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List of works by Diether Lambrechts

(Epi)genetic variation in ageing of metabolic fitness.

scientific article

11q13 is a susceptibility locus for hormone receptor positive breast cancer

scientific article

19p13.1 is a triple-negative-specific breast cancer susceptibility locus

scientific article published on 13 February 2012

2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

scientific article

9q31.2-rs865686 as a susceptibility locus for estrogen receptor-positive breast cancer: evidence from the Breast Cancer Association Consortium

scientific article published on 02 August 2012

A Complex Network of Tumor Microenvironment in Human High-Grade Serous Ovarian Cancer

scientific article published on 2 October 2017

A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer

scientific article published on 30 October 2011

A genetic Xenopus laevis tadpole model to study lymphangiogenesis

scientific article

A genetic predisposition score associates with reduced aerobic capacity in response to acute normobaric hypoxia in lowlanders

article

A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.

scientific article published on 19 September 2010

A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46,450 cases and 42,461 controls from the breast cancer association consortium

scientific article

A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population

scientific article

A network analysis to identify mediators of germline-driven differences in breast cancer prognosis

scientific article published on 16 January 2020

A new approach to imprinting mutation detection in GNAS by Sequenom EpiTYPER system

scientific article published on 31 August 2010

A new protocol for single-cell RNA-seq reveals stochastic gene expression during lag phase in budding yeast

scientific article published on 18 May 2020

A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling

scientific article published in 2023

A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling

scientific article published on 19 June 2020

A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients

scientific article published on 16 December 2015

A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer

scientific article published on 18 June 2018

A variant at chromosome 9p21 is associated with recurrent myocardial infarction and cardiac death after acute coronary syndrome: the GRACE Genetics Study

scientific article

A variant in FTO gene shows association with histological ulceration in cutaneous melanoma

scientific article published on 12 September 2019

ABCA transporter gene expression and poor outcome in epithelial ovarian cancer

scientific article

ABCG2 Polymorphism rs2231142 and hypothyroidism in metastatic renal cell carcinoma patients treated with sunitinib.

scientific article

Abstract CT135: Uncovering the genomic heterogeneity of multifocal breast cancer

Accelerated lung function decline in smokers: spotlight on vitamin D deficiency

scientific article published on 01 October 2012

Acriflavine Inhibits Acquired Drug Resistance by Blocking the Epithelial-to-Mesenchymal Transition and the Unfolded Protein Response

scientific article

Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial ⬇️

scientific article published on June 5, 2011

Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study

scientific article published on 10 July 2016

Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study

scientific article published on 20 March 2018

Age-related changes in DNA methylation affect renal histology and post-transplant fibrosis

scientific article published on 10 July 2019

Allele-specific DNA methylation reinforces PEAR1 enhancer activity

scientific article

Amplification of 1q32.1 Refines the Molecular Classification of Endometrial Carcinoma

scientific article published on 22 September 2017

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

scientific article published on 01 March 2020

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

scientific article published on 01 January 2020

An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression

scientific article

Analyses of germline variants associated with ovarian cancer survival identify functional candidates at the 1q22 and 19p12 outcome loci

scientific article published on 15 June 2017

Analysis of over 10,000 Cases finds no association between previously reported candidate polymorphisms and ovarian cancer outcome

scientific article published on 19 March 2013

Analysis ofFGGYas a risk factor for sporadic amyotrophic lateral sclerosis

article

Another angiogenic gene linked to amyotrophic lateral sclerosis

scientific article published on 14 July 2006

Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study

scientific article

Assessing the genetic architecture of epithelial ovarian cancer histological subtypes

scientific article

Assessment of concordance between fresh-frozen and formalin-fixed paraffin embedded tumor DNA methylation using a targeted sequencing approach

scientific article

Assessment of hepatocyte growth factor in ovarian cancer mortality

scientific article

Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy

scientific article

Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer

scientific article published on 21 June 2016

Association analysis identifies 65 new breast cancer risk loci.

scientific article published on 23 October 2017

Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer

scientific article

Association of CDH11 with non-syndromic ASD.

scientific article published on 19 May 2014

Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events

scientific article published on 21 March 2019

Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21.

scientific article published on 21 October 2016

Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment

scientific article published on 18 August 2021

Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study

scientific article published on 4 September 2016

Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies

scientific article

Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium

scientific article published on 18 August 2011

Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis

article by Xiang Shu et al published 1 October 2018 in International Journal of Epidemiology

Author Correction: CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

scientific article published on 01 May 2019

Author Correction: PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

correction of a scholarly article

BCL(X)L and BCL2 increase the metabolic fitness of breast cancer cells: a single-cell imaging study

scientific article published on 16 December 2020

BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer

scientific article published on 10 March 2017

BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers

scientific article

Biology of breast cancer during pregnancy using genomic profiling

scientific article published on 13 May 2014

Body mass index and breast cancer survival: a Mendelian randomization analysis

scientific article published in December 2017

Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk

scientific article published on 28 September 2020

Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2

scientific article

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.

scientific article

Breast cancer susceptibility polymorphisms and endometrial cancer risk: a Collaborative Endometrial Cancer Study

scientific article published on 30 September 2011

CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer

scientific article

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

scientific article published on 24 May 2017

CRAF mutations in lung cancer can be oncogenic and predict sensitivity to combined type II RAF and MEK inhibition

scientific article published on 08 July 2019

CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer

scientific article

CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations

scientific article published on 23 September 2013

Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop

scientific article published in 2023

Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop

scientific article published in 2022

Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk

scientific article published in February 2015

Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals

scientific article

Characterization of patient-derived tumor xenograft models of endometrial cancer for preclinical evaluation of targeted therapies

scientific article published on 28 July 2015

Characterization of stromal tumor-infiltrating lymphocytes and genomic alterations in metastatic lobular breast cancer

scientific article published on 17 September 2020

Chromosomal Instability in Cell-Free DNA as a Highly Specific Biomarker for Detection of Ovarian Cancer in Women with Adnexal Masses

scientific article published on 14 November 2016

Chromosome 18q11.2 loss as a predictive marker for response to bevacizumab in metastatic colorectal cancer

Chronic Fatigue Syndrome and DNA Hypomethylation of the Glucocorticoid Receptor Gene Promoter 1F Region: Associations With HPA Axis Hypofunction and Childhood Trauma

scientific article published on 30 July 2015

Cigarette Smoke-Induced Emphysema Exhausts Early Cytotoxic CD8+ T Cell Responses against Nascent Lung Cancer Cells

scientific article published on 23 July 2018

Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer

scientific article published on 22 September 2015

Clinical and genetic risk factors for epirubicin-induced cardiac toxicity in early breast cancer patients

scientific article published on 28 May 2015

Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host

scientific article published on 29 October 2021

Combination of variations in inflammation- and endoplasmic reticulum-associated genes as putative biomarker for bevacizumab response in KRAS wild-type colorectal cancer

scientific article published on 17 June 2020

Combined associations of a polygenic risk score and classical risk factors with breast cancer risk

scientific article published on 02 May 2020

Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk

scientific article published on 19 June 2015

Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC).

scientific article

Common breast cancer susceptibility loci are associated with triple-negative breast cancer

scientific article published on 15 August 2011

Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium

scientific article

Common variants at 19p13 are associated with susceptibility to ovarian cancer

scientific article

Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer

scientific article

Common variants in breast cancer risk loci predispose to distinct tumor subtypes

scientific article published on 4 January 2022

Comparative oncogenomics identifies tyrosine kinase FES as a tumor suppressor in melanoma

scientific article published on 2 May 2017

Comparison of 6q25 breast cancer hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)

scientific article

Comprehensive fine mapping of chr12q12-14 and follow-up replication identify activin receptor 1B (ACVR1B) as a muscle strength gene

scientific article

Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer

scientific article published in October 2015

Comprehensive mutation analysis in colorectal flat adenomas ⬇️

scientific article

Confirmation of 5p12 as a susceptibility locus for progesterone-receptor-positive, lower grade breast cancer

scientific article

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

scientific article published on 07 January 2021

Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk

scientific article

Controlling cellular development in a single cell system of Nicotiana

scientific article published on 01 March 1992

Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy

scientific article published in Nature Communications

Correction: Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)

scientific article published in PLoS ONE

Correlation of Immunological and Molecular Profiles with Response to Crizotinib in Alveolar Soft Part Sarcoma: An Exploratory Study Related to the EORTC 90101 "CREATE" Trial

scientific article published on 19 May 2022

Corrigendum to "Genetic heterogeneity after first-line chemotherapy in high-grade serous ovarian cancer" [Eur J Cancer 53 (2016) 51-64].

scientific article published on 19 April 2016

Cross-cancer genome-wide association study of endometrial cancer and epithelial ovarian cancer identifies genetic risk regions associated with risk of both cancers

scientific article published on 03 November 2020

DNA methylation analysis of Homeobox genes implicates HOXB7 hypomethylation as risk factor for neural tube defects

scientific article

DNA methylation profiling of non-small cell lung cancer reveals a COPD-driven immune-related signature

scientific article published on 08 September 2015

DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance

scientific article published on 27 July 2020

DNA methylation-driven EMT is a common mechanism of resistance to various therapeutic agents in cancer

scientific article published on 14 February 2020

Decoding the activated stem cell phenotype of the neonatally maturing pituitary

scientific article published in 2022

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

scientific article

Developing Organoids from Ovarian Cancer as Experimental and Preclinical Models

scientific article published on 17 March 2020

Differences in MWCNT- and SWCNT-induced DNA methylation alterations in association with the nuclear deposition

scientific article published on 9 February 2018

Discriminating Mild from Critical COVID-19 by Innate and Adaptive Immune Single-cell Profiling of Bronchoalveolar Lavages

scientific article

Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages

scientific article

Do COPD subtypes really exist? COPD heterogeneity and clustering in 10 independent cohorts

scientific article published on 21 June 2017

Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGFdelta/delta mouse model of amyotrophic lateral sclerosis

scientific article

Dual blockade of PI3K/AKT/mTOR (NVP-BEZ235) and Ras/Raf/MEK (AZD6244) pathways synergistically inhibit growth of primary endometrioid endometrial carcinoma cultures, whereas NVP-BEZ235 reduces tumor growth in the corresponding xenograft models

scientific article published on 28 April 2015

Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis

scientific article

Efflux pump ABCB1 single nucleotide polymorphisms and dose reductions in patients with metastatic renal cell carcinoma treated with sunitinib

scientific article

Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci

scientific article published on 19 January 2017

Epidermal Growth Factor Receptor (EGFR) Pathway Biomarkers in the Randomized Phase III Trial of Erlotinib Versus Observation in Ovarian Cancer Patients with No Evidence of Disease Progression after First-Line Platinum-Based Chemotherapy

scientific article

Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer

scientific article published in 2013

Epigenetic effects of carbon nanotubes in human monocytic cells

Epithelial ovarian cancer: rationale for changing the one-fits-all standard treatment regimen to subtype-specific treatment

scientific article published in March 2014

Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk

scientific article

Erratum to: Epidermal Growth Factor Receptor (EGFR) Pathway Biomarkers in the Randomized Phase III Trial of Erlotinib Versus Observation in Ovarian Cancer Patients with No Evidence of Disease Progression after First-Line Platinum-Based Chemotherapy

scientific article published on 8 April 2016

Erratum: Corrigendum: Common variants at 19p13 are associated with susceptibility to ovarian cancer

scholarly article published in Nature Genetics

Erratum: Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma

scientific article published on 01 February 2016

Erratum: Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations

scientific article published on 6 June 2017

Establishing a Unified COVID-19 "Immunome": Integrating Coronavirus Pathogenesis and Host Immunopathology

scientific article published on 03 July 2020

Establishment and Characterization of Histologically and Molecularly Stable Soft-tissue Sarcoma Xenograft Models for Biological Studies and Preclinical Drug Testing

scientific article published on 08 April 2019

Establishment and characterization of uterine sarcoma and carcinosarcoma patient-derived xenograft models.

scientific article published on 16 June 2017

Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study

scientific article published on 17 December 2014

Evaluation of efficacy and safety markers in a phase II study of metastatic colorectal cancer treated with aflibercept in the first-line setting

scientific article

Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women

article

Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors

scientific article published on 27 March 2013

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

scientific article

Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation

scientific article published on 03 September 2016

Exome sequencing reveals HINT1 mutations as a cause of distal hereditary motor neuropathy

scientific article

Experimental and computational modeling for signature and biomarker discovery of renal cell carcinoma progression

scientific article published on 20 October 2021

Exposure-response analysis of endoxifen serum concentrations in early-breast cancer

scientific article published on 29 May 2020

Expression of immune-related genes in rectum and colon descendens of Irritable Bowel Syndrome patients is unrelated to clinical symptoms

scientific article published on 10 March 2019

Expression profiling of budding cells in colorectal cancer reveals an EMT-like phenotype and molecular subtype switching

scientific article

FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium

scientific article published on February 2014

FISH analysis of PTEN in endometrial carcinoma. Comparison with SNP arrays and MLPA.

scientific article

Fibroblast Growth Factor Receptor-2 Polymorphism rs2981582 is Correlated With Progression-free Survival and Overall Survival in Patients With Metastatic Clear-cell Renal Cell Carcinoma Treated With Sunitinib

scientific article published on 16 November 2018

Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs).

scientific article published on 07 September 2016

Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2.

scientific article published on 4 February 2015

Fine-mapping of 150 breast cancer risk regions identifies 178 high confidence target genes

article

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

scientific article published on 07 January 2020

Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk

scientific article

Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer

scientific article

Fine-scale mapping of the 4q24 locus identifies two independent loci associated with breast cancer risk

scientific article

Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1.

scientific article

Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1.

scientific article

Five endometrial cancer risk loci identified through genome-wide association analysis

scientific article published on 02 May 2016

Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element

scientific article published in July 2021

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

scientific article published on 7 September 2016

Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers

scientific article

Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers

scientific article published on 27 March 2013

GLI2 promoter hypermethylation in saliva of children with a respiratory allergy.

scientific article published on 11 April 2018

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer

scientific article published on April 2013

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

Gemcitabine Recruits M2-Type Tumor-Associated Macrophages into the Stroma of Pancreatic Cancer

scientific article published on 04 March 2020

Gene prioritization through genomic data fusion

scientific article

Gene-based interaction analysis shows GABAergic genes interacting with parenting in adolescent depressive symptoms.

scientific article

Gene-environment interactions involving functional variants: Results from the Breast Cancer Association Consortium

scientific article published on 3 July 2017

Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk

scientific article published on 17 December 2018

Genetic Risk Score Mendelian Randomization Shows that Obesity Measured as Body Mass Index, but not Waist:Hip Ratio, Is Causal for Endometrial Cancer

scientific article published on 22 August 2016

Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus

scientific article published on 15 July 2021

Genetic biomarkers in the VEGF pathway predicting response to anti-VEGF therapy in age-related macular degeneration

scientific article published on 17 December 2019

Genetic changes in nonepithelial ovarian cancer

scientific article published on July 2013

Genetic heterogeneity after first-line chemotherapy in high-grade serous ovarian cancer

scientific article published on 13 December 2015

Genetic markers of bevacizumab-induced hypertension

scientific article published on 21 February 2014

Genetic modifiers of CHEK2*1100delC-associated breast cancer risk

scientific article published on 06 October 2016

Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses.

scientific article published on 2 April 2018

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

scientific article published on 21 March 2016

Genetic predisposition scores associate with muscular strength, size, and trainability

scientific article published in August 2013

Genetic predisposition to ductal carcinoma in situ of the breast

scientific article published on 17 February 2016

Genetic predisposition to in situ and invasive lobular carcinoma of the breast

scientific article

Genetic variability in drug transport, metabolism or DNA repair affecting toxicity of chemotherapy in ovarian cancer

scientific article

Genetic variability in the multidrug resistance associated protein-1 (ABCC1/MRP1) predicts hematological toxicity in breast cancer patients receiving (neo-)adjuvant chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide (FEC).

scientific article

Genetic variability of VEGF pathway genes in six randomized phase III trials assessing the addition of bevacizumab to standard therapy

scientific article published on 11 July 2014

Genetic variant in the osteoprotegerin gene is associated with aromatase inhibitor-related musculoskeletal toxicity in breast cancer patients

scientific article published on 19 January 2016

Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome

scientific article

Genetic variants in VEGF pathway genes in neoadjuvant breast cancer patients receiving bevacizumab: Results from the randomized phase III GeparQuinto study

scientific article published on 23 June 2015

Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study

scientific article

Genetic variation in caveolin-1 affects survival after lung transplantation

scientific article published on August 2014

Genetic variation in immunoglobulin G receptor affects survival after lung transplantation

scientific article published on 6 May 2014

Genetic variation in interleukin-17 receptor A is functionally associated with chronic rejection after lung transplantation

scientific article published in December 2013

Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade

scientific article

Genetic variation in the lymphotoxin-α (LTA)/tumour necrosis factor-α (TNFα) locus as a risk factor for idiopathic achalasia

scientific article published on 20 November 2013

Genetics in zebrafish, mice, and humans to dissect congenital heart disease: insights in the role of VEGF.

scientific article

Genetics, epigenetics and pharmaco-(epi)genomics in angiogenesis

scientific article published on December 2008

Genome dynamics of the human embryonic kidney 293 (HEK293) lineage in response to cell biology manipulations

scholarly article by Morgane Boone published in July 2014

Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations

scientific article

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

scientific article published in September 2016

Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium

scientific article

Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2

scientific article

Genome-wide association analysis identifies three new breast cancer susceptibility loci

scientific article published on 22 January 2012

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

scientific article

Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

article

Genome-wide association studies identify four ER negative-specific breast cancer risk loci

scientific article published in April 2013

Genome-wide association study for ovarian cancer susceptibility using pooled DNA.

scientific article published on 13 July 2012

Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

scientific article published on 18 May 2020

Genome-wide association study identifies a common variant associated with risk of endometrial cancer

scientific article

Genome-wide association study identifies a possible susceptibility locus for endometrial cancer

scientific article

Genome-wide association study of germline variants and breast cancer-specific mortality

scientific article published on 21 February 2019

Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA.

scientific article published on 5 November 2013

Genomic Characterisation and Response to Trastuzumab and Paclitaxel in Advanced or Recurrent HER2-positive Endometrial Carcinoma

scientific article published in October 2016

Genomic Characterization of Primary Invasive Lobular Breast Cancer

scientific article

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

scientific article published on 23 September 2016

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

scientific article published on 24 April 2017

Genomic and epigenomic analysis of high-risk prostate cancer reveals changes in hydroxymethylation and TET1.

scientific article published on 21 March 2016

Genomic copy number determines functional expression of {beta}-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease.

scientific article published on 8 April 2010

Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma

scientific article published on 13 July 2015

Genomic signatures as predictive biomarkers of homologous recombination deficiency in ovarian cancer

scientific article published on 23 September 2017

Germline mutation in BRCA1 or BRCA2 and ten-year survival for women diagnosed with epithelial ovarian cancer

scientific article

Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer

scientific article published on 31 January 2016

Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis

scientific article published on 5 October 2021

Global and gene-specific DNA methylation effects of different asbestos fibres on human bronchial epithelial cells

article

Glucocorticoid receptor DNA methylation and childhood trauma in chronic fatigue syndrome patients

scientific article published on 20 November 2017

HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival

scientific article published in February 2016

Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization

scientific article

Heterogeneity in motoneuron disease

scientific article published on 06 September 2007

High-throughput interrogation of PIK3CA, PTEN, KRAS, FBXW7 and TP53 mutations in primary endometrial carcinoma

scientific article published on 4 December 2012

Huvariome: a web server resource of whole genome next-generation sequencing allelic frequencies to aid in pathological candidate gene selection

scientific article published on 19 November 2012

IL1β promotes immune suppression in the tumor microenvironment independent of the inflammasome and gasdermin

scientific article published on 23 December 2020

Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk

scientific article

Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31.

scientific article published on January 2013

Identification and prioritization of NUAK1 and PPP1CC as positional candidate loci for skeletal muscle strength phenotypes

scientific article

Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk

scientific article published on 27 March 2013

Identification of a Locus Near <i>ULK1</i> Associated With Progression-Free Survival in Ovarian Cancer

publication published on 23 June 2021

Identification of a novel predictive genomic biomarker for response to combination bevacizumab in metastatic colorectal cancer (mCRC)

Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer

scientific article published on 27 April 2016

Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus

scientific article

Identification of new genetic susceptibility loci for breast cancer through consideration of gene-environment interactions

scientific article

Identification of nine new susceptibility loci for endometrial cancer

scientific article published in Nature Communications

Identification of novel genetic markers of breast cancer survival

scientific article published on 18 April 2015

Identification of six new susceptibility loci for invasive epithelial ovarian cancer

scientific article published on 12 January 2015

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

scientific article published on 23 October 2017

Identification, clinical-pathological characteristics and treatment outcomes of patients with metastatic breast cancer and somatic human epidermal growth factor receptor 2 (ERBB2) mutations

scientific article published on 19 November 2018

Impact of genetic variability and treatment-related factors on outcome in early breast cancer patients receiving (neo-) adjuvant chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide, and docetaxel

scientific article published on 29 August 2014

Impaired Autonomic Regulation of Resistance Arteries in Mice With Low Vascular Endothelial Growth Factor or Upon Vascular Endothelial Growth Factor Trap Delivery

scientific article published on 06 July 2010

Implementing liquid biopsies into clinical decision making for cancer immunotherapy

scientific article

Improved metabolite identification with MIDAS and MAGMa through MS/MS spectral dataset-driven parameter optimization

scientific article published in 2016

Incorporating progesterone receptor expression into the PREDICT breast prognostic model

scientific article published in 2022

Induction and recovery of CpG site specific methylation changes in human bronchial cells after long-term exposure to carbon nanotubes and asbestos

scientific article published on 18 February 2020

Influence of 23 coronary artery disease variants on recurrent myocardial infarction or cardiac death: the GRACE Genetics Study

scientific article

Influence of rs5065 atrial natriuretic peptide gene variant on coronary artery disease

scientific article published in May 2012

Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: results from a large-scale collaboration

scientific article published on July 2016

Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer

scientific article

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy.

scientific article published on 8 November 2016

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties

scientific article

Integrated genome analysis of uterine leiomyosarcoma to identify novel driver genes and targetable pathways.

scientific article

Interleukin-17 receptor polymorphism predisposes to primary graft dysfunction after lung transplantation

scientific article published on 26 March 2015

International Experts Panel Meeting of the Italian Association of Thoracic Oncology on Antiangiogenetic Drugs for Non-Small Cell Lung Cancer: Realities and Hopes

scientific article published on 5 April 2016

Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors

scientific article

Ischemia-Induced DNA Hypermethylation during Kidney Transplant Predicts Chronic Allograft Injury

It's T Time for Normal Blood Vessels

scientific article published in April 2017

Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium

scientific article published on 5 January 2018

K-ras mutations and cetuximab in colorectal cancer

scientific article published in February 2009

Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair

scientific article published in December 2015

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

scientific article

Large-scale evaluation of common variation in regulatory T cell-related genes and ovarian cancer outcome

scientific article published on 27 January 2014

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

scientific article published in November 2015

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

scientific article

Lessons From the Adjuvant Bevacizumab Trial on Colon Cancer: What Next?

scientific article published on 29 November 2010

Limited potential of genetic predisposition scores to predict muscle mass and strength performance in Flemish Caucasians between 19 and 73 years of age.

scientific article published on 30 December 2016

Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer

scientific article published on 25 May 2020

Lineage-specific functions of TET1 in the postimplantation mouse embryo.

scientific article

Lipid availability determines fate of skeletal progenitor cells via SOX9

scientific article published on 26 February 2020

Loss of 1p36.33 Frequent in Low-Grade Serous Ovarian Cancer

article

Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab

scientific article published on 24 May 2018

Low expression VEGF haplotype increases the risk for tetralogy of Fallot: a family based association study

scientific article

Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium

scientific article

Markers of response for the antiangiogenic agent bevacizumab

scientific article published on 11 February 2013

Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1

scientific article published on 01 November 2010

Medicine: genetic spotlight on a blood defect

scientific article published in February 2004

Melanoma susceptibility variant rs869330 in the MTAP gene is associated with melanoma outcome

scientific article published on 01 December 2019

Mendelian randomisation study of smoking exposure in relation to breast cancer risk

scientific article published in October 2021

Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer

scientific article published on 13 July 2020

Menopausal hormone therapy prior to the diagnosis of ovarian cancer is associated with improved survival

scientific article published on 05 July 2020

Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

scientific article

Meta-analysis of vascular endothelial growth factor variations in amyotrophic lateral sclerosis: increased susceptibility in male carriers of the -2578AA genotype

scientific article published on 15 April 2008

Methylation defect in imprinted genes detected in patients with an Albright's hereditary osteodystrophy like phenotype and platelet Gs hypofunction

scientific article

MicroRNA related polymorphisms and breast cancer risk

scientific article

Microglial upregulation of progranulin as a marker of motor neuron degeneration

scientific article published in December 2010

Microsatellite instable and microsatellite stable primary endometrial carcinoma cells and their subcutaneous and orthotopic xenografts recapitulate the characteristics of the corresponding primary tumor.

scientific article published in March 2015

Mismatch repair deficiency endows tumors with a unique mutation signature and sensitivity to DNA double-strand breaks

scientific article

Mixed adenoneuroendocrine carcinoma of the colon: molecular pathogenesis and treatment.

scientific article published on October 2014

Molecular characterization of 7 new established cell lines from high grade serous ovarian cancer

scientific article

Molecularly targeted therapies for colorectal cancer: Strategies for implementing translational research in clinical trials.

scientific article published on December 2010

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

scientific article published on April 2013

Multivariable regression analysis of febrile neutropenia occurrence in early breast cancer patients receiving chemotherapy assessing patient-related, chemotherapy-related and genetic risk factors

scientific article

Mutation profile and clinical outcome of mixed endometrioid-serous endometrial carcinomas are different from that of pure endometrioid or serous carcinomas

scientific article published on 13 February 2015

Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk

scientific article

Neurogenic Radial Glia-like Cells in Meninges Migrate and Differentiate into Functionally Integrated Neurons in the Neonatal Cortex

scientific article published on 17 November 2016

Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons

scientific article published on 19 January 2011

Neurovascular signalling defects in neurodegeneration

scientific article published on March 2008

Newborn genome-wide DNA methylation in association with pregnancy anxiety reveals a potential role for GABBR1.

scientific article published on 3 October 2017

No Evidence That Genetic Variation in the Myeloid-Derived Suppressor Cell Pathway Influences Ovarian Cancer Survival

scientific article published on 27 September 2016

No association between FTO or HHEX and endometrial cancer risk

scientific article

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.

scientific article published in May 2015

No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing

scientific article published on 26 February 2016

Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration

scientific article

Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium

scientific article

Olmsted syndrome: exploration of the immunological phenotype

scientific article published on 21 May 2013

Opportunities and challenges in the genetics of COPD 2010: an International COPD Genetics Conference report

scientific article

Optimized filtering reduces the error rate in detecting genomic variants by short-read sequencing.

scientific article published on 18 December 2011

Organoids from human tooth showing epithelial stemness phenotype and differentiation potential

scientific article published on 26 February 2022

Outcome of Colorectal Cancer Patients Treated with Combination Bevacizumab Therapy: A Pooled Retrospective Analysis of Three European Cohorts from the Angiopredict Initiative

scientific article published on 19 October 2016

PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS

scientific article published in December 2016

PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

scientific article published in 2022

PHIP - a novel candidate breast cancer susceptibility locus on 6q14.1.

scientific article published on 12 October 2017

PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer

scientific article

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

scientific article

Patient-derived cell line models revealed therapeutic targets and molecular mechanisms underlying disease progression of high grade serous ovarian cancer

scientific article published on 28 May 2019

Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening

scientific article published on 01 August 2019

Pharmaco-epigenomics: discovering therapeutic approaches and biomarkers for cancer therapy

scientific article published on 14 April 2010

Phenotype molding of stromal cells in the lung tumor microenvironment

scientific article published on 09 July 2018

Phospholipase C gamma 1 (PLCG1) R707Q mutation is counterselected under targeted therapy in a patient with hepatic angiosarcoma

scientific article published on 10 October 2015

Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations

scientific article

Phylogenetic reconstruction of breast cancer reveals two routes of metastatic dissemination associated with distinct clinical outcome

scientific article published on 05 June 2020

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

scientific article (publication date: 11 August 2012)

Plasma circulating tumor DNA as an alternative to metastatic biopsies for mutational analysis in breast cancer

scientific article

Platinum sensitivity-related germline polymorphism discovered via a cell-based approach and analysis of its association with outcome in ovarian cancer patients

scientific article

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

scientific article

Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression

scientific article published on 11 June 2015

Polymorphisms in inflammation pathway genes and endometrial cancer risk

scientific article published on 5 December 2012

Polymorphisms in stromal genes and susceptibility to serous epithelial ovarian cancer: a report from the Ovarian Cancer Association Consortium

scientific article published on 27 May 2011

Polymorphisms in the Von Hippel-Lindau Gene Are Associated With Overall Survival in Metastatic Clear-Cell Renal-Cell Carcinoma Patients Treated With VEGFR Tyrosine Kinase Inhibitors.

scientific article published on 5 February 2018

Postmortem Examination of an Aggressive Case of Medullary Thyroid Carcinoma Characterized by Catastrophic Genomic Abnormalities

scientific article published on 05 June 2017

Prediction and clinical utility of a contralateral breast cancer risk model

scientific article published on 17 December 2019

Prediction of breast cancer risk based on profiling with common genetic variants

scientific article published on 8 April 2015

Prediction of contralateral breast cancer: external validation of risk calculators in 20 international cohorts

scientific article published on 11 April 2020

Prediction of lymph node involvement in breast cancer from primary tumor tissue using gene expression profiling and miRNAs

scientific article published on 30 November 2010

Predictors of pretreatment CA125 at ovarian cancer diagnosis: a pooled analysis in the Ovarian Cancer Association Consortium

scientific article published on 3 January 2017

Prevalent breast cancer patients with a homozygous mutant status for CYP2D6*4: response and biomarkers in tamoxifen users.

scientific article published on 12 July 2009

Progesterone receptor gene variants and risk of endometrial cancer

scientific article

Prognostic significance of POLE proofreading mutations in endometrial cancer.

scientific article

Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

scientific article published on 31 March 2008

Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.

scientific article published on 10 April 2018

Publisher Correction: Shared heritability and functional enrichment across six solid cancers

scientific article published on 23 September 2019

Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis ⬇️

scientific article published on 23 August 2018

RNA-sequencing in non-small cell lung cancer shows gene downregulation of therapeutic targets in tumor tissue compared to non-malignant lung tissue

scientific article published on 17 July 2018

Rare germline copy number variants (CNVs) and breast cancer risk

scientific article published on 18 January 2022

Regeneration Defects in Yap and Taz Mutant Mouse Livers are Caused by Bile Duct Disruption and Cholestasis

scientific article published on 27 October 2020

Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis

scientific article published on 08 February 2016

Reproductive profiles and risk of breast cancer subtypes: a multi-center case-only study.

scientific article published on 7 November 2017

Risk of ovarian cancer and the NF-κB pathway: genetic association with IL1A and TNFSF10

scientific article published on 22 November 2013

Role and therapeutic potential of VEGF in the nervous system

scientific article published on April 2009

Role of Gas6 in erythropoiesis and anemia in mice

scientific journal article

Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1

scientific article

Role of VEGF-D and VEGFR-3 in developmental lymphangiogenesis, a chemicogenetic study in Xenopus tadpoles.

scientific article

S3.3d Influenza versus COVID-19-associated pulmonary aspergillosis: Profiling lower respiratory tract epithelial and myeloid innate immunity in patient samples

scientific article published in 2022

SYST-25 MICROGLIA-SECRETED LIPID SPECIES DRIVE GLIOMA INVASION

scientific article published in 2023

Sculpting heart valves with NFATc and VEGF.

scientific article published in September 2004

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis

scientific article published on 01 January 2019

Semiautomated isolation and molecular characterisation of single or highly purified tumour cells from CellSearch enriched blood samples using dielectrophoretic cell sorting

scientific article published on 7 March 2013

Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins

scientific article

Shared genetics underlying epidemiological association between endometriosis and ovarian cancer

scientific article published on 30 July 2015

Shared heritability and functional enrichment across six solid cancers

scientific article published in Nature Communications

Shared heritability and functional enrichment across six solid cancers

Single-cell transcriptome analysis of the Akimba mouse retina reveals cell-type-specific insights into the pathobiology of diabetic retinopathy

scientific article published on 30 July 2020

Single-nucleotide polymorphisms associated with outcome in metastatic renal cell carcinoma treated with sunitinib

scientific article published on March 2013

Solar Lentigines are Associated with Better Outcome in Cutaneous Melanoma

scientific article published on 17 July 2019

Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.

scientific article published on 31 March 2018

Somatic copy number alterations predict response to platinum therapy in epithelial ovarian cancer

scientific article published on 2 October 2014

Somatic mutation profiling and associations with prognosis and trastuzumab benefit in early breast cancer

scientific article published on 05 June 2013

Somatic profiling of the epidermal growth factor receptor pathway in tumors from patients with advanced colorectal cancer treated with chemotherapy ± cetuximab

scientific article published on 05 June 2013

Subsequent Event Risk in Individuals With Established Coronary Heart Disease

scientific article published on 21 March 2019

Successful application of endoscopic ultrasound-guided fine needle biopsy to establish pancreatic patient-derived tumor xenografts: a pilot study

scientific article published on 14 September 2016

Systemic anti-vascular endothelial growth factor therapies induce a painful sensory neuropathy

scientific article published on 25 June 2012

TET enzymes as oxygen-dependent tumor suppressors: exciting new avenues for cancer management.

scientific article

TP53-based interaction analysis identifies cis-eQTL variants for TP53BP2, FBXO28, and FAM53A that associate with survival and treatment outcome in breast cancer

scientific article published on 5 February 2017

Tamoxifen metabolism and efficacy in breast cancer- a prospective multicentre trial

scientific article published on 19 February 2018

Targeting the RhoGEF βPIX/COOL-1 in Glioblastoma: Proof of Concept Studies

scientific article published on 26 November 2020

The 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysema

scientific article published on 10 December 2009

The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin

scientific article published on May 2016

The BRCA2 c.68-7T > A variant is not pathogenic: A model for clinical calibration of spliceogenicity

scientific article published on 20 February 2018

The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts

scientific article published on 28 July 2015

The Emerging Role of DNA Methylation in Kidney Transplantation: A Perspective

scientific article

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

scientific article published on 01 November 2019

The P450 oxidoreductase *28 SNP is associated with low initial tacrolimus exposure and increased dose requirements in CYP3A5-expressing renal recipients

scientific article published on 19 July 2011

The SNP rs6500843 in 16p13.3 is associated with survival specifically among chemotherapy-treated breast cancer patients

scientific article published on April 2015

The antitumor effect of metformin with and without carboplatin on primary endometrioid endometrial carcinoma in vivo

scientific article published on 4 June 2015

The association of the 4q25 susceptibility variant for atrial fibrillation with stroke is limited to stroke of cardioembolic etiology

scientific article

The diagnostic value of next generation sequencing in familial nonsyndromic congenital heart defects

scientific article published on 30 April 2015

The footprint of the ageing stroma in older patients with breast cancer

scientific article

The genetic landscape of 5T models for multiple myeloma

scientific article published in Scientific Reports

The genetic landscape of 87 ovarian germ cell tumors

scientific article published on 28 August 2018

The genomic landscape of nonsmall cell lung carcinoma in never smokers

scientific article published on 10 December 2019

The molecular genetic basis of ovarian cancer and its roadmap towards a better treatment

scientific article published on 07 March 2010

The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing

scientific article published on 8 March 2011

The role of fatty acid β-oxidation in lymphangiogenesis

scientific article published on 26 December 2016

The role of genetic breast cancer susceptibility variants as prognostic factors

scientific article

TheTERT-CLPTM1Llocus for lung cancer predisposes to bronchial obstruction and emphysema ⬇️

scientific article published on May 26, 2011

Therapeutic potential of VEGF and VEGF-derived peptide in peripheral neuropathies

scientific article published on 11 April 2013

Thrombomodulin mutations in atypical hemolytic-uremic syndrome

scientific article

Transcriptome-wide association study of breast cancer risk by estrogen-receptor status

scientific article published on 01 March 2020

Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis.

scientific article published on 23 November 2015

Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.

scientific article

Tumors smother their epigenome

scientific article published on 30 September 2016

Tumour hypoxia causes DNA hypermethylation by reducing TET activity

scientific article published on 17 August 2016

Two truncating variants in FANCC and breast cancer risk

scientific article published on 29 August 2019

Uncovering the genomic heterogeneity of multifocal breast cancer

scientific article

Underestimated and under-recognized: the late consequences of acute coronary syndrome (GRACE UK-Belgian Study).

scientific article published on 30 August 2010

Use of different genetic predisposition score techniques to predict muscle mass and muscle function over the adult life span in Flemish Caucasians.

scientific article published on 17 September 2015

VEGF at the neurovascular interface: therapeutic implications for motor neuron disease

scientific article

VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death

scientific article published in August 2003

VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: an analysis of data from the AViTA and AVOREN randomised trials

scientific article

VEGF receptor-2 (Flk-1) overexpression in mice counteracts focal epileptic seizures

scientific article

VEGF: a modifier of the del22q11 (DiGeorge) syndrome?

scientific article published on 21 January 2003

VEGF: necessary to prevent motoneuron degeneration, sufficient to treat ALS?

scientific article published on June 2004

VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection

scientific article

VEGFR1 single nucleotide polymorphisms associated with outcome in patients with metastatic renal cell carcinoma treated with sunitinib - a multicentric retrospective analysis.

scientific article published on 20 February 2013

Validation of VEGFR1 rs9582036 as predictive biomarker in metastatic clear-cell renal cell carcinoma patients treated with sunitinib

scientific article published on 15 July 2016

Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility

scientific article published in PLoS ONE

Variants in the 15q24/25 locus associate with lung function decline in active smokers

scientific article

Variation in NF-κB signaling pathways and survival in invasive epithelial ovarian cancer

scientific article published on 16 April 2014

Vascular endothelial growth factor pathway in endometriosis: genetic variants and plasma biomarkers

scientific article published on 7 January 2016

Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene

scientific article published on 08 December 2009

Vitamin D status at breast cancer diagnosis: correlation with tumor characteristics, disease outcome, and genetic determinants of vitamin D insufficiency

scientific article published on 23 May 2012

Whole-genome sequencing reveals a coding non-pathogenic variant tagging a non-coding pathogenic hexanucleotide repeat expansion in C9orf72 as cause of amyotrophic lateral sclerosis

scientific article

Why should results from metastatic trials no longer matter for early-stage disease?

scientific article published on 17 June 2013

p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity

scientific article published on 4 July 2016

rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology

scientific article published on 21 August 2018

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