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List of works by Paul Tempst

A CK2-dependent mechanism for degradation of the PML tumor suppressor

scientific article

A Drosophila Polycomb group complex includes Zeste and dTAFII proteins

scientific article published in August 2001

A Rad26-Def1 complex coordinates repair and RNA pol II proteolysis in response to DNA damage

scientific article

A Rsc3/Rsc30 zinc cluster dimer reveals novel roles for the chromatin remodeler RSC in gene expression and cell cycle control

scientific article

A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast

scientific article

A direct interaction between the RAG2 C terminus and the core histones is required for efficient V(D)J recombination

scientific article published on August 2005

A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation

scientific article

A human telomeric protein

scientific article

A multiprotein complex that interacts with RNA polymerase II elongator

scientific article published on 4 June 2001

A new role for Nogo as a regulator of vascular remodeling

scientific article

A novel Rad24 checkpoint protein complex closely related to replication factor C.

scientific article

A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system

scientific article

A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae

scientific article

A prototype antibody microarray platform to monitor changes in protein tyrosine phosphorylation

scientific article published on 8 September 2004

A sequence-specific exopeptidase activity test (SSEAT) for "functional" biomarker discovery

scientific article

A v-SNARE implicated in intra-Golgi transport

scientific article

ASAP, a novel protein complex involved in RNA processing and apoptosis

scientific article

ATP hydrolysis-dependent disassembly of the 26S proteasome is part of the catalytic cycle

retracted scientific article

Activated ADP-ribosylation Factor Assembles Distinct Pools of Actin on Golgi Membranes

scientific article published in Journal of Biological Chemistry

Adhesion signaling by a novel mitotic substrate of src kinases

scientific article

Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha

scientific article

Affinity capture of specific DNA-binding proteins for mass spectrometric identification

scientific article published in December 2003

Aminopeptidase activities as prospective urinary biomarkers for bladder cancer

scientific article

An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells

scientific article

An iron delivery pathway mediated by a lipocalin

scientific article (publication date: November 2002)

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

scientific article

Analytical validation of protein-based multiplex assays: a workshop report by the NCI-FDA interagency oncology task force on molecular diagnostics

scientific article published on 10 December 2009

Architecture of the Mediator head module

scientific article

Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs

scientific article

Automated serum peptide profiling

scientific article

BAFF controls B cell metabolic fitness through a PKC beta- and Akt-dependent mechanism

scientific article

Brd4 links chromatin targeting to HPV transcriptional silencing

scientific article

Bromodomain protein 7 interacts with PRMT5 and PRC2, and is involved in transcriptional repression of their target genes

scientific article

CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis

scientific journal article

COMPASS: a complex of proteins associated with a trithorax-related SET domain protein

scientific article

Catalytic properties of ADAM19

scientific article (publication date: 20 June 2003)

Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing

scientific article

Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA.

scientific article published on 15 July 2004

Cloning and characterization of PSF, a novel pre-mRNA splicing factor

scientific article

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

scientific article

Cloning, heterologous expression, and distinct substrate specificity of protein farnesyltransferase from Trypanosoma brucei

scientific article

Coatomer-bound Cdc42 regulates dynein recruitment to COPI vesicles

scientific article

Communication between Distant Sites in RNA Polymerase II through Ubiquitylation Factors and the Polymerase CTD

article by Baggavalli P. Somesh et al published April 2007 in Cell

Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair

scientific article published on December 2002

Correcting common errors in identifying cancer-specific serum peptide signatures

scientific article published in July 2005

Cyclin A-dependent phosphorylation of the ETS-related protein, MEF, restricts its activity to the G1 phase of the cell cycle

scientific article published on 14 August 2001

Cytosol-derived proteins are sufficient for Arp2/3 recruitment and ARF/coatomer-dependent actin polymerization on Golgi membranes

scientific journal article

DAPP1 undergoes a PI 3-kinase-dependent cycle of plasma-membrane recruitment and endocytosis upon cell stimulation

scientific article

DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA

scientific article

Data analysis of assorted serum peptidome profiles

scientific article

Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex

scientific article

Delayed-late activation of a myeloid defensin minimal promoter by retinoids and inflammatory mediators

scientific article

Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae?

scientific article

Design, implementation and multisite evaluation of a system suitability protocol for the quantitative assessment of instrument performance in liquid chromatography-multiple reaction monitoring-MS (LC-MRM-MS)

scientific article (publication date: September 2013)

Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3

scientific journal article

Differential exoprotease activities confer tumor-specific serum peptidome patterns

scientific article published in January 2006

ERS-24, a mammalian v-SNARE implicated in vesicle traffic between the ER and the Golgi

scientific article

Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo

scientific article

FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments

scientific article

FK506 binding protein associated with the calcium release channel (ryanodine receptor) ⬇️

scientific article published on May 15, 1992

Fas-associated death domain (FADD) and the E3 ubiquitin-protein ligase TRIM21 interact to negatively regulate virus-induced interferon production

scientific article

Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin

scientific article

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

scientific journal article

Genome-wide dynamics of SAPHIRE, an essential complex for gene activation and chromatin boundaries

scientific article published on 19 March 2007

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation

scientific article

Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway

scientific article (publication date: 2 June 2006)

Heterogeneous fatty acylation of Src family kinases with polyunsaturated fatty acids regulates raft localization and signal transduction

scientific article

Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo

scientific article published on 30 March 2009

Highly efficient selenomethionine labeling of recombinant proteins produced in mammalian cells

scientific article

Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage

scientific article (publication date: 5 May 2006)

Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex

scientific article

Histone deimination antagonizes arginine methylation

scientific article

Histone demethylation by a family of JmjC domain-containing proteins

scientific article

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

scientific article

Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases

scientific article

Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes

scientific article

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

scientific article

Identification and functional characterization of the p66/p68 components of the MeCP1 complex.

scientific article

Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices

scientific article

Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase

scientific article

Identification of a putative effector protein for rab11 that participates in transferrin recycling

scientific article

Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription

scientific article

Induction of terminal differentiation in epithelial cells requires polymerization of hensin by galectin 3

scientific journal article

Inhibition of circulating dipeptidyl peptidase 4 activity in patients with metastatic prostate cancer

scientific article

Interlaboratory study characterizing a yeast performance standard for benchmarking LC-MS platform performance.

scientific article

Isolation and mass spectrometry of specific DNA binding proteins

scientific article published in January 2006

Isolation and mass spectrometry of transcription factor complexes

scientific article

Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans

scientific article

JAMP optimizes ERAD to protect cells from unfolded proteins

scientific article published on 10 September 2008

JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor

scientific article

L3MBTL1, a histone-methylation-dependent chromatin lock

scientific article

L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure

scientific article

LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs

scientific article

Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma.

scientific article

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex

scientific article

Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association

scientific article

MTERF2 is a nucleoid component in mammalian mitochondria

scientific article

MTERF3 is a negative regulator of mammalian mtDNA transcription

scientific article

MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome

scientific article

Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways

scientific article

Mass-Encoded, Synthetic Biomarkers and Multiplexed Urinary Monitoring: New Frontiers in Disease Monitoring ⬇️

scientific article published on July 16, 2013

Merlin/NF2 Functions Upstream of the Nuclear E3 Ubiquitin Ligase CRL4DCAF1 to Suppress Oncogenic Gene Expression

article

Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus

scientific article

Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein

scientific article

Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity

scientific article

Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance

scientific article

Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain

scientific journal article

Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity

scientific article

Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor

scientific article (publication date: 3 August 2001)

Microflow-based automated chemistries: application to protein sequencing

scientific article published on February 2001

Monitoring peptidase activities in complex proteomes by MALDI-TOF mass spectrometry

scientific article

Monoubiquitination of filamin B regulates vascular endothelial growth factor-mediated trafficking of histone deacetylase 7.

scientific article published on 11 February 2013

Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation

scientific article

Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma

scientific article

Multiple mechanisms confining RNA polymerase II ubiquitylation to polymerases undergoing transcriptional arrest

scientific article published in June 2005

Mutual targeting of mediator and the TFIIH kinase Kin28.

scientific article published on 4 May 2004

Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes

scientific journal article

Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function

scientific journal article

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

scientific article

NGAL (Lcn2) monomer is associated with tubulointerstitial damage in chronic kidney disease

scientific article

Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism

scientific article

OvaCheck: let's not dismiss the concept

scientific article published in Nature

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

scientific article

PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator

scientific article (publication date: April 2005)

PINdb: a database of nuclear protein complexes from human and yeast

scientific article published on 15 April 2004

PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation

scientific article published on 15 March 2007

PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin

scientific journal article

PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming

scientific article

PRDM16 controls a brown fat/skeletal muscle switch

scientific article

PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex

scientific article

PU.1 and a TTTAAA element in the myeloid defensin-1 promoter create an operational TATA box that can impose cell specificity onto TFIID function

scientific article published on June 2006

Parkinson's Disease-associated α-Synuclein Is a Calmodulin Substrate

scientific article published in Journal of Biological Chemistry

Pathway-based biomarker search by high-throughput proteomics profiling of secretomes

scientific article

Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates

scientific journal article

Performance metrics for liquid chromatography-tandem mass spectrometry systems in proteomics analyses

scientific article

Phagocytosis in macrophages lacking Cbl reveals an unsuspected role for Fc gamma receptor signaling and actin assembly in target binding

scientific article published in May 2009

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

scientific article (publication date: 22 April 2005)

Phosphorylation of Thyroid Hormone Receptor-associated Nuclear Receptor Corepressor Holocomplex by the DNA-dependent Protein Kinase Enhances Its Histone Deacetylase Activity

scientific article published in Journal of Biological Chemistry

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

scientific article

Physical and functional interaction between Elongator and the chromatin-associated Kti12 protein

scientific article

Processing of autophagic protein LC3 by the 20S proteasome

scientific article published on 14 January 2010

Proteasome-mediated processing of Def1, a critical step in the cellular response to transcription stress

scientific article published on August 2013

Protein Biomarkers for Early Detection of Pancreatic Ductal Adenocarcinoma: Progress and Challenges

scientific article published on 7 March 2018

Protein S-nitrosylation: a physiological signal for neuronal nitric oxide

scientific article (publication date: February 2001)

Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

scientific article

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox

article

Purification and characterization of the human elongator complex

scientific article

Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase

scientific article

Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase.

scientific article

Purification, microsequencing, and immunolocalization of p36, a new interferon-alpha-induced protein that is associated with human lupus inclusions

scientific article

RNA polymerase II elongator holoenzyme is composed of two discrete subcomplexes

scientific article

Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing

scientific article published on November 2007

Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah

scientific article

Regulation of cell cycle progression and gene expression by H2A deubiquitination

scientific article

Regulation of p53 activity through lysine methylation

scientific article

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex

scientific journal article

Repeatability and reproducibility in proteomic identifications by liquid chromatography-tandem mass spectrometry

scientific article

Requirement of a corepressor for Dr1-mediated repression of transcription

scientific article

Retracted: SETDB1 Is Involved in Postembryonic DNA Methylation and Gene Silencing in Drosophila

retracted article

Reversal of RNA polymerase II ubiquitylation by the ubiquitin protease Ubp3.

scientific article

Revised subunit structure of yeast transcription factor IIH (TFIIH) and reconciliation with human TFIIH.

scientific article

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

scientific article

Role of hPHF1 in H3K27 methylation and Hox gene silencing

scientific article

Role of histone H2A ubiquitination in Polycomb silencing

scientific article

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

scientific article (publication date: November 2002)

Role of integrins in the assembly and function of hensin in intercalated cells

scientific article published on 12 March 2008

Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1).

scientific article

S-nitroso proteome of Mycobacterium tuberculosis: Enzymes of intermediary metabolism and antioxidant defense

scientific article

SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex

scientific article

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

scientific article

Serum peptide profiling by magnetic particle-assisted, automated sample processing and MALDI-TOF mass spectrometry

scientific article

Serum peptidome patterns that distinguish metastatic thyroid carcinoma from cancer-free controls are unbiased by gender and age.

scientific article published on 8 August 2006

Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation

scientific article

Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia

scientific article

Super-SILAC for tumors and tissues

Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines

scientific article

Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK

scientific article

Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases

scientific article

T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity

scientific article

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.

scientific article

TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1.).

scientific article published on 14 January 2013

Tandem bromodomains in the chromatin remodeler RSC recognize acetylated histone H3 Lys14

scientific article published on 04 March 2004

The C-terminal domain phosphatase and transcription elongation activities of FCP1 are regulated by phosphorylation

scientific article

The Drosophila fragile X protein functions as a negative regulator in the orb autoregulatory pathway

scientific article published in March 2005

The Elp2 Subunit of Elongator and Elongating RNA Polymerase II Holoenzyme Is a WD40 Repeat Protein

scientific article published in Journal of Biological Chemistry

The H3K4 demethylase lid associates with and inhibits histone deacetylase Rpd3

scientific article

The HSA domain binds nuclear actin-related proteins to regulate chromatin-remodeling ATPases ⬇️

scientific article

The Hsp70-Ydj1 molecular chaperone represses the activity of the heme activator protein Hap1 in the absence of heme

scientific article published on December 2001

The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain

scientific article

The RNA processing exosome is linked to elongating RNA polymerase II in Drosophila

scientific article published on December 2002

The RSC chromatin remodeling complex bears an essential fungal-specific protein module with broad functional roles

scientific article

The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres

scientific article

The budding yeast Rad9 checkpoint complex: chaperone proteins are required for its function

scientific article

The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans

scientific article

The genome-wide localization of Rsc9, a component of the RSC chromatin-remodeling complex, changes in response to stress

scientific article

The histone chaperone TAF-I/SET/INHAT is required for transcription in vitro of chromatin templates

scientific article

The histone variant MacroH2A1 regulates target gene expression in part by recruiting the transcriptional coregulator PELP1.

scientific article

The human PAF complex coordinates transcription with events downstream of RNA synthesis

scientific article

The laminin receptor modulates granulocyte-macrophage colony-stimulating factor receptor complex formation and modulates its signaling

scientific article

The retinoblastoma binding protein RBP2 is an H3K4 demethylase

scientific article published on 22 February 2007

The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.

scientific article

The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase

scientific article published on 11 March 2007

The yeast capping enzyme represses RNA polymerase II transcription

scientific article

Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching

scientific article

Tuning of an electrospray ionization source for maximum peptide-ion transmission into a mass spectrometer

scientific article

USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing

scientific article

Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling

scientific article

Ubiquitination regulates PTEN nuclear import and tumor suppression

scientific article

Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation

scientific article published on 20 March 2007

Unique Transcriptional Programs Identify Subtypes of AKI.

scientific article

WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity

scientific article

Ykt6p, a Prenylated SNARE Essential for Endoplasmic Reticulum-Golgi Transport ⬇️

scientific article published on July 11, 1997

mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression

scientific article (publication date: August 2003)

mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad

scientific article

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

scientific article

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