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List of works by Ariel Fernández

A lipid-mediated conformational switch modulates the thermosensing activity of DesK.

scientific article published on 12 February 2014

A parallel computation revealing the role of the in vivo environment in shaping the catalytic structure of a mitochondrial RNA transcript

scientific article published on August 21, 1992

A priori inference of cross reactivity for drug-targeted kinases.

scientific article

A unifying motif of intermolecular cooperativity in protein associations

scientific article published on 16 July 2012

Abstract 5468: JNK-1 inhibition leads to antitumor activity in ovarian cancer

Acid-base chemistry of frustrated water at protein interfaces

scientific article published on 22 December 2015

Activation-energy landscape for metastable RNA folding

scientific article published on 01 September 1990

Adherence of packing defects in soluble proteins.

scientific article

All-in-focus image reconstruction under severe defocus

scientific article

An Integrated Flow Analysis System for the Recalculation of Hydraulic Machinery Bladings

Analog image contouring using a twisted-nematic liquid-crystal display ⬇️

scientific article published on August 30, 2010

Artificial Intelligence Steering Molecular Therapy in the Absence of Information on Target Structure and Regulation

scientific article published on 04 December 2019

Ascribing weights to folding histories: explaining the expediency of biopolymer folding

Autocorrelations in the center manifold of dissipative systems

scientific article published on 01 May 1986

Binding of the Highly Toxic Tetracycline Derivative, Anhydrotetracycline, to Bovine Serum Albumin

article

Biomolecular Interfaces

article

Biomolecular Interfaces Provide Universal Markers for Drug Specificity and Personalized Medicine

Bottom-up engineering of peptide cell translocators based on environmentally modulated quadrupole switches

scientific article

Buffering the entropic cost of hydrophobic collapse in protein chains

scientific article published on 01 December 2004

COVID-19 Evolution in the Post-Vaccination Phase: Endemic or Extinct?

scholarly article

Center-manifold extension of the adiabatic-elimination method

scientific article published on 01 November 1985

Center-manifold renormalization in dynamic critical phenomena for dissipative spin systems

scientific article published on 01 June 1987

Challenges of Implementing mHealth Interventions for Lifestyle Modification in Prehypertensive Subjects in Argentina, Guatemala, and Peru

article

ChemInform Abstract: Protein Wrapping: A Molecular Marker for Association, Aggregation and Drub Design

Chemical Functionality of the Aqueous Interface in Soluble Proteins

Color encoding of binary fringes for gamma correction in 3-D profiling ⬇️

scientific article published on April 15, 2012

Communication: Chemical functionality of interfacial water enveloping nanoscale structural defects in proteins

scientific article published on 01 June 2014

Communication: Epistructural thermodynamics of soluble proteins ⬇️

scientific article published on March 7, 2012

Communication: Nanoscale electrostatic theory of epistructural fields at the protein-water interface

scientific article published in December 2012

Computation of the fraction of RNA sequences that fold sequentially into a unique free-energy minimum

scientific article published in October 1992

Constraints on the time-reversible Liouville equation in order to derive a stochastic order-parameter equations at the onset of a convective roll pattern

Controlling Induced Folding Through Wrapping Drug Design

Correlation of pause sites in MDV-1 RNA replication with kinetic refolding of the growing chain. A Monte Carlo simulation of the Markov process

scientific article published on 01 June 1989

Correlation of subsystems for the transition to a convective pattern

Deep Learning to Therapeutically Target Unreported Complexes

scientific article published on 21 May 2019

Dehydration propensity of order-disorder intermediate regions in soluble proteins

scientific article published on 2 August 2007

Dehydron analysis: quantifying the effect of hydrophobic groups on the strength and stability of hydrogen bonds

scientific article published in January 2010

Dehydron: a structurally encoded signal for protein interaction

scientific article

Denaturation of proteins in methanol/water mixtures

scientific article published in March 1985

Describing RNA sequential folding by dynamic coarse graining of the extended conformation space

scientific article published on 01 October 1994

Desolvation shell of hydrogen bonds in folded proteins, protein complexes and folding pathways

scientific article published on 01 September 2002

Determination of an Optimal Assembly Misalignment in Sugar Cane Mills

scholarly article published 2005

Dielectric Modulation of Biological Water

scientific article published in Physical Review Letters

Directed graphs of structurally stable potential energy surfaces representing a-priori reaction pathways

Discretized torsional dynamics and the folding of an RNA chain

scientific article published on August 1999

Dispersion of tertiary structures for an ensemble of primary sequences at an externally induced transition of correlation regimes

scientific article published in December 1988

Distinguishing foldable proteins from nonfolders: when and how do they differ?

scientific article published in October 2002

Dramatic saccharide-mediated protection of chaotropic-induced deactivation of concanavalin A.

scientific article published on April 1997

Drug leads for interactive protein targets with unknown structure

scientific article published on 17 October 2015

Drug-Based Disruption of Protein Complexes with Unknown Structure: Towards a Novel Platform for Drug Discovery

Drug-based cancer therapy to overcome immune resistance by steering tumor evolution

scientific article published on 29 November 2018

Dynamics of Hydrogen Bond Desolvation in Protein Folding

article

Edge enhancement of color images using a digital micromirror device ⬇️

scientific article published on June 1, 2012

Editorial

Editors & Editorial Board

Effective propagators for quenched disorder in linear polymers

article

Effectiveness of an mHealth intervention to improve the cardiometabolic profile of people with prehypertension in low-resource urban settings in Latin America: a randomised controlled trial

scientific article published on 30 November 2015

Efficiency Increase in the Extraction of Sugar Cane Juice in the Sugar Cane Mills by Means of the Regulation of Hydraulic Pressures

scholarly article published 2005

Electrostatic Exploration of Biomolecular Interfaces: The Chemical Function of Interfacial Water

Energy-level statistics in the fine conformational resolution of RNA folding dynamics

scientific article published on 01 November 1999

Engineering Therapeutic Alignments Between Immune Response and Molecularly Targeted Cancer Treatment

Engineering productive enzyme confinement

scientific article published on 26 March 2007

Entrainment by periodic perturbations in the center manifold at Ginzburg-Landau critical regimes

scientific article published on 01 September 1986

Epistructural Tension Promotes Protein Associations ⬇️

scientific article published on May 4, 2012

Evidence of a tertiary interaction functional in group I 3′-splicing

article

Evolution of Protein Structure Degradation and Lessons for the Drug Designer

article published in 2015

Evolution of Protein Wrapping and Implications for the Drug Designer

Evolutionary Roots of Proteomic Complexity and Lessons for the Drug Designer

Evolutionary constraints imposed by gene dosage balance

scientific article published on May 2008

Excluded-volume effects on the stacking of RNA base pairs

scientific article published on 01 December 1991

Extent of hydrogen-bond protection in folded proteins: a constraint on packing architectures

scientific article published on November 2002

Externally induced phase transition for random inhomogeneous polymers

Feature-similarity protein classifier as a ligand engineering tool

scientific article

Fluctuations and resulting competing pathways in RNA folding: The activation of splicing

scientific article published on 01 January 1991

Folding Cooperativity and the Wrapping of Intermediate States of Soluble Natural Proteins

Folding RNA with the minimal loss of entropy

scientific article published on 01 August 1995

Folding a protein by discretizing its backbone torsional dynamics

scientific article published in May 1999

Folding and wrapping soluble proteins exploring the molecular basis of cooperativity and aggregation

scientific article published on January 2008

Folding pathway leading to the most stable conformation of a random RNA chain

scientific article published on 01 June 1992

From residue matching patterns to protein folding topographies: general model and bovine pancreatic trypsin inhibitor

scientific article published on November 1999

Fulfilling a Therapeutic Imperative in Cancer Treatment: Control of Multi-target Drug Impact

Functionality of wrapping defects in soluble proteins: what cannot be kept dry must be conserved.

scientific article

Fundamental sensitivity propagators in dissipative systems with a statistical enslaving of fast-relaxing variables

scientific article published on 01 March 1986

Glassy kinetic barriers between conformational substates in RNA

scientific article published in Physical Review Letters

Golden rule for buttressing vulnerable soluble proteins

scientific article published in May 2010

High-Level Quantum Chemistry Empowers the Wrapping Technology for Drug Design

scholarly article published 2015

How do we probe ubiquitin's pathway heterogeneity?

scientific article published in June 2002

Human capacitance to dosage imbalance: coping with inefficient selection

scientific article published on 09 October 2009

Hydration profiles of amyloidogenic molecular structures

scientific article

Image segmentation by nonlinear filtering of optical Hough transform

scientific article published on 01 May 2016

In silico drug profiling of the human kinome based on a molecular marker for cross reactivity

scientific article

In vitro RNA folding: the principle of sequential minimization of entropy loss at work

scientific article published on 01 February 1996

Incoherent optical processor for nondirectional edge enhancement of color images ⬇️

scientific article published on December 1, 2011

Incomplete protein packing as a selectivity filter in drug design

scientific article

Induced disorder in protein-ligand complexes as a drug-design strategy

scientific article

Inducing Folding By Crating the Target

Inhibitor design by wrapping packing defects in HIV-1 proteins

scholarly article

Insufficient hydrogen-bond desolvation and prion-related disease

scientific article published in September 2002

Insufficiently dehydrated hydrogen bonds as determinants of protein interactions

scholarly article

Intrinsic Fluctuations in Macromolecular Self-Replicating Systems

scholarly article published October 1987

Intrinsic fluctuations associated with the onset of a centre manifold

Intrinsic fluctuations determined by the existence of a centre manifold

Is there a case for selectively promiscuous anticancer drugs?

scientific article

Keeping dry and crossing membranes

scientific article published in September 2004

Kinase packing defects as drug targets

scientific article published on 30 October 2007

Kinetic assembling of the biologically active secondary structure for CAR, the target sequence for the Rev protein of HIV-1.

scientific article

Large-scale context in protein folding: villin headpiece

scientific article published on January 2003

Last Frontier and Back to the Drawing Board: Protein–Water Interfacial Tension in Drug Design

Likelihood of side effects depends on desired clinical impact: Affinities within a very small set of targets enables inference of promiscuity or specificity of kinase inhibitors

Localization of strain in the RNA backbone and its functional implication

scientific article published in Physical Review Letters

Magnesium-aided folding of group I ribozymes with a minimal loss of entropy

scientific article published on 01 August 1996

Membrane thickness cue for cold sensing in a bacterium

scientific article published on 12 August 2010

Metastable RNA folding and the enhancement of autocatalytic activity

scientific article published on 01 November 1989

Modulating drug impact by wrapping target proteins

scientific article published on February 2007

Molecular Biology Clues Portray SARS-CoV-2 as a Gain-of-Function Laboratory Manipulation of Bat CoV RaTG13

scholarly article

Molecular basis for evolving modularity in the yeast protein interaction network

scientific article

Molecular dimension explored in evolution to promote proteomic complexity

scientific article

Multitarget Control of Drug Impact: A Therapeutic Imperative in Cancer Systems Biology

article

Nanoscale thermodynamics of biological interfacial tension

scientific article published in 2010

Non-adaptive origins of interactome complexity

scientific article

Noncoexisting structural elements in catalytic pre-messenger RNA's

scientific article published on November 1, 1992

Nucleation theory for helix unfolding in peptide chains

scientific article published in October 1999

On how hydrolysis at the 3' end is prevented in the splicing of a sequentially folded group I intron

scientific article published on 01 February 1992

On renormalisation of fluctuations at the onset of a centre manifold

article published in 1988

Oncogenic mutations and packing defects in protein structure.

scientific article

Optical implementation of the generalized Hough transform with totally incoherent light

scientific article published in August 2015

Optical processing of color images with incoherent illumination: orientation-selective edge enhancement using a modified liquid-crystal display ⬇️

scientific article published on October 10, 2011

Packing Defects and Protein Hydration: Dynamics of the Aqueous Interface

article

Packing defects as selectivity switches for drug-based protein inhibitors

scientific article

Packing defects functionalize soluble proteins

scientific article published on 13 March 2015

Partial relaxation of enzyme-product binding by refolding of the growing chain in autocatalytic RNA replication

scientific article published in February 1989

Passive water-lipid peptide translocators with conformational switches: from single-molecule probe to cellular assay

scientific article published on 29 November 2007

Pathway diversity and concertedness in protein folding: an ab-initio approach

scientific article published in April 2002

Pathway heterogeneity in protein folding

scientific article published on 01 August 2002

Pause sites and regulatory role of secondary structure in RNA replication

scientific article

Peptide translocators with engineered dehydration-prone hydrogen bonds

scientific article published in February 2007

Pharmaceutical Industry at the Post-Genomic Junction

Phase-ordering dynamics for the onset of a center manifold

article

Prediction of the Sugar Mill Shaft Failure Using a Fracture Mechanics Method

Preservation of a kinetically originated folding of the cis antirepressor sequence for transport of HIV-1 viral RNA.

scientific article

Productive induced metastability in allosteric modulation of kinase function.

scientific article

Protein Cooperativity and Wrapping: Two Themes in the Transformative Platform of Molecular Targeted Therapy

article

Protein Folding: Is Hierarchical versus Nonhierarchical a Productive Issue?

scientific article published on 01 April 2002

Protein Folding: Where is the Paradox?

scientific article published on 01 December 2002

Protein Under-wrapping Causes Dosage Sensitivity and Decreases Gene Duplicability

article

Protein folding: could hydrophobic collapse be coupled with hydrogen-bond formation?

scientific article published on 01 February 2003

Protein packing defects "heat up" interfacial water

scientific article published on 25 June 2013

Protein promiscuity: drug resistance and native functions--HIV-1 case

scientific article published in June 2005

Protein structural defects enable pharmaceutical targeting while functionalizing the M2 proton channel

scientific article published on 23 April 2019

Protein structure protection commits gene expression patterns.

scientific article

Protein under-wrapping causes dosage sensitivity and decreases gene duplicability

scientific article

Protein wrapping: a molecular marker for association, aggregation and drug design.

scientific article

Proteins in the Order–Disorder Twilight: Unstable Interfaces Promote Protein Aggregation

Proteins with H-bond packing defects are highly interactive with lipid bilayers: Implications for amyloidogenesis

scholarly article

Provisional theory of nanoscale water dielectrics

Purposely engineered drug–target mismatches for entropy-based drug optimization

scientific article published on 08 September 2011

Random energy model for the kinetics of RNA folding

scientific article published in Physical Review Letters

Rational drug redesign to overcome drug resistance in cancer therapy: imatinib moving target

scientific article published on May 2007

Re-engineering an Anticancer Drug to Make It Safer: Modifying Imatinib to Curb Its Side Effects

article

Real-time pattern recognition using an optical generalized Hough transform

scientific article published on 01 December 2015

Reconstruction of perspective shifts and refocusing of a three-dimensional scene from a multi-focus image stack

scientific article published on March 2016

Redesigning kinase inhibitors to enhance specificity

scientific article

Selective antagonism of anticancer drugs for side-effect removal

scientific article published in August 2009

Selectivity filters to edit out deleterious side effects in kinase inhibitors

scientific article published on January 2011

Self-organisation in the centre manifold of a dissipative system

Semiempirical Solution to the Protein Folding Problem Through a Combination of Structural and Epistructural Approaches

Semiempirical prediction of protein folds

scientific article published on 10 July 2001

Sequentially folded SV-11 RNA: metastability is relevant to biological function

scientific article published on 01 October 1996

Simulating an exploration of RNA conformation space with an appropriate parallel-updating strategy

article

Solvent environment conducive to protein aggregation

scientific article published on 01 October 2002

Solvent-exposed backbone loosens the hydration shell of soluble folded proteins

scientific article published in June 2007

Solvophobic forces and molecular surface area changes in drug-biomolecule associations as with actinomycin-deoxyguanosine in a wide range of methanol/water mixtures

scientific article published on 01 March 1985

Spatial-temporal dissipative structures arising in open reactive systems with a negative feedback loop

scientific article published on 01 January 1984

Statistical mechanical model for proton transfer in RNA

Statistics of Disordered Polymers: An Effective Hamiltonian and its Associated Gibbs Measure

Stochastic dynamical constraints in de novo RNA replication

scientific article published in October 1988

Stress Localization in the RNA Backbone: A Mechanical Footprint for Predicting Base-Backbone Tertiary Contacts

scientific article published on 01 February 1994

Structural defects and the diagnosis of amyloidogenic propensity

scholarly article

Structural phase transitions and the catalytic role of RNA in proton transfer events

article

Structure-induced strain determining the internal cyclization site in the yeast cobI5 autocatalytic intron: theory and experimental tests

scientific article published in September 1993

Sub-nanoscale surface ruggedness provides a water-tight seal for exposed regions in soluble protein structure

scientific article

Subfunctionalization reduces the fitness cost of gene duplication in humans by buffering dosage imbalances

scientific article

Subordination of fast-relaxing degrees of freedom to order parameters under Ginzburg-Landau regimes

scientific article published on 01 April 1985

Subordination of the fast-relaxing degree of freedom in the center manifold of the Belousov-Zhabotinsky system

scientific article published on 01 April 1985

Supramolecular Evolution of Protein Organization

scientific article published on 26 June 2013

Synergizing immunotherapy with molecular-targeted anticancer treatment

scientific article published on 28 March 2014

Taming the induced folding of drug-targeted kinases

scientific article

Targeted therapy to annihilate the immune-evading phenotype in cancer evolution.

scientific article published on 8 March 2018

The Aqueous Interface of a Soluble Protein or the Birth of Epistructural Biology

article published in 2015

The Biomolecular Interface as a Selectivity Filter for Drug-Based Targeted Therapy

The RNA folding problem: a variational problem within an adiabatic approximation

scientific article published on 01 August 1998

The denaturation maxima of proteins and of drug-biomolecule complex formation in a wide range of methanol/water mixtures. Solvophobic theory predictions as compared to experiments

scientific article published in March 1985

The integrated development of network complexity modulates the diverse evolutionary mutation rates of individual proteins

article

The onset of macroscopically detectable amplification of template concentration for self-replicating RNA.

scientific article published in April 1988

The principle of minimal episteric distortion of the water matrix and its steering role in protein folding

scientific article published in August 2013

Theory of scaling for fluctuations in thermal explosion conditions

Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma

scientific article published on November 2007

Three-dimensional profiling with binary fringes using phase-shifting interferometry algorithms

scientific article

Time-resolved backbone desolvation and mutational hot spots in folding proteins

scientific article published in June 2002

Topology to geometry in protein folding: beta-lactoglobulin

scientific article

Transformative Concepts for Drug Design: Target Wrapping

article

Transition to a convective roll pattern as obtained from the stochastic center-manifold theory

scientific article published on 01 January 1987

Turning promiscuous kinase inhibitors into safer drugs

scientific article published on 09 April 2008

Under-Wrapped Proteins in the Order–Disorder Twilight: Unraveling the Molecular Etiology of Aberrant Aggregation

Water promotes the sealing of nanoscale packing defects in folding proteins

scientific article published on 25 April 2014

What factor drives the fibrillogenic association of β-sheets?

scientific article published on 09 November 2005

Wrapper Drugs as Therapeutic Editors of Side Effects

Wrapper Drugs for Personalized Medicine

article

Wrapping Defects and the Architecture of Soluble Proteins

scholarly article published 2010

Wrapping Deficiencies and De-wetting Patterns in Soluble Proteins: A Blueprint for Drug Design

Wrapping Drug Combinations for Therapeutic Editing of Side Effects: Systems Biology Meets Wrapping Technology

Wrapping Patterns as Universal Markers for Specificity in the Therapeutic Interference with Signaling Pathways

Wrapping as a Selectivity Filter for Molecular Targeted Therapy: Preliminary Evidence

article

Wrapping mimicking in drug-like small molecules disruptive of protein-protein interfaces

scientific article published on 16 April 2012

Wrapping technology and the enhancement of specificity in cancer drug treatment

scientific article published on May 2007

Wrapping-Based Re-engineering of an Anticancer Drug to Make it Safer

c-Jun-NH2-kinase-1 inhibition leads to antitumor activity in ovarian cancer

scientific article

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