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List of works by Amanda Swart

11β-Hydroxyandrostenedione: Downstream metabolism by 11βHSD, 17βHSD and SRD5A produces novel substrates in familiar pathways.

scientific article published on 23 December 2014

11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: a putative role in castration resistant prostate cancer?

scientific article published on 13 July 2013

11β-hydroxyandrostenedione returns to the steroid arena: biosynthesis, metabolism and function.

scientific article published on 25 October 2013

11β-hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione

scientific article published on 16 May 2013

16α-hydroxyprogesterone: origin, biosynthesis and receptor interaction.

scientific article

A high-throughput UPC2-MS/MS method for the separation and quantification of C19 and C21 steroids and their C11-oxy steroid metabolites in the classical, alternative, backdoor and 11OHA4 steroid pathways.

scientific article published on 20 February 2018

A single amino acid residue, Ala 105, confers 16alpha-hydroxylase activity to human cytochrome P450 17alpha-hydroxylase/17,20 lyase

scientific article published on 4 January 2010

Adrenal C11-oxy C21 steroids contribute to the C11-oxy C19 steroid pool via the backdoor pathway in the biosynthesis and metabolism of 21-deoxycortisol and 21-deoxycortisone.

scientific article published on 31 July 2017

Advances in the analytical methodologies: Profiling steroids in familiar pathways-challenging dogmas.

scientific article published on 10 April 2015

Allosteric interaction between 3β-hydroxysteroid dehydrogenase/Δ⁵-Δ⁴ isomerase and cytochrome b5 influences cofactor binding

scientific article

Baboon cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17).

scientific article published on November 2002

Biological activities of the shrub Salsola tuberculatiformis Botsch.: contraceptive or stress alleviator?

scientific article published in June 2003

C11-oxy C19 and C11-oxy C21 steroids in neonates: UPC2-MS/MS quantification of plasma 11β-hydroxyandrostenedione, 11-ketotestosterone and 11-ketoprogesterone

scientific article published on 06 June 2018

CYP17 causes hypocortisolism in the South African Angora goat.

scientific article published on 17 September 2008

Corrigendum to “The influence of Aspalathus linearis (Rooibos) and dihydrochalcones on adrenal steroidogenesis: Quantification of steroid intermediates and end products in H295R cells” [J. Steroid Biochem. Mol. Biol. 128 (2012) 128–138]

scientific article published in January 2013

Cytochrome P450 side-chain cleavage: insights gained from homology modeling

scientific article published on 12 January 2007

Cytochrome b(5) forms homomeric complexes in living cells

scientific article published on 31 July 2012

Cytochrome b5 augments 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase activity

scientific article published on 14 September 2011

Cytochrome b5 modulates multiple reactions in steroidogenesis by diverse mechanisms.

scientific article

Cytochrome b5: novel roles in steroidogenesis

scientific article published on 07 December 2012

Evidence for the functional role of residues in the B'-C loop of baboon cytochrome P450 side-chain cleavage (CYP11A1) obtained by site-directed mutagenesis, kinetic analysis and homology modelling.

scientific article published in November 2006

Falsely elevated plasma testosterone concentrations in neonates: importance of LC-MS/MS measurements.

scientific article published on 8 January 2018

Functional expression and characterisation of human cytochrome P45017alpha in Pichia pastoris.

scientific article

Hypocortisolism in the South African angora goat: the role of 3betaHSD.

scientific article published on 4 August 2009

Inefficient UGT-conjugation of adrenal 11β-hydroxyandrostenedione metabolites highlights C11-oxy C19 steroids as the predominant androgens in prostate cancer

scientific article published on 19 September 2017

Modulation of glucocorticoid, mineralocorticoid and androgen production in H295 cells by Trimesemine™, a mesembrine-rich Sceletium extract.

scientific article published on 19 November 2015

Ovine steroid 17alpha-hydroxylase cytochrome P450: characteristics of the hydroxylase and lyase activities of the adrenal cortex enzyme

scientific article published on January 2003

Profiling adrenal 11β-hydroxyandrostenedione metabolites in prostate cancer cells, tissue and plasma: UPC2-MS/MS quantification of 11β-hydroxytestosterone, 11keto-testosterone and 11keto-dihydrotestosterone.

scientific article published on 21 June 2016

Rooibos flavonoids inhibit the activity of key adrenal steroidogenic enzymes, modulating steroid hormone levels in H295R cells.

scientific article published on 24 March 2014

Rooibos influences glucocorticoid levels and steroid ratios in vivo and in vitro: a natural approach in the management of stress and metabolic disorders?

scientific article published on 11 September 2013

Sheep adrenal cytochrome b5: active as a monomer or a tetramer in vivo?

scientific article published in November 2002

The development of an ultra performance liquid chromatography-coupled atmospheric pressure chemical ionization mass spectrometry assay for seven adrenal steroids

scientific article

The identification of two CYP17 alleles in the South African Angora goat

scientific article published on 01 January 2007

The in vitro metabolism of 11β-hydroxyprogesterone and 11-ketoprogesterone to 11-ketodihydrotestosterone in the backdoor pathway.

scientific article published on 22 December 2017

The influence of Aspalathus linearis (Rooibos) and dihydrochalcones on adrenal steroidogenesis: quantification of steroid intermediates and end products in H295R cells

scientific article

The influence of Sutherlandia frutescens on adrenal steroidogenic cytochrome P450 enzymes

scientific article published on 7 April 2008

Two CYP17 genes in the South African Angora goat (Capra hircus) - the identification of three genotypes that differ in copy number and steroidogenic output

scientific article published on 4 July 2008

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