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List of works by Arthur Weiss

A CRISPR-Based Toolbox for Studying T Cell Signal Transduction

scientific article

A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.

scientific article published on 11 July 2017

A clue to antigen receptor tails

scientific article published on May 2014

A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells

scientific article

A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity

scientific article published on 31 October 2010

A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity

scientific article published on 19 October 2009

A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70

scientific article

A proline-rich motif in the C terminus of Akt contributes to its localization in the immunological synapse

scientific article published on May 2004

Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'.

scientific article published on April 2011

Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription

scientific article

Alternative splicing of CD45: the tip of the iceberg.

scientific article published in December 2008

An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor.

scientific article published on 04 October 2016

An extracatalytic function of CD45 in B cells is mediated by CD22.

scientific article

Antigen receptor signaling in the rheumatic diseases

scientific article published on 30 January 2009

B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency

scientific article published on 10 November 2008

Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells ⬇️

scientific article published on August 16, 2012

Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression

scientific article

CD28 Costimulation: From Mechanism to Therapy

scientific article published on May 2016

CD45 functions as a signaling gatekeeper in T cells

scientific article published on 22 October 2019

CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development

scientific article

CD45: a critical regulator of signaling thresholds in immune cells

scientific article

CRACR2a is a calcium-activated dynein adaptor protein that regulates endocytic traffic

scientific article published on 27 February 2019

Ca2+-dependent Ras/Erk signaling mediates negative selection of autoreactive B cells ⬇️

scientific article published on September 1, 2011

Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila

scientific article

Chemotherapy for bone sarcoma does not affect fertility rates or childbirth.

scientific article

Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor.

scientific article

Combined immunodeficiency due to MALT1 mutations, treated by hematopoietic cell transplantation

scientific article

Commentary: "The Role of T3 Surface Molecules in the Activation of Human Cells: A Two-Stimulus Requirement for IL-2 Production Reflects Events Occurring at a Pretranslational Level".

scientific article

Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases

scientific article published in April 2007

DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape

scientific article published on 26 May 2013

Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness

scientific article published on 3 February 2017

Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissues.

scientific article

Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses

scholarly article

Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinases ⬇️

scientific article published on January 18, 2011

Digital signaling and hysteresis characterize ras activation in lymphoid cells

scientific article

Discovering the TCR beta-chain by subtraction

scientific article published in September 2005

Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns

scientific article

Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation

scientific article published on 7 March 2004

Distinct roles for Syk and ZAP-70 during early thymocyte development

scientific article

Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL

scientific article published on 04 March 2014

Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1.

scientific article

Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation

scientific article published on December 2002

Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production

scholarly article

Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells.

scientific article published on 9 December 2016

Endogenous antigen tunes the responsiveness of naive B cells but not T cells

scientific article

Erratum: Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia

scientific article published on 09 March 2016

Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling

scientific article (publication date: May 2016)

Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec

scientific article published on March 2004

Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia

scientific article published on 8 August 2002

Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4⁺ T cells

scientific journal article

Feedback Circuits Monitor and Adjust Basal Lck-Dependent Events in T Cell Receptor Signaling ⬇️

scientific article published on September 13, 2011

Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen

scientific article published on 16 March 2018

Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

scientific article

Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm

scientific article published on 26 June 2013

Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation.

scientific article published on 9 April 2018

How the T cell signaling network processes information to discriminate between self and agonist ligands

scientific article published on 05 October 2020

Human LAT mutation results in immune deficiency and autoimmunity but also raises questions about signaling pathways

scientific article published on June 2016

IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level

scientific article published on 3 February 2017

IL-2Rβ abundance differentially tunes IL-2 signaling dynamics in CD4+ and CD8+ T cells.

scientific article published on 19 December 2017

Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen

scientific article published on 13 December 2016

Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function

scientific article

Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling

scientific article published on 31 March 2008

Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling

scientific article published on 08 December 2013

Insights into the initiation of TCR signaling

scientific article published on September 2014

Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases.

scientific article

It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activation.

scientific article

Itk Promotes the Integration of TCR and CD28 Costimulation through Its Direct Substrates SLP-76 and Gads

scientific article published on 30 April 2021

Jurkat T cells and development of the T-cell receptor signalling paradigm

scientific article published on April 2004

Kinases and phosphatases of the immune system.

scientific article

Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT

scientific article published on 18 June 2018

Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization

scientific article published in July 2003

Lymphocyte signaling: a Tuscan affair ⬇️

scientific article published on December 16, 2011

LynA regulates an inflammation-sensitive signaling checkpoint in macrophages

scientific article

Maintenance of murine platelet homeostasis by the kinase Csk and the phosphatase CD148.

scientific article published on 4 January 2018

Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding

scientific article

Molecular and genetic insights into T cell antigen receptor signal transduction

scientific article published in January 1994

Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes.

scientific article published on 14 April 2009

Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases

scientific article published on January 2013

Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms

scientific article

Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210.

scientific article published on 09 March 2014

Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45

scientific article

Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.

scientific article

Origin of the sharp boundary that discriminates positive and negative selection of thymocytes

scholarly article

Overview of the Alliance for Cellular Signaling

scientific article

PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.

scientific article published on April 2009

Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation

scientific article

Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4

scientific article

Phosphorylation of a Tyrosine Residue on Zap70 by Lck and Its Subsequent Binding via an SH2 Domain May Be a Key Gatekeeper of T Cell Receptor Signaling In Vivo

scientific article published on 27 June 2016

Pillars article: Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science. 1994. 263: 1136-1139.

scientific article published in November 2014

Positive Regulation of Lyn Kinase by CD148 Is Required for B Cell Receptor Signaling in B1 but Not B2 B Cells

scientific article published on 15 November 2016

Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate

scientific article

Protein kinase Cδ promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance

scientific article published on 10 February 2014

Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.

scientific article

Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival ⬇️

scientific article published on November 30, 2011

Receptor-like Tyrosine Phosphatases CD45 and CD148 Have Distinct Functions in Chemoattractant-Mediated Neutrophil Migration and Response to S. aureus ⬇️

scientific article published on November 10, 2011

Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases

scientific article

Regulated expression of the receptor-like tyrosine phosphatase CD148 on hemopoietic cells

scientific article

Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148.

scientific article

Regulation of thymocyte positive selection and motility by GIT2.

scientific article

Requirement for CD45 in fine-tuning mast cell responses mediated by different ligand-receptor systems.

scientific article published on 27 March 2009

SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling

scientific article

SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase

scientific article

SLAP, a regulator of immunoreceptor ubiquitination, signaling, and trafficking

scientific article

SRC-like adaptor protein regulates B cell development and function

scientific article

STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development.

scientific article published on 27 March 2011

Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia

scientific article published on 23 March 2015

Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination

scientific article published on 14 October 2019

Small molecule inhibition of Csk alters affinity recognition by T cells

scientific article

Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner

scholarly article

Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation

scientific article published on July 2005

Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex

scientific article published on 4 December 2005

Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response

scientific article

Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker

scientific article

Structural basis for the inhibition of tyrosine kinase activity of ZAP-70

scientific article

Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling.

scientific article published on 31 January 2008

Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains

scientific article

T cell receptor engagement leads to phosphorylation of clathrin heavy chain during receptor internalization

scientific article

T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression

scientific article

TCR signal transduction: opening the black box.

scientific article published in October 2009

The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3

scientific journal article

The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation

scientific article published on 10 January 2011

The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.

scientific article published on 19 May 2015

The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cells

scientific article published in July 2002

The juxtamembrane wedge negatively regulates CD45 function in B cells.

scientific article

The membrane environment can promote or suppress bistability in cell signaling networks

scientific article published on 13 March 2012

The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases.

scientific article

The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes

scientific article published on 13 April 2008

The right team at the right time to go for a home run: tyrosine kinase activation by the TCR.

scientific article published on February 2010

The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.

scientific article published on 8 February 2013

The structure, regulation, and function of ZAP-70.

scientific article

The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis

scientific journal article

The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling

scientific article

The ubiquitin ligase Cbl-b limits Pseudomonas aeruginosa exotoxin T-mediated virulence

scientific article published on 18 January 2007

Tony Pawson: Modular protein domains and the links to intracellular signaling

scientific article published on 17 October 2013

Twisting tails exposed: the evidence for TCR conformational change

scientific article

Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice

scholarly article

Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production

scientific article published on 13 March 2015

Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease.

scientific article published on 14 November 2011

Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes

scientific article

ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia

scientific article published in August 2004

ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia

scientific article published on 28 October 2004

ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia

scientific article

ZAP-70 in Signaling, Biology, and Disease

scientific article published on 13 December 2017

ZAP-70: an essential kinase in T-cell signaling

scientific article published on May 2010

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