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List of works by Gordon J. Freeman

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection

scientific article published on 8 July 2011

5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers

scientific article published on 18 October 2016

A New B7:CD28 Family Checkpoint Target for Cancer Immunotherapy: HHLA2.

scientific article published on 13 April 2015

A cell type-specific enhancer in the human B7.1 gene regulated by NF-kappaB

scientific article published in March 1996

A negative regulatory function of B7 revealed in B7-1 transgenic mice

scientific article published on 01 August 1994

A new therapeutic strategy for malaria: targeting T cell exhaustion

scientific article published on 19 January 2012

A novel alloantigen-specific CD8+PD1+ regulatory T cell induced by ICOS-B7h blockade in vivo

scientific article

A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humans

scientific article

A secreted PD-L1 splice variant that covalently dimerizes and mediates immunosuppression

scientific article published on 18 December 2018

Abundant PD-L1 expression in Epstein-Barr Virus-infected gastric cancers

scientific article published on 28 April 2016

Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy

scientific article published on 24 August 2020

Acidity changes immunology: a new VISTA pathway

scientific article published on 01 January 2020

Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation

scientific article published on December 1993

Activation of human T cell lymphotropic virus type I-infected T cells is independent of B7 costimulation

scientific article published in October 1996

Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors

scientific article published on 27 September 2013

Activation primes human B lymphocytes to respond to heat shock

scientific article

Acute depletion of activated memory B cells involves the PD-1 pathway in rapidly progressing SIV-infected macaques.

scientific article

Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints.

scientific article

All advanced stage non-Hodgkin's lymphomas with a polymerase chain reaction amplifiable breakpoint of bcl-2 have residual cells containing the bcl-2 rearrangement at evaluation and after treatment ⬇️

scientific article published on December 15, 1991

An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells

scientific journal article

An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma ⬇️

scientific article published on June 1, 2013

Anti-PD-1/PD-L1 therapy augments lenvatinib's efficacy by favorably altering the immune microenvironment of murine anaplastic thyroid cancer

scientific article published on 24 January 2019

Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells ⬇️

scientific article published on April 1, 1992

Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection.

scientific article published on 12 December 2011

Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

scientific article

Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity

scientific article

Arming an oncolytic herpes simplex virus Type 1 with a single chain fragment variable antibody against PD-1 for experimental glioblastoma therapy

article

Aspirin Use and Colorectal Cancer Survival According to Tumor CD274 (Programmed Cell Death 1 Ligand 1) Expression Status.

scientific article

Association of PD-L1 expression on tumor-infiltrating mononuclear cells and overall survival in patients with urothelial carcinoma

scientific article published on 18 January 2015

Author Correction: Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance

scientific article published on 01 July 2019

B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2.

scientific article published on August 1991

B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance

scientific article

B7, a B-cell-restricted antigen that identifies preactivated B cells

scientific article published on 01 November 1987

B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells

scientific article

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4.

scientific article published on May 1995

B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation

scientific article published on 01 March 1997

B7-1 is superior to B7-2 costimulation in the induction and maintenance of T cell-mediated antileukemia immunity. Further evidence that B7-1 and B7-2 are functionally distinct

scientific article published on 01 February 1996

B7-2 expressed on EL4 lymphoma suppresses antitumor immunity by an interleukin 4-dependent mechanism

scientific article

B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality

scientific article published on 26 March 2015

B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4.

scientific article

B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors.

scientific article published on March 1997

BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non-Small Cell Lung Cancer

scientific article published on 07 August 2018

BTLA expression declines on B cells of the aged and is associated with low responsiveness to the trivalent influenza vaccine

scientific article

Binding of Hepatitis A Virus to Its Cellular Receptor 1 Inhibits T-Regulatory Cell Functions in Humans ⬇️

scientific article published on March 16, 2012

Biologic Activity of Autologous, Granulocyte-Macrophage Colony-Stimulating Factor Secreting Alveolar Soft-Part Sarcoma and Clear Cell Sarcoma Vaccines

scientific article published on 24 March 2015

Blockade of RGMb inhibits allergen-induced airways disease

scientific article published on 29 January 2019

Blockade of TIM-1 on the donor graft ameliorates graft-versus-host disease following hematopoietic cell transplantation

scientific article published on 01 November 2019

Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

scientific article published on 28 January 2016

Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production

scientific article

Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance

scientific article published on October 1994

Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate phosphatidylinositol 3-kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 secretion.

scientific article published in June 1995

Breast cancer-associated antigen, DF3/MUC1, induces apoptosis of activated human T cells

scientific article published on December 1996

CD101 is expressed by skin dendritic cells. Role in T-lymphocyte activation.

scientific article

CD160 Stimulates CD8+ T Cell Responses and Is Required for Optimal Protective Immunity to Listeria monocytogenes

scientific article published on 27 August 2018

CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator

scientific article published on 13 January 2008

CD160Ig fusion protein targets a novel costimulatory pathway and prolongs allograft survival

scientific article

CD161 defines a transcriptional and functional phenotype across distinct human T cell lineages.

scientific article published on 23 October 2014

CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy

scientific article

CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions

scientific article published on August 2005

CD4 + CD25 + Regulatory Cells from Human Peripheral Blood Express Very High Levels of CD25 Ex Vivo ⬇️

scientific article published on 01 January 2003

CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion

scientific article

CD4+CD25high regulatory cells in human peripheral blood

scientific article published on 01 August 2001

CD40L-Tri, a novel formulation of recombinant human CD40L that effectively activates B cells ⬇️

scientific article published on August 25, 2012

CD48-deficient mice have a pronounced defect in CD4(+) T cell activation

scientific article

CDK4/6 Inhibition Augments Anti-Tumor Immunity by Enhancing T Cell Activation.

scientific article published on 3 November 2017

CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

scientific article published on 26 December 2019

CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production ⬇️

scientific article published on December 15, 1992

CTLA4 mediates antigen-specific apoptosis of human T cells

scientific article

Cell-Intrinsic Abrogation of TGF-β Signaling Delays but Does Not Prevent Dysfunction of Self/Tumor-Specific CD8 T Cells in a Murine Model of Autochthonous Prostate Cancer ⬇️

scientific article published on September 14, 2012

Characterization of CTLA-4 structure and expression on human T cells.

scientific article

Characterization of endogenous Chinese hamster ovary cell surface molecules that mediate T cell costimulation

scientific article published on 01 November 2001

Characterization of the murine B7-1 genomic locus reveals an additional exon encoding an alternative cytoplasmic domain and a chromosomal location of chromosome 16, band B5.

scientific article published on December 1994

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

scientific article

Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model

scientific article published on 29 April 2016

Clonal tracing reveals diverse patterns of response to immune checkpoint blockade

scientific article published on 15 October 2020

Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation ⬇️

scientific article published on November 5, 1993

Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes ⬇️

scientific article published on September 15, 1998

Coinhibitory Pathways in Immunotherapy for Cancer

scientific article published on 25 February 2016

Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family

scientific article published on May 2016

Combination anti-PD-1 and antiretroviral therapy provides therapeutic benefit against SIV

scientific article published on 20 September 2018

Combination cancer immunotherapy and new immunomodulatory targets

scientific article

Combinations of BRAF inhibitor and anti-PD-1/PD-L1 antibody improve survival and tumour immunity in an immunocompetent model of orthotopic murine anaplastic thyroid cancer

scientific article published on 17 October 2018

Comment on "Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection".

scientific article published in July 2014

Complete blockade of B7 family-mediated costimulation is necessary to induce human alloantigen-specific anergy: a method to ameliorate graft-versus-host disease and extend the donor pool

scientific article published on 01 June 1996

Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma

scientific article published on 25 November 2020

Constitutive expression of B7 restores immunogenicity of tumor cells expressing truncated major histocompatibility complex class II molecules ⬇️

scientific article published on June 15, 1993

Constitutive neuronal expression of the immune regulator, programmed death 1 (PD-1), identified during experimental autoimmune uveitis

scientific article published in January 2009

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

scientific article

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

scientific article

Correction: Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy

scientific article published on 01 February 2020

Correlation of Apobec Mrna Expression with overall Survival and pd-l1 Expression in Urothelial Carcinoma

scientific article published on 10 June 2016

Costimulatory genes: hotspots of conflict between host defense and autoimmunity.

scientific article published on June 2013

Critical role of CD81 in cognate T-B cell interactions leading to Th2 responses

scientific article published in May 2002

Cutting edge: CD94/NKG2 is expressed on Th1 but not Th2 cells and costimulates Th1 effector functions

scientific article published on November 2002

Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance

scientific article published on 16 November 2017

DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8⁺ T cells independently of PD-1 and PD-L1

scientific article published on 10 September 2013

Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging

scientific article published on 2 July 2015

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

scientific article published on 02 August 2016

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.

scientific article

Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function.

scientific article published on 12 March 2018

Differential Expression of PD-L1 between Primary and Metastatic Sites in Clear-Cell Renal Cell Carcinoma

scientific article

Differential Expression of PD-L1 in High Grade T1 vs Muscle Invasive Bladder Carcinoma and its Prognostic Implications

scientific article published on 6 May 2017

Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation

scientific article

Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues

scientific article

Differential expression of alternate mB7-2 transcripts.

scientific article published in December 1995

Differential impact of PD-1 and/or interleukin-10 blockade on HIV-1-specific CD4 T cell and antigen-presenting cell functions

scientific article published on 18 December 2013

Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen

scientific article published on 01 September 1994

Down-regulation of CTLA-4 by HIV-1 Nef protein

scientific article published on 23 January 2013

Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors--response

article

Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors.

scientific article published on 30 April 2013

Dual control of antitumor CD8 T cells through the programmed death-1/programmed death-ligand 1 pathway and immunosuppressive CD4 T cells: regulation and counterregulation.

scientific article

Early signaling defects in human T cells anergized by T cell presentation of autoantigen ⬇️

scientific article published on July 1, 1992

Elevated expression levels of inhibitory receptor programmed death 1 on simian immunodeficiency virus-specific CD8 T cells during chronic infection but not after vaccination

scientific article published on 21 March 2007

Endothelial Programmed Death-1 Ligand 1 (PD-L1) Regulates CD8 + T-Cell–Mediated Injury in the Heart

scientific article published on 15 October 2007

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8+ T cell activation and cytolysis ⬇️

scientific article published on 01 November 2003

Engagement of CD83 ligand induces prolonged expansion of CD8+ T cells and preferential enrichment for antigen specificity

scientific article published on 20 October 2005

Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

scientific article

Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy

scientific article published in September 2017

Enhancing SIV-specific immunity in vivo by PD-1 blockade

scientific article

Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection

scientific article

Epithelial PD-L2 Expression Marks Barrett's Esophagus and Esophageal Adenocarcinoma

scientific article

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

scientific article published on 3 November 2017

Ex vivo generation of human anti-pre-B leukemia-specific autologous cytolytic T cells ⬇️

scientific article published on July 15, 1997

Examination of CD8+ T cell function in humans using MHC class I tetramers: similar cytotoxicity but variable proliferation and cytokine production among different clonal CD8+ T cells specific to a single viral epitope

scientific article

Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation ⬇️

scientific article published on 01 February 1998

Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells ⬇️

scientific article published on May 1, 1992

Expression and regulation of the PD-L1 immunoinhibitory molecule on microvascular endothelial cells

scientific article published on April 2002

Expression of MHC class II-associated invariant chain (Ii;CD74) in thymic epithelial neoplasms

scientific article

Expression of PD-1 and Its Ligands, PD-L1 and PD-L2, in Smokers and Never Smokers with KRAS-Mutant Lung Cancer

scientific article published in December 2015

Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10

scientific article

Expression of Programmed Cell Death 1 Ligands (PD-L1 and PD-L2) in Histiocytic and Dendritic Cell Disorders

scientific article published on 01 April 2016

Expression of T-cell Exhaustion Molecules and Human Endogenous Retroviruses as Predictive Biomarkers for response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma

scientific article published on 20 November 2020

Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4 ⬇️

scientific article published on November 15, 1997

Expression of lectin-like transcript-1 in human tissues

scientific article published on 29 December 2016

Expression of programmed cell death 1 ligand 2 (PD-L2) is a distinguishing feature of primary mediastinal (thymic) large B-cell lymphoma and associated with PDCD1LG2 copy gain

scientific article published on December 2014

Extracellular Vesicles Transfer the Receptor Programmed Death-1 in Rheumatoid Arthritis.

scientific article

Follicular lymphomas can be induced to present alloantigen efficiently: a conceptual model to improve their tumor immunogenicity

scientific article

Functional Restoration of HCV-Specific CD8 T Cells by PD-1 Blockade Is Defined by PD-1 Expression and Compartmentalization

scientific article

Fusobacterium nucleatum and T Cells in Colorectal Carcinoma

scientific article

Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis

scientific article published on 26 August 2015

Genetic Basis for PD-L1 Expression in Squamous Cell Carcinomas of the Cervix and Vulva

scientific article

Glioblastoma Eradication Following Immune Checkpoint Blockade in an Orthotopic, Immunocompetent Model

scientific article published on 6 November 2015

High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8 and CD4 T Cells during Acute HCV Infection, Irrespective of Clinical Outcome

scientific article published in May 2011

High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8+ and CD4+ T Cells during Acute HCV Infection, Irrespective of Clinical Outcome

scientific article

High-fidelity detection and sorting of nanoscale vesicles in viral disease and cancer.

scientific article published on 19 June 2019

Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality

scientific article published on 12 September 2013

Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation

scientific article

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation ⬇️

scientific article published on July 15, 1993

Human alveolar macrophages present antigen ineffectively due to defective expression of B7 costimulatory cell surface molecules

scientific article published on March 1995

ICOS is critical for CD40-mediated antibody class switching

scientific journal article

ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival

scientific article

ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity.

scientific article

IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection

scholarly article

IMMU-10. EXPRESSION OF PD-L2, IN GLIOBLASTOMA; IMPLICATIONS AS A BIOMARKER FOR IMMUNOTHERAPY

IMMU-15. PD-1 BLOCKADE ACTIVATES CD4 T CELLS AND THE INNATE IMMUNE RESPONSE FOR GLIOBLASTOMA ERADICATION

IMMU-19. PD-1 BLOCKADE ACTIVATES CD4 T CELLS AND THE INNATE IMMUNE RESPONSE FOR GLIOBLASTOMA ERADICATION

IMMU-28. DEFINING MOLECULAR MECHANISMS OF RESISTANCE TO GLIOBLASTOMA (GBM) IMMUNITY USING A NOVEL CRISPR/CAS9 IN VIVO LOSS-OF-FUNCTION SCREENING PLATFORM

IMMUNE CHECKPOINT BLOCKADE FOR GLIOBLASTOMA: PRECLINICAL ACTIVITY OF SINGLE AGENT AND COMBINATORIAL THERAPY.

scientific article published in July 2014

IT-29IMMUNE CHECKPOINT BLOCKADE FOR GLIOBLASTOMA: PRECLINICAL ACTIVITY OF SINGLE AGENT AND COMBINATORIAL THERAPY.

scientific article published in November 2014

Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family ⬇️

scientific article (publication date: December 2001)

Identification of the Cell-Intrinsic and -Extrinsic Pathways Downstream of EGFR and IFNγ That Induce PD-L1 Expression in Head and Neck Cancer

scientific article published on 16 December 2015

Identification, by protein sequencing and gene transfection, of sgp-60 as the murine homologue of CD48.

scientific article

Immune Checkpoint Blockade Restores HIV-Specific CD4 T Cell Help for NK Cells

scientific article published on 22 June 2018

Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition

scientific article published on 26 June 2017

Immune Profiling and Quantitative Analysis Decipher the Clinical Role of Immune-Checkpoint Expression in the Tumor Immune Microenvironment of DLBCL

scientific article published on 11 February 2019

Immune Profiling of Adenoid Cystic Carcinoma: PD-L2 Expression and Associations with Tumor-Infiltrating Lymphocytes

scientific article published on 16 June 2016

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles.

scientific article

Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model

scientific article published on February 2012

Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade

scientific article published on 02 August 2019

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy

scientific article published on 09 February 2016

Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions

scientific article

Immunologic profiling of adenoid cystic carcinoma (acc).

scientific article published on 4 November 2015

Immunology: hepatitis A virus link to atopic disease

scientific article (publication date: 9 October 2003)

Immunotherapy advances for glioblastoma

scientific article

Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1) ⬇️

scientific article published on August 26, 2013

Impaired Hepatitis C Virus (HCV)-Specific Effector CD8+ T Cells Undergo Massive Apoptosis in the Peripheral Blood during Acute HCV Infection and in the Liver during the Chronic Phase of Infection

scientific article

Impairment of the Programmed Cell Death-1 Pathway Increases Atherosclerotic Lesion Development and Inflammation ⬇️

scientific article published on March 10, 2011

In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma

scientific article published on 19 November 2019

In vivo expression of B7-1 and B7-2 by follicular lymphoma cells can prevent induction of T-cell anergy but is insufficient to induce significant T-cell proliferation

scientific article published on 01 December 1997

In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy

scientific article published on May 2017

In-fusion assembly: seamless engineering of multidomain fusion proteins, modular vectors, and mutations

scientific article published in September 2007

Inactivation of Fbxw7 impairs dsRNA sensing and confers resistance to PD-1 blockade

scientific article published on 05 May 2020

Inadequate T follicular cell help impairs B cell immunity during HIV infection.

scientific article published on 10 March 2013

Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses

scientific article published on 27 January 2014

Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

scientific article

Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans

scientific article

Increased expression of programmed death ligand 1 (PD-L1) in human pituitary tumors

scientific article published on 15 September 2016

Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma

scientific article published on March 2015

Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed cell death ⬇️

scientific article published on October 1, 1997

Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity

scientific article

Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice

scientific article published on 06 May 2009

Inhibition of transplant rejection following treatment with anti-B7-2 and anti-B7-1 antibodies

scientific article published on 01 November 1995

Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis

scientific article published on 15 February 2021

Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1 ⬇️

scientific article

Innate immunity in multiple sclerosis: myeloid dendritic cells in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response

scientific article published on 01 September 2006

Intact B7-H3 signaling promotes allograft prolongation through preferential suppression of Th1 effector responses

scientific article published on September 2012

Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation

scientific article published on 17 March 2020

Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance

scientific journal article

Interaction of human PD-L1 and B7-1.

scientific article

Intercellular adhesion molecule 1 is critical for activation of CD28-deficient T cells

scientific article published on 01 December 2000

Interferon-γ-induced activation of JAK1 and JAK2 suppresses tumor cell susceptibility to NK cells through upregulation of PD-L1 expression

scientific article published on 2 March 2015

Interleukin 6 gene expression in normal and neoplastic B cells

scientific article

Interleukin-17A Promotes Lung Tumor Progression through Neutrophil Attraction to Tumor Sites and Mediating Resistance to PD-1 Blockade

scientific article published on 5 May 2017

Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection

scientific article

Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma

scientific article published on 29 May 2020

Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade

scientific article published on February 2009

Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy

scientific article published on 13 May 2019

Isolated human follicular dendritic cells display a unique antigenic phenotype

scientific article

KIR3DL3 is an inhibitory receptor for HHLA2 that mediates an alternative immunoinhibitory pathway to PD1

scientific article published on 23 November 2020

LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation.

scientific article published on February 2016

LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

scientific article published on 21 June 2018

Labeling Extracellular Vesicles for Nanoscale Flow Cytometry

scientific article

Learning from PD-1 Resistance: New Combination Strategies.

scientific article published on 9 May 2016

Level of PD-1 expression on CD8+ T cells influence prognosis and respond to PD-1 therapy in a murine model.

scientific article published on 4 November 2015

Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors

scientific article published on 19 October 2013

Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression

scientific article

Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression

scientific article

Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma

scientific article published in February 2017

Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1 ⬇️

scientific article published on 01 October 1997

Metabolomic adaptations and correlates of survival to immune checkpoint blockade

scientific article published on 25 September 2019

MicroRNA MIR21 and T Cells in Colorectal Cancer

scientific article

Minicircle DNA-based gene therapy coupled with immune modulation permits long-term expression of α-L-iduronidase in mice with mucopolysaccharidosis type I

scientific article

Modeling tumor immunity of mouse glioblastoma by exhausted CD8+ T cells

scientific article published on 9 January 2018

Monitoring PD-1 Phosphorylation to Evaluate PD-1 Signaling during Antitumor Immune Responses

scientific article published on 11 October 2021

Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells

scientific article published on 01 November 2000

Murine B7 antigen provides a sufficient costimulatory signal for antigen-specific and MHC-restricted T cell activation ⬇️

scientific article published on December 15, 1992

Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex ⬇️

scientific article published on January 1, 1992

Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production

scientific article published on December 1993

Nef promotes evasion of human immunodeficiency virus type 1-infected cells from the CTLA-4-mediated inhibition of T-cell activation

scientific article

New Cancer Immunotherapy Agents in Development: a report from an associated program of the 31stAnnual Meeting of the Society for Immunotherapy of Cancer, 2016

scientific article

Nivolumab in Patients With Relapsed or Refractory Hematologic Malignancy: Preliminary Results of a Phase Ib Study

scientific article

No evidence for MUC 1-induced apoptosis ⬇️

scientific article published on 01 October 1998

Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation

scientific article

Novel roles of c-Met in the survival of renal cancer cells through the regulation of HO-1 and PD-L1 expression

scientific article

OR.86. TIM-4 Negatively Regulates Immune Responses by Reducing Antigen Specific T Cell Numbers

article

OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence

scientific article

Orchestration and Prognostic Significance of Immune Checkpoints in the Microenvironment of Primary and Metastatic Renal Cell Cancer

scientific article published on 16 February 2015

Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions

scientific article published on December 1999

PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer

scientific article published on 01 December 2018

PD-1 Status in CD8+ T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer.

scientific article

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

scientific article

PD-1 and its ligands in tolerance and immunity

scientific article (publication date: 2008)

PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques

scientific article published on 23 April 2012

PD-1 blockade in chronically HIV-1-infected humanized mice suppresses viral loads

scientific article

PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma

scientific article (publication date: 22 January 2015)

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

scientific article (publication date: 21 September 2006)

PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status.

scientific article

PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells

scientific article published in August 2004

PD-1 on immature and PD-1 ligands on migratory human Langerhans cells regulate antigen-presenting cell activity

scientific article published on 6 May 2010

PD-1 regulates self-reactive CD8+ T cell responses to antigen in lymph nodes and tissues

scientific article

PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance

scientific article published on 01 January 2021

PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2

scientific article (publication date: March 2002)

PD-1:PD-L1 interactions contribute to the functional suppression of virus-specific CD8+ T lymphocytes in the liver.

scientific article

PD-L1 Antibodies to Its Cytoplasmic Domain Most Clearly Delineate Cell Membranes in Immunohistochemical Staining of Tumor Cells

scientific article

PD-L1 Binds to B7-1 Only on the Same Cell Surface

scientific article published on 05 June 2018

PD-L1 Expression Is Characteristic of a Subset of Aggressive B-cell Lymphomas and Virus-Associated Malignancies ⬇️

scientific article published on May 14, 2013

PD-L1 Expression and Clinical Outcomes to Cabozantinib, Everolimus, and Sunitinib in Patients with Metastatic Renal Cell Carcinoma: Analysis of the Randomized Clinical Trials METEOR and CABOSUN

scientific article published on 01 August 2019

PD-L1 and PD-L2 Genetic Alterations Define Classical Hodgkin Lymphoma and Predict Outcome

scientific article

PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis

scientific article published on 01 January 2006

PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions

scientific article

PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells

scientific article published on 15 May 2013

PD-L1 expression in nonclear-cell renal cell carcinoma

scientific article

PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity.

scientific article published on 16 March 2017

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

scientific article published on 14 December 2009

PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells

scholarly article

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

scientific article

PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity

scientific article published on 16 September 2019

Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway

scientific article

Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults

scientific article published on 07 March 2011

Pillars article: CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1994. 1: 405-413

scientific article published on October 1, 2011

Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity ⬇️

scientific article published on November 15, 1994

Pre-B acute lymphoblastic leukemia cells may induce T-cell anergy to alloantigen

scientific article published on 01 July 1996

Pre-exposure of human B cells to recombinant IL-1 enhances subsequent proliferation

scientific article published on 01 November 1988

Preclinical investigation of combined gene-mediated cytotoxic immunotherapy and immune checkpoint blockade in glioblastoma

scientific article published on 24 July 2017

Prevalence and predictors of androgen receptor and programmed death-ligand 1 in BRCA1-associated and sporadic triple-negative breast cancer

scientific article

Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor

scientific article published on November 1994

Proceedings of the third international molecular pathological epidemiology (MPE) meeting

scientific article

Programmed death ligand 2 - A link between inflammation and bone loss in rheumatoid arthritis

scientific article published on 18 December 2019

Programmed death ligand-1 expression in adrenocortical carcinoma: an exploratory biomarker study

scientific article

Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality

scientific article published on 13 June 2016

Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma

scientific article published on July 2006

Programmed death-1 (PD-1):PD-ligand 1 interactions inhibit TCR-mediated positive selection of thymocytes

scientific article

Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses

scientific article

Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection

scientific article published on 03 December 2019

Protect the killer: CTLs need defenses against the tumor

scientific article published on 01 August 2002

RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance

scientific article

RGMb protects against acute kidney injury by inhibiting tubular cell necroptosis via an MLKL-dependent mechanism

scientific article

RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion

scientific article

Rap1-GTP is a negative regulator of Th cell function and promotes the generation of CD4+CD103+ regulatory T cells in vivo

scientific article published on 01 September 2005

Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses ⬇️

scientific article published on October 1, 2003

Regulation of T-cell chemotaxis by programmed death-ligand 1 (PD-L1) in dry eye-associated corneal inflammation

scientific article published on 17 December 2009

Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade

scientific article

Replenish the source within: Rescuing tumor-infiltrating lymphocytes by double checkpoint blockade.

scientific article published on 2 August 2013

Repulsive Guidance Molecule b (RGMb) Is Dispensable for Normal Gonadal Function in Mice.

scientific article published on 24 February 2016

Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent.

scientific article

Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade

scientific article

Responsiveness of HIV-specific CD4 T cells to PD-1 blockade

scientific article

Restoring function in exhausted CD8 T cells during chronic viral infection

scientific article

Results of a Multicenter Phase II Study of Atezolizumab and Bevacizumab for Patients With Metastatic Renal Cell Carcinoma With Variant Histology and/or Sarcomatoid Features

scientific article published on 13 November 2019

Retinoblastoma protein expression and its predictors in triple-negative breast cancer

scientific article published on 05 June 2020

Role of B7-1 in mediating an immune response to myeloid leukemia cells

scientific article

Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice

scientific article published on 24 September 2007

Role of PD-1 during effector CD8 T cell differentiation.

scientific article published on 13 April 2018

Role of PD-1 in regulating acute infections.

scientific article

Role of the CD40 and CD95 (APO-1/Fas) antigens in the apoptosis of human B-cell malignancies

scientific article published on 01 May 1997

Role of the immune modulator programmed cell death-1 during development and apoptosis of mouse retinal ganglion cells

scientific article published on 6 May 2009

STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment.

scientific article published on February 2016

Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade

scholarly article

Selective induction of B7/BB-1 on interferon-γ stimulated monocytes: A potential mechanism for amplification of T cell activation through the CD28 pathway ⬇️

scientific article published on October 15, 1991

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

scientific article published on 20 August 2018

Simian immunodeficiency virus (SIV)-specific CD8+ T-cell responses in vervet African green monkeys chronically infected with SIVagm.

scientific article published on October 2008

Soluble PD-L1 as a Biomarker in Malignant Melanoma Treated with Checkpoint Blockade.

scientific article published on 18 May 2017

Spatial Signatures Identify Immune Escape via PD-1 as a Defining Feature of T-cell/Histiocyte-rich Large B-cell Lymphoma

scientific article published on 01 September 2020

Strength of PD-1 signaling differentially affects T-cell effector functions.

scientific article published on 22 April 2013

Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7

scientific article

Structures of PD-1 with its ligands: sideways and dancing cheek to cheek

scholarly article

Structures of T Cell Immunoglobulin Mucin Protein 4 Show a Metal-Ion-Dependent Ligand Binding Site where Phosphatidylserine Binds

scientific article

Studies of in vitro activated CD5+ B cells

scientific article

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

scientific article (publication date: February 2009)

Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer.

scientific article published on 16 June 2016

T Cell/Transmembrane, Ig, and Mucin-3 Allelic Variants Differentially Recognize Phosphatidylserine and Mediate Phagocytosis of Apoptotic Cells

scientific article

T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity

scientific article published on 23 November 2017

T-cell immunoglobulin and mucin domain 1 deficiency eliminates airway hyperreactivity triggered by the recognition of airway cell death ⬇️

scientific article published on May 11, 2013

T.14.5. TIM-4 Negatively Regulates Immune Responses by Reducing Antigen Specific T Cell Numbers

article

TIM gene family and their role in atopic diseases

scientific article published on January 2008

TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity

scientific article published on May 2010

TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.

scientific article

TIM-1 induces T cell activation and inhibits the development of peripheral tolerance

scientific article (publication date: May 2005)

TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells.

scientific article

TIM-4, expressed by medullary macrophages, regulates respiratory tolerance by mediating phagocytosis of antigen-specific T cells

scientific article

TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine

scientific article published in March 2013

TIME (Tumor Immunity in the MicroEnvironment) classification based on tumor CD274 (PD-L1) expression status and tumor-infiltrating lymphocytes in colorectal carcinomas

scientific article published on 19 March 2018

TISMO: syngeneic mouse tumor database to model tumor immunity and immunotherapy response

scientific article published on 01 January 2022

TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy.

scientific article published on 19 April 2018

Targetable genetic features of primary testicular and primary central nervous system lymphomas

scientific article published on 23 December 2015

Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.

scholarly article

Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM).

scientific article published on 23 December 2004

Telomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors

scientific article published on 26 August 2008

Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

scientific article

The B7 family revisited

scientific article (publication date: 2005)

The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen.

scientific article published on September 1994

The B7-CD28 superfamily

scientific article

The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity

scientific article (publication date: 13 June 2003)

The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a third CD28/CTLA-4 counterreceptor ⬇️

scientific article published on September 15, 1998

The CD160, BTLA, LIGHT/HVEM pathway: a bidirectional switch regulating T-cell activation

scientific article published on May 2009

The ICOS-ligand B7-H2, expressed on human type II alveolar epithelial cells, plays a role in the pulmonary host defense system

scientific article published on April 2006

The IgV domain of human B7-2 (CD86) is sufficient to co-stimulate T lymphocytes and induce cytokine secretion

The Leukocyte Semaphorin CD100 Is Expressed in Most T-Cell, but Few B-Cell, Non-Hodgkin's Lymphomas ⬇️

scientific article published on July 1, 1998

The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma

scientific article

The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection

scientific article published on 01 June 2020

The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum

scholarly article

The Programmed Death-1 Ligand 1:B7-1 Pathway Restrains Diabetogenic Effector T Cells In Vivo ⬇️

scientific article published on June 22, 2011

The TIM gene family: emerging roles in immunity and disease

scientific article

The critical role of CD28 signalling in the prevention of human T-cell anergy

scientific article published on March 1995

The function of donor versus recipient programmed death-ligand 1 in corneal allograft survival

scientific article published on 01 September 2007

The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

scientific article published on March 2007

The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21 ⬇️

scientific article published on January 15, 1992

The great debate at "Immunotherapy Bridge 2018", Naples, November 29th, 2018

scientific article published on 15 August 2019

The human semaphorin-like leukocyte cell surface molecule CD100 associates with a serine kinase activity.

scientific article published on September 1997

The importance of exosomal PDL1 in tumour immune evasion

scientific article published on 21 January 2020

The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapy

scientific article

The murine Cd48 gene: allelic polymorphism in the IgV-like region

scientific article published on 01 December 1998

The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo

scientific article

The phosphatidylserine receptors, T cell immunoglobulin mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histiocytic and dendritic cell neoplasms

scientific article published on 24 July 2010

The role of B7-1/B7-2:CD28/CLTA-4 pathways in the prevention of anergy, induction of productive immunity and down-regulation of the immune response

scientific article

The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1.

scientific article published on 9 February 2011

The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity.

scientific article published on July 2003

Therapeutic PD-1 Pathway Blockade Augments with Other Modalities of Immunotherapy T-Cell Function to Prevent Immune Decline in Ovarian Cancer ⬇️

scientific article published on August 23, 2013

Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade

scientific article published on 15 February 2021

Tight Regulation of Memory CD8+ T Cells Limits Their Effectiveness during Sustained High Viral Load ⬇️

scientific article published on August 26, 2011

Tissue expression of PD-L1 mediates peripheral T cell tolerance.

scientific article

Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustion

scientific article

Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells ⬇️

scientific article (publication date: December 2001)

Topological analysis reveals a PD-L1-associated microenvironmental niche for Reed-Sternberg cells in Hodgkin lymphoma.

scientific article published on 11 September 2017

Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF

scientific article published on 3 October 2010

Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice

scientific article published on 23 June 2008

Tumor PDCD1LG2 (PD-L2) Expression and the Lymphocytic Reaction to Colorectal Cancer.

scientific article published on 16 October 2017

Tumour CD274 (PD-L1) expression and T cells in colorectal cancer.

scientific article published on 5 May 2016

Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes

scientific article

Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation

scientific article

Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T-cell costimulator-inducible T-cell costimulator ligand interaction

scientific article

ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer

scientific article published on 17 May 2021

USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy

scientific article published on 31 March 2022

Uncovering of Functional Alternative CTLA-4 Counter-Receptor in B7-Deficient Mice ⬇️

scientific article published on November 5, 1993

Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction

scientific article

Upregulation of interleukin 7 receptor alpha and programmed death 1 marks an epitope-specific CD8+ T-cell response that disappears following primary Epstein-Barr virus infection

scientific article published on 15 July 2009

Variable Patterns of Programmed Death-1 Expression on Fully Functional Memory T Cells after Spontaneous Resolution of Hepatitis C Virus Infection

scientific article

Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection

scholarly article

Weak peptide agonists reveal functional differences in B7-1 and B7-2 costimulation of human T cell clones ⬇️

scientific article published on August 15, 1997

[Failing B7 costimulation engenders a peripheral clonal T-cell anergy in a human antigen-specific model]

scientific article published on 01 November 1993

irRECIST for the Evaluation of Candidate Biomarkers of Response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma: Analysis of a Phase II Prospective Clinical Trial

scientific article published on 22 January 2019

mAb 104, a new monoclonal antibody, recognizes the B7 antigen that is expressed on activated B cells and HTLV-1-transformed T cells

scientific article published on April 1990

p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes

scientific article published on 01 March 2000

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