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List of works by Arlene Sharpe

4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses

scientific article published in November 2004

A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system

article

A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade

scientific article published on 09 September 2020

A phase II study of combined therapy with a BRAF inhibitor (vemurafenib) and interleukin-2 (aldesleukin) in patients with metastatic melanoma

scientific article published in February 2018

A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection

scientific article published in June 2003

Abstract 2701: Functionally specialized subsets of exhausted CD8+ T cells mediate tumor control and differentially respond to checkpoint blockade

scholarly article

Adverse Events Following Cancer Immunotherapy: Obstacles and Opportunities

scientific article published on 30 April 2019

An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells

scientific journal article

Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade

scientific article published on 14 June 2016

Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo

article

Anti-CD48 Monoclonal Antibody Attenuates Experimental Autoimmune Encephalomyelitis by Limiting the Number of Pathogenic CD4+ T Cells

scientific article

Antigen Recognition Is Facilitated by Invadosome-like Protrusions Formed by Memory/Effector T Cells ⬇️

scientific article published on March 21, 2012

Author Correction: Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

scientific article published on 01 November 2019

Auto-antibody production and glomerulonephritis in congenic Slamf1-/- and Slamf2-/- [B6.129] but not in Slamf1-/- and Slamf2-/- [BALB/c.129] mice

scientific article

B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells.

scientific article published in November 2017

B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions [corrections].

scientific article published in January 2004

B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function.

scientific article

B7-1/B7-2 costimulation regulates plaque antigen-specific T-cell responses and atherogenesis in low-density lipoprotein receptor-deficient mice

scientific article published on 19 April 2004

BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes

scientific article published on 15 October 2013

Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling

scientific article published on 26 July 2016

Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo

scientific article published on 01 October 2006

Brief report: increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice

scientific article published on March 2013

CD160 Stimulates CD8+ T Cell Responses and Is Required for Optimal Protective Immunity to Listeria monocytogenes

scientific article published on 27 August 2018

CD28 costimulation regulates genome-wide effects on alternative splicing

scientific article (publication date: 2012)

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells

scientific article published on 20 October 2015

CD4 T Cells Promote Rather than Control Tuberculosis in the Absence of PD-1–Mediated Inhibition ⬇️

scientific article published on December 20, 2010

CD48 controls T-cell and antigen-presenting cell functions in experimental colitis

scientific article

CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivo.

scientific article published in February 2005

CTLA-4 regulates cell cycle progression during a primary immune response.

scientific article

Circulating T follicular regulatory and helper cells have memory-like properties

scientific article

Coinfection with Streptococcus pneumoniae modulates the B cell response to influenza virus

scientific article

Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma

scientific article published on 25 November 2020

Correction: B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells

scientific article published on 23 February 2018

Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation

scientific journal article

Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice

scientific article

Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells

scientific article

Cutting edge: TIGIT has T cell-intrinsic inhibitory functions

scientific journal article

Cutting edge: a crucial role for B7-CD28 in transmitting T help from APC to CTL.

scientific article published on October 2002

Cutting edge: transplantation tolerance through enhanced CTLA-4 expression

scientific article published in December 2003

Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice

article published in the Proceedings of the National Academy of Sciences of the United States of America

Deletion of a conserved Il4 silencer impairs T helper type 1–mediated immunity

scientific article published on 31 October 2004

Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function.

scientific article published on 12 March 2018

Distinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma

scientific article published on 2 February 2016

Distinct populations of innate CD8+ T cells revealed in a CXCR3 reporter mouse

scientific article

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8+ T cell activation and cytolysis ⬇️

scientific article published on 01 November 2003

Epstein-Barr virus nuclear antigen 1 does not induce lymphoma in transgenic FVB mice

scientific article

Erratum: The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection

scientific article published on September 2017

Expression of T-cell Exhaustion Molecules and Human Endogenous Retroviruses as Predictive Biomarkers for response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma

scientific article published on 20 November 2020

GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses

scientific article

Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells

scientific article published in June 2015

Genetic background determines the requirement for B7 costimulation in induction of autoimmunity

scientific article published in September 2002

Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.

scientific article

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target.

scientific article published on 19 July 2017

Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation

scientific article

Induction of B7-1 in podocytes is associated with nephrotic syndrome

scientific article

Inhibitors of the PD-1 Pathway in Tumor Therapy

scientific article

Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1.

scientific article published on 21 June 2012

Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V

scientific article published on 9 February 2012

Introduction to checkpoint inhibitors and cancer immunotherapy.

scientific article

Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients

scientific article published on 09 January 2003

Loss of Programmed Death Ligand-1 Expression on Donor T Cells Lessens Acute Graft-Versus-Host Disease Lethality ⬇️

scholarly article

Mechanism of action of donor-specific transfusion in inducing tolerance: role of donor MHC molecules, donor co-stimulatory molecules, and indirect antigen presentation

scientific article published on 01 September 2004

Mechanisms of costimulation

scientific article

Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation.

scientific article published on July 2016

Mitochondrial metabolism in T cell activation and senescence: a mini-review

scientific article

Modulation of surgical fibrosis by microbial zwitterionic polysaccharides

scientific article

Monitoring PD-1 Phosphorylation to Evaluate PD-1 Signaling during Antitumor Immune Responses

scientific article published on 11 October 2021

Negative co-receptors on lymphocytes

scientific article

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

scientific article published on 07 December 2020

Oncometabolite d-2HG alters T cell metabolism to impair CD8 T cell function

scientific article published on 30 September 2022

Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunity

scientific article published on 28 November 2011

PD-1 Protects against Inflammation and Myocyte Damage in T Cell-Mediated Myocarditis ⬇️

scientific article published on April 9, 2012

PD-1 dependent exhaustion of CD8+ T cells drives chronic malaria.

scientific article

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

scientific article

PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice.

scientific article

Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand

scientific article published on 01 December 2003

Paradoxical effect of reduced costimulation in T cell-mediated colitis

scientific article published in May 2007

Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells

scientific article published on 04 December 2020

Physiologic Control of IDO Competence in Splenic Dendritic Cells ⬇️

scientific article published on August 3, 2011

Prevention of CAR-T-cell dysfunction

scientific article published on 01 January 2020

Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice.

scientific article

Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia.

scientific article

Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4(+) T Cell Immunity

scientific article published on August 2016

Progressive immune dysfunction with advancing disease stage in renal cell carcinoma

scientific article published on 11 March 2021

Recovery from EAE is associated with decreased survival of encephalitogenic T cells in the CNS of B7-1/B7-2-deficient mice

scientific article published on 01 July 2003

Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses ⬇️

scientific article published on October 1, 2003

Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions

scientific journal article

Role of PD-1/PD-L1 in Acute and Chronic Graft Versus Host Disease ⬇️

scholarly article

Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins

scientific article published in May 2018

Role of the B7-CD28/CTLA-4 pathway in autoimmune disease

scientific article (publication date: 2002)

SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase

scientific journal article

Small-molecule BCL6 inhibitor effectively treats mice with non-sclerodermatous chronic graft-versus-host disease

article

SnapShot: B7/CD28 costimulation

scientific article

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

scientific article published on 18 February 2019

Summary and Recommendations from the National Cancer Institute's Clinical Trials Planning Meeting on Novel Therapeutics for Non-Muscle Invasive Bladder Cancer ⬇️

scientific article published on 27 April 2016

Suppression by TFR cells leads to durable and selective inhibition of B cell effector function

scientific article published on 3 October 2016

Synergistic costimulation by both B7 molecules regulates colitis pathogenesis

scientific article published on August 2006

T Cell Activation Depends on Extracellular Alanine

scientific article published on 01 September 2019

T Follicular Regulatory Cell-Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity

scientific article published on 09 November 2020

T follicular regulatory cells

scientific article published on May 2016

T follicular regulatory cells in the regulation of B cell responses

scientific article

TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection

scientific article published on 09 July 2008

Taming tissue-specific T cells: CTLA-4 reins in self-reactive T cells

scientific article published on February 2010

Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state

scientific article published on September 2017

Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease

scientific article published on 19 March 2019

The CD154/CD40 interaction required for retrovirus-induced murine immunodeficiency syndrome is not mediated by upregulation of the CD80/CD86 costimulatory molecules

scientific article

The ICOS molecule plays a crucial role in the development of mucosal tolerance

scientific article published on 01 December 2005

The PD-1 pathway in tolerance and autoimmunity

scientific article

The PTEN pathway in Tregs functions as a critical driver of the immunosuppressive tumor microenvironment and tolerance to apoptotic cells.

scientific article published on 4 November 2015

The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment

scientific article published on 6 November 2015

The effects of age and systemic metabolism on anti-tumor T cell responses

scientific article published on 10 November 2020

The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells

scientific article published on 22 May 2015

The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection

scientific article published on 22 May 2017

The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus

scientific journal article

The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin

scientific article published on 17 August 2003

Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses

scientific article

Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells

scientific article published in 2022

Workshop on challenges, insights, and future directions for mouse and humanized models in cancer immunology and immunotherapy: a report from the associated programs of the 2016 annual meeting for the Society for Immunotherapy of cancer.

scientific article published on 19 September 2017

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