List of works - François Morvan

3'-Deoxy phosphoramidate dinucleosides as improved inhibitors of hepatitis C virus subgenomic replicon and NS5B polymerase activity

scientific article published on September 2010

5'-Bis-conjugation of oligonucleotides by amidative oxidation and click chemistry

scientific article published on October 2010

5-Propynylamino α-deoxyuridine promotes DNA duplex stabilization of anionic and neutral but not cationic α-oligonucleotides

scientific article published on 18 November 2006

A versatile reagent for the synthesis of 5′-phosphorylated, 5′-thiophosphorylated or 5′-phosphoramidate-conjugated oligonucleotides

Alpha are more stable than beta anomer oligonucleotides in 3T3 cellular extracts

scientific article published on December 1988

Alpha-DNA. IV: Alpha-anomeric and beta-anomeric tetrathymidylates covalently linked to intercalating oxazolopyridocarbazole. Synthesis, physicochemical properties and poly (rA) binding.

scientific article

Alpha-anomeric DNA: beta-RNA hybrids as new synthetic inhibitors of Escherichia coli RNase H, Drosophila embryo RNase H and M-MLV reverse transcriptase.

scientific article published in December 1988

An efficient reagent for 5′-azido oligonucleotide synthesis

Assessment of the Full Compatibility of Copper(I)-Catalyzed Alkyne-Azide Cycloaddition and Oxime Click Reactions for bis-Labelling of Oligonucleotides

scientific article published on 10 December 2014

Azide solid support for 3'-conjugation of oligonucleotides and their circularization by click chemistry

scientific article

Bis- and Tris-Alkyne Phosphoramidites for Multiple 5′-Labeling of Oligonucleotides by Click Chemistry

Combinatorial and automated synthesis of phosphodiester galactosyl cluster on solid support by click chemistry assisted by microwaves

scientific article

Comparative Stability of Eight Different Triple Helices Formed by Differently Modified DNA or RNA Pyrimidine Strands and a DNA Hairpin ⬇️

scientific article published on August 1, 1997

Comparative evaluation of seven oligonucleotide analogues as potential antisense agents.

scientific article

Conformational and Chiral Selection of Oligonucleotides

scientific article published on 01 April 2007

Convenient synthesis of N2-isobutyryl-2′-O-methyl guanosine by efficient alkylation of O6-trimethylsilylethyl-3′,5′-di-tert-butylsilanediyl guanosine

article

DNA directed immobilization glycocluster array: applications and perspectives

scientific article published on 16 January 2014

DNA glycoclusters and DNA-based carbohydrate microarrays: From design to applications

article by François Morvan et al published 2012 in RSC Advances

DNA-based carbohydrate biochips: a platform for surface glyco-engineering

scientific article published in January 2007

DNA-directed immobilisation of glycomimetics for glycoarrays application: comparison with covalent immobilisation, and development of an on-chip IC50 measurement assay

scientific article published on 14 January 2009

Deciphering multivalent glycocluster-lectin interactions through AFM characterization of the self-assembled nanostructures

scientific article published on 01 September 2019

Delta-di-carboxybutyl phosphoramidate of 2'-deoxycytidine-5'-monophosphate as substrate for DNA polymerization by HIV-1 reverse transcriptase

scientific article published on 8 August 2009

Deoxygenation of 5-O-benzoyl-1,2-isopropylidene-3-O-imidazolylthiocarbonyl-α-d-xylofuranose using dimethyl phosphite: an efficient alternate method towards a 3′-deoxynucleoside glycosyl donor

scientific article published on 21 March 2008

Design and Synthesis of Galactosylated Bifurcated Ligands with Nanomolar Affinity for Lectin LecA from Pseudomonas aeruginosa

scientific article

Design of triazole-tethered glycoclusters exhibiting three different spatial arrangements and comparative study of their affinities towards PA-IL and RCA 120 by using a dna-based glycoarray.

scientific article published in May 2009

Design, Synthesis and Characterization of Cyclic NU172 Analogues: A Biophysical and Biological Insight

scientific article published on 29 May 2020

Development of innovative and versatile polythiol probes for use on ELOSA or electrochemical biosensors: application in hepatitis C virus genotyping

scientific article published on 19 September 2013

Effects of the Surface Densities of Glycoclusters on the Determination of Their IC50 and Kd Value Determination by Using a Microarray

scientific article published on 11 September 2015

Efficient Solid-Phase Chemical Synthesis of 5′-Triphosphates of DNA, RNA, and their Analogues

scientific article published on 01 May 2010

Electrochemical detection of nucleic acids using pentaferrocenyl phosphoramidate α-oligonucleotides

First synthesis of alternating SATE-phosphotriester/phosphodiester prooligonucleotides on solid support

scientific article published on 01 October 1998

Fluorescence enhancement upon G-quadruplex folding: synthesis, structure, and biophysical characterization of a dansyl/cyclodextrin-tagged thrombin binding aptamer.

scientific article published on 25 October 2013

Fluorescent thrombin binding aptamer-tagged nanoparticles for an efficient and reversible control of thrombin activity

scientific article

Fucosylated Pentaerythrityl Phosphodiester Oligomers (PePOs): Automated Synthesis of DNA-Based Glycoclusters and Binding toPseudomonas aeruginosaLectin (PA-IIL)

article

Glycoclusters on oligonucleotide and PNA scaffolds: synthesis and applications.

scientific article published on 19 December 2012

H-Phosphonate oligonucleotides from phosphoramidite chemistry

Hetero-Click Conjugation of Oligonucleotides with Glycosides Using Bifunctional Phosphoramidites

High-Yield Solution-Phase Synthesis of Di- and Trinucleotide Blocks Assisted by Polymer-Supported Reagents

scientific article published in 2005

Importance of topology for glycocluster binding to Pseudomonas aeruginosa and Burkholderia ambifaria bacterial lectins

scientific article published on 28 September 2015

Improved Performance of DNA Microarray Multiplex Hybridization Using Probes Anchored at Several Points by Thiol-Ene or Thiol-Yne Coupling Chemistry

scientific article

Kinetics study of the biotransformation of an oligonucleotide prodrug in cells extract by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry

scientific article

Lewis acid deprotection of silyl-protected oligonucleotides and base-sensitive oligonucleotide analogues

Mannose-centered aromatic galactoclusters inhibit the biofilm formation of Pseudomonas aeruginosa

scientific article published in July 2015

Measurement of enzymatic activity and specificity of human and avian influenza neuraminidases from whole virus by glycoarray and MALDI-TOF mass spectrometry.

scientific article

Microwave Assisted “Click” Chemistry for the Synthesis of Multiple Labeled-Carbohydrate Oligonucleotides on Solid Support†

Multiplexed binding determination of seven glycoconjugates for Pseudomonas aeruginosa Lectin I (PA-IL) using a DNA-based carbohydrate microarray

New Strategies for Cyclization and Bicyclization of Oligonucleotides by Click Chemistry Assisted by Microwaves

Oligonucleotide Conjugation by Tyrosine‐Click Reaction

scientific article published in 2022

Oligonucleotide Mimics for Antisense Therapeutics: Solution Phase and Automated Solid-Support Synthesis of MMI Linked Oligomers

scientific article published in 1996

Oligonucleotide carbohydrate-centered galactosyl cluster conjugates synthesized by click and phosphoramidite chemistries

scientific article published on August 2010

Optimized Synthesis of Functionalized Fluorescent Oligodeoxynucleotides for Protein Labeling

Phosphoramidate dinucleosides as hepatitis C virus polymerase inhibitors

scientific article

Phthalimide-Oxy Derivatives for 3′- or 5′-Conjugation of Oligonucleotides by Oxime Ligation and Circularization of DNA by “Bis- or Tris-Click” Oxime Ligation

Polarity of annealing and structural analysis of the RNase H resistant alpha-5'-d[TACACA].beta-5'-r[AUGUGU] hybrid determined by high-field 1H, 13C, and 31P NMR analysis

scientific article published in November 1990

Prooligonucleotides exhibit less serum-protein binding than phosphodiester and phosphorothioate oligonucleotides

scientific article published on May 2000

Quantitative analysis (K(d) and IC(50)) of glycoconjugates interactions with a bacterial lectin on a carbohydrate microarray with DNA Direct Immobilization (DDI).

scientific article published on 17 July 2012

Rapid determination of the affinity of 28- and 14-mer phosphorothioate oligonucleotides for HIV-1 reverse transcriptase by fluorescence spectroscopy

article

Screening of a Library of Oligosaccharides Targeting Lectin LecB of Pseudomonas Aeruginosa and Synthesis of High Affinity Oligoglycoclusters.

scientific article published on 24 November 2018

Solid Supports for the Synthesis of 3'-Aminooxy Deoxy- or Ribo-oligonucleotides and Their 3'-Conjugation by Oxime Ligation

scientific article published on 25 October 2019

Solution-Phase Synthesis of Phosphorothioate Oligonucleotides Using a Solid-Supported Acyl Chloride withH-Phosphonate Chemistry

Specific recognition of lectins by oligonucleotide glycoconjugates and sorting on a DNA microarray

Stability Is Not Everything: The Case of the Cyclisation of a Thrombin-Binding Aptamer

scientific article published on 14 May 2019

Structure and conformation in solution of the parallel-stranded hybrid alpha-d(CGCAATTCGC).beta-d(GCGTTAAGCG) by high-resolution 2D NMR

scientific article published on 01 May 1992

Structure binding relationship of galactosylated Glycoclusters toward Pseudomonas aeruginosa lectin LecA using a DNA-based carbohydrate microarray.

scientific article published on 30 January 2014

Sugar modified oligonucleotides. III (1). Synthesis, nuclease resistance and base pairing properties of alpha- and beta-L-octathymidylates.

scientific article published in October 1990

Sugar modified oligonucleotides: synthesis, nuclease resistance and base pairing of oligodeoxynucleotides containing 1-(4'-thio-beta-D-ribofuranosyl)-thymine.

scientific article

Synthesis of 5' cap-0 and cap-1 RNAs using solid-phase chemistry coupled with enzymatic methylation by human (guanine-N⁷)-methyl transferase.

scientific article published on 14 February 2012

Synthesis of Galactoclusters by Metal-Free Thiol “Click Chemistry” and Their Binding Affinities forPseudomonas aeruginosaLectin LecA

article published in 2014

Synthesis of Homo- and Heterofunctionalized Glycoclusters and Binding to Pseudomonas aeruginosa Lectins PA-IL and PA-IIL

Synthesis of Monoconjugated and Multiply Conjugated Oligonucleotides by “Click Thiol” Thiol-Michael-Type Additions and by Combination with CuAAC “Click Huisgen”

article

Synthesis of Oligonucleotide Prodrugs BearingN-Acetyl Nucleobases ⬇️

scientific article published on May 1, 2003

Synthesis of a library of fucosylated glycoclusters and determination of their binding toward Pseudomonas aeruginosa lectin B (PA-IIL) using a DNA-based carbohydrate microarray

scientific article

Synthesis of branched-phosphodiester and mannose-centered fucosylated glycoclusters and their binding studies with Burkholderia ambifaria lectin (BambL)

article

Synthesis of mannose and galactose oligonucleotide conjugates by bi-click chemistry

scientific article

Template. Phosphorothioate oligonucleotides duplexes as inhibitors of HIV-1 reverse transcriptase

scientific article (publication date: 14 August 1992)

The anti-adhesive effect of glycoclusters on Pseudomonas aeruginosa bacteria adhesion to epithelial cells studied by AFM single cell force spectroscopy

The influence of the aromatic aglycon of galactoclusters on the binding of LecA: a case study with O-phenyl, S-phenyl, O-benzyl, S-benzyl, O-biphenyl and O-naphthyl aglycons

scientific article

Toward the Rational Design of Galactosylated Glycoclusters That Target Pseudomonas aeruginosa Lectin A (LecA): Influence of Linker Arms That Lead to Low-Nanomolar Multivalent Ligands

scientific article

Triple helix formation by alpha-oligodeoxynucleotides: a vibrational spectroscopy and molecular modeling study

scientific article published on 01 October 1993

Universal solid supports for the synthesis of oligonucleotides via a transesterification of H-phosphonate diester linkage

scientific article

Uptake and quantification of intracellular concentration of lipophilic pro-oligonucleotides in HeLa cells

scientific article

Use of 2-(tert-butyldiphenylsilyloxymethyl) benzoyl as N-protecting group for the synthesis of prooligonucleotides.

scientific article

Use of MALDI-TOF mass spectrometry to monitor solid-phase synthesis of oligonucleotides

scientific article

Use of a solid-supported coupling reagent for a selective phosphitylation of the primary alcohol of N2-isobutyryl-2′-deoxy or 2′-O-methyl guanosine

alpha-Oligodeoxynucleotide stability in serum, subcellular extracts and culture media

scientific article published on 01 August 1988

List of works by François Morvan

3'-Deoxy phosphoramidate dinucleosides as improved inhibitors of hepatitis C virus subgenomic replicon and NS5B polymerase activity

5'-Bis-conjugation of oligonucleotides by amidative oxidation and click chemistry

5-Propynylamino α-deoxyuridine promotes DNA duplex stabilization of anionic and neutral but not cationic α-oligonucleotides

A versatile reagent for the synthesis of 5′-phosphorylated, 5′-thiophosphorylated or 5′-phosphoramidate-conjugated oligonucleotides

Alpha are more stable than beta anomer oligonucleotides in 3T3 cellular extracts

Alpha-DNA. IV: Alpha-anomeric and beta-anomeric tetrathymidylates covalently linked to intercalating oxazolopyridocarbazole. Synthesis, physicochemical properties and poly (rA) binding.

Alpha-anomeric DNA: beta-RNA hybrids as new synthetic inhibitors of Escherichia coli RNase H, Drosophila embryo RNase H and M-MLV reverse transcriptase.

An efficient reagent for 5′-azido oligonucleotide synthesis

Assessment of the Full Compatibility of Copper(I)-Catalyzed Alkyne-Azide Cycloaddition and Oxime Click Reactions for bis-Labelling of Oligonucleotides

Azide solid support for 3'-conjugation of oligonucleotides and their circularization by click chemistry

Bis- and Tris-Alkyne Phosphoramidites for Multiple 5′-Labeling of Oligonucleotides by Click Chemistry

Combinatorial and automated synthesis of phosphodiester galactosyl cluster on solid support by click chemistry assisted by microwaves

Comparative Stability of Eight Different Triple Helices Formed by Differently Modified DNA or RNA Pyrimidine Strands and a DNA Hairpin ⬇️

Comparative evaluation of seven oligonucleotide analogues as potential antisense agents.

Conformational and Chiral Selection of Oligonucleotides

Convenient synthesis of N2-isobutyryl-2′-O-methyl guanosine by efficient alkylation of O6-trimethylsilylethyl-3′,5′-di-tert-butylsilanediyl guanosine

DNA directed immobilization glycocluster array: applications and perspectives

DNA glycoclusters and DNA-based carbohydrate microarrays: From design to applications

DNA-based carbohydrate biochips: a platform for surface glyco-engineering

DNA-directed immobilisation of glycomimetics for glycoarrays application: comparison with covalent immobilisation, and development of an on-chip IC50 measurement assay

Deciphering multivalent glycocluster-lectin interactions through AFM characterization of the self-assembled nanostructures

Delta-di-carboxybutyl phosphoramidate of 2'-deoxycytidine-5'-monophosphate as substrate for DNA polymerization by HIV-1 reverse transcriptase

Deoxygenation of 5-O-benzoyl-1,2-isopropylidene-3-O-imidazolylthiocarbonyl-α-d-xylofuranose using dimethyl phosphite: an efficient alternate method towards a 3′-deoxynucleoside glycosyl donor

Design and Synthesis of Galactosylated Bifurcated Ligands with Nanomolar Affinity for Lectin LecA from Pseudomonas aeruginosa

Design of triazole-tethered glycoclusters exhibiting three different spatial arrangements and comparative study of their affinities towards PA-IL and RCA 120 by using a dna-based glycoarray.

Design, Synthesis and Characterization of Cyclic NU172 Analogues: A Biophysical and Biological Insight

Development of innovative and versatile polythiol probes for use on ELOSA or electrochemical biosensors: application in hepatitis C virus genotyping

Effects of the Surface Densities of Glycoclusters on the Determination of Their IC50 and Kd Value Determination by Using a Microarray

Efficient Solid-Phase Chemical Synthesis of 5′-Triphosphates of DNA, RNA, and their Analogues

Electrochemical detection of nucleic acids using pentaferrocenyl phosphoramidate α-oligonucleotides

First synthesis of alternating SATE-phosphotriester/phosphodiester prooligonucleotides on solid support

Fluorescence enhancement upon G-quadruplex folding: synthesis, structure, and biophysical characterization of a dansyl/cyclodextrin-tagged thrombin binding aptamer.

Fluorescent thrombin binding aptamer-tagged nanoparticles for an efficient and reversible control of thrombin activity

Fucosylated Pentaerythrityl Phosphodiester Oligomers (PePOs): Automated Synthesis of DNA-Based Glycoclusters and Binding toPseudomonas aeruginosaLectin (PA-IIL)

Glycoclusters on oligonucleotide and PNA scaffolds: synthesis and applications.

H-Phosphonate oligonucleotides from phosphoramidite chemistry

Hetero-Click Conjugation of Oligonucleotides with Glycosides Using Bifunctional Phosphoramidites

High-Yield Solution-Phase Synthesis of Di- and Trinucleotide Blocks Assisted by Polymer-Supported Reagents

Importance of topology for glycocluster binding to Pseudomonas aeruginosa and Burkholderia ambifaria bacterial lectins

Improved Performance of DNA Microarray Multiplex Hybridization Using Probes Anchored at Several Points by Thiol-Ene or Thiol-Yne Coupling Chemistry

Kinetics study of the biotransformation of an oligonucleotide prodrug in cells extract by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry

Lewis acid deprotection of silyl-protected oligonucleotides and base-sensitive oligonucleotide analogues

Mannose-centered aromatic galactoclusters inhibit the biofilm formation of Pseudomonas aeruginosa

Measurement of enzymatic activity and specificity of human and avian influenza neuraminidases from whole virus by glycoarray and MALDI-TOF mass spectrometry.

Microwave Assisted “Click” Chemistry for the Synthesis of Multiple Labeled-Carbohydrate Oligonucleotides on Solid Support†

Multiplexed binding determination of seven glycoconjugates for Pseudomonas aeruginosa Lectin I (PA-IL) using a DNA-based carbohydrate microarray

New Strategies for Cyclization and Bicyclization of Oligonucleotides by Click Chemistry Assisted by Microwaves

Oligonucleotide Conjugation by Tyrosine‐Click Reaction

Oligonucleotide Mimics for Antisense Therapeutics: Solution Phase and Automated Solid-Support Synthesis of MMI Linked Oligomers

Oligonucleotide carbohydrate-centered galactosyl cluster conjugates synthesized by click and phosphoramidite chemistries

Optimized Synthesis of Functionalized Fluorescent Oligodeoxynucleotides for Protein Labeling

Phosphoramidate dinucleosides as hepatitis C virus polymerase inhibitors

Phthalimide-Oxy Derivatives for 3′- or 5′-Conjugation of Oligonucleotides by Oxime Ligation and Circularization of DNA by “Bis- or Tris-Click” Oxime Ligation

Polarity of annealing and structural analysis of the RNase H resistant alpha-5'-d[TACACA].beta-5'-r[AUGUGU] hybrid determined by high-field 1H, 13C, and 31P NMR analysis

Prooligonucleotides exhibit less serum-protein binding than phosphodiester and phosphorothioate oligonucleotides

Quantitative analysis (K(d) and IC(50)) of glycoconjugates interactions with a bacterial lectin on a carbohydrate microarray with DNA Direct Immobilization (DDI).

Rapid determination of the affinity of 28- and 14-mer phosphorothioate oligonucleotides for HIV-1 reverse transcriptase by fluorescence spectroscopy

Screening of a Library of Oligosaccharides Targeting Lectin LecB of Pseudomonas Aeruginosa and Synthesis of High Affinity Oligoglycoclusters.

Solid Supports for the Synthesis of 3'-Aminooxy Deoxy- or Ribo-oligonucleotides and Their 3'-Conjugation by Oxime Ligation

Solution-Phase Synthesis of Phosphorothioate Oligonucleotides Using a Solid-Supported Acyl Chloride withH-Phosphonate Chemistry

Specific recognition of lectins by oligonucleotide glycoconjugates and sorting on a DNA microarray

Stability Is Not Everything: The Case of the Cyclisation of a Thrombin-Binding Aptamer

Structure and conformation in solution of the parallel-stranded hybrid alpha-d(CGCAATTCGC).beta-d(GCGTTAAGCG) by high-resolution 2D NMR

Structure binding relationship of galactosylated Glycoclusters toward Pseudomonas aeruginosa lectin LecA using a DNA-based carbohydrate microarray.

Sugar modified oligonucleotides. III (1). Synthesis, nuclease resistance and base pairing properties of alpha- and beta-L-octathymidylates.

Sugar modified oligonucleotides: synthesis, nuclease resistance and base pairing of oligodeoxynucleotides containing 1-(4'-thio-beta-D-ribofuranosyl)-thymine.

Synthesis of 5' cap-0 and cap-1 RNAs using solid-phase chemistry coupled with enzymatic methylation by human (guanine-N⁷)-methyl transferase.

Synthesis of Galactoclusters by Metal-Free Thiol “Click Chemistry” and Their Binding Affinities forPseudomonas aeruginosaLectin LecA

Synthesis of Homo- and Heterofunctionalized Glycoclusters and Binding to Pseudomonas aeruginosa Lectins PA-IL and PA-IIL

Synthesis of Monoconjugated and Multiply Conjugated Oligonucleotides by “Click Thiol” Thiol-Michael-Type Additions and by Combination with CuAAC “Click Huisgen”

Synthesis of Oligonucleotide Prodrugs BearingN-Acetyl Nucleobases ⬇️

Synthesis of a library of fucosylated glycoclusters and determination of their binding toward Pseudomonas aeruginosa lectin B (PA-IIL) using a DNA-based carbohydrate microarray

Synthesis of branched-phosphodiester and mannose-centered fucosylated glycoclusters and their binding studies with Burkholderia ambifaria lectin (BambL)

Synthesis of mannose and galactose oligonucleotide conjugates by bi-click chemistry

Template. Phosphorothioate oligonucleotides duplexes as inhibitors of HIV-1 reverse transcriptase

The anti-adhesive effect of glycoclusters on Pseudomonas aeruginosa bacteria adhesion to epithelial cells studied by AFM single cell force spectroscopy

The influence of the aromatic aglycon of galactoclusters on the binding of LecA: a case study with O-phenyl, S-phenyl, O-benzyl, S-benzyl, O-biphenyl and O-naphthyl aglycons

Toward the Rational Design of Galactosylated Glycoclusters That Target Pseudomonas aeruginosa Lectin A (LecA): Influence of Linker Arms That Lead to Low-Nanomolar Multivalent Ligands

Triple helix formation by alpha-oligodeoxynucleotides: a vibrational spectroscopy and molecular modeling study