List of works by Wolfgang Wick

-OMICS AND PROGNOSTIC MARKERS

scientific article published on 21 October 2011

A Phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma

scientific article published on 21 February 2016

A comprehensive analysis of vascular complications in 3,889 glioma patients from the German Glioma Network

scientific article published on 27 October 2012

A malignant cellular network in gliomas: potential clinical implications

scientific article published on April 2016

A novel tool to analyze MRI recurrence patterns in glioblastoma

scientific article published on 31 July 2008

A phase II, randomized, study of weekly APG101+reirradiation versus reirradiation in progressive glioblastoma

scientific article published on 22 October 2014

A prospective trial of mechanical physiotherapy for lumbar disk prolapse

scientific article published on 01 June 2003

A vaccine targeting mutant IDH1 induces antitumour immunity

scientific article published on 25 June 2014

ACNU-based chemotherapy for recurrent glioma in the temozolomide era.

scientific article

ANGIOGENESIS AND INVASION

APO010, a synthetic hexameric CD95 ligand, induces human glioma cell death in vitro and in vivo

scientific article

ATCT-16CODEL (ALLIANCE-N0577; EORTC-26081/2208; NRG-1071; NCIC-CEC-2): PHASE III RANDOMIZED STUDY OF RT VS. RT + TMZ VS. TMZ FOR NEWLY DIAGNOSED 1p/19q-CODELETED ANAPLASTIC GLIOMA. ANALYSIS OF PATIENTS TREATED ON THE ORIGINAL PROTOCOL DESIGN.

scientific article

ATIM-35. VXM01 PHASE I STUDY IN PATIENTS WITH PROGRESSIVE GLIOBLASTOMA – FINAL RESULTS

ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma

scientific article published on 27 November 2014

ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis

scientific article

Abstract 4736: N-myc downstream regulated gene 1: A novel mediator of hypoxia-driven chemoresistance in glioblastoma

article

Abstracts of the 10th Congress of the European Association of NeuroOncology. Marseille, France. September 6-9, 2012

scientific article published in September 2012

Adenoviral expression of XIAP antisense RNA induces apoptosis in glioma cells and suppresses the growth of xenografts in nude mice

scientific article published on 7 September 2006

Adenoviral natural born killer gene therapy for malignant glioma

scientific article published in September 2003

Adjuvant therapy

scientific article published on January 2009

Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities

scientific article published on 19 June 2015

Advances in malignant glioma drug discovery

scientific article published on 07 June 2011

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

scientific article

Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations.

scientific article published on 21 March 2018

Anaplastic glioma. Neuropathology, molecular diagnostics and current study concepts

scientific article published on August 2010

Anaplastic gliomas: an emerging entity

scientific article published on September 2011

Anaplastic oligodendroglioma: a new treatment paradigm and current controversies

scientific article

Announcing cIMPACT-NOW: the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy

scientific article

Antagonism of the mammalian target of rapamycin selectively mediates metabolic effects of epidermal growth factor receptor inhibition and protects human malignant glioma cells from hypoxia-induced cell death.

scientific article published on 4 May 2009

Anti-Angiogenics: Their Role in the Treatment of Glioblastoma.

scientific article published on 23 March 2018

Antiangiogenic therapy for glioblastoma: current status and future prospects

scientific article

Anticoagulation for radiation-induced neurotoxicity revisited

scientific article published on 22 August 2008

Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine

scientific article published on 3 July 2006

Are we ready to demystify age in glioblastoma? Or does older age matter in glioblastoma?

scientific article published on April 2011

Aryl hydrocarbon receptor inhibition downregulates the TGF-beta/Smad pathway in human glioblastoma cells

scientific article

Assessing CpG island methylator phenotype, 1p/19q codeletion, and MGMT promoter methylation from epigenome-wide data in the biomarker cohort of the NOA-04 trial

scientific article

Assessment of tumor oxygenation and its impact on treatment response in bevacizumab-treated recurrent glioblastoma

scientific article published on 9 February 2016

Association of overall survival in patients with newly diagnosed glioblastoma with contrast-enhanced perfusion MRI: Comparison of intraindividually matched T1 - and T2 (*) -based bolus techniques

scientific article published on 22 September 2014

Astrocytic gliomas WHO grades II and III.

scientific article published on January 2016

Automatic Analysis of Cellularity in Glioblastoma and Correlation with ADC Using Trajectory Analysis and Automatic Nuclei Counting

scientific article

BCL-2 promotes migration and invasiveness of human glioma cells

scientific article published in December 1998

BCL-2-induced glioma cell invasiveness depends on furin-like proteases

scientific article

BCL-xL: time-dependent dissociation between modulation of apoptosis and invasiveness in human malignant glioma cells

scientific article published on 28 October 2005

BI-32RISK FACTOR ANALYSIS FOR PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA WHO DID NOT RECEIVE SALVAGE THERAPY.

scientific article published in November 2014

Betulinic acid-induced apoptosis in glioma cells: A sequential requirement for new protein synthesis, formation of reactive oxygen species, and caspase processing

scientific article (publication date: June 1999)

Bevacizumab Prevents Brain Metastases Formation in Lung Adenocarcinoma

scientific article published on 25 January 2016

Bevacizumab alone or in combination with irinotecan in recurrent WHO grade II and grade III gliomas

scientific article published on 22 November 2012

Bevacizumab and recurrent malignant gliomas: a European perspective

scientific article

Bevacizumab does not increase the risk of remote relapse in malignant glioma.

scientific article

Bevacizumab for newly diagnosed glioblastoma

scientific article

Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma

scientific article published in February 2014

Bevacizumab, temozolomide, and radiotherapy for newly diagnosed glioblastoma: comprehensive safety results during and after first-line therapy

scientific article

Biomarker and Histopathology Evaluation of Patients with Recurrent Glioblastoma Treated with Galunisertib, Lomustine, or the Combination of Galunisertib and Lomustine

scientific article

Blood-brain barrier and brain edema

scientific article published on January 2012

Brain Tumor Segmentation Using Large Receptive Field Deep Convolutional Neural Networks

scholarly article published 2017

CD95/CD95 ligand-independent potentiation of treosulfan cytotoxicity by BSO in malignant glioma cells in vitro and in vivo

scientific article

CELL BIOLOGY AND SIGNALING

article

CMV infection and glioma, a highly controversial concept struggling in the clinical arena

scientific article published on March 2014

Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors

scientific article

Capillary Transit Time Heterogeneity Is Associated with Modified Rankin Scale Score at Discharge in Patients with Bilateral High Grade Internal Carotid Artery Stenosis

scientific article

Carbon irradiation overcomes glioma radioresistance by eradicating stem cells and forming an antiangiogenic and immunopermissive niche

Challenging cytomegalovirus data in glioblastoma

scientific article published on 18 December 2013

Characterization of Tu-2449, a glioma cell line derived from a spontaneous tumor in GFAP-v-src-transgenic mice: comparison with established murine glioma cell lines.

scientific article published on October 1999

Chemoradiotherapy of newly diagnosed glioblastoma with intensified temozolomide

scientific article published on 14 October 2009

Chemotherapie bei Gliomen

Chemotherapy for intracranial ependymoma in adults

scientific article

Chemotherapy-induced cell death in primary cerebellar granule neurons but not in astrocytes: in vitro paradigm of differential neurotoxicity

scientific article published in December 2004

Chimeric tumor suppressor 1, a p53-derived chimeric tumor suppressor gene, kills p53 mutant and p53 wild-type glioma cells in synergy with irradiation and CD95 ligand.

scientific article

Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial

scientific article

Cilengitide modulates attachment and viability of human glioma cells, but not sensitivity to irradiation or temozolomide in vitro

scientific article published on December 2009

Cilengitide treatment of newly diagnosed glioblastoma patients does not alter patterns of progression

scientific article

Classification and management of anaplastic gliomas

scientific article published on December 2009

Clinical outcome with bevacizumab in patients with recurrent high-grade glioma treated outside clinical trials.

scientific article published on 18 April 2011

Clinical parameters outweigh diffusion- and perfusion-derived MRI parameters in predicting survival in newly diagnosed glioblastoma

scientific article published on 13 June 2016

Comment to: Parametric response map as an imaging biomarker to distinguish progression from pseudoprogression in high-grade glioma: pitfalls in perfusion MRI in brain tumors : Tsien C, Galbán CJ, Chenevert TL, Johnson TD, Hamstra DA, Sundgren PC, Ju

scientific article

Complete resection of contrast-enhancing tumor volume is associated with improved survival in recurrent glioblastoma-results from the DIRECTOR trial

scientific article published on 27 January 2016

Comprehensive allelotype and genetic anaysis of 466 human nervous system tumors

scientific article

Concepts in glioma immunotherapy

scientific article

Consensus recommendations for a standardized Brain Tumor Imaging Protocol in clinical trials

scientific article (publication date: September 2015)

Correlated MRI and Ultramicroscopy (MR-UM) of Brain Tumors Reveals Vast Heterogeneity of Tumor Infiltration and Neoangiogenesis in Preclinical Models and Human Disease

Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity

scientific article published on September 2008

Costimulatory protein 4IgB7H3 drives the malignant phenotype of glioblastoma by mediating immune escape and invasiveness.

scientific article

Current status and future directions of anti-angiogenic therapy for gliomas

scientific article published on 12 October 2015

DNA methylation, transcriptome and genetic copy number signatures of diffuse cerebral WHO grade II/III gliomas resolve cancer heterogeneity and development

DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

scientific article published on 14 March 2017

DNA methylation-based classification of central nervous system tumours.

scientific article published on 14 March 2018

De novo erythropoietin receptor (EPO-R) expression in human neoplastic glial cells decreases with grade of malignancy but is favourably associated with patient survival

scientific article

Deciphering the systems biology of mTOR inhibition by integrative transcriptome analysis

scientific article published on January 2014

Defective p53 antiangiogenic signaling in glioblastoma

scientific article

Diagnostic Challenges in Meningioma

scientific article published on 20 May 2017

Differential Effects of Ang-2/VEGF-A Inhibiting Antibodies in Combination with Radio- or Chemotherapy in Glioma

Differential expression of egr1 and activation of microglia following irradiation in the rat brain

scientific article

Differential expression of the tumor suppressor A-kinase anchor protein 12 in human diffuse and pilocytic astrocytomas is regulated by promoter methylation

scientific article published in October 2013

Differentiation of glioblastoma and primary CNS lymphomas using susceptibility weighted imaging

scientific article published on 10 December 2012

Differentiation of pseudoprogression and real progression in glioblastoma using ADC parametric response maps

scientific article

Distinct molecular mechanisms of acquired resistance to temozolomide in glioblastoma cells

scientific article published on 28 May 2012

Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system

scientific article published on 24 October 2013

Does Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma

scientific article published on 19 January 2016

Does age matter? - A MRI study on peritumoral edema in newly diagnosed primary glioblastoma

scientific article

Downfield-NOE-suppressed amide-CEST-MRI at 7 Tesla provides a unique contrast in human glioblastoma

scientific article

Drug Repositioning Meets Precision in Glioblastoma

scientific article

EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with leptomeningeal metastasis from solid tumours†

EH1.3 EORTC 26101 phase III trial exploring the combination of bevacizumab and lomustine versus lomustine in patients with first progression of a glioblastoma.

scientific article published on 21 September 2016

EORTC topics in neurooncology: The long path from a focus on neurological complications of cancer towards molecularly defined trials and therapies in neurooncology

Efficacy and tolerability of temozolomide in an alternating weekly regimen in patients with recurrent glioma

scientific article published in August 2007

Enzastaurin before and concomitant with radiation therapy, followed by enzastaurin maintenance therapy, in patients with newly diagnosed glioblastoma without MGMT promoter hypermethylation

scientific article published on August 2013

Enzastaurin-induced apoptosis in glioma cells is caspase-dependent and inhibited by BCL-XL.

scientific article

Epidermal growth factor receptor and mammalian target of rapamycin as therapeutic targets in malignant glioma: current clinical status and perspectives ⬇️

scientific article published on September 19, 2010

Epilepsy meets cancer: when, why, and what to do about it?

scientific article published on September 2012

Evaluation of dynamic contrast-enhanced MRI derived microvascular permeability in recurrent glioblastoma treated with bevacizumab

scientific article published on 31 October 2014

Evaluation of microvascular permeability with dynamic contrast-enhanced MRI for the differentiation of primary CNS lymphoma and glioblastoma: radiologic-pathologic correlation.

scientific article

Evaluation of pseudoprogression rates and tumor progression patterns in a phase III trial of bevacizumab plus radiotherapy/temozolomide for newly diagnosed glioblastoma

scientific article published on 11 August 2016

Evidence for a novel tumor suppressor gene on chromosome 15 associated with progression to a metastatic stage in breast cancer

scientific article

Examining cognitive emotion regulation in frontal lobe patients: The mediating role of response inhibition

scientific article published in August 2015

Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275.

scientific article

Expression and functional activity of osteoprotegerin in human malignant gliomas ⬇️

scientific article published on September 23, 2003

Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma

scientific article published on 21 August 2014

Feasibility of real-time molecular profiling for patients with newly diagnosed glioblastoma without MGMT promoter-hypermethylation - the NCT Neuro Master Match (N2M2) pilot study

scientific article published on 18 November 2017

GDF-15 contributes to proliferation and immune escape of malignant gliomas

scientific article published on 9 June 2010

Gadofluorine M enhanced MRI in experimental glioma: superior and persistent intracellular tumor enhancement compared with conventional MRI.

scientific article

Gadolinium retention in the dentate nucleus and globus pallidus is dependent on the class of contrast agent

scientific article published on 6 April 2015

Gain of 12p encompassing CCND2 is associated with gemistocytic histology in IDH mutant astrocytomas

scientific article published on 20 December 2016

Gene-Tailored Treatments for Brain Disorders: Challenges and Opportunities

scientific article published on June 2016

General control non-derepressible 2 (GCN2) in T cells controls disease progression of autoimmune neuroinflammation

scientific article published on 20 May 2016

Generation and validation of a prognostic score to predict outcome after re-irradiation of recurrent glioma

scientific article published on 11 June 2012

Geriatric neuro-oncology: from mythology to biology

scientific article published on December 2011

German Cancer Consortium (DKTK) - A national consortium for translational cancer research

article

Glioblastoma: what's ischemia got to do with it?

scientific article published in November 2006

Glioma cell invasion: regulation of metalloproteinase activity by TGF-beta.

scientific article

Glioma tropism of lentivirally transduced hematopoietic progenitor cells.

scientific article published in June 2010

Glioma.

scientific article published on 16 July 2015

Gliomatosis cerebri: molecular pathology and clinical course

scientific article published in October 2002

Go, no-go decision making for phase 3 clinical trials: ACT IV revisited - Authors' reply

scientific article published in December 2017

Good maths is needed to understand CMV data in glioblastoma

scientific article

Harmful networks in the brain and beyond.

scientific article

Health-Related Quality of Life in a Randomized Phase III Study of Bevacizumab, Temozolomide, and Radiotherapy in Newly Diagnosed Glioblastoma

scientific article published on 26 May 2015

High-Signal Intensity in the Dentate Nucleus and Globus Pallidus on Unenhanced T1-Weighted Images: Evaluation of the Macrocyclic Gadolinium-Based Contrast Agent Gadobutrol

scientific article published on 30 October 2015

Higher dosing of temozolomide? Regression of an anaplastic oligoastrocytoma over more than three years

scientific article

Highlights in Central Nervous System Tumors.

scientific article

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma

scientific article published in October 2012

How lymphotoxic is dose-intensified temozolomide? The glioblastoma experience

scientific article published in June 2005

Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins

scientific article (publication date: June 2003)

IDH mutant diffuse and anaplastic astrocytomas have similar age at presentation and little difference in survival: a grading problem for WHO.

scientific article published on 12 May 2015

IDH mutation status is associated with a distinct hypoxia/angiogenesis transcriptome signature which is non-invasively predictable with rCBV imaging in human glioma

scientific article

IMMUNOLOGY RESEARCH

scholarly article published in November 2013

Immature mesenchymal stem cell-like pericytes as mediators of immunosuppression in human malignant glioma

scientific article published on 20 September 2013

Immunotherapy for neuro-oncology: the critical rationale for combinatorial therapy

scientific article

Immunotherapy response assessment in neuro-oncology: a report of the RANO working group

scientific article

Impact of delays in initiating postoperative chemoradiation while determining the MGMT promoter-methylation statuses of patients with primary glioblastoma

scientific article published on 30 July 2015

Impact of tapering and discontinuation of bevacizumab in patients with progressive glioblastoma

scientific article published on 15 July 2016

Impaired remission from autoimmune neuroinflammation upon T cell-specific knockout of the stress kinase GCN2

scholarly article by Jana Sonner et al published October 2014 in Journal of Neuroimmunology

In situ proximity ligation assay to evaluate presentation of a mutated CD4 epitope in human glioma tissue

scholarly article by Lukas Bunse et al published October 2014 in Journal of Neuroimmunology

Increased Delay Between Gadolinium Chelate Administration and T1-Weighted Magnetic Resonance Imaging Acquisition Increases Contrast-Enhancing Tumor Volumes and T1 Intensities in Brain Tumor Patients

scientific article published on 28 November 2017

Increased Signal Intensity in the Dentate Nucleus on Unenhanced T1-Weighted Images After Gadobenate Dimeglumine Administration

scientific article published on 8 September 2015

Increasing the sensitivity of MRI for the detection of multiple sclerosis lesions by long axial coverage of the spinal cord: a prospective study in 119 patients

scientific article published in December 2016

Individualized targeted therapy for glioblastoma: fact or fiction?

scientific article published on January 2012

Infiltrative patterns of glioblastoma: Identification of tumor progress using apparent diffusion coefficient histograms

scientific article published on 30 September 2013

Inhibiting TGF-beta signaling restores immune surveillance in the SMA-560 glioma model

scientific article published on 23 May 2007

Inhibition of CD95/CD95L Signaling with APG101 Prevents Invasion and Enhances Radiation Therapy for Glioblastoma

scientific article published on 16 February 2018

Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma

scientific article published on 10 July 2014

Interim results from the CATNON trial (EORTC study 26053-22054) of treatment with concurrent and adjuvant temozolomide for 1p/19q non-co-deleted anaplastic glioma: a phase 3, randomised, open-label intergroup study

scientific article

Interpretation of meta-analysis evaluating progression-free survival as a surrogate endpoint for overall survival in glioblastoma

scientific article published on 26 February 2015

Intracranial metastatic esthesioneuroblastoma responsive to temozolomide

scientific article published in October 2004

Intraindividual Analysis of Signal Intensity Changes in the Dentate Nucleus After Consecutive Serial Applications of Linear and Macrocyclic Gadolinium-Based Contrast Agents

scientific article published on 4 August 2016

Irradiation and hypoxia promote homing of haematopoietic progenitor cells towards gliomas by TGF-beta-dependent HIF-1alpha-mediated induction of CXCL12.

scientific article published on 10 July 2006

Is there a role for benzodiazepines in the management of lumbar disc prolapse with acute sciatica?

scientific article published in April 2010

Isocitrate dehydrogenase mutations: a challenge to traditional views on the genesis and malignant progression of gliomas

scientific article published on 03 February 2011

K27M-mutant histone-3 as a novel target for glioma immunotherapy

scientific article

KIAA1797/FOCAD encodes a novel focal adhesion protein with tumour suppressor function in gliomas

scientific article

LAB-OMICS AND PROGNOSTIC MARKERS

article

Large-scale Radiomic Profiling of Recurrent Glioblastoma Identifies an Imaging Predictor for Stratifying Anti-Angiogenic Treatment Response

scientific article

Lessons from the bone marrow: how malignant glioma cells attract adult haematopoietic progenitor cells

scientific article published on 9 June 2005

Limited role for extended maintenance temozolomide for newly diagnosed glioblastoma

scientific article

Lomustine and Bevacizumab in Progressive Glioblastoma

scientific article published in November 2017

Long-term analysis of the NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with PCV or temozolomide

scientific article published on July 2016

Long-term survival of patients with glioblastoma treated with radiotherapy and lomustine plus temozolomide

scientific article

Loss of histone H3K27me3 identifies a subset of meningiomas with increased risk of recurrence.

scientific article published on 7 April 2018

MGMT Promoter Methylation Is a Strong Prognostic Biomarker for Benefit from Dose-Intensified Temozolomide Rechallenge in Progressive Glioblastoma: The DIRECTOR Trial

scientific article published on 5 February 2015

MGMT promoter methylation in malignant gliomas: ready for personalized medicine?

scientific article published on 08 December 2009

MGMT testing--the challenges for biomarker-based glioma treatment

scientific article

MR Perfusion-derived Hemodynamic Parametric Response Mapping of Bevacizumab Efficacy in Recurrent Glioblastoma

scientific article published on 16 November 2015

Malignant astrocytoma in elderly patients: where do we stand?

scientific article published on December 2013

Malignant astrocytomas of elderly patients lack favorable molecular markers: an analysis of the NOA-08 study collective

scientific article published on 17 April 2013

Malignant glioma biology: role for TGF-beta in growth, motility, angiogenesis, and immune escape

scientific article

Malignant glioma cells counteract antitumor immune responses through expression of lectin-like transcript-1.

scientific article published on April 2007

Malignant melanoma S3-guideline "diagnosis, therapy and follow-up of melanoma".

scientific article published in August 2013

Mechanisms of chemoresistance to alkylating agents in malignant glioma

scientific article published on May 2008

Mechanisms of resistance of human glioma cells to Apo2 ligand/TNF-related apoptosis-inducing ligand

scientific article

Metabolic Pathways

scholarly article published in 2013

Migratory neural stem cells for improved thymidine kinase-based gene therapy of malignant gliomas.

scientific article published on March 2005

Modulation of MDR/MRP by wild-type and mutant p53.

scientific article published in March 2001

Modulation of TGF-beta activity by latent TGF-beta-binding protein 1 in human malignant glioma cells

scientific article

Molecular characterization of long-term survivors of glioblastoma using genome- and transcriptome-wide profiling.

scientific article

Molecular classification of diffuse cerebral WHO grade II/III gliomas using genome- and transcriptome-wide profiling improves stratification of prognostically distinct patient groups

scientific article published on 18 March 2015

Molecular determinants of glioma cell migration and invasion

scientific article published in June 2001

Molecular diagnostics of gliomas: the clinical perspective

scientific article published on 23 September 2010

Molecular differences in IDH wildtype glioblastoma according to MGMT promoter methylation.

scientific article published on 24 August 2017

Molecular neuro-oncology in clinical practice: a new horizon

scientific article published on August 2013

Molecular neuro-oncology: a forward-looking perspective

scientific article

Molecular predictors of outcome in low-grade glioma

scientific article published on December 2012

Mouse mesenchymal stem cells suppress antigen-specific TH cell immunity independent of indoleamine 2,3-dioxygenase 1 (IDO1).

scientific article

Multicenter pilot study of radio-chemotherapy as first-line treatment for adults with medulloblastoma (NOA-07).

scientific article published on 21 August 2017

Mutant IDH1: An immunotherapeutic target in tumors

scientific article published in December 2014

Mutant IDH1R132H bears a mutation-specific CD4 T cell epitope suitable for vaccination of human CNS tumors

scholarly article by Theresa Schumacher et al published October 2014 in Journal of Neuroimmunology

N-[3,4-dimethoxycinnamoyl]-anthranilic acid (tranilast) inhibits transforming growth factor-beta relesase and reduces migration and invasiveness of human malignant glioma cells

scientific article published on July 2001

N-[3,4-dimethoxycinnamoyl]-anthranilic acid (tranilast) suppresses microglial inducible nitric oxide synthase (iNOS) expression and activity induced by interferon-gamma (IFN-gamma)

scientific article

NDRG1 overexpressing gliomas are characterized by reduced tumor vascularization and resistance to antiangiogenic treatment

scientific article published on 19 August 2015

NDRG1 prognosticates the natural course of disease in WHO grade II glioma.

scientific article published on 7 January 2014

NIMG-56IMMUNOTHERAPY RESPONSE ASSESSMENT IN NEURO-ONCOLOGY (iRANO): A REPORT OF THE RANO WORKING GROUP.

scientific article

NIMG-75. NECROSIS DURING TREATMENT IS ASSOCIATED WITH WORSE SURVIVAL IN RECURRENT GLIOBLASTOMA PATIENTS – POST HOC IMAGE ANALYSIS OF EORTC 26101

NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide

scientific article published on 9 November 2009

Neoadjuvant gemcitabine/treosulfan chemotherapy for newly diagnosed glioblastoma: a phase II study

scientific article published in September 2002

Neuro-oncology in 2013: improving outcome in newly diagnosed malignant glioma

scientific article published on 14 January 2014

Neurological sequelae of cancer immunotherapies and targeted therapies

scientific article published on December 2016

Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt.

scientific article published in August 2002

Neuroradiological response criteria for high-grade gliomas

scientific article

New (alternative) temozolomide regimens for the treatment of glioma

scientific article published on 04 September 2008

Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets

scientific article published on 15 December 2015

No Signal Intensity Increase in the Dentate Nucleus on Unenhanced T1-weighted MR Images after More than 20 Serial Injections of Macrocyclic Gadolinium-based Contrast Agents

scientific article

No preferential loss of paternal 19q alleles in oligodendroglial tumors

scientific article published in August 2003

No prognostic value of IDH1 mutations in a series of 100 WHO grade II astrocytomas

scientific article published on 19 April 2012

Normal mast cell numbers in the tissues of AhR-deficient mice

scientific article published on 7 October 2015

Novel, improved grading system(s) for IDH-mutant astrocytic gliomas.

scientific article published on 23 April 2018

Nuclear Overhauser Enhancement imaging of glioblastoma at 7 Tesla: region specific correlation with apparent diffusion coefficient and histology

scientific article

Nuclear overhauser enhancement mediated chemical exchange saturation transfer imaging at 7 Tesla in glioblastoma patients

scientific article

O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells

scientific article published on 9 January 2006

O6.10GLIOMA CELL VEGFR-2 EXPRESSION IMPAIRS CHEMOTHERAPEUTIC AND ANTIANGIOGENIC TREATMENTS IN PTEN-DEFICIENT GLIOBLASTOMA.

scientific article published in September 2014

OMICS AND PROGNSTIC MARKERS

article

OS09.9 Identification of IDH1R132H-specific T cell receptors from glioma patients and from MHC-humanized mice.

scientific article

OS1.3 N-Myc downstream regulated gene 1 (NDRG1) influences the glioma tumor microenvironment

scientific article published on 21 September 2016

OS1.6 Tumor Microtubes contribute to resistance against surgical lesions, and chemotherapy in malignant glioma.

scientific article published on 21 September 2016

OS11.5 ACT IV: An international, double-blind, phase 3 trial of rindopepimut in newly diagnosed, EGFRvIII-expressing glioblastoma.

scientific article

OS2.3 A mutation-specific vaccination approach for Histon H3.3 K27M-mutated gliomas.

scientific article

OS2.4 Expression and relevance of tumoral and stromal MHC class II in gliomas

scientific article published on 21 September 2016

OS2.6 Identification of IDH1R132H-specific T cell receptors from a humanized mouse model and from glioma patients treated with an IDH1R132H-specific peptide vaccine.

scientific article published on 21 September 2016

OS3.1 Differential impact of Ang-2, VEGF-A and dual Ang-2/VEGF-A blocking on the efficacy of radio- and chemotherapy in a glioblastoma model.

scientific article published on 21 September 2016

OS5.1 Sequence of bevacizumab and lomustine in patients with first progression of a glioblastoma: phase II EORTC study 26101.

scientific article published on 21 September 2016

OS5.2 Health-Related Quality of Life (HRQoL) in patients with progressive glioblastoma treated with combined bevacizumab and lomustine versus lomustine only (randomized phase III EORTC study 26101).

scientific article published on 21 September 2016

One week on/one week off: a novel active regimen of temozolomide for recurrent glioblastoma

scientific article

Optimal management of elderly patients with glioblastoma

scientific article published on 19 June 2012

Outcome and prognostic factors of desmoplastic medulloblastoma treated within a multidisciplinary treatment concept

scientific article

Outcome and prognostic factors of radiation therapy for medulloblastoma

scientific article published on 23 February 2011

Outcome of patients with proximal vessel occlusion of the anterior circulation and DWI-PWI mismatch is time-dependent

scientific article

P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.

scientific article published on October 2003

P01.32 NDRG1 induced downregulation of CCL2 influences the migration of macrophages and impacts the tumor microenvironement.

scientific article published on 19 April 2017

P04.04 Ex vivo expansion of human glioma-infiltrating lymphocytes alters the exhaustion phenotype of T cells.

scientific article

P04.27 Texture feature analysis to predict overall survival in recurrent glioblastoma treated in the DIRECTOR trial.

scientific article

P06.08 BRAINTuNE: Brain Tumor Neoepitope Evaluation for personalized glioma immunotherapy.

scientific article

P08.19 Resistance towards the MDM2 inhibitor idasanutlin is mediated via the NFkB pathway and IGFBP1 upregulation in glioblastoma.

scientific article published on 19 April 2017

P08.31 A perivascular niche for progression and resistance in glioblastoma.

scientific article published on 21 September 2016

P08.64 A NF-κB in vivo reporter system allows molecular insights into glioma progression and therapy response.

scientific article published on 19 April 2017

PATHOLOGY

scholarly article by J.-i. Adachi et al published 1 November 2013 in Neuro-Oncology

PD-1 Antibody-induced Guillain-Barré Syndrome in a Patient with Metastatic Melanoma

scientific article published on 14 October 2016

PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis.

scientific article published in July 1999

Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo

scientific article published on 25 January 2017

Pathway inhibition: emerging molecular targets for treating glioblastoma

scientific article

Patients With Proneural Glioblastoma May Derive Overall Survival Benefit From the Addition of Bevacizumab to First-Line Radiotherapy and Temozolomide: Retrospective Analysis of the AVAglio Trial

scientific article published on 29 June 2015

Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas

scientific article

Patterns of progression in malignant glioma following anti-VEGF therapy: perceptions and evidence

scientific article

Pediatric Brain: No Increased Signal Intensity in the Dentate Nucleus on Unenhanced T1-weighted MR Images after Consecutive Exposure to a Macrocyclic Gadolinium-based Contrast Agent

scientific article

Perfusion Magnetic Resonance Imaging for Parametric Response Maps in Tumors: Is It Really That Easy? ⬇️

scientific article published on September 13, 2010

Peripheral nerve involvement in multiple sclerosis: Demonstration by magnetic resonance neurography

scientific article published on 10 October 2017

Personalized care in neuro-oncology coming of age: why we need MGMT and 1p/19q testing for malignant glioma patients in clinical practice

scientific article

Personalized neurooncology

scientific article

Pharmacotherapy of epileptic seizures in glioma patients: who, when, why and how long?

scientific article

Phase 2 trial design in neuro-oncology revisited: a report from the RANO group

scientific article published on May 2012

Phase II trial of lomustine plus temozolomide chemotherapy in addition to radiotherapy in newly diagnosed glioblastoma: UKT-03.

scientific article published in September 2006

Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma

scientific article

Pirfenidone inhibits TGF-beta expression in malignant glioma cells

scientific article published on 10 January 2007

Posterior Circulation Acute Stroke Prognosis Early Computed Tomography Score Using Hypointense Vessels on Susceptibility Weighted Imaging Independently Predicts Outcome in Patients with Basilar Artery Occlusion

scientific article published on 15 July 2015

Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience.

scientific article

Predictive impact of MGMT promoter methylation in glioblastoma of the elderly

scientific article published on 11 January 2012

Preirradiation gemcitabine chemotherapy for newly diagnosed glioblastoma. A phase II study

scientific article

Primary central nervous system lymphoma and atypical glioblastoma: multiparametric differentiation by using diffusion-, perfusion-, and susceptibility-weighted MR imaging

scientific article

Primary glioblastoma cultures: can profiling of stem cell markers predict radiotherapy sensitivity?

scientific article published on 18 July 2014

Prognostic or predictive value of MGMT promoter methylation in gliomas depends on IDH1 mutation

scientific article published on 25 September 2013

Prognostic relevance of miRNA-155 methylation in anaplastic glioma

scientific article published on 18 November 2016

Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: one step forward, and one step back?

scientific article

Prognostic value of combined visualization of MR diffusion and perfusion maps in glioblastoma.

scientific article published on 30 October 2015

Prognostic value of three different methods of MGMT promoter methylation analysis in a prospective trial on newly diagnosed glioblastoma

scientific article (publication date: 2012)

Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma

scientific article published on 29 October 2014

Progression types after antiangiogenic therapy are related to outcome in recurrent glioblastoma.

scientific article

Progression-free survival as a surrogate endpoint for overall survival in glioblastoma: a literature-based meta-analysis from 91 trials

scientific article published on 12 December 2013

Promotion of glioblastoma cell motility by enhancer of zeste homolog 2 (EZH2) is mediated by AXL receptor kinase

scientific article

Protein kinase Cβ as a therapeutic target stabilizing blood-brain barrier disruption in experimental autoimmune encephalomyelitis

scientific article published on 19 August 2013

Proximity ligation assay evaluates IDH1R132H presentation in gliomas

scientific article

Pseudoprogression in patients with glioblastoma: clinical relevance despite low incidence

scientific article published on 18 July 2014

Quantification of tumor vessels in glioblastoma patients using time-of-flight angiography at 7 Tesla: a feasibility study

scientific article

Quantitative and qualitative analysis of study-related patient information sheets in randomised neuro-oncology phase III-trials

scientific article

Quantitative susceptibility mapping differentiates between blood depositions and calcifications in patients with glioblastoma

scientific article

RADIOLOGY

list of radiology abstracts from the 4th Quadrennial Meeting of the World Federation of Neuro-Oncology

RNA interference targeting transforming growth factor-beta enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo.

scientific article

RTOG 9802: good wines need aging

scientific article published on 7 January 2013

Radiogenomic rCBV-imaging visualizes the moleculare signature of IDH-mutant and wildtype gliomas

Radiogenomics of Glioblastoma: Machine Learning-based Classification of Molecular Characteristics by Using Multiparametric and Multiregional MR Imaging Features

scientific article

Radiomic Profiling of Glioblastoma: Identifying an Imaging Predictor of Patient Survival with Improved Performance over Established Clinical and Radiologic Risk Models

scientific article published on 20 June 2016

Radiomic subtyping improves disease stratification beyond key molecular, clinical and standard imaging characteristics in patients with glioblastoma

scientific article published on 28 September 2017

Randomised phase I/II study to evaluate carbon ion radiotherapy versus fractionated stereotactic radiotherapy in patients with recurrent or progressive gliomas: the CINDERELLA trial

scientific article

Randomized phase II study evaluating a carbon ion boost applied after combined radiochemotherapy with temozolomide versus a proton boost after radiochemotherapy with temozolomide in patients with primary glioblastoma: the CLEOPATRA trial

scientific article

Rapid detection of 2-hydroxyglutarate in frozen sections of IDH mutant tumors by MALDI-TOF mass spectrometry.

scientific article

Rechallenge with temozolomide in patients with recurrent gliomas

scientific article published on 25 February 2009

Relative cerebral blood volume is a potential predictive imaging biomarker of bevacizumab efficacy in recurrent glioblastoma

scientific article published on 9 March 2015

Relaxation-compensated CEST-MRI of the human brain at 7T: Unbiased insight into NOE and amide signal changes in human glioblastoma

scientific article

Relevance of T2 signal changes in the assessment of progression of glioblastoma according to the Response Assessment in Neurooncology criteria

scientific article published on 6 December 2011

Reply to F. Felix et al and M.F. Fay et al.

scientific article published on 13 June 2016

Reply to T.J. Kruser et al.

scientific article published on 16 February 2016

Response

Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial

scientific article published on 22 August 2017

Role of TGF-? in oncogenesis

Role of TGF-beta in oncogenesis

scientific article published on 01 February 2001

S3-guideline "diagnosis, therapy and follow-up of melanoma" -- short version

scientific article published in June 2013

SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo

scientific article

Sequential proton boost after standard chemoradiation for high-grade glioma

scientific article published on 16 October 2017

Shaping the glioma immune microenvironment through tryptophan metabolism

scientific article

Short-Course Radiation plus Temozolomide in Elderly Patients with Glioblastoma

scientific article published on March 2017

Should biomarkers be used to design personalized medicine for the treatment of glioblastoma?

scientific article published on September 2010

Slowing down glioblastoma progression in mice by running or the anti-malarial drug dihydroartemisinin? Induction of oxidative stress in murine glioblastoma therapy

scientific article published on 20 July 2016

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

scientific article

Soluble decoy receptor 3 is expressed by malignant gliomas and suppresses CD95 ligand-induced apoptosis and chemotaxis

scientific article published in March 2001

Standards of care for treatment of recurrent glioblastoma--are we there yet?

scientific article published on 7 November 2012

Stem cell-mediated gene therapies for malignant gliomas: a promising targeted therapeutic approach?

scientific article published on June 2011

Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma

scientific article

Steroids in neurooncology: actions, indications, side-effects

scientific article published on December 2010

Suberoylanilide hydroxamic acid (SAHA) has potent anti-glioma properties in vitro, ex vivo and in vivo

scientific article

Sublethal irradiation promotes migration and invasiveness of glioma cells: implications for radiotherapy of human glioblastoma

scientific article published on March 2001

Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway

scientific article published on 5 August 2014

Suppression of Th1 differentiation by tryptophan supplementation in vivo

scientific article published on 18 April 2017

Suppression of proinvasive RGS4 by mTOR inhibition optimizes glioma treatment

scientific article published on 7 May 2012

Supraagonistic, bispecific single-chain antibody purified from the serum of cloned, transgenic cows induces T-cell-mediated killing of glioblastoma cells in vitro and in vivo.

scientific article published in December 2005

Surviving glioblastoma for more than 5 years: the patient's perspective

scientific article published in January 2006

Synergistic antiglioma activity of radiotherapy and enzastaurin

scientific article published in February 2007

T1ρ-weighted Dynamic Glucose-enhanced MR Imaging in the Human Brain

scientific article

TTFields: where does all the skepticism come from?

scientific article published on March 2016

Targeting self-renewal in high-grade brain tumors leads to loss of brain tumor stem cells and prolonged survival

scientific article published on 15 May 2014

Temozolomide and 13-cis retinoic acid in patients with anaplastic gliomas: a prospective single-arm monocentric phase-II study (RNOP-05).

scientific article

Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial

scientific article

Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study

scientific article published on 26 September 2016

Temozolomide: a milestone in the pharmacotherapy of brain tumors

scientific article

The aryl hydrocarbon receptor as a promoter of malignant glioma.

scientific article published in February 2012

The aryl hydrocarbon receptor in tumor immunity

scientific article published on May 2012

The endogenous tryptophan metabolite and NAD+ precursor quinolinic acid confers resistance of gliomas to oxidative stress

scientific article published on 2 April 2013

The indoleamine-2,3-dioxygenase (IDO) inhibitor 1-methyl-D-tryptophan upregulates IDO1 in human cancer cells

scientific article (publication date: 2011)

The mTOR signaling pathway as a treatment target for intracranial neoplasms

scientific article

The potential of relaxation-weighted sodium magnetic resonance imaging as demonstrated on brain tumors.

scientific article published in September 2011

Therapeutic options in recurrent glioblastoma--An update

scientific article published on 21 January 2016

Time-dependent parameter of perfusion imaging as independent predictor of clinical outcome in symptomatic carotid artery stenosis

scientific article

Toll-like receptor engagement enhances the immunosuppressive properties of human bone marrow-derived mesenchymal stem cells by inducing indoleamine-2,3-dioxygenase-1 via interferon-beta and protein kinase R.

scientific article published in April 2009

Towards optimizing the sequence of bevacizumab and nitrosoureas in recurrent malignant glioma.

scientific article

Toxicity of teriflunomide in aryl hydrocarbon receptor deficient mice

scientific article published on 2 September 2015

Trabedersen to target transforming growth factor-beta: when the journey is not the reward, in reference to Bogdahn et al. (Neuro-Oncology 2011;13:132-142).

scientific article published on May 2011

Transforming growth factor-beta: a molecular target for the future therapy of glioblastoma

scientific article

Transforming growth factors beta(1) (TGF-beta(1)) and TGF-beta(2) promote glioma cell migration via Up-regulation of alpha(V)beta(3) integrin expression.

scientific article published in February 2000

Treatment of anaplastic glioma

scientific article

Treatment of optic neuritis with erythropoietin (TONE): a randomised, double-blind, placebo-controlled trial-study protocol

scientific article published on March 2016

Treatment of patients with atypical meningiomas Simpson grade 4 and 5 with a carbon ion boost in combination with postoperative photon radiotherapy: the MARCIE trial

scientific article

Tregs in gliomas - the jury is still out.

scientific article published on 9 March 2015

Treosulfan chemotherapy for recurrent malignant glioma.

scientific article published in September 2000

Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion

scientific article published on 22 October 2012

Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis

scientific article published on 24 January 2017

Tryptophan-2,3-dioxygenase is regulated by prostaglandin E2 in malignant glioma via a positive signaling loop involving prostaglandin E receptor-4.

scientific article

Tumor Infiltration in Enhancing and Non-Enhancing Parts of Glioblastoma: A Correlation with Histopathology

scientific article

Tumor microtubes convey resistance to surgical lesions and chemotherapy in gliomas

scientific article

Tumortherapiefelder mit längerem Überleben bei Glioblastompatienten assoziiert

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.

scientific article published on 25 June 2009

Understanding and targeting alkylator resistance in glioblastoma

scientific article published in October 2014

Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group

scientific article published on 15 March 2010

Upfront bevacizumab may extend survival for glioblastoma patients who do not receive second-line therapy: an exploratory analysis of AVAglio

scientific article

VEGF-dependent induction of CD62E on endothelial cells mediates glioma tropism of adult haematopoietic progenitor cells

scientific article

VXM01 phase I study in patients with progressive glioblastoma: Final results

Vaccine Strategies in Gliomas.

scientific article published on 28 March 2018

Vaccine-based immunotherapeutic approaches to gliomas and beyond

scientific article published on 12 May 2017

Validation of post-operative residual contrast enhancing tumor volume as an independent prognostic factor for overall survival in newly diagnosed glioblastoma.

scientific article published on 5 April 2018

Virtual Raters for Reproducible and Objective Assessments in Radiology

scientific article

What's New in Grade II and Grade III Gliomas?

scientific article published in February 2018

[Treatment of brain tumor patients: hyperthermia, hyperbaric oxygenation, electric fields or nanoparticles].

scientific article

cIMPACT-NOW (the consortium to inform molecular and practical approaches to CNS tumor taxonomy): a new initiative in advancing nervous system tumor classification

scientific article published on 20 December 2016

cIMPACT-NOW update 1: Not Otherwise Specified (NOS) and Not Elsewhere Classified (NEC).

scientific article

cIMPACT-NOW update 2: diagnostic clarifications for diffuse midline glioma, H3 K27M-mutant and diffuse astrocytoma/anaplastic astrocytoma, IDH-mutant.

scientific article published in March 2018

mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy

scientific article

mTORC 2:1 for chemotherapy sensitization in glioblastoma

scientific article

Paulina is supported by:

About Paulina

Help