Search filters

List of works by Wolfgang Wiechert

(13)C Tracers for Glucose Degrading Pathway Discrimination in Gluconobacter oxydans 621H.

scientific article published on 2 September 2015

13C labeling experiments at metabolic nonstationary conditions: an exploratory study.

scientific article

13C-flux spectral analysis of host-pathogen metabolism reveals a mixed diet for intracellular Mycobacterium tuberculosis

scientific article published on August 2013

13CFLUX2--high-performance software suite for (13)C-metabolic flux analysis.

scientific article

40 Years of Biotechnology Research at Forschungszentrum Jülich

scientific article

A FRET-based biosensor for the quantification of glucose in culture supernatants of mL scale microbial cultivations

scientific article published on 21 August 2019

A Pareto approach to resolve the conflict between information gain and experimental costs: Multiple-criteria design of carbon labeling experiments

scientific article

A Primer to13C Metabolic Flux Analysis

A Toolbox of Genetically Encoded FRET-Based Biosensors for Rapid l-Lysine Analysis

scientific article

A closer look at Aspergillus: online monitoring via scattered light enables reproducible phenotyping

scientific article published on 05 August 2019

A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level.

scientific article published on 17 April 2012

A framework for accelerated phototrophic bioprocess development: integration of parallelized microscale cultivation, laboratory automation and Kriging-assisted experimental design.

scientific article published on 31 January 2017

A scientific workflow framework for (13)C metabolic flux analysis.

scientific article published on 22 December 2015

Absolute quantification of Corynebacterium glutamicum glycolytic and anaplerotic enzymes by QconCAT.

scientific article published on 25 October 2014

An Efficient Route to Both Enantiomers of allo-Threonine by Simultaneous Amino Acid Racemase-Catalyzed Isomerization of Threonine and Crystallization

An Enzymatic 2-Step Cofactor and Co-Product Recycling Cascade towards a Chiral 1,2-Diol. Part I: Cascade Design.

scientific article published on 14 May 2019

An Online Provenance Service for Distributed Metabolic Flux Analysis Workflows

An evaluation of genetically encoded FRET-based biosensors for quantitative metabolite analyses in vivo

scientific article published on 5 August 2014

An introduction to 13C metabolic flux analysis.

scientific article

Analyzing Microbial Population Heterogeneity-Expanding the Toolbox of Microfluidic Single-Cell Cultivations

scientific article published on 26 April 2019

Assessment of robustness against dissolved oxygen/substrate oscillations for C. glutamicum DM1933 in two-compartment bioreactor.

scientific article published on 12 November 2013

Atomic Force Microscope Cantilevers Used as Sensors for Monitoring Microdrop Evaporation

Automated growth rate determination in high-throughput microbioreactor systems.

scientific article published on 25 November 2017

Automation of a Nile red staining assay enables high throughput quantification of microalgal lipid production

scientific article

Bayesian calibration, process modeling and uncertainty quantification in biotechnology

scientific article published on 07 March 2022

Beyond growth rate 0.6: Corynebacterium glutamicum cultivated in highly diluted environments

scientific article published on 13 August 2012

Beyond growth rate 0.6: What drives Corynebacterium glutamicum to higher growth rates in defined medium.

scientific article

Bioprocess automation on a Mini Pilot Plant enables fast quantitative microbial phenotyping.

scientific article published on 11 March 2015

Characterization of Sigma Factor Genes in TK24 Using a Genomic Library-Based Approach for Multiple Gene Deletions ⬇️

article

Chassis organism from Corynebacterium glutamicum – Genome reduction as a tool toward improved strains for synthetic biology and industrial biotechnology

scholarly article by Meike Baumgart published in July 2016

Chassis organism from Corynebacterium glutamicum--a top-down approach to identify and delete irrelevant gene clusters

scientific article published on 8 October 2014

Cloud MapReduce for Monte Carlo bootstrap applied to Metabolic Flux Analysis

Coarse-graining bacteria colonies for modelling critical solute distributions in picolitre bioreactors for bacterial studies on single-cell level.

scientific article

Collisional fragmentation of central carbon metabolites in LC-MS/MS increases precision of ¹³C metabolic flux analysis

scientific article

Combinatorial impact of Sec signal peptides from Bacillus subtilis and bioprocess conditions on heterologous cutinase secretion by Corynebacterium glutamicum

scientific article published on 31 December 2018

Combined fluxomics and transcriptomics analysis of glucose catabolism via a partially cyclic pentose phosphate pathway in Gluconobacter oxydans 621H.

scientific article

Comparative 13C metabolic flux analysis of pyruvate dehydrogenase complex-deficient, L-valine-producing Corynebacterium glutamicum.

scientific article published on 22 July 2011

Comparative evaluation of phototrophic microtiter plate cultivation against laboratory-scale photobioreactors

scientific article published on 18 January 2017

Comprehensive analysis of metabolic sensitivity of 1,4-butanediol producing Escherichia coli toward substrate and oxygen availability

scientific article published on 01 November 2019

Computational tools for isotopically instationary 13C labeling experiments under metabolic steady state conditions.

scientific article published on 12 June 2006

Corrigendum: The Design of FluxML: A Universal Modeling Language for 13C Metabolic Flux Analysis

scientific article published on 30 July 2019

Corynebacterium glutamicum Chassis C1*: Building and Testing a Novel Platform Host for Synthetic Biology and Industrial Biotechnology.

scientific article published on 14 August 2017

Customizable Visualization of Multi-omics Data in the Context of Biochemical Networks

scholarly article published July 2009

Customizable Visualization on Demand for Hierarchically Organized Information in Biochemical Networks

scholarly article by Peter Droste et al published 2010 in Lecture Notes in Computer Science

Cutting the Gordian Knot: Identifiability of anaplerotic reactions in Corynebacterium glutamicum by means of (13) C-metabolic flux analysis

scientific article published on 16 September 2015

Design and validation of a parallelized micro-photobioreactor enabling phototrophic bioprocess development at elevated throughput.

scientific article published on 18 July 2016

Determination of flux directions by thermodynamic network analysis: Computing informative metabolite pools

Developing a new production host from a blueprint: Bacillus pumilus as an industrial enzyme producer

scientific article published on 24 March 2014

Differential transcriptomic analysis reveals hidden light response in Streptomyces lividans

scientific article

Discrete-continuous reaction-diffusion model with mobile point-like sources and sinks.

scientific article published on 29 January 2016

Dynamic flux balance analysis with nonlinear objective function.

scientific article published on 11 April 2017

Editorial: Synthetic biology--ready for application.

scientific article published in February 2015

Effective Production of (S)-α-Hydroxy ketones: An Reaction Engineering Approach

article

Emerging Corynebacterium glutamicum systems biology

scientific article

Engineering of Corynebacterium glutamicum for minimized carbon loss during utilization of D-xylose containing substrates

scientific article published on 7 October 2014

Error propagation analysis for quantitative intracellular metabolomics

scientific article published on 21 November 2012

Experimental design principles for isotopically instationary 13C labeling experiments

scientific article published in June 2006

Extensive exometabolome analysis reveals extended overflow metabolism in various microorganisms

scientific article published on 11 September 2012

Fast and reliable strain characterization of Streptomyces lividans through micro-scale cultivation.

scientific article

FeedER: a feedback-regulated enzyme-based slow-release system for fed-batch cultivation in microtiter plates

scientific article published on 09 August 2019

First- and second-order parameter sensitivities of a metabolically and isotopically non-stationary biochemical network model

scholarly article published 19 November 2012

Fluxomics: mass spectrometry versus quantitative imaging

scientific article

From stationary to instationary metabolic flux analysis

scientific article

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

scientific article published on 15 December 2017

Germination and Growth Analysis of at the Single-Cell Level Under Varying Medium Compositions

article

Homogenizing bacterial cell factories: Analysis and engineering of phenotypic heterogeneity.

scientific article

How to measure metabolic fluxes: a taxonomic guide for (13)C fluxomics

scientific article published on 19 December 2014

Hydroxynitrile Lyase from Arabidopsis thaliana: Identification of Reaction Parameters for Enantiopure Cyanohydrin Synthesis by Pure and Immobilized Catalyst

Image-Based Single Cell Profiling: High-Throughput Processing of Mother Machine Experiments.

scientific article

Improved microscale cultivation of Pichia pastoris for clonal screening.

scientific article

Influence of Organic Solvents on Enzymatic Asymmetric Carboligations

scientific article published on 4 October 2012

Interpretation of metabolic flux maps by limitation potentials and constrained limitation sensitivities

scientific article published on 01 June 2006

Investigating the dynamic behavior of biochemical networks using model families

scientific article published on 16 December 2004

Isotopically non-stationary metabolic flux analysis: complex yet highly informative

scientific article published on 24 April 2013

Kriging with trend functions nonlinear in their parameters: Theory and application in enzyme kinetics

scientific article published on 09 August 2017

Laboratory-scale photobiotechnology-current trends and future perspectives.

scientific article

Less sacrifice, more insight: Repeated low-volume sampling of microbioreactor cultivations enables accelerated deep phenotyping of microbial strain libraries

scientific article published on 19 November 2018

Light-responsive control of bacterial gene expression: precise triggering of the lac promoter activity using photocaged IPTG.

scientific article

Live cell imaging of SOS and prophage dynamics in isogenic bacterial populations

scientific article published on 3 August 2015

MMT--a pathway modeling tool for data from rapid sampling experiments

scientific article

Mechanistic pathway modeling for industrial biotechnology: challenging but worthwhile

scientific article published on 23 February 2011

Metabolic Flux Analysis in the Cloud

Metabolic Footprinting of Microbial Systems Based on Comprehensive In Silico Predictions of MS/MS Relevant Data

scientific article published on 17 March 2022

Metabolic flux analysis at ultra short time scale: isotopically non-stationary 13C labeling experiments

scientific article published in December 2006

Metabolic isotopomer labeling systems. Part II: structural flux identifiability analysis

scientific article published in June 2003

Metabolic isotopomer labeling systems. Part III: path tracing

scientific article published on 16 March 2013

Metabolic profile of 1,5-diaminopentane producing Corynebacterium glutamicum under scale-down conditions: Blueprint for robustness to bioreactor inhomogeneities.

scientific article published on 19 September 2016

Microbial single-cell analysis in picoliter-sized batch cultivation chambers

scientific article published on 14 March 2018

Microbioreactor systems for accelerated bioprocess development

scientific article published on 28 December 2017

Microfluidic growth chambers with optical tweezers for full spatial single-cell control and analysis of evolving microbes

scientific article

Microfluidic picoliter bioreactor for microbial single-cell analysis: fabrication, system setup, and operation

scientific article

Miniaturized and automated adaptive laboratory evolution: Evolving Corynebacterium glutamicum towards an improved d-xylose utilization

scientific article published on 12 May 2017

Modeling and CFD simulation of nutrient distribution in picoliter bioreactors for bacterial growth studies on single-cell level

scientific article published on 8 September 2015

Modeling and simulation: tools for metabolic engineering

scientific article

Modeling languages for biochemical network simulation: reaction vs equation based approaches

scientific article

Multi-Omics and Targeted Approaches to Determine the Role of Cellular Proteases in Streptomyces Protein Secretion.

scientific article

Multiscale dynamic modeling and simulation of a biorefinery

scientific article published on 21 July 2019

New tools for mass isotopomer data evaluation in (13)C flux analysis: mass isotope correction, data consistency checking, and precursor relationships.

scientific article

Non-Invasive Microbial Metabolic Activity Sensing at Single Cell Level by Perfusion of Calcein Acetoxymethyl Ester

scientific article (publication date: 2015)

Nondestructive and noncontact method for determining the spring constant of rectangular cantilevers

scientific article

Omix - A Visualization Tool for Metabolic Networks with Highest Usability and Customizability in Focus

scholarly article by Peter Droste et al published 25 April 2013 in Chemie Ingenieur Technik

Optical sensors for monitoring dynamic changes of intracellular metabolite levels in mammalian cells

scientific article

Parallelized microscale fed-batch cultivation in online-monitored microtiter plates: implications of media composition and feed strategies for process design and performance

scientific article published on 31 October 2019

Photocaged Arabinose: A Novel Optogenetic Switch for Rapid and Gradual Control of Microbial Gene Expression

scientific article published on 16 December 2015

Process inhomogeneity leads to rapid side product turnover in cultivation of Corynebacterium glutamicum

scientific article published on 10 January 2014

Quantitative measurements in single-cell analysis: towards scalability in microbial bioprocess development

scientific article published on 27 March 2018

Quantitative metabolomics: a phantom?

scientific article

Rapid and comprehensive evaluation of microalgal fatty acids via untargeted gas chromatography and time-of-flight mass spectrometry

scientific article published on 16 September 2019

Rapid assessment of oxygen transfer impact for Corynebacterium glutamicum

scientific article published in July 2014

Rapid inoculation of single bacteria into parallel picoliter fermentation chambers

Real-time monitoring of fungal growth and morphogenesis at single-cell resolution

scientific article published on 27 July 2016

Revisiting the Growth Modulon of Corynebacterium glutamicum Under Glucose Limited Chemostat Conditions

scientific article published on 15 October 2020

Screening of a genome-reduced Corynebacterium glutamicum strain library for improved heterologous cutinase secretion

scientific article published on 06 September 2020

Semi-automatic drawing of metabolic networks

Serial 13C-based flux analysis of an L-phenylalanine-producing E. coli strain using the sensor reactor.

scientific article

Sessile-drop-induced bending of atomic force microscope cantilevers: a model system for monitoring microdrop evaporation

Simultaneous utilization of glucose and gluconate in Penicillium chrysogenum during overflow metabolism

scientific article published on 05 July 2013

Single-cell microfluidics: opportunity for bioprocess development

scientific article published on 16 March 2014

Spatiotemporal microbial single-cell analysis using a high-throughput microfluidics cultivation platform

scientific article published on 8 September 2015

Stationary versus non-stationary 13C-MFA: A comparison using a consistent dataset

scientific article published on 16 July 2010

Tailor-made catalytically active inclusion bodies for different applications in biocatalysis

Tailoring a Stabilized Variant of Hydroxynitrile Lyase from Arabidopsis thaliana

scientific article published on 29 February 2012

Technical bias of microcultivation environments on single-cell physiology

scientific article published on April 2015

The Design of FluxML: A Universal Modeling Language for 13C Metabolic Flux Analysis

scientific article published on 24 May 2019

The benefits of being transient: isotope-based metabolic flux analysis at the short time scale ⬇️

scientific article published on 06 July 2011

The effect of composition on diffusion of macromolecules in a crowded environment.

scientific article

The linkage between nutrient supply, intracellular enzyme abundances and bacterial growth: New evidences from the central carbon metabolism of Corynebacterium glutamicum

scientific article

The thermodynamic meaning of metabolic exchange fluxes

scientific article published on 25 May 2007

The topology of metabolic isotope labeling networks

scientific article

Time-resolved, single-cell analysis of induced and programmed cell death via non-invasive propidium iodide and counterstain perfusion

scientific article

To be certain about the uncertainty: Bayesian statistics for 13 C metabolic flux analysis.

scientific article published on 11 July 2017

Translating biochemical network models between different kinetic formats

scientific article published on 22 October 2008

Use of a Sec signal peptide library from Bacillus subtilis for the optimization of cutinase secretion in Corynebacterium glutamicum

scientific article

Visual workflows for 13C-metabolic flux analysis

scientific article

Visualizing multi-omics data in metabolic networks with the software Omix: a case study

scientific article

Visualizing regulatory interactions in metabolic networks

scientific article

Vizardous: interactive analysis of microbial populations with single cell resolution.

scientific article published on 10 August 2015

Workflows for Metabolic Flux Analysis: Data Integration and Human Interaction

bletl - A Python package for integrating BioLector microcultivation devices in the Design-Build-Test-Learn cycle

scientific article published on 01 March 2022

mycelyso - high-throughput analysis of Streptomyces mycelium live cell imaging data

scientific article published on 04 September 2019

pH fluctuations imperil the robustness of C. glutamicum to short term oxygen limitation

scientific article

μMORE: A microfluidic magnetic oscillation reactor for accelerated parameter optimization in biocatalysis

scientific article published on 8 June 2016

Paulina is supported by:

About Paulina

Help