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List of works by Daniel A. Portnoy

(p)ppGpp and c-di-AMP Homeostasis Is Controlled by CbpB in Listeria monocytogenes

scientific article published on 25 August 2020

A Multiorgan Trafficking Circuit Provides Purifying Selection of Listeria monocytogenes Virulence Genes

scientific article published on 17 December 2019

A Potent and Effective Suicidal Listeria Vaccine Platform

scientific article published on 23 July 2019

A bacterial pore-forming toxin forms aggregates in cells that resemble those associated with neurodegenerative diseases

scientific article published on 6 December 2007

A flavin-based extracellular electron transfer mechanism in diverse Gram-positive bacteria

scientific article published in Nature

A prl mutation in SecY suppresses secretion and virulence defects of Listeria monocytogenes secA2 mutants

scientific article

A specific gene expression program triggered by Gram-positive bacteria in the cytosol

scholarly article

Actin-based motility allows Listeria monocytogenes to avoid autophagy in the macrophage cytosol

scientific article published on 30 May 2018

Activation of immature hepatic NK cells as immunotherapy for liver metastatic disease

scientific article published on December 2007

Activation of the Listeria monocytogenes Virulence Program by a Reducing Environment.

scientific article published on 17 October 2017

Activity of the Pore-Forming Virulence Factor Listeriolysin O Is Reversibly Inhibited by Naturally Occurring S-Glutathionylation.

scientific article published on 30 January 2017

An In Vivo Selection Identifies Listeria monocytogenes Genes Required to Sense the Intracellular Environment and Activate Virulence Factor Expression.

scientific article

An Inducible Cre-lox System to Analyze the Role of LLO in Listeria monocytogenes Pathogenesis

scientific article published on 07 January 2020

Avoidance of autophagy mediated by PlcA or ActA is required for Listeria monocytogenes growth in macrophages

scientific article

Bacterial growth in the cytosol: lessons from Listeria

Bacterial ligands generated in a phagosome are targets of the cytosolic innate immune system

scientific article

Comparison of widely used Listeria monocytogenes strains EGD, 10403S, and EGD-e highlights genomic variations underlying differences in pathogenicity

scientific article published on 25 March 2014

Construction, Characterization, and Use of Two Site-Specific Phage Integration Vectors

scientific article published in 2003

Construction, characterization, and use of two Listeria monocytogenes site-specific phage integration vectors

scientific article

Correction: Listeria monocytogenes Traffics from Maternal Organs to the Placenta and Back

scientific article published on 28 July 2006

Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection

scientific article published on 28 May 2013

Cytosolic entry controls CD8+-T-cell potency during bacterial infection

scientific article

Detoxification of methylglyoxal by the glyoxalase system is required for glutathione availability and virulence activation in Listeria monocytogenes

scientific article published on 18 August 2021

Development of a Single-Gene, Signature-Tag-Based Approach in Combination with Alanine Mutagenesis To Identify Listeriolysin O Residues Critical for theIn VivoSurvival of Listeria monocytogenes ⬇️

scientific article published on March 26, 2012

Development of a mariner-based transposon and identification of Listeria monocytogenes determinants, including the peptidyl-prolyl isomerase PrsA2, that contribute to its hemolytic phenotype

scientific article published on 17 April 2009

Distinct TLR- and NLR-mediated transcriptional responses to an intracellular pathogen

scientific article

Drosophila S2 cells: an alternative infection model for Listeria monocytogenes

scientific article published on December 2003

Dynamic imaging of the effector immune response to listeria infection in vivo

scientific article

Ena/VASP proteins contribute to Listeria monocytogenes pathogenesis by controlling temporal and spatial persistence of bacterial actin-based motility.

scientific article published in September 2003

Extracellular electron transfer powers flavinylated extracellular reductases in Gram-positive bacteria

scientific article published on 09 December 2019

Glutathione activates virulence gene expression of an intracellular pathogen.

scientific article

Growth of Listeria monocytogenes in the guinea pig placenta and role of cell-to-cell spread in fetal infection

scientific article published on 26 April 2005

Host actin polymerization tunes the cell division cycle of an intracellular pathogen.

scientific article

Hyperinduction of Host Beta Interferon by a Listeria monocytogenes Strain Naturally Overexpressing the Multidrug Efflux Pump MdrT ⬇️

scientific article published on January 30, 2012

Identification of Coxiella burnetii CD8+ T-Cell Epitopes and Delivery by Attenuated Listeria monocytogenes as a Vaccine Vector in a C57BL/6 Mouse Model

scientific article

Identification of a second Listeria secA gene associated with protein secretion and the rough phenotype

scientific article published in August 2002

Inducible control of virulence gene expression in Listeria monocytogenes: temporal requirement of listeriolysin O during intracellular infection

scientific article

Innate immune pathways triggered by Listeria monocytogenes and their role in the induction of cell-mediated immunity

scientific article published on January 2012

Innate recognition of bacteria by a macrophage cytosolic surveillance pathway

scientific article

Killed but metabolically active Bacillus anthracis vaccines induce broad and protective immunity against anthrax

scientific article published on 21 January 2009

Listening to each other: Infectious disease and cancer immunology

scientific article

Listeria intracellular growth and virulence require host-derived lipoic acid

scientific article published on October 2003

Listeria monocytogenes 6-Phosphogluconolactonase mutants induce increased activation of a host cytosolic surveillance pathway

scientific article published on 27 April 2009

Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity ⬇️

scientific article published on July 11, 2011

Listeria monocytogenes is resistant to lysozyme through the regulation, not the acquisition, of cell wall-modifying enzymes

scientific article

Listeria monocytogenes multidrug resistance transporters activate a cytosolic surveillance pathway of innate immunity

scholarly article

Listeria monocytogenes mutants that fail to compartmentalize listerolysin O activity are cytotoxic, avirulent, and unable to evade host extracellular defenses

scientific article

Listeria monocytogenes traffics from maternal organs to the placenta and back

scientific article

Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol.

scientific article

Listeria monocytogenes triggers noncanonical autophagy upon phagocytosis, but avoids subsequent growth-restricting xenophagy

scientific article published on 26 December 2017

Listeria-based cancer vaccines that segregate immunogenicity from toxicity

scholarly article

Listeriolysin O is necessary and sufficient to induce autophagy during Listeria monocytogenes infection

scientific article

Listeriolysin O secreted by Listeria monocytogenes into the host cell cytosol is degraded by the N-end rule pathway

scientific article

Listeriolysin O: A phagosome-specific cytolysin revisited

scientific article published on 15 January 2019

Listeriolysin O: a phagosome-specific lysin

scientific article published on 07 May 2007

Listeriosis in the pregnant guinea pig: a model of vertical transmission

scientific article

Manipulation of innate immunity by bacterial pathogens

scientific article

Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes

scientific article

Microbial pathogenesis and the eukaryotic cytoskeleton at the American Society for Cell Biology annual meeting

scientific article published in March 2002

Modified STING-activating cyclic dinucleotide derivatives significantly enhance the anti-tumor activity of therapeutic vaccines

scientific article published on 7 November 2013

Mutations of the Listeria monocytogenes peptidoglycan N-deacetylase and O-acetylase result in enhanced lysozyme sensitivity, bacteriolysis, and hyperinduction of innate immune pathways

scientific article

Mycobacterium Tuberculosis Activates the DNA-Dependent Cytosolic Surveillance Pathway within Macrophages ⬇️

scientific article published on May 17, 2012

Oral infection with signature-tagged Listeria monocytogenes reveals organ-specific growth and dissemination routes in guinea pigs

scientific article published on 14 November 2011

Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system

scientific article published on July 2009

Phosphorylation, ubiquitination and degradation of listeriolysin O in mammalian cells: role of the PEST-like sequence

scientific article

Posttranslocation Chaperone PrsA2 Regulates the Maturation and Secretion of Listeria monocytogenes Proprotein Virulence Factors ⬇️

scientific article published on September 9, 2011

RNA-Based Fluorescent Biosensors for Live Cell Imaging of Second Messenger Cyclic di-AMP.

scientific article published on 15 May 2015

Recombinant Listeria promotes tumor rejection by CD8+ T cell-dependent remodeling of the tumor microenvironment

scientific article published on 23 July 2018

Ribosome hibernation facilitates tolerance of stationary-phase bacteria to aminoglycosides

scientific article

STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

scientific article published in April 2015

STING-Activating Adjuvants Elicit a Th17 Immune Response and Protect against Mycobacterium tuberculosis Infection.

scientific article published in May 2018

STING-dependent type I IFN production inhibits cell-mediated immunity to Listeria monocytogenes

scientific article

SecA2-dependent secretion of autolytic enzymes promotes Listeria monocytogenes pathogenesis ⬇️

scientific article published on October 3, 2003

Secondary structure of the mRNA encoding listeriolysin O is essential to establish the replicative niche of L. monocytogenes

scientific article published on 02 September 2020

Secretion of c-di-AMP by Listeria monocytogenes leads to a STING-dependent antibacterial response during enterocolitis

scientific article published on 05 October 2020

SpoVG Is a Conserved RNA-Binding Protein That Regulates Listeria monocytogenes Lysozyme Resistance, Virulence, and Swarming Motility.

scientific article

Strategies Used by Bacteria to Grow in Macrophages

scientific article published on June 2016

Suppression of cell-mediated immunity following recognition of phagosome-confined bacteria

scientific article

TLR2 and endosomal TLR-mediated secretion of IL-10 and immune suppression in response to phagosome-confined Listeria monocytogenes

scientific article published on 07 July 2020

The Listeria monocytogenes hemolysin has an acidic pH optimum to compartmentalize activity and prevent damage to infected host cells

scientific article

The Listeria monocytogenes hibernation-promoting factor is required for the formation of 100S ribosomes, optimal fitness, and pathogenesis

scientific article

The Listeriolysin O PEST-like Sequence Co-opts AP-2-Mediated Endocytosis to Prevent Plasma Membrane Damage during Listeria Infection.

scientific article

The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides

scientific article

The Nonmevalonate Pathway of Isoprenoid Biosynthesis Supports Anaerobic Growth of Listeria monocytogenes

scientific article published on 22 January 2020

The PAMP c-di-AMP Is Essential for Listeria monocytogenes Growth in Rich but Not Minimal Media due to a Toxic Increase in (p)ppGpp. [corrected]

scientific article published on 28 May 2015

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

scientific article

The cell biology of Listeria monocytogenes infection: the intersection of bacterial pathogenesis and cell-mediated immunity

scientific article

The host cytosol: front-line or home front?

scientific article

Use of RNA interference in Drosophila S2 cells to identify host pathways controlling compartmentalization of an intracellular pathogen

scientific article

Why is Listeria monocytogenes such a potent inducer of CD8+ T-cells?

scientific article published on 01 April 2020

Yogi Berra, Forrest Gump, and the discovery ofListeriaactin comet tails ⬇️

scientific article published on April 1, 2012

c-di-AMP modulates Listeria monocytogenes central metabolism to regulate growth, antibiotic resistance and osmoregulation

scientific article published on 18 January 2017

c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response

scientific article

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