List of works by Christos Socrates Mantzoros

A brief history of insulin resistance: from the first insulin radioimmunoassay to selectively targeting protein kinase C pathways

scientific article published on 02 February 2012

A dietary pattern characterized by high consumption of whole-grain cereals and low-fat dairy products and low consumption of refined cereals is positively associated with plasma adiponectin levels in healthy women.

scientific article

A prospective study of maternal prenatal weight and offspring cardiometabolic health in midchildhood

scientific article

A prospective study of soluble tumor necrosis factor-alpha receptor II (sTNF-RII) and risk of coronary heart disease among women with type 2 diabetes

scientific article published in June 2005

AMPK↔Sirt1: From a signaling network to a combination drug

scientific article published on 03 August 2016

ATP synthase inhibitory factor 1 (IF1), a novel myokine, regulates glucose metabolism by AMPK and Akt dual pathways

scientific article published on 31 October 2019

Abdominal obesity, independent from caloric intake, accounts for the development of intestinal tumors in Apc(1638N/+) female mice

scientific article published on March 2013

Abnormal Peri-organ-Intra-organ Fat (APIFat) and Rheumatoid Arthritis: An Under-investigated Link for Increased Cardiovascular Risk?

scientific article published on 01 January 2020

Activin A and follistatin in patients with nonalcoholic fatty liver disease

scientific article published on 25 July 2016

Adherence to Mediterranean diet is favorably associated with metabolic parameters in HIV-positive patients with the highly active antiretroviral therapy-induced metabolic syndrome and lipodystrophy.

scientific article

Adherence to the Mediterranean dietary pattern is positively associated with plasma adiponectin concentrations in diabetic women

scientific article

Adipokines in nonalcoholic fatty liver disease

scientific article

Adipokines in the HIV/HAART-associated lipodystrophy syndrome

scientific article published on 24 May 2013

Adiponectin administration prevents weight gain and glycemic profile changes in diet-induced obese immune deficient Rag1-/- mice lacking mature lymphocytes.

scientific article published on 22 September 2016

Adiponectin and breast cancer risk

scientific article published in March 2004

Adiponectin and leptin in the diagnosis and therapy of NAFLD

scientific article published on 27 November 2019

Adiponectin and metformin additively attenuate IL1β-induced malignant potential of colon cancer

scientific article

Adiponectin and resistin are associated with risk for myelodysplastic syndrome, independently from the insulin-like growth factor-I (IGF-I) system

scientific article published on 01 August 2008

Adiponectin as a target for the treatment of nonalcoholic steatohepatitis with thiazolidinediones: A systematic review

scientific article

Adiponectin genetic variability, plasma adiponectin, and cardiovascular risk in patients with type 2 diabetes

scientific article published in May 2006

Adiponectin in insulin resistance: lessons from translational research

scientific article

Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence

scientific article published on September 2007

Adiponectin receptor expression in human malignant tissues.

scientific article

Adiponectin, lipids and atherosclerosis

scientific article published on 29 April 2017

Adiponectin: a link between obesity and cancer

scientific article

Adipose tissue and reproductive health

scientific article published on 16 November 2017

Adipose tissue, obesity and non-alcoholic fatty liver disease

scientific article

Advances at the intersection of sleep and metabolism research

scientific article published on 07 April 2018

Advances in metabolism

scientific article published on 7 October 2013

Alpha linolenic acid and oleic acid additively down-regulate malignant potential and positively cross-regulate AMPK/S6 axis in OE19 and OE33 esophageal cancer cells

scientific article published on 25 July 2014

An update on the validity of irisin assays and the link between irisin and hepatic metabolism

scientific article published on 11 June 2015

Antitumor and antimetastatic effects of walnut oil in esophageal adenocarcinoma cells

scientific article published in November 2017

Association between circulating irisin and homocysteine in patients with nonalcoholic fatty liver disease

scientific article published on 09 November 2014

Association of Adipokines with Development and Progression of Nonalcoholic Fatty Liver Disease.

scientific article

Association of circulating FGF-21 levels in the first week of life and postnatal growth in hospitalized preterm infants

scientific article published on 05 March 2020

Association of maternal short sleep duration with adiposity and cardiometabolic status at 3 years postpartum

scientific article

Association of the +45T>G and +276G>T polymorphisms in the adiponectin gene with insulin resistance in nondiabetic Greek women

scientific article

Associations of cord blood metabolites with perinatal characteristics, newborn anthropometry, and cord blood hormones in project viva

scientific article published on 17 July 2017

Associations of maternal prenatal smoking with umbilical cord blood hormones: the Project Viva cohort

scientific article published on 8 April 2017

Attachment and the metabolic syndrome in midlife: the role of interview-based discourse patterns

scientific article

B-cell chronic lymphocytic leukemia risk in association with serum leptin and adiponectin: a case-control study in Greece

scientific article

Beyond glycemic control: New guidance on cardio-renal protection

scientific article published on 22 February 2019

Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans.

scientific article published in April 2003

Body fat redistribution and metabolic abnormalities in HIV-infected patients on highly active antiretroviral therapy: novel insights into pathophysiology and emerging opportunities for treatment.

scientific article

Bone metabolism in anorexia nervosa and hypothalamic amenorrhea

scientific article published on 28 October 2017

Brain responses to food images during the early and late follicular phase of the menstrual cycle in healthy young women: relation to fasting and feeding

scientific article

Caffeinated Coffee Does Not Acutely Affect Energy Intake, Appetite, or Inflammation but Prevents Serum Cortisol Concentrations from Falling in Healthy Men

scientific article published on 23 February 2011

Can a selective PPARγ modulator improve glycemic control in patients with type 2 diabetes with fewer side effects compared with pioglitazone?

scientific article published on 10 April 2014

Central nervous system regulation of eating: Insights from human brain imaging

scientific article

Changes in Thyroid Hormone Levels Within the Normal and/or Subclinical Hyper- or Hypothyroid Range Do Not Affect Circulating Irisin Levels in Humans

scientific article

Chemerin is expressed mainly in pancreas and liver, is regulated by energy deprivation, and lacks day/night variation in humans.

scientific article

Chemerin levels as predictor of acute coronary events: a case-control study nested within the veterans affairs normative aging study

scientific article

Ciliary neurotrophic factor upregulates follistatin and Pak1, causes overexpression of muscle differentiation related genes and downregulation of established atrophy mediators in skeletal muscle.

scientific article

Circulating ApoJ is closely associated with insulin resistance in human subjects

scientific article published on 3 October 2017

Circulating adiponectin and endometrial cancer risk

scientific article

Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: associations with metabolic parameters and insulin resistance and regulation by physical training.

scientific article

Circulating adiponectin and leptin in relation to myelodysplastic syndrome: a case-control study

scientific article

Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers, and vascular reactivity in diabetic patients and subjects at risk for diabetes

scientific article published in October 2004

Circulating adiponectin is inversely associated with risk of thyroid cancer: in vivo and in vitro studies

scientific article

Circulating adiponectin levels and expression of adiponectin receptors in relation to lung cancer: two case-control studies

scientific article published on January 2007

Circulating adiponectin levels are associated with better glycemic control, more favorable lipid profile, and reduced inflammation in women with type 2 diabetes

scientific article published on 24 May 2005

Circulating alanine transaminase (ALT) and γ-glutamyl transferase (GGT), but not fetuin-A, are associated with metabolic risk factors, at baseline and at two-year follow-up: the prospective Cyprus Metabolism Study.

scientific article

Circulating clusterin (apolipoprotein J) levels do not have any day/night variability and are positively associated with total and LDL cholesterol levels in young healthy individuals

scientific article

Circulating fetuin-A in patients with pancreatic cancer: a hospital-based case-control study

scientific article published on 27 October 2014

Circulating follistatin displays a day-night rhythm and is associated with muscle mass and circulating leptin levels in healthy, young humans

scientific article published on 8 July 2016

Circulating insulin and c-peptide levels and risk of breast cancer among predominately premenopausal women.

scientific article published in January 2007

Circulating irisin in healthy, young individuals: day-night rhythm, effects of food intake and exercise, and associations with gender, physical activity, diet, and body composition

scientific article published on 10 June 2014

Circulating irisin in relation to insulin resistance and the metabolic syndrome.

scientific article published on 20 September 2013

Circulating irisin levels are lower in patients with either stable coronary artery disease (CAD) or myocardial infarction (MI) versus healthy controls, whereas follistatin and activin A levels are higher and can discriminate MI from CAD with similar

scientific article

Circulating irisin levels are not affected by coffee intake: a randomized controlled trial

scientific article

Circulating irisin, omentin-1, and lipoprotein subparticles in adults at higher cardiovascular risk

scientific article

Circulating leptin in non-alcoholic fatty liver disease: a systematic review and meta-analysis

scientific article published on 26 September 2015

Circulating levels of gastrointestinal hormones in response to the most common types of bariatric surgery and predictive value for weight loss over one year: Evidence from two independent trials

scientific article published on 28 October 2019

Circulating levels of the components of the GH/IGF-1/IGFBPs axis total and intact IGF-binding proteins (IGFBP) 3 and IGFBP 4 and total IGFBP 5, as well as PAPPA, PAPPA2 and Stanniocalcin-2 levels are not altered in response to energy deprivation and

scientific article published on 17 May 2019

Circulating lipocalin 2 is associated with body fat distribution at baseline but is not an independent predictor of insulin resistance: the prospective Cyprus Metabolism Study.

scientific article published in September 2011

Circulating melanin-concentrating hormone, agouti-related protein, and alpha-melanocyte-stimulating hormone levels in relation to body composition: alterations in response to food deprivation and recombinant human leptin administration

scientific article published on 16 November 2004

Circulating profile of Activin-Follistatin-Inhibin Axis in women with hypothalamic amenorrhea in response to leptin treatment

scientific article published on 09 October 2020

Circulating resistin in lean, obese, and insulin-resistant mouse models: lack of association with insulinemia and glycemia

scientific article

Circulating resistin levels are not associated with fat redistribution, insulin resistance, or metabolic profile in patients with the highly active antiretroviral therapy-induced metabolic syndrome

scientific article published on 14 June 2005

Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects

scientific article

Circulating vaspin and visfatin are not affected by acute or chronic energy deficiency or leptin administration in humans

scientific article published on 21 March 2011

Classic and Novel Adipocytokines at the Intersection of Obesity and Cancer: Diagnostic and Therapeutic Strategies

scientific article published on 01 December 2018

Clusterin (apolipoprotein J): wither link with diabetes and cardiometabolic risk?

scientific article published on 17 February 2011

Coffee consumption is associated with higher plasma adiponectin concentrations in women with or without type 2 diabetes: a prospective cohort study

scientific article published on 10 December 2007

Cohort profile: project viva

scientific article

Commentary: COVID-19 and Obesity Pandemics Converge into a Syndemic Requiring Urgent and Multidisciplinary Action

scientific article published on 17 October 2020

Commentary: COVID-19 in Patients with Diabetes

scientific article published on 24 March 2020

Commentary: Could iron chelators prove to be useful as an adjunct to COVID-19 Treatment Regimens?

scientific article published on 08 May 2020

Commentary: From mice to men: In search for dietary interventions to form the background on which pharmacotherapy for non-alcoholic fatty liver disease should be based

scientific article published on 27 June 2020

Commentary: Nonalcoholic or metabolic dysfunction-associated fatty liver disease? The epidemic of the 21st century in search of the most appropriate name

scientific article published on 22 October 2020

Commentary: Phosphodiesterase 4 inhibitors as potential adjunct treatment targeting the cytokine storm in COVID-19

scientific article published on 01 June 2020

Cord Blood Adipocyte Fatty Acid-Binding Protein Levels Correlate With Gestational Age and Birth Weight in Neonates

scientific article published on 31 January 2017

Cord Leptin is Associated with Neuropsychomotor Development in Childhood

scientific article published on 03 September 2019

Cord blood irisin levels are positively correlated with birth weight in newborn infants

scientific article published on 29 July 2015

Cord blood leptin and adiponectin as predictors of adiposity in children at 3 years of age: a prospective cohort study

scientific article published on February 2009

Cord blood leptin levels in relation to child growth trajectories

scientific article

Cord blood levels of osteopontin as a phenotype marker of gestational age and neonatal morbidities.

scientific article

Corrigendum to "Variants of the adiponectin gene and diabetic microvascular complications in patients with type 2 diabetes" [Metab. Clin. Exp. 62 (2013) 677-685].

scientific article published on 29 November 2016

Could the endocrine disruptor bisphenol-A be implicated in the pathogenesis of oral and oropharyngeal cancer? Metabolic considerations and future directions

scientific article published on 17 November 2018

Covid-19 and Disparities in Nutrition and Obesity

scientific article published on 15 July 2020

Current and emerging pharmacological options for the treatment of nonalcoholic steatohepatitis

scientific article published on 06 March 2020

Current child, but not maternal, snoring is bi-directionally related to adiposity and cardiometabolic risk markers: A cross-sectional and a prospective cohort analysis

scientific article published on 29 June 2017

Decreasing Lean Body Mass with Age: Challenges and Opportunities for Novel Therapies.

scientific article published in December 2017

Detailed assessments of childhood adversity enhance prediction of central obesity independent of gender, race, adult psychosocial risk and health behaviors

scientific article

Diet patterns, adipokines, and metabolism: where are we and what is next?

scientific article published on 12 November 2013

Diet quality and diet patterns in relation to circulating cardiometabolic biomarkers

scientific article

Diet quality is associated with circulating C-reactive protein but not irisin levels in humans

scientific article

Dietary factors associated with plasma high molecular weight and total adiponectin levels in apparently healthy women.

scientific article published in July 2008

Dietary fibers and glycemic load, obesity, and plasma adiponectin levels in women with type 2 diabetes

scientific article (publication date: July 2006)

Dietary patterns and risk of mortality from cardiovascular disease, cancer, and all causes in a prospective cohort of women

scientific article

Dietary walnut suppression of colorectal cancer in mice: Mediation by miRNA patterns and fatty acid incorporation

scientific article published on April 2015

Dietary walnuts inhibit colorectal cancer growth in mice by suppressing angiogenesis

scientific article published on 27 July 2011

Differential Effects of Oral and Intravenous Lipid Administration on Key Molecules Related to Energy Homeostasis

scientific article published on 10 March 2016

Differential associations of leptin with adiposity across early childhood

scientific article published on 25 May 2013

Direct role of adiponectin and adiponectin receptors in endometrial cancer: in vitro and ex vivo studies in humans

scientific article

Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns

scientific article

Drug Insight: the role of leptin in human physiology and pathophysiology--emerging clinical applications

scientific article

Drug-drug interactions in HIV medicine: a not so simple and straightforward road to the future

scientific article published on 13 July 2011

Duration of lactation and maternal adipokines at 3 years postpartum.

scientific article

Early life adversity and/or posttraumatic stress disorder severity are associated with poor diet quality, including consumption of trans fatty acids, and fewer hours of resting or sleeping in a US middle-aged population: A cross-sectional and prospe

scientific article

Early life adversity is associated with elevated levels of circulating leptin, irisin, and decreased levels of adiponectin in midlife adults.

scientific article published on 20 March 2014

Effect of dieting on plasma leptin, soluble leptin receptor, adiponectin and resistin levels in healthy volunteers

scientific article published in September 2004

Effect of liraglutide vs. placebo treatment on circulating proglucagon-derived peptides that mediate improvements in body weight, insulin secretion and action: a randomized controlled trial

scientific article published on 02 November 2020

Effects of a 1-year exercise and lifestyle intervention on irisin, adipokines, and inflammatory markers in obese children

scientific article published on 25 March 2014

Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trial

scientific article

Effects of combined low-dose spironolactone plus vitamin E vs vitamin E monotherapy on insulin resistance, non-invasive indices of steatosis and fibrosis, and adipokine levels in non-alcoholic fatty liver disease: a randomized controlled trial

scientific article published on 28 April 2017

Effects of ezetimibe and/or simvastatin on LDL receptor protein expression and on LDL receptor and HMG-CoA reductase gene expression: a randomized trial in healthy men.

scientific article published on 5 November 2007

Effects of leptin and adiponectin on pancreatic β-cell function

scientific article published on 31 May 2011

Effects of lipid-lowering drugs on irisin in human subjects in vivo and in human skeletal muscle cells ex vivo ⬇️

scientific article

Effects of simvastatin and ezetimibe on interleukin-6 and high-sensitivity C-reactive protein.

scientific article published on 18 October 2012

Effects of sodium-glucose co-transporter-2 (SGLT2) inhibitors on non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: Ex quo et quo vadimus?

scientific article published on 11 July 2019

Effects of trans fatty acids on glucose homeostasis: a meta-analysis of randomized, placebo-controlled clinical trials

scientific article

Efficacy of metreleptin in obese patients with type 2 diabetes: cellular and molecular pathways underlying leptin tolerance

scientific article

Elevated leptin fragments in renal failure correlate with BMI and haematopoiesis and are normalized by haemodialysis

scientific article published in April 2004

Energy deprivation alters in a leptin- and cortisol-independent manner circulating levels of activin A and follistatin but not myostatin in healthy males

scientific article

Exercise and vitamin E intake are independently associated with metabolic abnormalities in human immunodeficiency virus-positive subjects: a cross-sectional study

scientific article published on 12 June 2003

Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation.

scientific article

Exercising insulin sensitivity: AMPK turns on autophagy!

scientific article published on 14 March 2015

FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise

scientific article

Fasting oxyntomodulin, glicentin, and GIP levels are associated with activation of reward and attention-related brain centers in response to visual food cues in adults with obesity: A cross-sectional fMRI study

scientific article published on 08 January 2021

Fatty liver in lipodystrophy: A review with a focus on therapeutic perspectives of adiponectin and/or leptin replacement

scientific article published on 06 May 2019

Fetuin-A levels and free leptin index are reduced in patients with chronic lymphocytic leukemia: a hospital-based case-control study

scientific article published on 28 August 2015

Fibroblast growth factor 21 levels in young healthy females display day and night variations and are increased in response to short-term energy deprivation through a leptin-independent pathway.

scientific article published on 27 November 2012

Fibroblast growth factor 21: A role in cardiometabolic disorders and cardiovascular risk prediction?

scientific article published on 16 January 2019

First and second trimester gestational weight gains are most strongly associated with cord blood levels of hormones at delivery important for glycemic control and somatic growth

scientific article published on 16 January 2017

Follistatins in glucose regulation of healthy and obese subjects

scientific article published on 03 December 2018

Free Cortisol Is a More Accurate Marker for Adrenal Function and Does Not Correlate with Renal Function in Cirrhosis

scientific article published on 19 January 2019

Free IGF-1, Intact IGFBP-4, and PicoPAPP-A are Altered in Acute Myocardial Infarction Compared to Stable Coronary Artery Disease and Healthy Controls

scientific article published on 29 November 2018

From rest to stressed: endothelin-1 levels in young healthy smokers and non-smokers

scientific article published on 16 June 2015

GEOFFREY HARRIS PRIZE LECTURE 2018: Novel pathways regulating neuroendocrine function, energy homeostasis and metabolism in humans

scientific article published on 01 February 2019

GLP-1 promotes angiogenesis in human endothelial cells in a dose-dependent manner, through the Akt, Src and PKC pathways.

scientific article

GLP-1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the GLP-1 analogue liraglutide alters brain activity related to highly desirable food cues in individuals with diabetes: a crossover, randomised, placebo-cont

scientific article

GLYCOSYLATED FIBRONECTIN AND INHIBIN ARE LOWER AND ANTI-MÜLLERIAN HORMONE IS HIGHER IN UMBILICAL CORD BLOOD WHEN MOTHERS HAVE PREECLAMPSIA

scientific article published on 20 December 2019

Gender and body mass index modify the effect of increasing amounts of caffeinated coffee on postprandial glucose and insulin concentrations; a randomized, controlled, clinical trial.

scientific article

Gender dimorphism and lack of day/night variation or effects of energy deprivation on undercarboxylated osteocalcin levels in humans

scientific article

Gene expression of PPARgamma and PGC-1alpha in human omental and subcutaneous adipose tissues is related to insulin resistance markers and mediates beneficial effects of physical training

scientific article

Gene expression of adiponectin receptors in human visceral and subcutaneous adipose tissue is related to insulin resistance and metabolic parameters and is altered in response to physical training

scientific article published on 18 September 2007

Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levels

scientific article

Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levels

Gestational glucose tolerance and cord blood leptin levels predict slower weight gain in early infancy

scientific article

Gestational glucose tolerance and maternal metabolic profile at 3 years postpartum

scientific article published on November 2011

Ghrelin levels are not regulated by recombinant leptin administration and/or three days of fasting in healthy subjects

scientific article

Growth hormone-binding protein is directly and IGFBP-3 is inversely associated with risk of female breast cancer.

scientific article published in February 2007

Helicobacter pylori infection and nonalcoholic fatty liver disease: Are the four meta-analyses favoring an intriguing association pointing to the right direction?

scientific article published on 20 May 2019

Higher fetuin-A, lower adiponectin and free leptin levels mediate effects of excess body weight on insulin resistance and risk for myelodysplastic syndrome.

scientific article

Human immunodeficiency virus type 1-related lipoatrophy and lipohypertrophy are associated with serum concentrations of leptin

scientific article published on 5 March 2003

Hypoadiponectinemia is associated with insulin resistance, hypertriglyceridemia, and fat redistribution in human immunodeficiency virus-infected patients treated with highly active antiretroviral therapy

scientific article published in February 2003

IGF1 and IGFBP3 in acute respiratory distress syndrome

scientific article published on 17 October 2011

Identification and saturable nature of signaling pathways induced by metreleptin in humans: comparative evaluation of in vivo, ex vivo, and in vitro administration

scientific article

Immune therapy in type 1 diabetes mellitus - Attempts to untie the Gordian knot?

scientific article

Impaired autophagy induces chronic atrophic pancreatitis in mice via sex- and nutrition-dependent processes

scientific article

Implication of circulating irisin levels with brown adipose tissue and sarcopenia in humans.

scientific article published on 29 April 2014

Improvement in highly active antiretroviral therapy-induced metabolic syndrome by treatment with pioglitazone but not with fenofibrate: a 2 x 2 factorial, randomized, double-blinded, placebo-controlled trial

scientific article published on 7 February 2005

In prostate cancer, low adiponectin levels are not associated with insulin resistance.

scientific article

Increased leptin levels in preeclampsia: associations with BMI, estrogen and SHBG levels

scientific article published on 01 January 2004

Inflammation: a key player linking obesity with malignancies

scientific article published on 5 January 2018

Insulin glargine and NPH insulin increase to a similar degree epithelial cell proliferation and aberrant crypt foci formation in colons of diabetic mice

scientific article published on December 2010

Insulin resistance and vascular dysfunction in nondiabetic Asian Indians

scientific article

Insulin resistance in relation to melanoma risk.

scientific article

Insulin resistance: an independent risk factor for lung cancer?

scientific article published on 19 January 2011

Intensive Weight Loss Intervention and Cancer Risk in Adults with Type 2 Diabetes: Analysis of the Look AHEAD Randomized Clinical Trial

scientific article published on 01 September 2020

Intracellular leptin signaling following effective weight loss

scientific article published in May 2015

Irisin and Leptin Concentrations in relation to Obesity, and Developing Type 2 Diabetes: a cross sectional and a prospective case-control study nested in the Normative Aging Study

scientific article published on 3 November 2017

Irisin in metabolic diseases

scientific article published on 23 November 2017

Irisin in patients with nonalcoholic fatty liver disease

scientific article

Irisin in response to acute and chronic whole-body vibration exercise in humans

scientific article published on 05 April 2014

Irisin in response to exercise in humans with and without metabolic syndrome.

scientific article published on 16 December 2014

Irisin mRNA and circulating levels in relation to other myokines in healthy and morbidly obese humans

scientific article published on 21 October 2013

Irisin physiology, oxidative stress, and thyroid dysfunction: What next?

scientific article published on 09 April 2015

Irisin: A true, circulating hormone

scientific article published on 10 September 2015

Irisin: a renaissance in metabolism?

scientific article

Irisin: good or bad for the bone? A new path forward after the reported discovery of irisin receptor?

scientific article published on 25 January 2019

Juvenile Paget disease

scientific article published on 25 October 2017

Leptin administration to overweight and obese subjects for 6 months increases free leptin concentrations but does not alter circulating hormones of the thyroid and IGF axes during weight loss induced by a mild hypocaloric diet.

scientific article

Leptin alters energy intake and fat mass but not energy expenditure in lean subjects

scientific article published on 13 October 2020

Leptin and Adiponectin in the HIV Associated Metabolic Syndrome: Physiologic and Therapeutic Implications

scientific article

Leptin and amylin act in an additive manner to activate overlapping signaling pathways in peripheral tissues: in vitro and ex vivo studies in humans ⬇️

scientific article

Leptin and soluble leptin receptor levels in plasma and risk of type 2 diabetes in U.S. women: a prospective study

scientific article

Leptin and the brain: influences on brain development, cognitive functioning and psychiatric disorders.

scientific article published on 10 July 2014

Leptin applications in 2015: what have we learned about leptin and obesity?

scientific article

Leptin as a modulator of neuroendocrine function in humans

scientific article

Leptin at the intersection of neuroendocrinology and metabolism: current evidence and therapeutic perspectives.

scientific article published on 13 June 2013

Leptin hormonal kinetics in the fed state: effects of adiposity, age, and gender on endogenous leptin production and clearance rates

scientific article

Leptin in autoimmune diseases

scientific article

Leptin in congenital and HIV-associated lipodystrophy.

scientific article published on 12 August 2014

Leptin in congenital or HIV-associated lipodystrophy and metabolic syndrome: a need for more mechanistic studies and large, randomized, placebo-controlled trials

scientific article published on 15 May 2012

Leptin in health and disease: facts and expectations at its twentieth anniversary

scientific article published on 23 October 2014

Leptin in human physiology and pathophysiology.

scientific article

Leptin in human physiology and therapeutics

scientific article

Leptin in humans: lessons from translational research

scientific article published on 28 January 2009

Leptin in nonalcoholic fatty liver disease: a narrative review

scientific article published on 23 October 2014

Leptin in reproduction

scientific article published on 01 December 2007

Leptin is an effective treatment for hypothalamic amenorrhea.

scientific article

Leptin mediates Clostridium difficile toxin A-induced enteritis in mice.

scientific article

Leptin replacement improves postprandial glycemia and insulin sensitivity in human immunodeficiency virus–infected lipoatrophic men treated with pioglitazone: a pilot study ⬇️

scientific article published on November 16, 2010

Leptin therapy alters appetite and neural responses to food stimuli in brain areas of leptin-sensitive subjects without altering brain structure.

scientific article

Leptin treatment reduces body fat but does not affect lean body mass or the myostatin-follistatin-activin axis in lean hypoleptinemic women

scientific article

Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals

scientific article

Levels of the Autophagy Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice

scientific article published on 06 October 2018

Lifestyle modification increases circulating adiponectin concentrations but does not change vaspin concentrations.

scientific article published on 12 April 2011

Linking hepatic transcriptional changes to high-fat diet induced physiology for diabetes-prone and obese-resistant mice

scientific article published in May 2007

Lipodystrophy: Time for a global registry and randomized clinical trials to assess efficacy, safety and cost-effectiveness of established and novel medications

scientific article published in July 2017

Lipodystrophy: pathophysiology and advances in treatment ⬇️

scientific article published on November 16, 2010

Long-term metreleptin treatment increases bone mineral density and content at the lumbar spine of lean hypoleptinemic women.

scientific article

Longer-term liraglutide administration at the highest dose approved for obesity increases reward-related orbitofrontal cortex activation in response to food cues: Implications for plateauing weight loss in response to anti-obesity therapies

scientific article published on 08 August 2019

Lorcaserin Administration Decreases Activation of Brain Centers in Response to Food Cues and These Emotion- and Salience-Related Changes Correlate With Weight Loss Effects: A 4-Week-Long Randomized, Placebo-Controlled, Double-Blind Clinical Trial.

scientific article

Lorcaserin treatment decreases body weight and reduces cardiometabolic risk factors in obese adults: A six-month, randomized, placebo-controlled, double-blind clinical trial

scientific article published on 18 March 2019

Low adiponectin levels are associated with renal cell carcinoma: a case-control study

scientific article

Low circulating adiponectin and resistin, but not leptin, levels are associated with multiple myeloma risk: a case-control study

scientific article

Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study

scientific article (publication date: 16 November 2005)

Making progress in nonalcoholic fatty liver disease (NAFLD) as we are transitioning from the era of NAFLD to dys-metabolism associated fatty liver disease (DAFLD)

scientific article published on 21 July 2020

Making progress towards a better pathophysiological understanding and more promising therapeutic options for treating non-alcoholic steatohepatitis (NASH) / DASH (dysmetabolism associated steatohepatitis)

scientific article published on 06 August 2020

Management of the metabolic syndrome and type 2 diabetes through lifestyle modification.

scientific article published on January 2009

Maternal diet and cord blood leptin and adiponectin concentrations at birth

scientific article

Maternal levels of corticotropin-releasing hormone during pregnancy in relation to adiponectin and leptin in early childhood

scientific article published on 03 February 2009

Maternal short sleep duration is associated with increased levels of inflammatory markers at 3 years postpartum ⬇️

scientific article published on October 30, 2010

Mechanisms underlying the cardiometabolic protective effect of walnut consumption in obese people: A cross-over, randomized, double-blind, controlled inpatient physiology study

scientific article published on 02 July 2019

Mediterranean diet and incidence of and mortality from coronary heart disease and stroke in women

scientific article

Mediterranean diet as a nutritional approach for COVID-19

scientific article published on 17 October 2020

Metabolic health and weight: Understanding metabolically unhealthy normal weight or metabolically healthy obese patients

scientific article published on 23 October 2015

Metabolic pathways link childhood adversity to elevated blood pressure in midlife adults

scientific article

Metabolic regulation of activins in healthy individuals and in obese patients undergoing bariatric surgery

scientific article published on 05 February 2020

Metformin and sulfonylureas in relation to cancer risk in type II diabetes patients: a meta-analysis using primary data of published studies

scientific article

Methylsulfonylmethane (MSM), an organosulfur compound, is effective against obesity-induced metabolic disorders in mice.

scientific article published on 20 July 2016

Narrative review: the role of leptin in human physiology: emerging clinical applications

scientific article

Necessity for timely noninvasive diagnosis of nonalcoholic fatty liver disease.

scientific article

Neonatal leptin levels are strongly associated with female gender, birth length, IGF-I levels and formula feeding

article

New American Diabetes Association (ADA)/European Association for the Study of Diabetes (EASD) guidelines for the pharmacotherapy of type 2 diabetes: Placing them into a practicing physician's perspective

scientific article published on 25 March 2020

New research developments and insights from Metabolism

scientific article published on 17 December 2014

New-onset diabetes and statins: throw the bath water out, but, please, keep the baby!

article by Niki Katsiki et al published 6 November 2014 in Metabolism

Non-Alcoholic Fatty Liver Disease Treatment in Patients with Type 2 Diabetes Mellitus; New Kids on the Block

scientific article published on 01 January 2020

Non-alcoholic fatty liver disease and colorectal cancer: A marker of risk or common causation?

scientific article published on 30 August 2018

Non-alcoholic fatty liver disease and dyslipidemia: An update

scientific article published on 13 May 2016

Non-alcoholic fatty liver disease and steatohepatitis: state-of-the-art on effective therapeutics based on the gold standard method for diagnosis

scientific article published on 13 July 2020

Non-invasive diagnosis of non-alcoholic steatohepatitis and fibrosis with the use of omics and supervised learning: A proof of concept study

scientific article published on 09 November 2019

Nonalcoholic fatty future disease

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Nonalcoholic fatty liver disease: Updates on associations with the metabolic syndrome and lipid profile and effects of treatment with PPAR-γ agonists

scientific article published on 09 August 2016

Novel Molecules Regulating Energy Homeostasis: Physiology and Regulation by Macronutrient Intake and Weight Loss

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Novel Noninvasive Approaches to the Treatment of Obesity: From Pharmacotherapy to Gene Therapy

scientific article published in 2021

Novel concepts in lipoprotein particle metabolism and regulation

scientific article published on 18 September 2013

Obese individuals with type 2 diabetes demonstrate decreased activation of the salience-related insula and increased activation of the emotion/salience-related amygdala to visual food cues compared to non-obese individuals with diabetes: A preliminar

scientific article published on 02 July 2018

Obesity and cancer risk: Emerging biological mechanisms and perspectives

scientific article published on 13 November 2018

Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics

scientific article published on 29 November 2018

Obesity as a Disease

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Obesity: seize the day, fight the fat

scientific article published on 06 January 2019

Obeticholic acid for the treatment of nonalcoholic steatohepatitis: Expectations and concerns

scientific article published on 11 January 2020

Of mice and men: Why progress in the pharmacological management of obesity is slower than anticipated and what could be done about it?

scientific article published on 22 March 2019

Of mice and men: incretin actions in the central nervous system

scientific article published on 04 June 2019

Old and new tools to study human brain physiology: Current state, future directions and implications for metabolic regulation

scientific article published on 07 August 2019

Omega-3 supplementation and cardiovascular disease: formulation-based systematic review and meta-analysis with trial sequential analysis

scientific article published on 20 August 2020

Omentin-1 levels are reduced by pharmacologic doses of leptin, but remain unaffected by energy deprivation and display no day-night variation.

scientific article

Omics, big data and machine learning as tools to propel understanding of biological mechanisms and to discover novel diagnostics and therapeutics

scientific article published on 08 August 2018

Optimizing bone health in anorexia nervosa and hypothalamic amenorrhea: new trials and tribulations.

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Outliers of bone metabolic diseases

scientific article published on 4 October 2017

Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: a case-control study

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Peptide YY levels are elevated after gastric bypass surgery.

scientific article published in February 2006

Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines

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Pharmacotherapy of obesity: available medications and drugs under investigation

scientific article published on 01 November 2018

Pharmacotherapy of type 2 diabetes: An update

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Phobic anxiety is associated with higher serum concentrations of adipokines and cytokines in women with diabetes

scientific article published on 17 February 2009

Physiological parameters regulating circulating levels of the IGFBP-4/Stanniocalcin-2/PAPP-A axis.

scientific article

Physiology of Activins/Follistatins: Associations With Metabolic and Anthropometric Variables and Response to Exercise

scientific article published on 01 October 2018

Placental proteases PAPP-A and PAPP-A2, the binding proteins they cleave (IGFBP-4 and -5), and IGF-I and IGF-II: Levels in umbilical cord blood and associations with birth weight and length

scientific article published on 08 August 2019

Plasma adiponectin concentrations and risk of incident breast cancer

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Plasma adiponectin concentrations in relation to endometrial cancer: a case-control study in Greece

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Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects

scientific article published on 11 June 2014

Potential cardioprotective action of GLP-1: from bench to bedside

scientific article published on 22 May 2014

Potential impact of Helicobacter pylori-related metabolic syndrome on upper and lower gastrointestinal tract oncogenesis

scientific article published on 21 June 2018

Preadipocyte factor-1 levels are higher in women with hypothalamic amenorrhea and are associated with bone mineral content and bone mineral density through a mechanism independent of leptin

scientific article

Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors: Shaping the future after the further cardiovascular outcomes research with PCSK9 inhibition in subjects with elevated risk (FOURIER) trial

scientific article published on 20 April 2017

Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-alpha receptor levels in humans with r

scientific article published on 21 December 2004

Recombinant methionyl human leptin administration to achieve high physiologic or pharmacologic leptin levels does not alter circulating inflammatory marker levels in humans with leptin sufficiency or excess.

scientific article published on 21 December 2004

Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy

scientific article published on 24 April 2006

Regulation of cell proliferation and malignant potential by irisin in endometrial, colon, thyroid and esophageal cancer cell lines

scientific article published on 23 October 2013

Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans

scientific article published in July 2002

Regulation of mouse hepatic genes in response to diet induced obesity, insulin resistance and fasting induced weight reduction

scientific article

Regulation of the activins-follistatins-inhibins axis by energy status: Impact on reproductive function

scientific article published on 09 May 2018

Relationship of plasma adiponectin with sex hormone and insulin-like growth factor levels

scientific article published in September 2007

Reproducibility of plasma and urine biomarkers among premenopausal and postmenopausal women from the Nurses' Health Studies

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Research advances in metabolism 2015

scientific article published on 21 October 2015

Research advances in metabolism 2016.

scientific article published on 6 November 2016

Research advances in metabolism 2017.

scientific article published on 25 January 2018

Research developments in metabolism 2018

scientific article published on 29 November 2018

Resistin is associated with biomarkers of inflammation while total and high-molecular weight adiponectin are associated with biomarkers of inflammation, insulin resistance, and endothelial function

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Resveratrol: is selectivity opening the key to therapeutic effects?

scientific article published on 09 November 2011

Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa

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SERUM ADIPONECTIN AND INSULIN-LIKE GROWTH FACTOR 1 IN PREDOMINANTLY FEMALE PATIENTS WITH THYROID CANCER: ASSOCIATION WITH THE HISTOLOGIC CHARACTERISTICS OF THE TUMOR.

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Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice

scientific article published on 26 June 2012

Secretion patterns of circulating osteoprotegerin and response to acute and chronic energy deprivation in young healthy adults.

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Selected dietary flavonoids are associated with markers of inflammation and endothelial dysfunction in U.S. women

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Selective PPARγ modulator INT131 normalizes insulin signaling defects and improves bone mass in diet-induced obese mice

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Selective capacity of metreleptin administration to reconstitute CD4+ T-cell number in females with acquired hypoleptinemia

scientific article published on 4 February 2013

Self-reported eating speed in relation to non-alcoholic fatty liver disease in adults

scientific article published on 4 February 2015

Serum adipocyte fatty acid-binding protein, retinol-binding protein 4, and adiponectin concentrations in relation to the development of the metabolic syndrome in Korean boys: a 3-y prospective cohort study.

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Serum adiponectin and leptin in relation to risk for preeclampsia: results from a large case-control study

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Serum adiponectin as a predictor of childhood non-Hodgkin's lymphoma: a nationwide case-control study.

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Serum adiponectin concentrations and tissue expression of adiponectin receptors are reduced in patients with prostate cancer: a case control study

scientific article published on 01 February 2007

Serum adiponectin concentrations in relation to maternal and perinatal characteristics in newborns

scientific article published in December 2004

Serum adiponectin levels and tissue expression of adiponectin receptors are associated with risk, stage, and grade of colorectal cancer.

scientific article

Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: cross-sectional and interventional studies

scientific article published in October 2003

Serum levels of activins, follistatins and growth factors in neoplasms of the breast: A case-control study

scientific article published on 01 February 2019

Sex disparities in the treatment and control of cardiovascular risk factors in type 2 diabetes

scientific article published on 28 March 2008

Sex specific effect of ATPase inhibitory factor 1 on body weight: studies in high fat diet induced obese mice and genetic association studies in humans

scientific article published on 30 January 2020

Sex-Specific Associations of Maternal Gestational Glycemia with Hormones in Umbilical Cord Blood at Delivery

scientific article published on 4 August 2016

Short-term administration of the GLP-1 analog liraglutide decreases circulating leptin and increases GIP levels and these changes are associated with alterations in CNS responses to food cues: A randomized, placebo-controlled, crossover study.

scientific article published on 18 March 2016

Short-term energy deprivation alters activin a and follistatin but not inhibin B levels of lean healthy women in a leptin-independent manner

scientific article published on 14 September 2011

Short-term treatment with ezetimibe, simvastatin or their combination does not alter circulating adiponectin, resistin or leptin levels in healthy men.

scientific article published on 31 October 2007

Short-term treatment with high dose liraglutide improves lipid and lipoprotein profile and changes hormonal mediators of lipid metabolism in obese patients with no overt type 2 diabetes mellitus: a randomized, placebo-controlled, cross-over, double-

scientific article published on 31 October 2019

Short-term walnut consumption increases circulating total adiponectin and apolipoprotein A concentrations, but does not affect markers of inflammation or vascular injury in obese humans with the metabolic syndrome: data from a double-blinded, random

scientific article

Sixty-six years of Metabolism, Clinical and Experimental: The journey of a journal and opportunities and challenges looking ahead

scientific article published in January 2018

Sleep apnea in relation to metabolism: An urgent need to study underlying mechanisms and to develop novel treatments for this unmet clinical need

scientific article

Sodium-glucose co-transporter-2 inhibitors (SGLT2i) use and risk of amputation: an expert panel overview of the evidence

scientific article published on 11 April 2019

Soluble leptin receptor and leptin are associated with baseline adiposity and metabolic risk factors, and predict adiposity, metabolic syndrome, and glucose levels at 2-year follow-up: the Cyprus Metabolism Prospective Cohort Study.

scientific article published on 5 November 2010

Statins in relation to adiponectin: A significant association with clinical implications.

scientific article

Stem cells in the treatment of diabetes mellitus - focus on mesenchymal stem cells

scientific article published on 18 October 2018

Stress- and PTSD-associated obesity and metabolic dysfunction: a growing problem requiring further research and novel treatments

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Sulfated oxysterols as candidates for the treatment of nonalcoholic fatty liver disease

scientific article published on 03 March 2012

Targeted Analysis of Three Hormonal Systems Identifies Molecules Associated with the Presence and Severity of NAFLD

scientific article published on 01 March 2020

The Leu72Met polymorphism of the ghrelin gene is associated with a decreased risk for type 2 diabetes

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The Selective Peroxisome Proliferator-Activated Receptor Gamma Modulator CHS-131 Improves Liver Histopathology and Metabolism in a Mouse Model of Obesity and Nonalcoholic Steatohepatitis

scientific article published on 28 July 2020

The effect of excess body fat on female and male reproduction

scientific article published on 28 February 2020

The effect of leptin replacement on parathyroid hormone, RANKL-osteoprotegerin axis, and Wnt inhibitors in young women with hypothalamic amenorrhea

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The effect of underweight on female and male reproduction

scientific article published on 11 April 2020

The effects of caffeinated and decaffeinated coffee on sex hormone-binding globulin and endogenous sex hormone levels: a randomized controlled trial

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The quest for the perfect biomarker of long-term glycemia: new studies, new trials and tribulations

scientific article published on 04 August 2011

The role of adipokines in relation to HIV lipodystrophy

scientific article published on 01 May 2007

The role of adiponectin in cancer: a review of current evidence

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The role of extracellular and intracellular nicotinamide phosphoribosyl-transferase in cancer: diagnostic and therapeutic perspectives and challenges.

scientific article published on 9 January 2018

The role of glicentin and oxyntomodulin in human metabolism: new evidence and new directions

scientific article published on 01 June 2020

The role of leptin in regulating bone metabolism.

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The role of leptin in regulating neuroendocrine function in humans

scientific article published in September 2004

The role of omics in the pathophysiology, diagnosis and treatment of non-alcoholic fatty liver disease

scientific article published on 23 July 2020

The use of statins alone, or in combination with pioglitazone and other drugs, for the treatment of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and related cardiovascular risk. An Expert Panel Statement

scientific article

Total and high-molecular weight adiponectin in relation to metabolic variables at baseline and in response to an exercise treatment program: comparative evaluation of three assays

scientific article published in February 2007

Total and high-molecular-weight adiponectin and resistin in relation to the risk for type 2 diabetes in women

scientific article

Treating prediabetes in the obese: are GLP-1 analogues the answer?

scientific article published on 23 February 2017

Treatment options to prevent diabetes in subjects with prediabetes: Efficacy, cost effectiveness and future outlook

scientific article published on 4 January 2017

Undiagnosed diabetes is prevalent in younger adults and associated with a higher risk cardiometabolic profile compared to diagnosed diabetes.

scientific article published on 26 July 2015

Variants of the adiponectin and adiponectin receptor-1 genes and posttransplantation diabetes mellitus in renal allograft recipients

scientific article published on 2 November 2011

Variants of the adiponectin gene and diabetic microvascular complications in patients with type 2 diabetes.

scientific article published on 20 December 2012

Walnut consumption increases activation of the insula to highly desirable food cues: A randomized, double-blind, placebo-controlled, cross-over fMRI study

scientific article published on 17 July 2017

Walnut consumption increases satiation but has no effect on insulin resistance or the metabolic profile over a 4-day period

scientific article

Walnut-enriched diet reduces fasting non-HDL-cholesterol and apolipoprotein B in healthy Caucasian subjects: a randomized controlled cross-over clinical trial

scientific article published on 12 November 2013

Will medications that mimic gut hormones or target their receptors eventually replace bariatric surgery?

scientific article published on 11 August 2019

r-metHuLeptin improves highly active antiretroviral therapy-induced lipoatrophy and the metabolic syndrome, but not through altering circulating IGF and IGF-binding protein levels: observational and interventional studies in humans

scientific article

trans-Fatty acids, insulin resistance/diabetes, and cardiovascular disease risk: should policy decisions be based on observational cohort studies, or should we be waiting for results from randomized placebo-controlled trials?

scientific article published on 01 July 2011

γ-Catenin is an independent prognostic marker in early stage colorectal cancer ⬇️

scientific article published on August 25, 2010

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