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List of works by Akseli Hemminki

2-Weekly versus 3-weekly docetaxel to treat castration-resistant advanced prostate cancer: a randomised, phase 3 trial

scientific article published on 4 January 2013

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

A canine conditionally replicating adenovirus for evaluating oncolytic virotherapy in a syngeneic animal model

scientific article published in February 2003

A fiber-modified, secretory leukoprotease inhibitor promoter-based conditionally replicating adenovirus for treatment of ovarian cancer.

scientific article published on February 2005

A new generation of serotype chimeric infectivity-enhanced conditionally replicative adenovirals: the safety profile of ad5/3-Δ24 in advance of a phase I clinical trial in ovarian cancer patients

scientific article

A phase I/II trial of gefitinib given concurrently with radiotherapy in patients with nonmetastatic prostate cancer

scientific article published on 11 December 2009

A phase II trial of gefitinib in patients with rising PSA following radical prostatectomy or radiotherapy ⬇️

scientific article published on 01 January 2012

A recombinant adenovirus type 35 fiber knob protein sensitizes lymphoma cells to rituximab therapy

scientific article

Abscopal Effect in Non-injected Tumors Achieved with Cytokine-Armed Oncolytic Adenovirus

Ad3-hTERT-E1A, a Fully Serotype 3 Oncolytic Adenovirus, in Patients With Chemotherapy Refractory Cancer ⬇️

scientific article published on August 7, 2012

Ad5/3 is able to avoid neutralization by binding to erythrocytes and lymphocytes

scientific article published on 12 September 2020

Adenoviral Delivery of Tumor Necrosis Factor-α and Interleukin-2 Enables Successful Adoptive Cell Therapy of Immunosuppressive Melanoma

scientific article published on 30 June 2016

Adenoviral E4orf3 and E4orf6 proteins, but not E1B55K, increase killing of cancer cells by radiotherapy in vivo

scientific article published on 9 September 2010

Adenoviral gene therapy for cancer: from vectors to targeted and replication competent agents (review).

scientific article

Adenoviral gene therapy for renal cancer requires retargeting to alternative cellular receptors

scientific article published in August 2002

Adenoviral production of interleukin-2 at the tumor site removes the need for systemic postconditioning in adoptive cell therapy

scientific article published on 14 June 2017

Adenovirus Coding for Interleukin-2 and Tumor Necrosis Factor Alpha Replaces Lymphodepleting Chemotherapy in Adoptive T Cell Therapy

scholarly article by João Manuel Santos published in September 2018

Adenovirus Improves the Efficacy of Adoptive T-cell Therapy by Recruiting Immune Cells to and Promoting Their Activity at the Tumor

scientific article

Adenoviruses for treatment of cancer

scientific article

Adenoviruses in oncology: a viable option?

scientific article

Adenoviruses with an RGD-4C modification of the fiber knob elicit a neutralizing antibody response but continue to allow enhanced gene delivery

scientific article published in February 2005

Adenoviruses with an αvβ integrin targeting moiety in the fiber shaft or the HI-loop increase tumor specificity without compromising antitumor efficacy in magnetic resonance imaging of colorectal cancer metastases

scientific article

Adjuvant capecitabine in combination with docetaxel and cyclophosphamide plus epirubicin for breast cancer: an open-label, randomised controlled trial

scientific article published on 10 November 2009

Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer

scientific article

An adenovirus vector with a chimeric fiber derived from canine adenovirus type 2 displays novel tropism

scientific article published on June 2004

An oncolytic adenovirus enhanced for toll-like receptor 9 stimulation increases antitumor immune responses and tumor clearance

scientific article

Analysis of epithelial and mesenchymal markers in ovarian cancer reveals phenotypic heterogeneity and plasticity

scientific article

Analysis of predictive and prognostic factors in 290 patients treated with oncolytic adenoviruses.

scientific article published on 4 November 2015

Anti-tumor activity of a miR-199-dependent oncolytic adenovirus

scientific article (publication date: 2013)

Antiangiogenic arming of an oncolytic vaccinia virus enhances antitumor efficacy in renal cell cancer models

scientific article

Antiviral and antitumor T-cell immunity in patients treated with GM-CSF-coding oncolytic adenovirus

scientific article

Biodistribution Analysis of Oncolytic Adenoviruses in Patient Autopsy Samples Reveals Vascular Transduction of Noninjected Tumors and Tissues

scientific article published on 9 July 2015

Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity ⬇️

scientific article published on April 21, 2003

CD40 is expressed on ovarian cancer cells and can be utilized for targeting adenoviruses

scientific article published in February 2003

CD40L coding oncolytic adenovirus allows long-term survival of humanized mice receiving dendritic cell therapy

scholarly article by Sadia Zafar et al published 2018 in OncoImmunology

Calcium gluconate in phosphate buffered saline increases gene delivery with adenovirus type 5.

scientific article

Cancer, stem cells, and oncolytic viruses

scientific article published on January 2008

Cancer-targeted oncolytic adenoviruses for modulation of the immune system

scientific article published on 2 May 2017

Capsid modifications overcome low heterogeneous expression of heparan sulfate proteoglycan that limits AAV2-mediated gene transfer and therapeutic efficacy in human ovarian carcinoma

scientific article published on 25 July 2006

Capsid-modified adenoviral vectors for improved muscle-directed gene therapy

scientific article published on 13 August 2012

Case-control estimation of the impact of oncolytic adenovirus on the survival of patients with refractory solid tumors

scientific article published on 10 November 2014

Causes of death in patients with extranodal cancer of unknown primary: searching for the primary site

scientific article

Chapter eight--Oncolytic adenoviruses for cancer immunotherapy: data from mice, hamsters, and humans

scientific article

Chlorpromazine and apigenin reduce adenovirus replication and decrease replication associated toxicity

scientific article published in January 2007

Chronic Activation of Innate Immunity Correlates With Poor Prognosis in Cancer Patients Treated With Oncolytic Adenovirus

scientific article published on 27 August 2015

Collection and use of family history in oncology clinics

scientific article published on 2 September 2014

Combinatorial treatment with oncolytic adenovirus and helper-dependent adenovirus augments adenoviral cancer gene therapy

scientific article published on 17 December 2014

Common cancers share familial susceptibility: implications for cancer genetics and counselling

scientific article

Comparison of survival of patients with metastases from known versus unknown primaries: survival in metastatic cancer

scientific article

Concordant and discordant familial cancer: Familial risks, proportions and population impact

scientific article published on 22 December 2016

Conditionally replicative adenoviruses for ovarian cancer therapy

scientific article

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

scientific article published on 01 March 2020

Consensus guidelines for the detection of immunogenic cell death

scientific article published on October 2014

Corrigendum to "Adenoviral Delivery of Tumor Necrosis Factor-α and Interleukin-2 Enables Successful Adoptive Cell Therapy of Immunosuppressive Melanoma".

scientific article published in November 2016

Dasatinib Changes Immune Cell Profiles Concomitant with Reduced Tumor Growth in Several Murine Solid Tumor Models

scientific article published on 10 January 2017

Defects in innate immunity render breast cancer initiating cells permissive to oncolytic adenovirus

scientific article

Deficiency of the complex I of the mitochondrial respiratory chain but improved adenylate control over succinate-dependent respiration are human gastric cancer-specific phenomena

scientific article

Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14.

scientific article

Discovery of a new PCC-mediated stereoselective oxidative spiroketalization process. An access to a new type of poly-THF spiroketal compound displaying anticancer activity

Discovery of a novel one-step RuO4-catalysed tandem oxidative polycyclization/double spiroketalization process. Access to a new type of polyether bis-spiroketal compound displaying antitumour activity

Effects of capsid-modified oncolytic adenoviruses and their combinations with gemcitabine or silica gel on pancreatic cancer

scientific article

Enhanced therapeutic efficacy for ovarian cancer with a serotype 3 receptor-targeted oncolytic adenovirus

scientific article published in September 2003

Epithelial phenotype confers resistance of ovarian cancer cells to oncolytic adenoviruses

scientific article published on 02 June 2009

Evaluation of a selectively oncolytic adenovirus for local and systemic treatment of cervical cancer

scientific article published in August 2004

Evaluation of tissue-specific promoters in carcinomas of the cervix uteri

scientific article published on November 2004

Familial Associations Between Prostate Cancer and Other Cancers

scientific article published on 4 August 2016

Familial Associations of Colorectal Cancer with Other Cancers

scientific article

Familial associations of female breast cancer with other cancers

scientific article published on 12 August 2017

Familial associations of male breast cancer with other cancers

scientific article

Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors

scientific article published on 24 June 2015

Fc-gamma receptor polymorphisms as predictive and prognostic factors in patients receiving oncolytic adenovirus treatment

scientific article published on 21 August 2013

GMCSF-armed vaccinia virus induces an antitumor immune response

scientific article published on 10 July 2014

Gene expression analysis of tumors demonstrates an induction of Th1 type immune response following intratumoral administration of ONCOS-102 in refractory solid tumor patients

scientific article published on 6 November 2014

Gene therapy of gynaecological diseases

scientific article published on September 2007

Gene transfer approaches for gynecological diseases

scientific article published on 2 May 2006

Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses

scientific article

Gene-expression profiling predicts recurrence in Dukes' C colorectal cancer

scientific article published in September 2005

Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific MicroRNA.

scientific article

Genetic replacement of the adenovirus shaft fiber reduces liver tropism in ovarian cancer gene therapy

scientific article published on May 2004

Genetics of gallbladder cancer

scientific article published in June 2017

Harmful impact of EU clinical trials directive

scientific article published in March 2006

Human adenovirus replication in immunocompetent Syrian hamsters can be attenuated with chlorpromazine or cidofovir

scientific article

Human mesenchymal stem cells lack tumor tropism but enhance the antitumor activity of oncolytic adenoviruses in orthotopic lung and breast tumors

scientific article published in July 2007

Identifying the safety profile of Ad5.SSTR/TK.RGD, a novel infectivity-enhanced bicistronic adenovirus, in anticipation of a phase I clinical trial in patients with recurrent ovarian cancer.

scientific article

Immune response is an important aspect of the antitumor effect produced by a CD40L-encoding oncolytic adenovirus

scientific article

Immunological data from cancer patients treated with Ad5/3-E2F-Δ24-GMCSF suggests utility for tumor immunotherapy ⬇️

scientific article

Immunological effects of a tumor necrosis factor alpha-armed oncolytic adenovirus

scientific article

Immunological effects of low-dose cyclophosphamide in cancer patients treated with oncolytic adenovirus

scientific article

Improving adoptive T cell therapy with adenoviruse armed with TNF-α and IL-2.

scientific article published on 4 November 2015

In vivo and in vitro distribution of type 5 and fiber-modified oncolytic adenoviruses in human blood compartments

scientific article published on 25 January 2011

In vivo molecular chemotherapy and noninvasive imaging with an infectivity-enhanced adenovirus

scientific article

Incidence Differences Between First Primary Cancers and Second Primary Cancers Following Skin Squamous Cell Carcinoma as Etiological Clues

scientific article published on 06 August 2020

Incidence of Hereditary Nonpolyposis Colorectal Cancer and the Feasibility of Molecular Screening for the Disease

article

Incomplete but infectious vaccinia virions are produced in the absence of oncolysis in feline SCCF1 cells

scientific article published on 23 March 2015

Increased expression of tumor-associated trypsin inhibitor, TATI, in prostate cancer and in androgen-independent 22Rv1 cells

scientific article published on 5 February 2007

Induction of Interferon Pathways Mediates In Vivo Resistance to Oncolytic Adenovirus ⬇️

scientific article published on July 26, 2011

Infectivity-enhanced adenoviruses deliver efficacy in clinical samples and orthotopic models of disseminated gastric cancer

scientific article published in May 2006

Integrin targeted oncolytic adenoviruses Ad5-D24-RGD and Ad5-RGD-D24-GMCSF for treatment of patients with advanced chemotherapy refractory solid tumors

scientific article published on 8 August 2011

Inter-patient variation in efficacy of five oncolytic adenovirus candidates for ovarian cancer therapy

scientific article

Interleukin 8 activity influences the efficacy of adenoviral oncolytic immunotherapy in cancer patients

scientific article published on 5 January 2018

Intestinal cancer in patients with a germline mutation in the down-regulated in adenoma (DRA) gene

article

Intravenously usable fully serotype 3 oncolytic adenovirus coding for CD40L as an enabler of dendritic cell therapy

scientific article published on 7 December 2016

Local immunotherapy with ONCOS-102 shapes harmful tumor associated CD68+ macrophages to become beneficial cells that correlate with increased overall survival

scientific article published on 4 November 2015

Location of metastases in cancer of unknown primary are not random and signal familial clustering

scientific article published on 9 March 2016

Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer

article

Metastatic spread in patients with gastric cancer

scientific article published on 20 July 2016

MicroRNA-mediated suppression of oncolytic adenovirus replication in human liver

scientific article

Mitochondrial myopathy induces a starvation-like response

scientific article published on 23 July 2010

Modified adenoviruses for cancer gene therapy

scientific article published on July 2004

Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression.

scientific article published in February 2003

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

scientific article

Molecular imaging and treatment of malignant gliomas following adenoviral transfer of the herpes simplex virus-thymidine kinase gene and the somatostatin receptor subtype 2 gene

scientific article published on February 2004

Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation

scientific article

Multicellular tumor spheroids in gene therapy and oncolytic virus therapy.

scientific article published in August 2004

Multimerization of adenovirus serotype 3 fiber knob domains is required for efficient binding of virus to desmoglein 2 and subsequent opening of epithelial junctions

scientific article published on 27 April 2011

Multimodal Primary Treatment of Metastatic Prostate Cancer with Androgen Deprivation and Radiation

scientific article published in December 2016

Multimodal approach using oncolytic adenovirus, cetuximab, chemotherapy and radiotherapy in HNSCC low passage tumour cell cultures

scientific article published on 16 December 2009

Multiple myeloma: family history and mortality in second primary cancers

scholarly article by Subhayan Chattopadhyay et al published 7 August 2018 in Blood Cancer Journal

Mutation of the fiber shaft heparan sulphate binding site of a 5/3 chimeric adenovirus reduces liver tropism

scientific article

Noninvasive imaging for evaluation of the systemic delivery of capsid-modified adenoviruses in an orthotopic model of advanced lung cancer

scientific article published in October 2006

Novel cGMP liposomal vectors mediate efficient gene transfer

scientific article published on April 2003

Oncograms Visualize Factors Influencing Long-Term Survival of Cancer Patients Treated with Adenoviral Oncolytic Immunotherapy.

scientific article published on 22 April 2018

Oncolytic Adenovirus Expressing Monoclonal Antibody Trastuzumab for Treatment of HER2-Positive Cancer

scientific article published on 25 July 2016

Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy

scientific article published on 31 December 2016

Oncolytic adenovirus Ad5/3-delta24 and chemotherapy for treatment of orthotopic ovarian cancer

scientific article published on 22 October 2007

Oncolytic adenovirus ICOVIR-7 in patients with advanced and refractory solid tumors

scientific article published on 25 May 2010

Oncolytic adenovirus and doxorubicin-based chemotherapy results in synergistic antitumor activity against soft-tissue sarcoma

scientific article

Oncolytic adenovirus coding for granulocyte macrophage colony-stimulating factor induces antitumoral immunity in cancer patients

scientific article

Oncolytic adenovirus improves anti-tumor efficacy of adoptive T cell therapy by breaking tumor-induced immunosuppression and peripheral tolerance.

scientific article published on 4 November 2015

Oncolytic adenovirus shapes the ovarian tumor microenvironment for potent tumor-infiltrating lymphocyte tumor reactivity

scientific article published on 01 January 2020

Oncolytic adenovirus treatment of a patient with refractory neuroblastoma

scientific article

Oncolytic adenovirus with temozolomide induces autophagy and antitumor immune responses in cancer patients

scientific article published on 02 April 2013

Oncolytic adenoviruses for the treatment of human cancer: focus on translational and clinical data

scientific article

Oncolytic adenoviruses kill breast cancer initiating CD44+CD24-/low cells

scientific article

Oncolytic adenoviruses: A potent form of tumor immunovirotherapy

scientific article published on September 2012

Oncolytic immunotherapy of advanced solid tumors with a CD40L-expressing replicating adenovirus: assessment of safety and immunologic responses in patients

scientific article published on 9 February 2012

Oncolytic immunotherapy: where are we clinically?

scientific article

Oncolytic vaccinia virus for the treatment of cancer

scientific article published on 22 February 2011

Oncolytic virotherapy for treatment of breast cancer, including triple-negative breast cancer

scientific article published on 27 August 2015

Oncolytic viruses for induction of anti-tumor immunity

scientific article

Optimized mouse model for the imaging of tumor metastasis upon experimental therapy

scientific article

Other cancers in lung cancer families are overwhelmingly smoking-related cancers

scientific article

Overcoming tumor resistance by heterologous adeno-poxvirus combination therapy

scientific article published on 7 January 2015

Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses.

scientific article published on 5 April 2018

Patterns of metastasis in colon and rectal cancer

scientific article published on 15 July 2016

Portrait of a leader in immunotherapeutics: oncolytic viruses for treatment of cancer

scientific article published on August 2012

Predictive and Prognostic Clinical Variables in Cancer Patients Treated With Adenoviral Oncolytic Immunotherapy

scientific article published on 4 April 2016

Production of an EGFR targeting molecule from a conditionally replicating adenovirus impairs its oncolytic potential

scientific article published in August 2003

Radiation-induced upregulation of gene expression from adenoviral vectors mediated by DNA damage repair and regulation

scientific article

Rate differences between first and second primary cancers may outline immune dysfunction as a key risk factor

scientific article published on 22 September 2020

Replacement of adenovirus type 5 fiber shaft heparan sulfate proteoglycan-binding domain with RGD for improved tumor infectivity and targeting

scientific article

Replication of an integrin targeted conditionally replicating adenovirus on primary ovarian cancer spheroids ⬇️

scientific article published on May 1, 2003

Risk of other Cancers in Families with Melanoma: Novel Familial Links

scientific article published on 15 February 2017

SMAD genes in juvenile polyposis

article

SMAD4 levels and response to 5-fluorouracil in colorectal cancer

scientific article

SPECT/CT imaging of hNIS-expression after intravenous delivery of an oncolytic adenovirus and 131I

scientific article

Safety and biodistribution of a double-deleted oncolytic vaccinia virus encoding CD40 ligand in laboratory Beagles

scientific article published on 10 December 2014

Safety of glucocorticoids in cancer patients treated with oncolytic adenoviruses

scientific article published on 8 November 2010

Second primary cancer after female breast cancer: Familial risks and cause of death.

scientific article published on 26 November 2018

Second primary cancers in non-Hodgkin lymphoma: Bidirectional analyses suggesting role for immune dysfunction

scientific article published on 21 September 2018

Second primary cancers in non-Hodgkin lymphoma: Family history and survival

scientific article published on 15 May 2019

Serotype chimeric and fiber-mutated adenovirus Ad5/19p-HIT for targeting renal cancer and untargeting the liver

scientific article

Serotype chimeric human adenoviruses for cancer gene therapy

scientific article published on 30 September 2010

Serotype chimeric oncolytic adenovirus coding for GM-CSF for treatment of sarcoma in rodents and humans

scientific article

Serum HMGB1 is a predictive and prognostic biomarker for oncolytic immunotherapy

scientific article published on March 2015

Serum and ascites neutralizing antibodies in ovarian cancer patients treated with intraperitoneal adenoviral gene therapy

scientific article published in August 2002

Site‐specific survival rates for cancer of unknown primary according to location of metastases ⬇️

scientific article published on January 15, 2013

Smoking and body mass index as risk factors for subtypes of cancer of unknown primary

scientific article published on 20 May 2014

Sodium iodide symporter SPECT imaging of a patient treated with oncolytic adenovirus Ad5/3-Δ24-hNIS

scientific article published on April 2011

Switching the fiber knob of oncolytic adenoviruses to avoid neutralizing antibodies in human cancer patients

scientific article published in May 2011

Syngeneic syrian hamster tumors feature tumor-infiltrating lymphocytes allowing adoptive cell therapy enhanced by oncolytic adenovirus in a replication permissive setting

scientific article published on 18 February 2016

Systemic adenoviral gene delivery to orthotopic murine breast tumors with ablation of coagulation factors, thrombocytes and Kupffer cells

scientific article

Systemic efficacy of oncolytic adenoviruses in imagable orthotopic models of hormone refractory metastatic breast cancer

scientific article published on July 2007

Systemic therapy for cervical cancer with potentially regulatable oncolytic adenoviruses ⬇️

scientific article

T-Cell Therapy Enabling Adenoviruses Coding for IL2 and TNFα Induce Systemic Immunomodulation in Mice With Spontaneous Melanoma

scientific article published on November 2016

TILT Biotherapeutics

scientific article published in March 2017

Targeted chemotherapy for head and neck cancer with a chimeric oncolytic adenovirus coding for bifunctional suicide protein FCU1.

scientific article published on 13 April 2010

Targeted radiotherapy for prostate cancer with an oncolytic adenovirus coding for human sodium iodide symporter

scientific article

Targeting adenovirus to the serotype 3 receptor increases gene transfer efficiency to ovarian cancer cells.

scientific article

The challenges of understanding cancer of unknown primary

scientific article published on 7 March 2013

The cyclo-oxygenase 2 promoter is induced in nontarget cells following adenovirus infection, but an AU-rich 3'-untranslated region destabilization element can increase specificity

scientific article

The epidemiology of metastases in neuroendocrine tumors

scientific article published on 23 August 2016

The flt-1 promoter for transcriptional targeting of teratocarcinoma.

scientific article

The secretory leukoprotease inhibitor (SLPI) promoter for ovarian cancer gene therapy ⬇️

scientific article published on April 1, 2003

Tissue-specific promoters active in CD44+CD24-/low breast cancer cells

scientific article

Tissue-specific promoters for cancer gene therapy

scientific article published on May 2004

Treatment efficacy and immune stimulation by AdCD40L gene therapy of spontaneous canine malignant melanoma

scientific article published on July 2013

Treatment of cancer patients with a serotype 5/3 chimeric oncolytic adenovirus expressing GMCSF.

scientific article

Treatment of chemotherapy-refractory cancer in the advanced therapy access program

scientific article published on September 2012

Treatment of melanoma with a serotype 5/3 chimeric oncolytic adenovirus coding for GM-CSF: Results in vitro, in rodents and in humans

scientific article

Treatment of metastatic renal cancer with capsid-modified oncolytic adenoviruses

scientific article published in October 2007

Treatment of ovarian cancer with a tropism modified oncolytic adenovirus.

scientific article published in March 2002

Treatment of prostate cancer with Ad5/3Delta24hCG allows non-invasive detection of the magnitude and persistence of virus replication in vivo

scientific article published in February 2007

Triple-targeted oncolytic adenoviruses featuring the cox2 promoter, E1A transcomplementation, and serotype chimerism for enhanced selectivity for ovarian cancer cells

scientific article published on 31 March 2006

VP22 does not significantly enhance enzyme prodrug cancer gene therapy as a part of a VP22-HSVTk-GFP triple fusion construct.

scientific article

Verapamil results in increased blood levels of oncolytic adenovirus in treatment of patients with advanced cancer

scientific article published on November 2011

Virotherapy as an approach against cancer stem cells

scientific article published on April 2008

[(18)F]-fluorodeoxyglucose positron emission tomography and computed tomography in response evaluation of oncolytic adenovirus treatments of patients with advanced cancer

scientific article published on 7 November 2013

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