List of works - Nicos A. Petasis

15-Epi-16-(para-fluorophenoxy)-lipoxin A(4)-methyl ester, a synthetic analogue of 15-epi-lipoxin A(4), is protective in experimental ischemic acute renal failure

scientific article published in June 2002

A Facile Stereocontrolled Synthesis ofanti-α-(Trifluoromethyl)-β-amino Alcohols

scientific article published on 01 October 2000

Activation of polyisoprenyl diphosphate phosphatase 1 remodels cellular presqualene diphosphate

scientific article

Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib

scientific article published on February 2008

Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes.

scientific article

Anti-inflammatory and pro-resolving properties of benzo-lipoxin A(4) analogs

scientific article published on 22 October 2009

Antiangiogenic activities of 2,5-dimethyl-celecoxib on the tumor vasculature

scientific article published on 2 March 2010

Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors

scientific article

Aspirin-triggered lipoxin A4 and B4 analogs block extracellular signal-regulated kinase-dependent TNF-alpha secretion from human T cells

scientific article (publication date: 15 June 2003)

Aspirin-triggered lipoxins override the apoptosis-delaying action of serum amyloid A in human neutrophils: a novel mechanism for resolution of inflammation

scientific article (publication date: July 2007)

Ataxin-1 Poly(Q)-induced Proteotoxic Stress and Apoptosis Are Attenuated in Neural Cells by Docosahexaenoic Acid-derived Neuroprotectin D1 ⬇️

scientific article published on April 16, 2012

Avermectins differentially affect ethanol intake and receptor function: implications for developing new therapeutics for alcohol use disorders.

scientific article

COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro

scientific article

Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib.

scientific article

Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs

scientific article

Component-Selective and Stereocontrolled One-Step Three-Component Reaction among Aldehydes, Amines, and Allenyl Boronic Acids or Allenyl Pinacolboronates

scientific article published on 19 March 2015

Cutting Edge: Lipoxins Rapidly Stimulate Nonphlogistic Phagocytosis of Apoptotic Neutrophils by Monocyte-Derived Macrophages

scientific article published on 01 February 2000

Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation

scientific article

Cystic fibrosis and lipoxins.

scientific article

Cytotoxic effects of celecoxib on Raji lymphoma cells correlate with aggravated endoplasmic reticulum stress but not with inhibition of cyclooxygenase-2.

scientific article published on February 2010

Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway

scientific article published on 21 March 2004

Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties

scientific article published on 9 January 2008

Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils

scientific article published in November 1995

Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirin-triggered lipoxins

scientific article

Dimethyl celecoxib as a novel non-cyclooxygenase 2 therapy in the treatment of non-small cell lung cancer

scientific article published on 13 October 2005

Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo.

scientific article

Discovery and preclinical evaluation of a novel class of cytotoxic propynoic acid carbamoyl methyl amides (PACMAs).

scientific article published on 28 March 2011

Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease models

scientific article

Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo

scientific article published on 18 May 2006

Elovanoids are a novel class of homeostatic lipid mediators that protect neural cell integrity upon injury

scientific article published on 27 September 2017

Elovanoids are novel cell-specific lipid mediators necessary for neuroprotective signaling for photoreceptor cell integrity

scientific article

Elovanoids counteract oligomeric β-amyloid-induced gene expression and protect photoreceptors

scientific article published on 11 November 2019

Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress

scientific article published on 3 April 2009

Enhancement of photodynamic therapy by 2,5-dimethyl celecoxib, a non-cyclooxygenase-2 inhibitor analog of celecoxib

scientific article published on 19 February 2011

Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro

scientific article (publication date: July 2011)

Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors.

scientific article

Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin d1.

scientific article

Identification of endogenous resolvin E1 and other lipid mediators derived from eicosapentaenoic acid via electrospray low-energy tandem mass spectrometry: spectra and fragmentation mechanisms

scientific article published in January 2007

Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent

scientific article

Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2 ⬇️

scientific article published on March 6, 2012

Interactions between lipoxin A4, the stable analogue 16-phenoxy-lipoxin A4 and leukotriene B4 in cytokine generation by human monocytes

scientific article

Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis.

scientific article

Interleukin-8 reduces post-surgical lymphedema formation by promoting lymphatic vessel regeneration.

scientific article

Ivermectin reduces alcohol intake and preference in mice.

scientific article

Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit human neutrophil migration: comparisons between synthetic 15 epimers in chemotaxis and transmigration with microvessel endothelial cells and epithelial cells

scientific article (publication date: March 2003)

Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes.

scientific article

Lipoxin A4 stable analogs inhibit leukocyte rolling and adherence in the rat mesenteric microvasculature: role of P-selectin.

scientific article published on September 1997

Lipoxin A4Analogues Inhibit Leukocyte Recruitment toPorphyromonas gingivalis: A Role for Cyclooxygenase-2 and Lipoxins in Periodontal Disease†

scientific article published on 01 April 2000

Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo

scientific article (publication date: October 2002)

Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo

scientific article

Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective

scientific article

Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages ⬇️

scientific article published on 06 October 2016

Metabolic Inactivation of Resolvin E1 and Stabilization of Its Anti-inflammatory Actions

scientific article published in Journal of Biological Chemistry

Modulation of leukotriene synthesis and actions by synthetic derivatives of arachidonic acid

Molecular characterization of the boron adducts of the proteasome inhibitor bortezomib with epigallocatechin-3-gallate and related polyphenols.

scientific article

Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogues ⬇️

scientific article published on February 15, 1998

Noscapine inhibits tumor growth in TMZ-resistant gliomas

scientific article published on 28 August 2011

Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke

scientific article

Novel polyisoprenyl phosphates block phospholipase D and human neutrophil activation in vitro and murine peritoneal inflammation in vivo

scientific article published in October 2005

Novel proresolving aspirin-triggered DHA pathway ⬇️

scientific article published on August 26, 2011

PCTR1 Enhances Repair and Bacterial Clearance in Skin Wounds

scientific article published on 06 March 2021

Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs ⬇️

scientific article published on May 1, 1998

Perillyl alcohol for the treatment of temozolomide-resistant gliomas

scientific article published on 28 August 2012

Polyisoprenyl phosphates in intracellular signalling

scientific article published in October 1997

Preclinical development of novel anti-glioma drugs targeting the endoplasmic reticulum stress response

scientific article published on January 2011

Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors

scientific article

Protective actions of aspirin-triggered (17R) resolvin D1 and its analogue, 17R-hydroxy-19-para-fluorophenoxy-resolvin D1 methyl ester, in C5a-dependent IgG immune complex-induced inflammation and lung injury

scientific article published on 29 August 2014

Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution.

scientific article

Regioselective conversion of arylboronic acids to phenols and subsequent coupling to symmetrical diaryl ethers

scientific article published in January 2001

Regulation of phosphatidylinositol 3-kinase by polyisoprenyl phosphates in neutrophil-mediated tissue injury.

scientific article

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

scientific article

Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms

scientific article published on 19 October 2006

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

scientific article

Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia.

scientific article

Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance

scientific article

Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis

scientific article

Resolvins and protectins in inflammation resolution.

scientific article

RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis

scientific article (publication date: February 2006)

Selective inhibition of 5-lipoxygenase by 5,6-methanoleukotriene A4 , a stable analogue of leukotriene A4

scientific article published on 01 June 1982

Simultaneous lipidomic analysis of three families of bioactive lipid mediators leukotrienes, resolvins, protectins and related hydroxy-fatty acids by liquid chromatography/electrospray ionisation tandem mass spectrometry.

scientific article published on January 2008

Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1

scientific article

Stereocontrolled total synthesis of neuroprotectin D1 / protectin D1 and its aspirin-triggered stereoisomer

scientific article

Stereocontrolled total synthesis of the potent anti-inflammatory and pro-resolving lipid mediator resolvin D3 and its aspirin-triggered 17R-epimer

scientific article published on 19 March 2013

Stereoselective synthesis of anti-alpha-(difluoromethyl)-beta-amino alcohols by boronic acid based three-component condensation. Stereoselective preparation of (2S,3R)-difluorothreonine

scientific article published in May 2002

Synthesis of 2H-chromenes and 1,2-dihydroquinolines from aryl aldehydes, amines, and alkenylboron compounds.

scientific article published on May 2009

The CXCR2 antagonist, SCH-527123, shows antitumor activity and sensitizes cells to oxaliplatin in preclinical colon cancer models

scientific article

The resolvin D1 analogue controls maturation of dendritic cells and suppresses alloimmunity in corneal transplantation

scientific article

ipso-Nitration of Arylboronic Acids with Chlorotrimethylsilane−Nitrate Salts

scientific article published on 01 June 2004

List of works by Nicos A. Petasis

15-Epi-16-(para-fluorophenoxy)-lipoxin A(4)-methyl ester, a synthetic analogue of 15-epi-lipoxin A(4), is protective in experimental ischemic acute renal failure

A Facile Stereocontrolled Synthesis ofanti-α-(Trifluoromethyl)-β-amino Alcohols

Activation of polyisoprenyl diphosphate phosphatase 1 remodels cellular presqualene diphosphate

Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib

Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes.

Anti-inflammatory and pro-resolving properties of benzo-lipoxin A(4) analogs

Antiangiogenic activities of 2,5-dimethyl-celecoxib on the tumor vasculature

Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors

Aspirin-triggered lipoxin A4 and B4 analogs block extracellular signal-regulated kinase-dependent TNF-alpha secretion from human T cells

Aspirin-triggered lipoxins override the apoptosis-delaying action of serum amyloid A in human neutrophils: a novel mechanism for resolution of inflammation

Ataxin-1 Poly(Q)-induced Proteotoxic Stress and Apoptosis Are Attenuated in Neural Cells by Docosahexaenoic Acid-derived Neuroprotectin D1 ⬇️

Avermectins differentially affect ethanol intake and receptor function: implications for developing new therapeutics for alcohol use disorders.

COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro

Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib.

Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs

Component-Selective and Stereocontrolled One-Step Three-Component Reaction among Aldehydes, Amines, and Allenyl Boronic Acids or Allenyl Pinacolboronates

Cutting Edge: Lipoxins Rapidly Stimulate Nonphlogistic Phagocytosis of Apoptotic Neutrophils by Monocyte-Derived Macrophages

Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation

Cystic fibrosis and lipoxins.

Cytotoxic effects of celecoxib on Raji lymphoma cells correlate with aggravated endoplasmic reticulum stress but not with inhibition of cyclooxygenase-2.

Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway

Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties

Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils

Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirin-triggered lipoxins

Dimethyl celecoxib as a novel non-cyclooxygenase 2 therapy in the treatment of non-small cell lung cancer

Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo.

Discovery and preclinical evaluation of a novel class of cytotoxic propynoic acid carbamoyl methyl amides (PACMAs).

Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease models

Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo

Elovanoids are a novel class of homeostatic lipid mediators that protect neural cell integrity upon injury

Elovanoids are novel cell-specific lipid mediators necessary for neuroprotective signaling for photoreceptor cell integrity

Elovanoids counteract oligomeric β-amyloid-induced gene expression and protect photoreceptors

Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress

Enhancement of photodynamic therapy by 2,5-dimethyl celecoxib, a non-cyclooxygenase-2 inhibitor analog of celecoxib

Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro

Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors.

Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin d1.

Identification of endogenous resolvin E1 and other lipid mediators derived from eicosapentaenoic acid via electrospray low-energy tandem mass spectrometry: spectra and fragmentation mechanisms

Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent

Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2 ⬇️

Interactions between lipoxin A4, the stable analogue 16-phenoxy-lipoxin A4 and leukotriene B4 in cytokine generation by human monocytes

Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis.

Interleukin-8 reduces post-surgical lymphedema formation by promoting lymphatic vessel regeneration.

Ivermectin reduces alcohol intake and preference in mice.

Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit human neutrophil migration: comparisons between synthetic 15 epimers in chemotaxis and transmigration with microvessel endothelial cells and epithelial cells

Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes.

Lipoxin A4 stable analogs inhibit leukocyte rolling and adherence in the rat mesenteric microvasculature: role of P-selectin.

Lipoxin A4Analogues Inhibit Leukocyte Recruitment toPorphyromonas gingivalis: A Role for Cyclooxygenase-2 and Lipoxins in Periodontal Disease†

Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo

Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo

Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective

Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages ⬇️

Metabolic Inactivation of Resolvin E1 and Stabilization of Its Anti-inflammatory Actions

Modulation of leukotriene synthesis and actions by synthetic derivatives of arachidonic acid

Molecular characterization of the boron adducts of the proteasome inhibitor bortezomib with epigallocatechin-3-gallate and related polyphenols.

Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogues ⬇️

Noscapine inhibits tumor growth in TMZ-resistant gliomas

Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke

Novel polyisoprenyl phosphates block phospholipase D and human neutrophil activation in vitro and murine peritoneal inflammation in vivo

Novel proresolving aspirin-triggered DHA pathway ⬇️

PCTR1 Enhances Repair and Bacterial Clearance in Skin Wounds

Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs ⬇️

Perillyl alcohol for the treatment of temozolomide-resistant gliomas

Polyisoprenyl phosphates in intracellular signalling

Preclinical development of novel anti-glioma drugs targeting the endoplasmic reticulum stress response

Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors

Protective actions of aspirin-triggered (17R) resolvin D1 and its analogue, 17R-hydroxy-19-para-fluorophenoxy-resolvin D1 methyl ester, in C5a-dependent IgG immune complex-induced inflammation and lung injury

Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution.

Regioselective conversion of arylboronic acids to phenols and subsequent coupling to symmetrical diaryl ethers

Regulation of phosphatidylinositol 3-kinase by polyisoprenyl phosphates in neutrophil-mediated tissue injury.

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia.

Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance

Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis

Resolvins and protectins in inflammation resolution.

RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis

Selective inhibition of 5-lipoxygenase by 5,6-methanoleukotriene A4 , a stable analogue of leukotriene A4