolysis and excretion of cytoplasmic cholesteryl esters by macrophages: stimulation by high density lipoprotein and other agents

scientific article published on 01 May 1980

Hyperlipidemia in coronary heart disease: a biochemical genetic approach

scientific article published on January 1, 1975

Identification of Complexes between the COOH-terminal Domains of Sterol Regulatory Element-binding Proteins (SREBPs) and SREBP Cleavage-Activating Protein ⬇️

scientific article published on August 8, 1997

Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication

scientific article

Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection

scientific article

Identification of a cholesterol-regulated 53,000-dalton cytosolic protein in UT-1 cells and cloning of its cDNA

scientific article

Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis

scientific article

Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene.

scientific article published on February 1990

Identification of promoter elements required for in vitro transcription of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase gene

scientific article

Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes

scientific article

Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone

scientific journal article

Imaging of hepatic low density lipoprotein receptors by radionuclide scintiscanning in vivo

scientific article published on December 1984

Immunoblot analysis of low density lipoprotein receptors in fibroblasts from subjects with familial hypercholesterolemia ⬇️

scientific article published on November 10, 1982

Immunocytochemical localization of mutant low density lipoprotein receptors that fail to reach the Golgi complex

scientific article

Immunocytochemical visualization of coated pits and vesicles in human fibroblasts: Relation to low density lipoprotein receptor distribution ⬇️

scientific article published on November 1, 1978

Immunologic cross-reactivity of the low density lipoprotein receptor from bovine adrenal cortex, human fibroblasts, canine liver and adrenal gland, and rat liver ⬇️

scientific article published on April 25, 1981

Inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro. An adenine nucleotide-dependent reaction catalyzed by a factor in human fibroblasts ⬇️

scientific article published on April 10, 1975

Increase in membrane cholesterol: a possible trigger for degradation of HMG CoA reductase and crystalloid endoplasmic reticulum in UT-1 cells

scientific article

Increased binding of low density lipoprotein to liver membranes from rats treated with 17 alpha-ethinyl estradiol ⬇️

scientific article published on November 25, 1979

Increased mRNA for low density lipoprotein receptor in livers of rabbits treated with 17 alpha-ethinyl estradiol

scientific article published on February 1986

Independent pathways for secretion of cholesterol and apolipoprotein E by macrophages

scientific article

Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver

scientific article

Induced ablation of ghrelin cells in adult mice does not decrease food intake, body weight, or response to high-fat diet

scientific article published on 15 May 2014

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase ⬇️

scientific article published on February 25, 1978

Inefficient internalization of receptor-bound low density lipoprotein in human carcinoma A-431 cells ⬇️

scientific article published on February 1, 1981

Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor ⬇️

scientific article published on June 25, 1979

Inhibition of cholesteryl ester formation in human fibroblasts by an analogue of 7-ketocholesterol and by progesterone ⬇️

scientific article published on April 1, 1978

Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides.

scholarly article

Inhibition of proteolytic degradation of low density lipoprotein in human fibroblasts by chloroquine, concanavalin A, and Triton WR 1339 ⬇️

scientific article published on October 10, 1975

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

scientific article

Inhibition of the binding of low-density lipoprotein to its cell surface receptor in human fibroblasts by positively charged proteins ⬇️

scientific article published on January 1, 1978

Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro

scientific article

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

scientific article

Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol

scientific article published on 16 October 2003

Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex

scientific article published on 05 July 2016

Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes

scholarly article

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

scientific article published on November 1999

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

scientific article

Interaction of swine lipoproteins with the low density lipoprotein receptor in human fibroblasts ⬇️

scientific article published on April 25, 1976

Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain

scientific article

Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change

scientific article

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

scientific article published on March 1997

Isolation of Chinese hamster cell mutants defective in the receptor-mediated endocytosis of low density lipoprotein ⬇️

scientific article published on 01 August 1981

Isolation of cholesterol-requiring mutant Chinese hamster ovary cells with defects in cleavage of sterol regulatory element-binding proteins at site 1.

scientific article published on October 1998

Jabotinsky and Jewish autonomy in the Diaspora

Joseph Goldstein and Michael Brown: demoting egos, promoting success. Interview by Ruth Williams

scientific article published in April 2010

Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis

scientific article

Juxtapositions in Trafalgar Square: tip-offs to creativity in art and science

scientific article

Kinetic defects in the processing of the low density lipoprotein receptor in fibroblasts from WHHL rabbits and a family with familial hypercholesterolemia

scientific article published on 01 October 1983

Koch's postulates for cholesterol

scientific article

LDL receptors in coated vesicles isolated from bovine adrenal cortex: Binding sites unmasked by detergent treatment ⬇️

scientific article published on July 1, 1980

LDL-receptor structure. Calcium cages, acid baths and recycling receptors.

scientific article published in August 1997

LXR-SREBP-1c-phospholipid transfer protein axis controls very low density lipoprotein (VLDL) particle size

scientific article

Lasker Awards 2002. Foreword: synergy and symbiosis à la Matisse-Picasso

scientific article

Lasker Awards and papal portraiture: turning fields upside down

scientific article published in October 2009

Lasker awards 2003. Foreword: It's a grand year for celebrating science

scientific article

Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine

scientific article published on 20 July 2020

Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis ⬇️

scientific article published on January 1, 1983

Lipoprotein receptors and the control of plasma LDL cholesterol levels ⬇️

scientific article published on July 1, 1992

Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic ⬇️

scientific article published on September 1, 1983

Lipoprotein receptors, cholesterol metabolism, and atherosclerosis

scientific article published on April 1, 1975

Lipoprotein receptors: therapeutic implications

scientific article published on March 1990

Lipoprotein-mediated regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesteryl ester metabolism in the adrenal gland of the rat ⬇️

scientific article published on March 10, 1977

Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia

scientific article

Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis

scientific article

Localization of low density lipoprotein receptors on plasma membrane of normal human fibroblasts and their absence in cells from a familial hypercholesterolemia homozygote ⬇️

scientific article published on July 1, 1976

Localization of mRNA for low density lipoprotein receptor and a cholesterol synthetic enzyme in rabbit nervous system by in situ hybridization

scientific article

Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells.

scientific article published on September 1989

Low Density Lipoprotein Receptors in Bovine Adrenal Cortex. I. Receptor-Mediated Uptake of Low Density Lipoprotein and Utilization of Its Cholesterol for Steroid Synthesis in Cultured Adrenocortical Cells* ⬇️

scientific article published on March 1, 1979

Low Density Lipoprotein Receptors in Bovine Adrenal Cortex. II. Low Density Lipoprotein Binding to Membranes Prepared from Fresh Tissue* ⬇️

scientific article published on March 1, 1979

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance

scientific article published in Journal of Biological Chemistry

Low density lipoprotein receptor-related protein mediates endocytosis of monoclonal antibodies in cultured cells and rabbit liver.

scientific article

Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins

scientific article

Low-density lipoprotein (LDL) receptor activity in human acute myelogenous leukemia cells ⬇️

scientific article published on December 1, 1978

Lowering Plasma Cholesterol by Raising LDL Receptors ⬇️

scientific article published on August 27, 1981

Lowering plasma cholesterol by raising ldl receptors. 1981.

scientific article published in October 2004

Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1

scientific article published on 26 July 2018

Mad Bet for Rab

scientific article published in Nature

Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice

scientific article

Medical care for the child at risk: on state supervention of parental autonomy

scientific article published on 01 March 1977

Medicine. HDL miR-ed down by SREBP introns

scientific article

Membrane topology of S2P, a protein required for intramembranous cleavage of sterol regulatory element-binding proteins

scientific article published on July 1999

Membrane topology of human insig-1, a protein regulator of lipid synthesis

scientific article (publication date: 27 February 2004)

Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme

scientific article

Metabolism of cationized lipoproteins by human fibroblasts: biochemical and morphologic correlations ⬇️

scientific article published on July 1, 1977

Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholeserolemia heterozygotes. 1983.

scientific article published in October 2004

Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes

scientific article published on July 1983

Mevinolin stimulates receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

scientific article published on January 1983

Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits

scientific article

Mobility of apolar lipids of reconstituted low density lipoprotein as monitored by electron spin resonance spectroscopy ⬇️

scientific article published on April 25, 1980

Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle

scientific article

Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins

scientific article

Molecular cloning of 3-hydroxy-3-methylglutaryl coenzyme a reductase and evidence for regulation of its mRNA.

scientific article

Molecular cloning of a histidine-rich Ca2+-binding protein of sarcoplasmic reticulum that contains highly conserved repeated elements

scientific article published in October 1989

Molecular genetics of the LDL receptor gene in familial hypercholesterolemia

scientific article published on January 1, 1992

Molecular medicine. The cholesterol quartet

scientific article published in May 2001

Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts ⬇️

scientific article published on May 1, 1981

Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor-mediated endocytosis and the genetics of familial hypercholesterolemia ⬇️

scientific article published on November 25, 1981

Mouse macrophages synthesize and secrete a protein resembling apolipoprotein E.

scientific article

Multiple crm- mutations in familial hypercholesterolemia. Evidence for 13 alleles, including four deletions

scientific article published on March 1988

Multiple genes encode nuclear factor 1-like proteins that bind to the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase

scientific article

Multiple mRNAs for 3-hydroxy-3-methylglutaryl coenzyme A reductase determined by multiple transcription initiation sites and intron splicing sites in the 5'-untranslated region

scientific article published in August 1985

Multiple sterol regulatory elements in promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A synthase

scientific article

Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme.

scientific article

Mutant clone of Chinese hamster ovary cells lacking 3-hydroxy-3 -methylglutaryl coenzyme A reductase

scientific article published on November 1983

Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis

scientific article

Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains

scientific article

Mutational analysis of alpha-subunit of protein farnesyltransferase. Evidence for a catalytic role

scientific article

Mutational analysis of the ligand binding domain of the low density lipoprotein receptor ⬇️

scientific article published on September 15, 1988

Mutations affecting the binding, internalization, and lysosomal hydrolysis of low density lipoprotein in cultured human fibroblasts, lymphocytes, and aortic smooth muscle cells ⬇️

scientific article published on January 1, 1977

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

scientific article

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor

scientific article

Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase

scientific article published in August 1991

Nonidentical subunits of p21H-ras farnesyltransferase. Peptide binding and farnesyl pyrophosphate carrier functions

scientific article published in June 1991

Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor ⬇️

scientific article published on August 29, 1995

Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence.

scientific article

Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization

scientific article

Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum

scientific article

Occurrence of low density lipoprotein receptors within large pits on the surface of human fibroblasts as demonstrated by freeze-etching ⬇️

scientific article published on April 1, 1978

Operator constitutive mutation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter abolishes protein binding to sterol regulatory element

scientific article

Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein

scientific article published on 01 June 1990

Optional exon in the 5'-untranslated region of 3-hydroxy-3-methylglutaryl coenzyme A synthase gene: conserved sequence and splicing pattern in humans and hamsters

scientific article

Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis

scientific article

Overexpression of human low density lipoprotein receptors leads to accelerated catabolism of Lp(a) lipoprotein in transgenic mice

scientific article

Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice

scientific article

Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum

scientific article

Overloading human aortic smooth muscle cells with low density lipoprotein-cholesteryl esters reproduces features of atherosclerosis in vitro ⬇️

scientific article published on June 1, 1977

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

scientific article published on October 1996

Paradigm shifts in science: insights from the arts

scientific article published in October 2012

Partial deletion of membrane-bound domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase eliminates sterol-enhanced degradation and prevents formation of crystalloid endoplasmic reticulum

scientific article

Partial purification and characterization of the low density lipoprotein receptor from bovine adrenal cortex ⬇️

scientific article published on December 10, 1980

Phosphorylation of serine 833 in cytoplasmic domain of low density lipoprotein receptor by a high molecular weight enzyme resembling casein kinase II

scientific article

Plasma lipoproteins: teaching old dogmas new tricks

scientific article

Point mutation in luminal loop 7 of Scap protein blocks interaction with loop 1 and abolishes movement to Golgi

scientific article published on 5 April 2013

Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.

scientific article published in March 1995

Posttranslational processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia ⬇️

scientific article published on October 1, 1982

Prenatal diagnosis of homozygous familial hypercholesterolaemia. Expression of a genetic receptor disease in utero

scientific article

Preparation of recombinant Rab geranylgeranyltransferase and Rab escort proteins

scientific article published on January 1995

Presentation of the Kober Medal for 1999 to Jean D. Wilson physician-scientist exemplar

scientific article published in September 1999

Presentation of the Kober Medal for 1999 to Jean D. Wilson physician-scientist exemplar

scientific article published in January 1999

Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acids

scientific article

Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol.

scientific article published on December 1984

Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes.

scientific article published in August 1982

Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit

scientific article

Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment

scientific article

Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins

scientific article

Purification of a protein doublet that binds to six TGG-containing sequences in the promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase

scientific article published on December 1988

Purification of a sarcoplasmic reticulum protein that binds Ca2+ and plasma lipoproteins

scientific article

Purification of an interleukin-1 beta converting enzyme-related cysteine protease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembrane domains

scientific article published on 01 July 1995

Purification of catalytic subunit of low density lipoprotein receptor kinase and identification of heat-stable activator protein

scientific article

Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product

scientific article

Purification of oxysterol binding protein from hamster liver cytosol

scientific article published on May 1989

Purification of the LDL receptor

scientific article published on 01 January 1985

Purification of the low density lipoprotein receptor, an acidic glycoprotein of 164,000 molecular weight ⬇️

scientific article published on March 10, 1982

Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein.

scientific article published on 6 November 2007

Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop

scientific article

PxF, a prenylated protein of peroxisomes.

scientific article published on May 1994

REP-2, a Rab escort protein encoded by the choroideremia-like gene

scientific article

Receptor-Mediated Control of Cholesterol Metabolism ⬇️

scientific article published on January 16, 1976

Receptor-Mediated Endocytosis and the Cellular Uptake of Low Density Lipoprotein ⬇️

scientific article published on 01 January 1982

Receptor-Mediated Uptake of Lipoprotein-Cholesterol and Its Utilization for Steroid Synthesis in the Adrenal Cortex

scientific article published on January 1, 1979

Receptor-dependent hydrolysis of cholesteryl esters contained in plasma low density lipoprotein ⬇️

scientific article published on August 1, 1975

Receptor-mediated endocytosis: concepts emerging from the LDL receptor system

scientific article published on January 1985

Receptor-mediated endocytosis: insights from the lipoprotein receptor system ⬇️

scientific article published on July 1, 1979

Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured mouse adrenal cells ⬇️

scientific article published on July 25, 1977

Receptor-mediated uptake of low density lipoprotein reconstituted with 25-hydroxycholesteryl oleate suppresses 3-hydroxy-3-methylglutaryl-coenzyme A reductase and inhibits growth of human fibroblasts ⬇️

scientific article published on October 1, 1978

Reconstituted low density lipoprotein: A vehicle for the delivery of hydrophobic fluorescent probes to cells ⬇️

scientific article published on January 1, 1979

Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs

scientific article (publication date: 12 September 2003)

Recycling of cell-surface receptors: observations from the LDL receptor system

scientific article published on 01 January 1982

Recycling receptors: The round-trip itinerary of migrant membrane proteins ⬇️

scientific article published on March 1, 1983

Reduced autophagy in livers of fasted, fat-depleted, ghrelin-deficient mice: reversal by growth hormone

scientific article

Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial hypercholesterolemia ⬇️

scientific article published on December 1, 1975

Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane

scientific article

Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes

scientific article published on 08 October 2009

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

scientific article (publication date: 18 February 2000)

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia.

scientific article published in February 1974

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by lipoproteins

scientific article

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its mRNA in rat liver as studied with a monoclonal antibody and a cDNA probe.

scientific article published on July 1983

Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila

scientific article published in May 2002

Regulation of cholesterol synthesis by low density lipoprotein in isolated human lymphocytes. Comparison of cells from normal subjects and patients with homozygous familial hypercholesterolemia and abetalipoproteinemia

scientific article

Regulation of low density lipoprotein receptors by adrenocorticotropin in the adrenal gland of mice and rats in vivo ⬇️

scientific article published on June 25, 1980

Regulation of plasma cholesterol by lipoprotein receptors

scientific article

Regulation of synthesis and degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by low density lipoprotein and 25-hydroxycholesterol in UT-1 cells

scientific article

Regulation of the activity of the low density lipoprotein receptor in human fibroblasts ⬇️

scientific article published on November 1, 1975

Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog

scientific article

Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans ⬇️

scientific article published on January 1, 1976

Replacement of endogenous cholesteryl esters of low density lipoprotein with exogenous cholesteryl linoleate. Reconstitution of a biologically active lipoprotein particle ⬇️

scientific article published on June 25, 1978

Replacement of neutral lipids of low density lipoprotein with esters of long chain unsaturated fatty acids ⬇️

scientific article published on May 25, 1979

Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion

scientific article

Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells

scientific article published on April 1996

Restoration of a regulatory response to low density lipoprotein in acid lipase-deficient human fibroblasts ⬇️

scientific article published on June 10, 1976

Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase

scientific article

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

scientific article published on 25 August 2017

Reversible accumulation of cholesteryl esters in macrophages incubated with acetylated lipoproteins ⬇️

scientific article published on September 1, 1979

Richard G.W. Anderson (1940-2011) and the birth of receptor-mediated endocytosis

scientific article

Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease ⬇️

scientific article published on November 10, 1975

Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts ⬇️

scientific article published on March 1, 1977

Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts ⬇️

scientific article published on April 1, 1975

SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

scientific article

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

scientific article

SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element

scientific article

SREBPs: transcriptional mediators of lipid homeostasis

scientific article

Saturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits ⬇️

scientific article published on March 1, 1981

Scavenger cell receptor shared.

scientific article

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins

scientific journal article

Science over politics.

scientific article

Scientific side trips: six excursions from the beaten path

scientific article

Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning

scientific article published on July 1998

Secreted site-1 protease cleaves peptides corresponding to luminal loop of sterol regulatory element-binding proteins

scientific article

Selective versus total insulin resistance: a pathogenic paradox

scientific article published on February 2008

Self-association of the low density lipoprotein receptor mediated by the cytoplasmic domain.

scientific article

Separate mechanisms for the uptake of high and low density lipoproteins by mouse adrenal gland in vivo ⬇️

scientific article published on June 25, 1979

Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase

scientific article published on February 1991

Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin

scientific journal article

Similar content of phospholipids and gangliosides in normal and homozygous familial hypercholesterolemia fibroblasts ⬇️

scientific article published on March 1, 1978

Solubilization of the low density lipoprotein receptor ⬇️

scientific article published on November 1, 1979

Specific, saturable, and high affinity binding of 125I-low density lipoprotein to glass beads ⬇️

scientific article published on February 21, 1977

Sphingomyelin depletion in cultured cells blocks proteolysis of sterol regulatory element binding proteins at site 1 ⬇️

scientific article published on October 14, 1997

Squalene synthetase activity in human fibroblasts: Regulation via the low density lipoprotein receptor ⬇️

scientific article published on October 1, 1979

Steroid Requirements for Suppression of HMG CoA Reductase Activity in Cultured Human Fibroblasts ⬇️

scientific article published on January 1, 1975

Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1

scientific article published on 01 March 1988

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins

scientific article

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig

scientific article

Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake

scientific article published in January 2006

Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2.

scientific article published on August 1994

Sterols accelerate degradation of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase encoded by a constitutively expressed cDNA.

scientific article published on April 1985

Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi

scientific article published on September 1999

Stimulation of cholesteryl ester synthesis in macrophages by extracts of atherosclerotic human aortas and complexes of albumin/cholesteryl esters ⬇️

scientific article published on May 1, 1981

Stimulation of the synthesis of very low density lipoproteins in rooster liver by estradiol

scientific article published on 01 September 1974

Stoichiometric binding of low density lipoprotein (LDL) and monoclonal antibodies to LDL receptors in a solid phase assay

scientific journal article

Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

scientific article

Structure of the LDL receptor extracellular domain at endosomal pH

scientific article

Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13

scientific article

Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and inhibition of growth of human fibroblasts by 7-ketocholesterol

scientific article published on 01 November 1974

Surface distribution and recycling of the low density lipoprotein receptor as visualized with antireceptor antibodies ⬇️

scientific article published on June 1, 1982

Surviving starvation: essential role of the ghrelin-growth hormone axis

scientific article published on 22 July 2011

Surviving starvation: essential role of the ghrelin-growth hormone axis

scientific article published in June 2012

Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance

scientific article published on December 2008

Synthesis of delta 2-isopentenyl tRNA from mevalonate in cultured human fibroblasts

scientific article published on 01 July 1980

Synthesis of ubiquinone and cholesterol in human fibroblasts: Regulation of a branched pathway ⬇️

scientific article published on January 1, 1979

Targeted killing of cultured cells by receptor-dependent photosensitization ⬇️

scientific article published on September 1, 1981

Tetrapeptide inhibitors of protein farnesyltransferase: amino-terminal substitution in phenylalanine-containing tetrapeptides restores farnesylation ⬇️

scientific article published on September 1, 1992

The J.D. mutation in familial hypercholesterolemia: amino acid substitution in cytoplasmic domain impedes internalization of LDL receptors

scientific article

The LDL Receptor Defect in Familial Hypercholesterolemia: Implications for Pathogenesis and Therapy ⬇️

scientific article published on March 1, 1982

The LDL receptor

scientific article

The LDL receptor gene: a mosaic of exons shared with different proteins

scientific article

The LDL receptor in familial hypercholesterolemia: use of human mutations to dissect a membrane protein.

scientific article

The LDL receptor locus and the genetics of familial hypercholesterolemia ⬇️

scientific article published on January 1, 1979

The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor ⬇️

scientific article published on March 1, 1983

The LDL receptor locus in familial hypercholesterolemia: mutational analysis of a membrane protein

scientific article published on January 1990

The Lebanese allele at the low density lipoprotein receptor locus. Nonsense mutation produces truncated receptor that is retained in endoplasmic reticulum

scientific article published on 01 January 1987

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis ⬇️

scientific article published on January 1, 1977

The Rule of Three for Prizes in Science and the Bold Triptychs of Francis Bacon

scientific article published on 3 September 2016

The SREBP pathway in Drosophila: regulation by palmitate, not sterols

scientific article published on February 2002

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

scientific article (publication date: 2 May 1997)

The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals

scientific article published on February 2012

The card players of Caravaggio, Cézanne and Mark Twain: tips for getting lucky in high-stakes research

scientific article

The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters.

scientific article published on October 1980

The clinical investigator: bewitched, bothered, and bewildered--but still beloved

scientific article published on June 1997

The estradiol-stimulated lipoprotein receptor of rat liver. A binding site that membrane mediates the uptake of rat lipoproteins containing apoproteins B and E ⬇️

scientific article published on November 10, 1980

The genetic basis of hypercholesterolemia: clinical and therapeutic implications

scientific article published on February 1, 1992

The ghrelin-growth hormone axis preserves gluconeogenesis to maintain blood glucose levels during starvation.

scientific article published in June 2012

The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA

scientific article

The low density lipoprotein receptor in Xenopus laevis. I. Five domains that resemble the human receptor ⬇️

scientific article published on June 5, 1991

The low density lipoprotein receptor in Xenopus laevis. II. Feedback repression mediated by conserved sterol regulatory element ⬇️

scientific article published on June 5, 1991

The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis

scientific article published on 01 March 1987

The low-density lipoprotein pathway in human fibroblasts: relation between cell surface receptor binding and endocytosis of low-density lipoprotein ⬇️

scientific article published on January 1, 1976

The scavenger cell pathway for lipoprotein degradation: Specificity of the binding site that mediates the uptake of negatively-charged LDL by macrophages ⬇️

scientific article published on January 1, 1980

The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins

scientific article

Three different rearrangements in a single intron truncate sterol regulatory element binding protein-2 and produce sterol-resistant phenotype in three cell lines. Role of introns in protein evolution

scientific article published on May 1995

Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene

scientific article published on 01 August 1987

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

scientific article

Tissue-specific sorting of the human LDL receptor in polarized epithelia of transgenic mice

scientific article

Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain

scientific article published in July 1998

Towering science: an ounce of creativity is worth a ton of impact

scientific article

Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding ⬇️

scientific article published on January 1, 1992

Transport-Dependent Proteolysis of SREBP

Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi

scientific article (publication date: 23 December 1999)

Ultrastructural analysis of crystalloid endoplasmic reticulum in UT-1 cells and its disappearance in response to cholesterol

scientific article published on 01 September 1983

Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells

scientific article

Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.

scientific article published in May 2001

Use of antipeptide antibodies to demonstrate external orientation of the NH2-terminus of the low density lipoprotein receptor in the plasma membrane of fibroblasts ⬇️

scientific article published on November 1, 1983

Use of monoclonal anti-receptor antibodies to probe the expression of the low density lipoprotein receptor in tissues of normal and Watanabe heritable hyperlipidemic rabbits ⬇️

scientific article published on September 1, 1984

Use of mutant 125I-perfringolysin O to probe transport and organization of cholesterol in membranes of animal cells

scientific article published on 10 June 2013

Use of mutant fibroblasts in the analysis of the regulation of cholesterol metabolism in human cells ⬇️

scientific article published on April 1, 1975

Venture science: climbing the ladder to telomerase, cognitive therapy and in situ hybridization

scientific article

Visualization of acidic organelles in intact cells by electron microscopy

scientific article published on August 1984

Visualization of lipoprotein receptors by ligand blotting ⬇️

scientific article published on April 10, 1983

Why is it so hard to pay attention, or is it? Mindfulness, the factors of awakening and reward-based learning

scientific article published on March 2013

beta-Carotene as a probe of lipid domains of reconstituted human plasma low-density lipoprotein: induced circular dichroism

scientific article published on 01 September 1980

cDNA cloning and expression of oxysterol-binding protein, an oligomer with a potential leucine zipper

scientific article published in October 1989

cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1.

scientific article published on January 1995

cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function ⬇️

scientific article published on November 15, 1992

cDNA cloning of human oxysterol-binding protein and localization of the gene to human chromosome 11 and mouse chromosome 19

scientific article

cDNA cloning of the bovine low density lipoprotein receptor: feedback regulation of a receptor mRNA ⬇️

scientific article published on December 1, 1983

mRNA for low density lipoprotein receptor in brain and spinal cord of immature and mature rabbits

scientific article

p21ras farnesyltransferase: purification and properties of the enzyme

scientific article

reply: Leptin and diabetes in lipoatrophic mice

scientific article published in Nature

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