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List of works by Rudi Westendorp

A Prospective Study of Pravastatin in the Elderly at Risk (PROSPER): Screening Experience and Baseline Characteristics

scientific article

A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer

scientific article published in March 2003

A functional single nucleotide polymorphism in the thrombin-activatable fibrinolysis inhibitor (TAFI) gene associates with outcome of meningococcal disease

article

A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention

scientific article published on 30 August 2011

A high response is not essential to prevent selection bias: results from the Leiden 85-plus study

scientific article published in November 2002

A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium

scientific article

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function

scientific article

A mixture model with random-effects components for classifying sibling pairs.

scientific article published on 9 September 2011

A prospective analysis of elevated fasting glucose levels and cognitive function in older people: results from PROSPER and the Rotterdam Study ⬇️

scientific article

APOE genotype modulates the effect of serum calcium levels on cognitive function in old age.

scientific article published in March 2009

ASSOCIATION OF BLOOD PRESSURE LOWERING MEDICATION WITH VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY AND COGNITIVE FUNCTION IN OLD AGE

Accelerated progression of white matter hyperintensities and subsequent risk of mortality: a 12-year follow-up study

scientific article published on 9 March 2015

Accuracy of Continuous Glucose Monitoring Measurements in Normo-Glycemic Individuals

scientific article published on 7 October 2015

Accuracy of direct segmental multi-frequency bioimpedance analysis in the assessment of total body and segmental body composition in middle-aged adult population

scientific article published on 8 May 2011

Activation of hemostasis and decline in cognitive function in older people

scientific article published on 23 December 2009

Added value of elder abuse definitions: a review.

scientific article published on 25 April 2012

Adherence to treatment guidelines and survival in patients with early-stage breast cancer by age at diagnosis

scientific article published on 11 April 2012

Adipocytokines and risk of stroke in older people: a nested case-control study

scientific article

Adverse environmental conditions influence age-related innate immune responsiveness

scientific article published on 30 May 2009

Advies Onderzoek medische zorg aan ouderen. In het bijzonder ouderen met multiple en complexe problematiek : Een advies van de Raad voor Gezondheidsonderzoek (RGO)

scientific article published on 01 February 2007

Age- and Functional Status-Dependent Association Between Blood Pressure and Cognition: The Milan Geriatrics 75+ Cohort Study

scientific article published on 17 August 2015

Age-related changes in normal-appearing brain tissue and white matter hyperintensities: more of the same or something else?

scientific article published in April 2005

Age-specific nonpersistence of endocrine therapy in postmenopausal patients diagnosed with hormone receptor-positive breast cancer: a TEAM study analysis

scientific article published on 30 December 2011

Ageing or cancer: a review on the role of caretakers and gatekeepers

scientific article (publication date: October 2007)

Aging as accelerated accumulation of somatic variants: whole-genome sequencing of centenarian and middle-aged monozygotic twin pairs

scientific article

Ambulant 24-h glucose rhythms mark calendar and biological age in apparently healthy individuals

scientific article published on 06 February 2013

An Emerging Epidemic of Noncommunicable Diseases in Developing Populations Due to a Triple Evolutionary Mismatch

scientific article published on 15 February 2016

An Internet-Based Physical Activity Intervention to Improve Quality of Life of Inactive Older Adults: A Randomized Controlled Trial.

scientific article published on 27 April 2016

An Unopposed Proinflammatory Response Is Beneficial for Survival in the Oldest Old. Results of the Leiden 85-Plus Study

article

An in vivo study on brain microstructure in biological and chronological ageing

scientific article

An individual participant data analysis of prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms

scientific article published on 05 November 2020

Ancestral stories of Ghanaian Bimoba reflect millennia-old genetic lineages

scientific article (publication date: 2013)

Angiotensin I-converting enzyme and plasminogen activator inhibitor-1 gene variants: risk of mortality and fatal cardiovascular disease in an elderly population-based cohort

scientific article published on 01 October 1999

Anti-inflammatory cytokine profile and mortality in febrile patients ⬇️

scientific article published on March 28, 1998

ApoE plasma levels and risk of cardiovascular mortality in old age

scientific article published on 9 May 2006

Apolipoprotein e genotype, plasma cholesterol, and cancer: a Mendelian randomization study

scientific article published on 4 November 2009

Are differences in interleukin 10 production associated with joint damage?

scientific article published on 01 November 2000

Are elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly

scientific article published on 22 November 2008

Are markers of inflammation more strongly associated with risk for fatal than for nonfatal vascular events?

scientific article published on 23 June 2009

Are skin senescence and immunosenescence linked within individuals?

scientific article published on 06 May 2019

Are we becoming less disposable?

scientific article

Arts and ageing; life expectancy of historical artists in the Low Countries.

scientific article

Assessment of appropriateness of screening community-dwelling older people to prevent functional decline

scientific article

Assessment of health status by molecular measures in adults ranging from middle-aged to old: Ready for clinical use?

scientific article published on April 2016

Assistive devices and community-based services among 85-year-old community-dwelling elderly in The Netherlands: ownership, use, and need for intervention

scientific article published in June 2006

Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism

scientific article published on 30 October 2019

Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study

scientific article

Association between age at diagnosis and disease-specific mortality among postmenopausal women with hormone receptor-positive breast cancer

scientific article published on 01 February 2012

Association between apolipoprotein E4 and cognitive decline in elderly adults

scientific article published in November 2007

Association between chronic diseases and disability in elderly subjects with low and high income: the Leiden 85-plus Study

scientific article published on 13 July 2005

Association between high-density lipoprotein and cognitive impairment in the oldest old.

scientific article

Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age.

scientific article published in January 2002

Association of Thyroid Hormone Therapy With Quality of Life and Thyroid-Related Symptoms in Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-analysis

scientific article published in The Journal of the American Medical Association

Association of diastolic blood pressure with cardiovascular events in older people varies upon cardiovascular history

scientific article published on 20 November 2017

Association of the tumour necrosis factor alpha -308G/A polymorphism with the risk of diabetes in an elderly population-based cohort

scientific article published on 01 June 2002

Association of visit-to-visit variability in blood pressure with cognitive function in old age: prospective cohort study

scientific article published on 29 July 2013

Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age.

scientific article published on 28 May 2015

Associations between total cerebral blood flow and age related changes of the brain

scientific article

Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults

scientific article published on 10 September 2020

Associations of Various Health-Ratings with Geriatric Giants, Mortality and Life Satisfaction in Older People.

scientific article

Asthma deaths in New Zealand: whodunnit?

scientific article published on 01 January 1995

Atherosclerosis and cognitive impairment are linked in the elderly. The Leiden 85-plus Study

scientific article published in December 2002

Atrial natriuretic peptide improves pulmonary gas exchange in subjects exposed to hypoxia

scientific article published on 01 August 1993

Atrial natriuretic peptide is a regulator of pulmonary vascular tone. A hypothesis

scientific article published on 01 December 1990

Basal cerebral blood flow is dependent on the nitric oxide pathway in elderly but not in young healthy men.

scientific article

Bedside manners: How to deal with delirium

scientific article published in September 2017

Being Active, Engaged, and Healthy: Older Persons' Plans and Wishes to Age Successfully

scientific article published on 3 September 2016

Benzodiazepine use and risk of mortality in individuals aged 85 years or older

scientific article

Beta-galactosidase activity as a biomarker of replicative senescence during the course of human fibroblast cultures.

scientific article

Better health, longer lives

scientific article

Biological correlates of blood pressure variability in elderly at high risk of cardiovascular disease

scientific article published on 8 October 2014

Blood Pressure Lowering Medication, Visit-to-Visit Blood Pressure Variability, and Cognitive Function in Old Age.

scientific article published on 8 July 2015

Blood pressure and 10-year mortality risk in the Milan Geriatrics 75+ Cohort Study: role of functional and cognitive status

scientific article published on November 2015

Blood pressure control and cognitive impairment--why low is not always better

scientific article published on 01 April 2015

Blood pressure trends and mortality: the Leiden 85-plus Study.

scientific article published in January 2013

Blood pressure variability and cardiovascular risk in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER).

scientific article

Brain tissue volumes in familial longevity: the Leiden Longevity Study

scientific article published on 4 September 2012

Breast cancer in elderly compared to younger patients in the Netherlands: stage at diagnosis, treatment and survival in 127,805 unselected patients.

scientific article

Breast-conserving surgery with or without radiotherapy in older breast patients with early stage breast cancer: a systematic review and meta-analysis

scientific article

C-Reactive Protein and Prediction of Coronary Heart Disease and Global Vascular Events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)

scientific article published on 05 February 2007

C-Reactive Protein, Fibrinogen, and Cardiovascular Disease Prediction ⬇️

scientific article published on October 4, 2012

C-reactive protein and genetic variants and cognitive decline in old age: the PROSPER study

scientific article (publication date: 2011)

C-reactive protein and glucose regulation in familial longevity

scientific article published on 19 January 2011

C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects

scientific article published on 7 October 2011

C-reactive protein is a strong but nonspecific risk factor of fatal stroke in elderly persons

scientific article published on 01 April 2000

C. elegans DAF-12, Nuclear Hormone Receptors and human longevity and disease at old age.

scientific article

CCR4+ Regulatory T Cells Accumulate in the Very Elderly and Correlate With Superior 8-Year Survival

scientific article published on 7 April 2015

Calculating the Rate of Senescence From Mortality Data: An Analysis of Data From the ERA-EDTA Registry.

scientific article published on 16 April 2015

Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies

scientific article

Cardiac-endothelium feedback

scientific article published on 01 October 1993

Cardioprotective effect of hormone replacement therapy: Authors' reply

scientific article

Cardiopulmonary resuscitation preferences in Dutch community-dwelling and hospitalized elderly people: an interaction between gender and quality of life.

scientific article published in October 2000

Carotid and basilar artery wall shear stress in Alzheimer's disease and mild cognitive impairment

scientific article published on 16 September 2009

Cellular senescence and chronological age in various human tissues: A systematic review and meta-analysis

scientific article published on 05 December 2019

Cerebral atrophy in elderly with subjective memory complaints

scientific article published on 13 December 2012

Cerebral hemodynamics and white matter hyperintensities in CADASIL.

scientific article published in May 2003

Cerebral microbleeds and cognitive functioning in the PROSPER study ⬇️

scientific article published on September 28, 2011

Cerebral microbleeds are predictive of mortality in the elderly

scientific article published on 13 January 2011

Cerebrovascular hemodynamics in Alzheimer's disease and vascular dementia: A meta-analysis of transcranial Doppler studies ⬇️

scientific article published on December 27, 2011

Changes in health care expenditure after the loss of a spouse: data on 6,487 older widows and widowers in the Netherlands

scientific article

Characterization of the Hypothalamic-Pituitary-Adrenal-Axis in Familial Longevity under Resting Conditions

scientific article published on 20 July 2015

Cholesterol and all-cause mortality in Honolulu

Cholesterol and risk of stroke: cholesterol, stroke, and age.

scientific article published on July 2006

Cholinesterase inhibitor treatment in patients with delirium

Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies

scientific article

Chronic inhibition of the respiratory chain in human fibroblast cultures: differential responses related to subject chronological and biological age.

scientific article published on 10 November 2011

Chronic stimulation of atrial natriuretic peptide attenuates the secretory response to postural changes

scientific article published on 01 December 1993

Chronology of age-related disease definitions: Osteoporosis and sarcopenia ⬇️

scientific article published on January 25, 2012

Circulating Interleukin-10 and Risk of Cardiovascular Events

scholarly article by Paul Welsh et al published October 2011 in Arteriosclerosis, Thrombosis, and Vascular Biology

Circulating Thyroid Hormone Profile in Response to a Triiodothyronine Challenge in Familial Longevity

scientific article published on 20 August 2020

Circulating interleukin-6 concentration and cognitive decline in old age: the PROSPER study

scientific article published on 11 March 2013

Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women

scholarly article by Diana G Taekema et al published February 2011 in European Journal of Endocrinology

Clinical relevance of a raised plasma N-terminal pro-brain natriuretic peptide level in a population-based cohort of nonagenarians.

scientific article published in May 2009

Clustering of child mortality in a contemporary polygamous population in Africa

scientific article published in January 2012

Cognitive decline in AD and mild cognitive impairment is associated with global brain damage

scientific article published in September 2002

Cognitive decline precedes late-life longitudinal changes in vascular risk factors

scientific article published on 11 June 2010

Cognitive function in the oldest old: women perform better than men

scientific article

Colony formation and colony size do not reflect the onset of replicative senescence in human fibroblasts

scientific article published in July 2008

Common CFTR gene variants influence body composition and survival in rural Ghana.

scientific article

Common chronic diseases and general impairments as determinants of walking disability in the oldest-old population

scientific article published on 01 August 2002

Common gene variants, mortality and extreme longevity in humans.

scientific article

Common paraoxonase gene variants, mortality risk and fatal cardiovascular events in elderly subjects

scientific article published on 01 March 2000

Complement Factor H polymorphism Y402H associates with inflammation, visual acuity, and cardiovascular mortality in the elderly population at large

scientific article

Complement factor H Y402H decreases cardiovascular disease risk in patients with familial hypercholesterolaemia

scientific article published on 19 December 2008

Contrasting associations of insulin resistance with diabetes, cardiovascular disease and all-cause mortality in the elderly: PROSPER long-term follow-up

scientific article published on 30 September 2014

Corporate culture: research can benefit.

scientific article

Correction: Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R.

scientific article published on 10 May 2012

Cortisol serum levels in familial longevity and perceived age: the Leiden longevity study.

scientific article

Cytomegalovirus infection and responsiveness to influenza vaccination in elderly residents of long-term care facilities.

scientific article published on 15 April 2011

Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study

scientific article

DNA damage markers in dermal fibroblasts in vitro reflect chronological donor age.

scientific article published on 30 January 2016

Daily functioning and health care utilization among persons 85 years old and older

scientific article published on November 8, 1997

Decline in total cerebral blood flow is linked with increase in periventricular but not deep white matter hyperintensities

scientific article

Decreased levels of bisecting GlcNAc glycoforms of IgG are associated with human longevity

scientific article

Defining sarcopenia: the impact of different diagnostic criteria on the prevalence of sarcopenia in a large middle aged cohort ⬇️

scientific article published on June 1, 2013

Delirium in elderly people

scientific article

Dementia at old age: a clinical end-point of atherosclerotic disease.

scientific article published in November 2001

Determinants of absence of osteoarthritis in old age ⬇️

scientific article published on 05 October 2010

Determinants of epidemiologic transition in rural Africa: the role of socioeconomic status and drinking water source

scientific article published on 8 May 2014

Determination of tumour necrosis factor-alpha and interleukin-10 production in a whole blood stimulation system: assessment of laboratory error and individual variation

scientific article published on 01 September 1998

Diagnostic accuracy of plasma NT-proBNP levels for excluding cardiac abnormalities in the very elderly

scientific article

Diagnostic criteria for sarcopenia relate differently to insulin resistance ⬇️

scientific article published on February 14, 2013

Diagnostic measures for sarcopenia and bone mineral density

scientific article published on 07 May 2013

Different progression rates for deep white matter hyperintensities in elderly men and women

scientific article published on 01 November 2004

Disability in the oldest old: "can do" or "do do"?

scientific article published on July 2001

Discrimination ability of comorbidity, frailty, and subjective health to predict mortality in community-dwelling older people: Population based prospective cohort study

scientific article published on 02 June 2017

Disentangling rectangularization and life span extension with the moving rectangle method

scientific article published on 12 January 2016

Disentangling the effects of circulating IGF-1, glucose, and cortisol on features of perceived age

scientific article

Dispensing epilepsy medication: A method of determining the frequency of symptomatic individuals with seizures ⬇️

scientific article published on September 1, 1997

Do psychosocial factors modify the negative association between disability and life satisfaction in old age?

scientific article published on 31 October 2019

Do senescence markers correlate in vitro and in situ within individual human donors?

scientific article published in February 2018

Do we know the effects of colorectal cancer screening? A short communication on selective uptake and differential effects of colorectal cancer screening in Scandinavia

scientific article published on 04 October 2020

Does depression in old age increase only cardiovascular mortality? The Leiden 85-plus Study

scientific article published in September 2004

Does depression specifically increase cardiovascular mortality?

scientific article published on 01 January 2005

Does low to moderate alcohol intake protect against cognitive decline in older people?

scientific article

Dose-response effects of a Web-based physical activity program on body composition and metabolic health in inactive older adults: additional analyses of a randomized controlled trial.

scientific article

Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium

scientific article

Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval

scientific article published on 05 March 2013

Dynamics of traditional metabolic risk factors associate with specific causes of death in old age.

scientific article published on 12 February 2010

EEG markers of future cognitive performance in the elderly.

scientific article

Early and extraordinary peaks in physical performance come with a longevity cost.

scientific article published on 19 August 2016

Early-life environment influencing susceptibility to cytomegalovirus infection: evidence from the Leiden Longevity Study and the Longitudinal Study of Aging Danish Twins

scientific article published on 25 July 2011

Effect of APOE ε4 allele on survival and fertility in an adverse environment

scientific article

Effect of Discontinuation of Antihypertensive Treatment in Elderly People on Cognitive Functioning--the DANTE Study Leiden: A Randomized Clinical Trial

scientific article published on 24 August 2015

Effect of Thyroid Hormone Therapy on Fatigability in Older Adults With Subclinical Hypothyroidism: A Nested Study Within a Randomized Placebo-Controlled Trial

scientific article published on 06 June 2020

Effect of anemia and comorbidity on functional status and mortality in old age: results from the Leiden 85-plus Study.

scientific article published on 27 July 2009

Effect of erythropoietin levels on mortality in old age: the Leiden 85-plus Study

scientific article

Effect of hyperinsulinemia on plasma leptin concentrations and food intake in rats

scientific article

Effect of insulin resistance, apoE2 allele, and smoking on combined hyperlipidemia

scientific article published in October 1994

Effect of intranasally administered insulin on cerebral blood flow and perfusion; a randomized experiment in young and older adults

scientific article

Effect of pravastatin on cerebral infarcts and white matter lesions

scientific article published in May 2005

Effects of a web-based intervention on physical activity and metabolism in older adults: randomized controlled trial.

scientific article

Effects of intranasal insulin application on the hypothalamic BOLD response to glucose ingestion

scientific article published on 17 October 2017

Elder abuse an international perspective: exploring the context of elder abuse

scientific article published on 14 June 2013

Elderly postmenopausal patients with breast cancer are at increased risk for distant recurrence: a tamoxifen exemestane adjuvant multinational study analysis

scientific article published on 20 December 2012

Electromyographic Activity in the EEG in Alzheimer′s Disease: Noise or Signal? ⬇️

scientific article published on March 29, 2011

Endothelium-dependent NO-mediated vasodilation in humans is attenuated by peripheral alpa1-adrenoceptor activation

scientific article published on January 2005

Endotoxin-lipoprotein hypothesis

scientific article published on 01 December 2000

Evidence for additional genetic risk indicators of relapse-onset MS within the HLA region

scientific article published on 01 August 2002

Evidence for non-random distribution of Fcgamma receptor genotype combinations

scientific article published on 26 June 2003

Evidence for the association of the S100beta gene with low cognitive performance and dementia in the elderly

scientific article published on 6 March 2007

Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity

scientific article published on 12 January 2012

Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study

scientific article published in January 2006

Executive function, but not memory, associates with incident coronary heart disease and stroke

scientific article published on 5 August 2015

External validity of a trial comprised of elderly patients with hormone receptor-positive breast cancer

scientific article

Facial appearance reflects human familial longevity and cardiovascular disease risk in healthy individuals.

scientific article published on 9 August 2012

Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality

scientific article

Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship.

scientific article published on 31 July 2015

Familial Longevity Is Not Associated with Major Differences in the Hypothalamic-Pituitary-Gonadal Axis in Healthy Middle-Aged Men.

scientific article

Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone

scientific article published on 18 April 2020

Familial longevity is associated with decreased thyroid function

scientific article published on 25 August 2010

Familial longevity is marked by better cognitive performance at middle age: the Leiden Longevity Study

scientific article

Familial longevity is marked by enhanced insulin sensitivity

scientific article

Familial longevity is marked by lower diurnal salivary cortisol levels: the Leiden Longevity Study.

scientific article

Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study

scientific article published in March 2010

Frailty Index Status of Canadian Home Care Clients Improves With Exercise Therapy and Declines in the Presence of Polypharmacy

scientific article published on 10 March 2020

Framing abuse: explaining the incidence, perpetuation, and intervention in elder abuse ⬇️

scientific article published on January 7, 2013

Framingham stroke risk score and cognitive impairment for predicting first-time stroke in the oldest old.

scientific article published on 16 May 2013

Frequency of functional interleukin-10 promoter polymorphism is different between relapse-onset and primary progressive multiple sclerosis

scientific article published on 01 April 2002

Gender-specific association of the factor V Leiden mutation with fertility and fecundity in a historic cohort. The Leiden 85-Plus Study

scientific article published on 26 January 2006

Gene dose of apolipoprotein E and age-related hearing loss

scientific article published on 28 April 2012

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways

scientific article

Generalized atherosclerosis, cognitive decline, and depressive symptoms in old age.

scientific article published in July 2005

Genes encoding longevity: from model organisms to humans

scientific article published on 15 January 2008

Genetic Variation in the Interleukin-10 Gene Promoter and Risk of Coronary and Cerebrovascular Events: The PROSPER Study

article

Genetic drift as an explanation for the reduced incidence of rheumatoid arthritis

scientific article published on 01 November 2002

Genetic influence on cytokine production and fatal meningococcal disease

scientific article published on 01 January 1997

Genetic influence on cytokine production in meningococcal disease

scientific article published on 01 June 1997

Genetic predictors of fibrin D-dimer levels in healthy adults

scientific article

Genetic variants determining survival and fertility in an adverse African environment: a population-based large-scale candidate gene association study.

scientific article published on 27 June 2016

Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study

scientific article published on 05 May 2006

Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER.

scientific article

Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly

scientific article

Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population

scientific article

Genetic variation at the SLCO1B1 gene locus and low density lipoprotein cholesterol lowering response to pravastatin in the elderly

scientific article published on 21 September 2011

Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies

article

Genetic variation in galectin-3 gene associates with cognitive function at old age.

scientific article

Genetic variation in pentraxin (PTX) 3 gene associates with PTX3 production and fertility in women.

scientific article published on 21 October 2009

Genetic variation in the interleukin-1 beta-converting enzyme associates with cognitive function. The PROSPER study

scientific article

Genetics of human aging. The search for genes contributing to human longevity and diseases of the old.

scientific article

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

scientific article

Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity

scientific article

Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.

scientific article

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

scientific article

Genome-wide association study of smoking initiation and current smoking

scientific article published on 05 March 2009

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

scientific article published on 06 February 2013

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

scientific article

Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy

scientific article (publication date: 2012)

Genomic studies in ageing research: the need to integrate genetic and gene expression approaches

article

Genomics of human longevity.

scientific article

Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity

scientific article published on 7 September 2016

HMG-CoA reductase inhibitors in the prevention of stroke

scientific article

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

scientific article published on 24 September 2014

Haemoglobin predicts length of hospital stay after hip fracture surgery in older patients.

scientific article published on 21 April 2012

Hallmark features of immunosenescence are absent in familial longevity

scientific article published on 20 September 2010

Handgrip strength and mortality in the oldest old population: the Leiden 85-plus study

scientific article

Handgrip strength as a predictor of functional, psychological and social health. A prospective population-based study among the oldest old.

scientific article

Handgrip strength at midlife and familial longevity : The Leiden Longevity Study

scientific article

Handgrip strength, ageing and mortality in rural Africa.

scientific article published on 20 October 2014

Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age

article

Health care expenditure in the last five years of life is driven by morbidity, not age: A national study of spending trajectories in Danish decedents over age 65

scientific article published on 18 December 2020

Heart rate variability, but not heart rate, is associated with handgrip strength and mortality in older Africans at very low cardiovascular risk: A population-based study.

scientific article published on 28 March 2015

Hematopoietic capacity and exceptional survival: the Leiden Longevity Study

scientific article published on 01 November 2008

Heritability estimates of innate immunity: an extended twin study

scientific article published on 01 March 2005

High Innate Production Capacity of Proinflammatory Cytokines Increases Risk for Death from Cancer: Results of the PROSPER Study

scientific article published on 01 December 2009

High blood pressure and resilience to physical and cognitive decline in the oldest old: the Leiden 85-plus Study

scientific article published on 5 November 2012

High blood pressure, physical and cognitive function, and risk of stroke in the oldest old: the Leiden 85-plus Study

scientific article published on 6 November 2012

High innate production capacity of tumor necrosis factor-alpha and decline of handgrip strength in old age

scientific article published on 07 July 2007

High serum glucose levels are associated with a higher perceived age.

scientific article published on 20 November 2011

High-density vs low-density lipoprotein cholesterol as the risk factor for coronary artery disease and stroke in old age.

scientific article

High-sensitivity cardiac troponin T is associated with cognitive decline in older adults at high cardiovascular risk

scientific article published on 16 February 2016

Higher Blood Pressure Is Associated With Higher Handgrip Strength in the Oldest Old ⬇️

scientific article published on September 2, 2010

Homocysteine and familial longevity: the Leiden Longevity Study

scientific article

Homocysteine levels and treatment effect in the PROspective Study of Pravastatin in the Elderly at Risk

scientific article

Homocysteine, B vitamins, and cardiovascular disease

scientific article published on 01 July 2006

Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: the Leiden 85-Plus study

scientific article published in October 2005

Hormone replacement therapy: Authors' reply

scientific article published in July 1994

How is Change in Physical Health Status Reflected by Reports of Nurses and Older People Themselves?

scientific article published on 8 June 2016

Human cytokine response to ex vivo amyloid-beta stimulation is mediated by genetic factors.

scientific article

Human in vivo longevity is reflected in vitro by differential metabolism as measured by 1H-NMR profiling of cell culture supernatants

article

Human insulin/IGF-1 and familial longevity at middle age.

scientific article

Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies

scientific article

Human longevity at the cost of reproductive success

scientific article published in Nature

Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism

scientific article published on 19 June 2015

Hyperlipoproteinemia affects cytokine production in whole blood samples ex vivo. The influence of lipid-lowering therapy

scientific article published on 01 February 2000

Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction

scientific article published on 17 November 2011

Hypertension in developing countries

Hypotension is more risky than hypertension in very old people

scientific article published on 31 January 2012

Hypoxia-induced arterial endothelin does not influence peripheral vascular tone

scientific article published on 01 January 1995

Idiopathic senile gait disorders are signs of subclinical disease

scientific article published in September 2000

Ill or just old? Towards a conceptual framework of the relation between ageing and disease

scientific article

Impact of Thyroid Hormone Therapy on Atherosclerosis in the Elderly With Subclinical Hypothyroidism: A Randomized Trial

scientific article published on 01 August 2018

Impact of genetic variations in the WRN gene on age related pathologies and mortality

scientific article published on 06 January 2006

Impact of mild cognitive impairment on survival in very elderly people: cohort study ⬇️

scientific article published on October 25, 1997

Impact of physical and mental health on life satisfaction in old age: a population based observational study

scientific article

Impact of valvular heart disease on activities of daily living of nonagenarians: the Leiden 85-plus study a population based study

scientific article

Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study

scientific article published on 01 September 2004

In a population-based prospective study, no association between high blood pressure and mortality after age 85 years

scientific article published on 01 February 2006

In an observational study elderly patients had an increased risk of falling due to home hazards

scientific article published in January 2005

In search for genetic determinants of clinically meaningful differential cardiovascular event reduction by pravastatin in the PHArmacogenetic study of Statins in the Elderly at risk (PHASE)/PROSPER study.

scientific article published on 26 April 2014

Incidence and predictive factors of lower respiratory tract infections among the very elderly in the general population. The Leiden 85-plus Study

scientific article published on 03 April 2008

Increase in periventricular white matter hyperintensities parallels decline in mental processing speed in a non-demented elderly population

scientific article

Increased reproductive success of women after prenatal undernutrition

scientific article published on 25 July 2008

Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans

scientific article published on 3 August 2011

Inflammation and interleukin-1 signaling network contribute to depressive symptoms but not cognitive decline in old age.

scientific article published on 4 February 2007

Inflammation and stroke: the Leiden 85-Plus Study

Inflammation in older subjects with early- and late-onset depression in the NESDO study: a cross-sectional and longitudinal case-only design

scientific article published on 24 August 2018

Inflammation underlying cardiovascular mortality is a late consequence of evolutionary programming

scientific article

Influence of old age on survival after prolonged mechanical ventilation

scientific article published on 01 April 2005

Influence of the TP53 codon 72 polymorphism on the cellular responses to X-irradiation in fibroblasts from nonagenarians

scientific article

Insulin and leptin concentrations in obese humans during long-term weight loss

scientific article published in September 1997

Insulin-like growth factor-1 and risk of late-onset Alzheimer's disease: findings from a family study

scientific article published on 20 September 2013

Insulin/Insulin-like growth factor-1 signaling and cognitive function in humans

scientific article published in September 2008

Interaction of atherosclerosis and inflammation in elderly subjects with poor cognitive function

scientific article published in December 2003

Interaction of indomethacin with cytokine production in whole blood. Potential mechanism for a brain-protective effect

scientific article published in October 2000

Interaction of medial temporal lobe atrophy and white matter hyperintensities in AD.

scientific article published in May 2004

Interleukin-10 promoter polymorphisms in male and female fertility and fecundity

scientific article published on 19 October 2006

International variation in GP treatment strategies for subclinical hypothyroidism in older adults: a case-based survey ⬇️

scientific article

Interrelationships Between Pituitary Hormones as Assessed From 24-hour Serum Concentrations in Healthy Older Subjects

scientific article published on 01 April 2020

Intrinsic and extrinsic mortality reunited.

scientific article published on 24 April 2015

Is depression in old age fatal only when people feel lonely?

scientific article

Is there evidence for a limit to human lifespan?

scientific article

L-Thyroxine Therapy for Older Adults With Subclinical Hypothyroidism and Hypothyroid Symptoms: Secondary Analysis of a Randomized Trial

scientific article published on 05 May 2020

LDL cholesterol still a problem in old age? A Mendelian randomization study

Lack of effect of pravastatin on cerebral blood flow or parenchymal volume loss in elderly at risk for vascular disease

scientific article published in August 2005

Lack of survival gain for elderly women with breast cancer

scientific article published on 15 March 2011

Late-onset dementia: structural brain damage and total cerebral blood flow

scientific article published on 12 July 2005

Leiden research program on ageing

scientific article published on 01 May 2002

Leisure Activities and the Risk of Dementia ⬇️

scientific article published on September 25, 2003

Leptin predicts diabetes but not cardiovascular disease: results from a large prospective study in an elderly population

scientific article

Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study

scientific article

Lifestyle and youthful looks.

scientific article published on 15 April 2015

Lipid metabolism in long-lived families: the Leiden Longevity Study

scientific article

Lipoprotein particle profiles mark familial and sporadic human longevity

scientific article

Liver X receptor alpha associates with human life span

scientific article published on 01 April 2007

Living with epilepsy: long-term prognosis and psychosocial outcomes

scientific article published in July 2003

Long-term effects of statin treatment in elderly people: extended follow-up of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER)

scientific article

Long-term exposure to air pollution and stroke incidence: A Danish Nurse cohort study

scientific article published on 24 June 2020

Long-term exposure to low levels of air pollution and mortality adjusting for road traffic noise: A Danish Nurse Cohort study

scientific article published on 28 July 2020

Low C-reactive protein levels in a traditional West-African population living in a malaria endemic area.

scientific article

Low blood pressure in the very old, a consequence of imminent heart failure: the Leiden 85-plus Study

scientific article published on 24 July 2008

Low blood pressure predicts increased mortality in very old age even without heart failure: the Leiden 85-plus Study.

scientific article published on 17 December 2012

Low computed tomography coronary artery calcium scores in familial longevity: the Leiden Longevity Study

scientific article

Low innate production of interleukin-1beta and interleukin-6 is associated with the absence of osteoarthritis in old age.

scientific article published on 22 April 2010

Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes : the Leiden 85-Plus Study

scientific article published in April 2002

Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study

scientific article published on 16 December 2009

Low-cost interventions accelerate epidemiological transition in Upper East Ghana

scientific article published on 5 November 2008

Lower Susceptibility to Cerebral Small Vessel Disease in Human Familial Longevity

article published in 2013

Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people

scientific article published on 04 June 2012

Lymphocyte count and mortality risk in older persons. The Leiden 85-Plus Study

scientific article published on 01 October 2003

Lymphotoxin-alpha C804A polymorphism is a risk factor for stroke. The PROSPER study

scientific article published on 22 April 2008

MMSE scores correlate with local ventricular enlargement in the spectrum from cognitively normal to Alzheimer disease

scientific article published on 17 November 2007

MRI measures and progression of cognitive decline in nondemented elderly attending a memory clinic

scientific article published in November 2005

Magnetization transfer imaging in normal aging, mild cognitive impairment, and Alzheimer's disease

scientific article published in July 2002

Management of primary metastatic breast cancer in elderly patients--an international comparison of oncogeriatric versus standard care

scientific article

Markers of autonomic tone on a standard ECG are predictive of mortality in old age

scientific article published on 01 February 2006

Markers of endothelial dysfunction and cerebral blood flow in older adults

scientific article

Measuring cognitive function with age: the influence of selection by health and survival

scientific article published in May 2008

Measuring longitudinal white matter changes: comparison of a visual rating scale with a volumetric measurement

scientific article

Memory complaints in patients with normal cognition are associated with smaller hippocampal volumes

scientific article published in June 2004

Men Have a Stronger Monocyte-Derived Cytokine Production Response upon Stimulation with the Gram-Negative Stimulus Lipopolysaccharide than Women: A Pooled Analysis Including 15 Study Populations

scientific article published on 21 June 2019

Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors

scientific article published on 29 November 2006

Meta-analysis of genome-wide association studies of HDL cholesterol response to statins

scientific article

Meta-analysis of nonsteroidal antiinflammatory drug use and risk of dementia

scientific article

Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts.

scientific article published on 18 June 2012

Microstructural brain tissue damage in metabolic syndrome

scientific article published on 2 October 2013

Morphometric skin characteristics dependent on chronological and biological age: the Leiden Longevity Study.

scientific article

Mortality in former Olympic athletes: retrospective cohort analysis ⬇️

scientific article published on December 13, 2012

Mortality risk in men is associated with a common mutation in the methylene-tetrahydrofolate reductase gene (MTHFR)

scientific article published on 01 February 1999

Multiple sclerosis and type 1 diabetes in Sardinia

scientific article published in October 2002

Muscle characteristics in patients with chronic systemic inflammation

scientific article published on August 2012

N-terminal pro-brain natriuretic peptide and cognitive decline in older adults at high cardiovascular risk

scientific article published on 9 July 2014

NT-proBNP, blood pressure, and cognitive decline in the oldest old: The Leiden 85-plus Study

scientific article

Natural history of depression in the oldest old: population-based prospective study

scientific article published in January 2006

Neuropsychological correlates of MRI measures in the continuum of cognitive decline at old age.

scientific article

New horizons: Reablement - supporting older people towards independence

scientific article published on 21 May 2016

Night shift work, long working hours and dementia: a longitudinal study of the Danish Work Environment Cohort Study.

scientific article

Night work and incidence of Parkinson's disease in the Danish Nurse Cohort

scientific article published on 15 December 2020

Nitric oxide mediates hypoxia-induced cerebral vasodilation in humans

scientific article published in March 2002

No Excess Mortality in Patients Aged 50 Years and Older Who Received Treatment for Ductal CarcinomaIn Situof the Breast ⬇️

scientific article published on May 13, 2012

No effect of enalapril on progression in autosomal dominant polycystic kidney disease ⬇️

scientific article published on November 1, 2003

No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects

scientific article

No increase in mortality and morbidity among carriers of the C282Y mutation of the hereditary haemochromatosis gene in the oldest old: the Leiden 85-plus study

scientific article published on 01 October 2002

No increased mortality risk in older persons with unexplained anaemia

scientific article published on 14 March 2012

Non-response to (statin) therapy: the importance of distinguishing non-responders from non-adherers in pharmacogenetic studies

scientific article published on 19 December 2015

Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study.

scientific article published on 17 July 2009

Not all age-related white matter hyperintensities are the same: a magnetization transfer imaging study.

scientific article published in October 2006

Oesophagostomum bifurcum-induced nodular pathology in a highly endemic area of Northern Ghana.

scientific article

Old age mortality and macroeconomic cycles

scientific article published on 07 October 2013

Older persons' definitions and explanations of elder abuse in the Netherlands

scientific article published on 5 January 2016

Onset of Workplace Bullying and Risk of Weight Gain: A Multicohort Longitudinal Study

scientific article published on 14 September 2020

Optimal screening for increased risk for adverse outcomes in hospitalised older adults

scientific article

Optimizing human fertility and survival

scientific article published on 01 August 2001

Outdoor Light at Night and Breast Cancer Incidence in the Danish Nurse Cohort

scientific article published on 17 December 2020

Overcoming Old in Age-Friendliness

scientific article published on January 2015

P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age.

scientific article published on 18 August 2015

PCR-based DNA test to confirm clinical diagnosis of autosomal recessive spinal muscular atrophy

scientific article published in The Lancet

PCSK9 SNP rs11591147 is associated with low cholesterol levels but not with cognitive performance or noncardiovascular clinical events in an elderly population

scientific article published on February 2013

Parallel lines: nothing has changed?

scientific article

Parameters of glucose metabolism and the aging brain: a magnetization transfer imaging study of brain macro- and micro-structure in older adults without diabetes

scientific article published on 17 July 2015

Parasitic infections and immune function: effect of helminth infections in a malaria endemic area.

scientific article published on 20 August 2012

Parental history of Alzheimer disease associated with lower plasma apolipoprotein E levels

scientific article published on September 2009

Parental longevity correlates with offspring's optimism in two cohorts of community-dwelling older subjects

scientific article published on 7 April 2011

Patients with Alzheimer's disease display a pro-inflammatory phenotype

scientific article published on 01 January 2001

Patterns of muscle strength loss with age in the general population and patients with a chronic inflammatory state

scientific article published on 27 May 2010

Perceived stress and dementia: Results from the Copenhagen city heart study

scientific article published on 11 June 2019

Performance of Cockcroft-Gault, MDRD, and CKD-EPI in estimating prevalence of renal function and predicting survival in the oldest old

scientific article

Performance of the whole-blood stimulation assay for assessing innate immune activation under field conditions

scientific article

Persistence of high-replicative capacity in cultured fibroblasts from nonagenarians

scientific article published on February 2007

Perspectives on the Etiology of Violence in Later Life

scientific article published on 8 May 2015

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

scientific article

Pharmacogenetics of statins: achievements, whole-genome analyses and future perspectives

scientific article published on May 2012

Physiological responding to stress in middle-aged males enriched for longevity: a social stress study

scientific article published on 9 October 2015

Plasma apolipoprotein CI protects against mortality from infection in old age.

scientific article published in February 2008

Plasma atrial natriuretic peptide concentrations in patients weaning from positive-pressure ventilation

scientific article published on June 1, 1991

Plasma hepcidin levels and anemia in old age. The Leiden 85-Plus Study

scientific article published on 12 October 2012

Plasma levels of apolipoprotein E and cognitive function in old age.

scientific article published in April 2007

Plasma levels of apolipoprotein E and risk of stroke in old age.

scientific article published in April 2007

Plasma lipoproteins and apolipoproteins as predictors of cardiovascular risk and treatment benefit in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER).

scientific article published on 7 November 2005

Plasma protein N-glycan profiles are associated with calendar age, familial longevity and health.

scientific article published on 23 February 2011

Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study

scientific article

Polymorphisms in TLR4 and TLR2 genes, cytokine production and survival in rural Ghana.

scientific article

Polymorphisms in or near tumour necrosis factor (TNF)-gene do not determine levels of endotoxin-induced TNF production

scientific article published on 01 February 2002

Pravastatin and cognitive function in the elderly. Results of the PROSPER study

scientific article published on 4 August 2009

Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial

scientific article (publication date: 23 November 2002)

Predicting kidney graft failure using time-dependent renal function covariates

scientific article

Predictive value of low ferritin in older persons with anemia with and without inflammation: the Leiden 85-plus Study

scientific article published on 01 August 2010

Predictors of weight loss during treatment with d-fenfluramine.

scientific article published in May 1997

Preexisting cardiopulmonary disease attenuating the atrial natriuretic peptide response. Results in patients with acute respiratory failure

scientific article published on 01 December 1992

Presence of human papillomavirus DNA in plucked eyebrow hairs is associated with a history of cutaneous squamous cell carcinoma

scientific article published in December 2003

Preserved white matter integrity is a marker of familial longevity

scientific article published in December 2013

Prevalence of five common clinical abnormalities in very elderly people: population based cross sectional study

scientific article

Pro-inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength

scientific article published on 27 May 2013

Production of IL-1beta and IL-1Ra as risk factors for susceptibility and progression of relapse-onset multiple sclerosis

scientific article published on 01 May 2002

Prognostic index for 4-year mortality in older adults

scientific article published on 01 August 2006

Prognostic value of cardiovascular disease status: the Leiden 85-plus study

scientific article published on 04 July 2012

Progression of brain atrophy and cognitive decline in diabetes mellitus: a 3-year follow-up

scientific article published on September 2010

Prospective Study of the Effect of Blood Pressure on Renal Function in Old Age: The Leiden 85-Plus Study

scientific article published on 16 August 2006

Proton magnetic resonance spectroscopy shows lower intramyocellular lipid accumulation in middle-aged subjects predisposed to familial longevity.

scientific article published on 15 November 2011

Quality and quantity of the humoral immune response in healthy elderly and young subjects after annually repeated influenza vaccination

scientific article published in January 1999

Quality-quantity trade-off of human offspring under adverse environmental conditions

scientific article published on 27 February 2009

Randomised controlled trial of unsolicited occupational therapy in community-dwelling elderly people: the LOTIS trial

scientific article

Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease

scientific article published on 01 December 2005

Rapid flow cytometric method for measuring senescence associated beta-galactosidase activity in human fibroblasts

scientific article published in November 2009

Reduced IFN-gamma production in elderly people following in vitro stimulation with influenza vaccine and endotoxin

scientific article published on 01 December 2000

Reduced glomerular filtration rate and its association with clinical outcome in older patients at risk of vascular events: secondary analysis

scientific article

Reduced insulin/IGF-1 signalling and human longevity.

scientific article

Regenerative potential of human muscle stem cells in chronic inflammation.

scientific article published on 15 December 2011

Regulation of human life histories: the role of the inflammatory host response

scientific article published on April 2007

Relation between body height and replicative capacity of human fibroblasts in nonagenarians

scientific article

Relation between maximum replicative capacity and oxidative stress-induced responses in human skin fibroblasts in vitro.

scientific article

Relation between replicative senescence of human fibroblasts and life history characteristics

scientific article published on 03 February 2009

Release of tumor necrosis factor: an innate host characteristic that may contribute to the outcome of meningococcal disease

scientific article published on 01 April 1995

Relevance of Fcgamma receptor and interleukin-10 polymorphisms for meningococcal disease

scientific article published on 03 December 2001

Renal function in familial longevity: the Leiden Longevity Study.

scientific article published on 2 January 2014

Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses

scientific article

Report from the second cytomegalovirus and immunosenescence workshop

scientific article published on 28 October 2011

Response

scientific article published on 15 September 2014

Responsiveness of the innate immune system and glucose concentrations in the oldest old.

scientific article published on 11 August 2011

Resting heart rate and incident heart failure and cardiovascular mortality in older adults: role of inflammation and endothelial dysfunction: the PROSPER study

scientific article published on 18 December 2012

Resting heart rate, heart rate variability and functional decline in old age.

scientific article

Risk of cardiovascular disease in a traditional African population with a high infectious load: a population-based study

scientific article

Role of statins in prevention of stroke and dementia

scientific article published on October 6, 2001

SIRT1 gene, age-related diseases, and mortality: the Leiden 85-plus study.

scientific article published in September 2007

Sarcopenia: toward its clinical utilisation

scientific article published on January 2015

Scarcity of atrial fibrillation in a traditional African population: a community-based study

scientific article

Searching for longevity hotspots in Denmark

scholarly article by Anne Vinkel Hansen et al published 13 October 2018 in Aging

Seasonal mood variation in the elderly: the Leiden 85-plus study

scientific article published in March 2005

Seasonal variation in child and old-age mortality in rural Ghana.

scientific article published on 28 January 2014

Secreted microvesicular miR-31 inhibits osteogenic differentiation of mesenchymal stem cells.

scientific article published on 04 May 2016

Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population

scientific article

Senescence rates in patients with end-stage renal disease: a critical appraisal of the Gompertz model

scientific article published on 29 December 2010

Sensory impairment and cognitive functioning in oldest-old subjects: the Leiden 85+ Study

scientific article published in September 2005

Seroreactivity to epidermodysplasia verruciformis-related human papillomavirus types is associated with nonmelanoma skin cancer ⬇️

scientific article published on May 15, 2003

Serum calcium and cognitive function in old age.

scientific article published in November 2007

Serum insulin-like growth factor 1 and facial ageing: high levels associate with reduced skin wrinkling in a cross-sectional study

scientific article

Serum triiodothyronine levels and inflammatory cytokine production capacity

scientific article published on 25 February 2011

Serum uric acid and cognitive function and dementia

scientific article published on 26 November 2008

Severe hypertriglyceridemia with insulin resistance is associated with systemic inflammation: reversal with bezafibrate therapy in a randomized controlled trial

scientific article published in March 2002

Shape Abnormalities of the Striatum in Alzheimer's Disease ⬇️

scientific article published on 01 January 2011

Shift work and incidence of dementia: A Danish Nurse Cohort study

scientific article published on 11 July 2020

Shift work, long working hours, and later risk of dementia: A long-term follow-up of the Copenhagen Male Study

scientific article published on 14 July 2017

Shuttling between species for pathways of lifespan regulation: a central role for the vitellogenin gene family?

scientific article

Skeletal Effects of Levothyroxine for Subclinical Hypothyroidism in Older Adults: A TRUST Randomized Trial Nested Study

scientific article published on 01 January 2020

Social Relations at Work and Incident Dementia: 29-Years' Follow-Up of the Copenhagen Male Study

scientific article published on 20 September 2017

Socio-economic status by rapid appraisal is highly correlated with mortality risks in rural Africa

scientific article published on August 2009

Socioeconomic differences in survival among breast cancer patients in the Netherlands not explained by tumor size ⬇️

scientific article published on November 13, 2010

Socioeconomic status determines sex-dependent survival of human offspring.

scientific article published on January 2013

Solar lentigines are strongly related to sun exposure in contrast to ephelides

scientific article published in June 2004

Statins and blood pressure

scientific article published in November 2008

Statins for prevention of stroke

scientific article published on 01 July 1998

Stress-induced responses of human skin fibroblasts in vitro reflect human longevity

scientific article published on 4 August 2009

Stroke, statins, and cholesterol. A meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors

scientific article published in May 1997

Strongly reduced volumes of putamen and thalamus in Alzheimer's disease: an MRI study

scientific article

Study protocol: a randomised controlled trial on the clinical effects of levothyroxine treatment for subclinical hypothyroidism in people aged 80 years and over

scientific article published on 19 September 2018

Study protocol; Thyroid hormone Replacement for Untreated older adults with Subclinical hypothyroidism - a randomised placebo controlled Trial (TRUST).

scientific article

Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individual Participant Data Analysis

scientific article

Subclinical Thyroid Dysfunction and Depressive Symptoms among the Elderly: A Prospective Cohort Study.

scientific article published on 14 July 2015

Subclinical Thyroid Dysfunction and the Risk of Heart Failure in Older Persons at High Cardiovascular Risk

scholarly article by David Nanchen et al published March 2012 in The Journal of Clinical Endocrinology and Metabolism

Subclinical hyperthyroidism and the risk of coronary heart disease and mortality.

scientific article published on May 2012

Subclinical hypothyroidism and cognitive function in people over 60 years: a systematic review and meta-analysis

scientific article

Subclinical hypothyroidism and the risk of coronary heart disease and mortality

scientific article published on September 2010

Subclinical thyroid dysfunction and cognitive decline in old age

scientific article

Subclinical thyroid dysfunction and depressive symptoms: protocol for a systematic review and individual participant data meta-analysis of prospective cohort studies

scientific article published on 26 July 2019

Subclinical thyroid dysfunction and fracture risk: a meta-analysis

scientific article

Subclinical thyroid dysfunction and functional capacity among elderly.

scientific article

Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts

scientific article

Subnormal vitamin B12 concentrations and anaemia in older people: a systematic review

scientific article

Successful ageing: A study of the literature using citation network analysis

scientific article

Successful aging in the oldest old: Who can be characterized as successfully aged?

scientific article published on 01 December 2001

Survival and relapse free period of 2926 unselected older breast cancer patients: a FOCUS cohort study.

scientific article published on 9 December 2014

Survival of patients with epilepsy: an estimate of the mortality risk

scientific article

Systemic markers of inflammation and cognitive decline in old age.

scientific article published in May 2007

TNF-alpha promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients

scientific article published on 01 February 1997

TNF-α antagonist infliximab in the treatment of depression in older adults: results of a prematurely ended, randomized, placebo-controlled trial

scientific article published on 01 June 2010

Telomere length and anaemia in old age: results from the Newcastle 85-plus Study and the Leiden 85-plus Study.

scientific article

Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study.

scientific article

Temporal relation between depression and cognitive impairment in old age: prospective population based study

scientific article published on 02 September 2004

Temporal relationship between handgrip strength and cognitive performance in oldest old people

scientific article published on 27 February 2012

Tetrapolar body impedance is influenced by body posture and plasma sodium concentration

scientific article published on January 1, 1992

The 15-item Geriatric Depression Scale (GDS-15) detects changes in depressive symptoms after a major negative life event. The Leiden 85-plus Study

scientific article published in January 2004

The Alzheimer Myth and Biomarker Research in Dementia ⬇️

scientific article published on January 1, 2012

The Effect of Age on the Association Between Blood Pressure and Cognitive Function Later in Life

The Impact of Levothyroxine on Cardiac Function in Older Adults with Mild Subclinical Hypothyroidism: a Randomized Clinical Trial

scientific article published on 11 March 2020

The Relation Between Thyroid Function and Anemia: A Pooled Analysis of Individual Participant Data

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The Trade-Off between Female Fertility and Longevity during the Epidemiological Transition in the Netherlands

scientific article published on 17 December 2015

The added value of health indicators to mortality predictions in old age: A systematic review

scientific article published on 14 July 2018

The additional value of routine electrocardiograms in cardiovascular risk management of older people

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The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials

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The causal pie model: an epidemiological method applied to evolutionary biology and ecology

scientific article published on 19 April 2014

The controversies of statin therapy: weighing the evidence

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The development, implementation and evaluation of a transitional care programme to improve outcomes of frail older patients after hospitalisation

scientific article published on 13 June 2016

The effect of chronological age on the inflammatory response of human fibroblasts

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The impact of diabetes mellitus on cognitive decline in the oldest of the old: a prospective population-based study

scientific article published on 28 June 2006

The incidence and risk factors for new onset atrial fibrillation in the PROSPER study

scientific article published on 16 February 2011

The influence of age on the association between cholesterol and cognitive function

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The influence of clan structure on the genetic variation in a single Ghanaian village.

scientific article published on 27 February 2013

The influence of genetic variation on innate immune activation in an environment with high infectious pressure

scientific article published on 11 August 2011

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

scientific article published on 14 March 2012

The inverse relationship between alanine aminotransferase in the normal range and adverse cardiovascular and non-cardiovascular outcomes

scientific article published on 17 November 2011

The maintenance gap: a new theoretical perspective on the evolution of aging ⬇️

scientific article published on November 1, 2011

The metabolic syndrome is associated with decelerated cognitive decline in the oldest old.

scientific article published in September 2007

The number of p16INK4a positive cells in human skin reflects biological age.

scientific article published on 11 June 2012

The prevalence of subclinical hypothyroidism at different total plasma cholesterol levels in middle aged men and women: a need for case-finding?

scientific article published on 01 February 1999

The risk of mortality and the factor V Leiden mutation in a population-based cohort.

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The routine electrocardiogram for cardiovascular risk stratification in old age: the Leiden 85-plus study.

scientific article published in June 2007

Thermolabile methylenetetrahydrofolate reductase gene and the risk of cognitive impairment in those over 85

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Thyroid Function Tests in the Reference Range and Fracture: Individual Participant Analysis of Prospective Cohorts.

scientific article published on 5 May 2017

Thyroid Function Within the Normal Range, Subclinical Hypothyroidism, and the Risk of Atrial Fibrillation

scientific article published on 23 October 2017

Thyroid Function Within the Reference Range and the Risk of Stroke: An Individual Participant Data Analysis

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Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism.

scientific article published on 3 April 2017

Thyroid Status and Mortality Risk in Older Adults With Normal Thyrotropin: Sex Differences in the Milan Geriatrics 75+ Cohort Study

scientific article published on 01 April 2017

Thyroid function within the normal range and risk of coronary heart disease: an individual participant data analysis of 14 cohorts

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Thyroid function, activities of daily living and survival in extreme old age: the 'Leiden 85-plus Study'

scientific article published in January 2006

Thyroid hormone signaling and homeostasis during aging

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Thyroid status and mortality in nonagenarians from long-lived families and the general population

scientific article published on 25 October 2017

Thyroid status, disability and cognitive function, and survival in old age.

scientific article published in December 2004

Thyroid stimulating hormone and bone mineral density: Evidence from a two-sample Mendelian randomization study and a candidate gene association study

scientific article published on 15 March 2018

Total cerebral blood flow and mortality in old age: a 12-year follow-up study

scientific article published on 30 October 2013

Total cholesterol and risk of mortality in the oldest old ⬇️

scientific article published on October 18, 1997

Total joint replacement in the past does not relate to a deteriorated functional level and health status in the oldest old.

scientific article published on 8 May 2012

Towards Inclusive Healthcare Delivery: Potentials and Challenges of Human-Centred Design in Health Innovation Processes to Increase Healthy Aging

scientific article published on 24 June 2020

Trade-off mediated effects on the genetics of human survival caused by increasingly benign living conditions

scientific article published on 05 July 2006

Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R

scientific article (publication date: 2012)

Unraveling the Directional Link between Adiposity and Inflammation: A Bidirectional Mendelian Randomization Approach.

scientific article published in December 2009

Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach

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Use of Framingham risk score and new biomarkers to predict cardiovascular mortality in older people: population based observational cohort study.

scientific article published on 08 January 2009

Use of benzodiazepines, depressive symptoms and cognitive function in old age.

scientific article published in May 2009

Use of calcium antagonists and cognitive decline in old age. The Leiden 85-plus study

scientific article published on 13 November 2006

VDR gene variants associate with cognitive function and depressive symptoms in old age.

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Variants of the IL-10 gene associate with muscle strength in elderly from rural Africa: a candidate gene study

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Variation in plasminogen-activator-inhibitor-1 gene and risk of meningococcal septic shock

scientific article published on 01 August 1999

Variation in the CBP gene involved in epigenetic control associates with cognitive function

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Variation in the SHC1 gene and longevity in humans

scientific article (publication date: February 2004)

Variation in the costs of dying and the role of different health services, socio-demographic characteristics, and preceding health care expenses

scientific article published on 11 September 2014

Variation in the human TP53 gene affects old age survival and cancer mortality.

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Vascular disease and apathy in old age. The Leiden 85-Plus Study

scientific article published in March 2008

Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease

scientific article published in November 2009

Visit-to-visit blood pressure variability and future functional decline in old age.

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Vitamin B12 and folate and the risk of anemia in old age: the Leiden 85-Plus Study.

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Voorbij de geraniums: vitaliteit en zelforganisatie van ouderen in de wijk

Walking and Talking as Predictors of Falls in the General Population: The Leiden 85‐Plus Study ⬇️

scientific article published on 01 October 2003

Weighted statistics for aggregation and linkage analysis of human longevity in selected families: the Leiden Longevity Study.

scientific article published in January 2009

What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?

scientific article

What are the effects of maternal and pre-adult environments on ageing in humans, and are there lessons from animal models?

scientific article

What is healthy aging in the 21st century?

scientific article

What to tell steroid-substituted patients about the effects of high altitude?

scientific article published in The Lancet

When Contact Is Not Enough: Affecting First Year Medical Students' Image towards Older Persons

scientific article

When grandmothers matter

scientific article published on 2 November 2009

When longevity meets vitality

scientific article

When subclinical hypothyroidism becomes clinically diagnosed

scientific article

White Matter Lesion Progression: Genome-Wide Search for Genetic Influences

scientific article

White blood cell count and C-reactive protein are independent predictors of mortality in the oldest old.

scientific article published on 27 January 2010

Will lifestyle changes in later life improve survival? ⬇️

scientific article published on October 17, 2012

Worse prognosis for older breast cancer patients

scientific article published on 01 January 2012

[Causes and consequences of cognitive decline in the very elderly; the 'Leiden 85-plus Study']

scientific article published on 01 May 2004

[Early coronary heart disease together with tyoe II diabetes mellitus in persons of Hindustani origin]

scientific article

[Immune activation and depression in the elderly]

scientific article

[Screening tools do not measure up against rigorous history taking]

scientific article published on 14 November 2019

[The immune system and Alzheimer's disease].

scientific article published in January 2011

[The prioritisation of genetic screening with primary haemochromatosis as an example]

scientific article published on 01 July 2003

[The relationship between atherosclerosis, cognitive impairment, and depression in old age]

scientific article published on 01 October 2006

[The use of age as a variable in clinical research]

scientific article published on 01 December 2005

beta-Adrenergic receptors contribute to hypoxaemia induced vasodilation in man.

scientific article published in November 1995

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