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List of works by Justin Yerbury

ANS binding reveals common features of cytotoxic amyloid species

scientific article published in August 2010

Addition of exogenous SOD1 aggregates causes TDP-43 mislocalisation and aggregation

scientific article published on 30 May 2017

Assessment of metal concentrations in the SOD1G93A mouse model of amyotrophic lateral sclerosis and its potential role in muscular denervation, with particular focus on muscle tissue

scientific article published on 07 March 2018

Association of Regulatory T-Cell Expansion With Progression of Amyotrophic Lateral Sclerosis: A Study of Humans and a Transgenic Mouse Model.

scientific article published on 5 March 2018

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia

scientific article published on 15 April 2016

Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex.

scientific article

Chapter 6: The chaperone action of Clusterin and its putative role in quality control of extracellular protein folding

scientific article published on January 2009

Clusterin facilitates in vivo clearance of extracellular misfolded proteins

scientific article published on 20 April 2011

Clusterin interacts with Paclitaxel and confer Paclitaxel resistance in ovarian cancer

scientific article published on September 2008

Clusterin protects neurons against intracellular proteotoxicity

scientific article published on 7 November 2017

Corrigendum: Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

scientific article published on 01 January 2019

CuATSM Protects Against the In Vitro Cytotoxicity of Wild-Type-Like Copper-Zinc Superoxide Dismutase Mutants but not Mutants That Disrupt Metal Binding

scientific article published on 07 December 2018

Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways.

scientific article published on 23 February 2016

Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions

scientific article

Dynamic interplay between H-current and M-current controls motoneuron hyperexcitability in amyotrophic lateral sclerosis

scientific article published on 05 April 2019

Dysregulation of microRNA biogenesis machinery and microRNA/RNA ratio in skeletal muscle of amyotrophic lateral sclerosis mice.

scientific article published on 13 December 2017

Evaluation of Skin Fibroblasts from Amyotrophic Lateral Sclerosis Patients for the Rapid Study of Pathological Features.

scientific article

Extracellular Chaperones

scientific article

Extracellular aggregated Cu/Zn superoxide dismutase activates microglia to give a cytotoxic phenotype.

scientific article

Extracellular chaperones

scientific article published on January 2013

Extracellular chaperones and proteostasis.

scientific article published on 23 January 2013

Extracellular chaperones modulate the effects of Alzheimer's patient cerebrospinal fluid on Abeta(1-42) toxicity and uptake

scientific article

Extracellular wildtype and mutant SOD1 induces ER-Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells.

scientific article published on 14 June 2013

Flow cytometric measurement of the cellular propagation of TDP-43 aggregation

scientific article

Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis

scientific article

Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles.

scientific article published on 30 August 2017

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

scientific article published on 18 February 2014

Longitudinal assessment of metal concentrations and copper isotope ratios in the G93A SOD1 mouse model of amyotrophic lateral sclerosis.

scientific article published on 9 January 2017

Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell

scientific article published on 14 January 2014

Network Approaches to the Understanding of Alzheimer's Disease: From Model Organisms to Humans.

scientific article

Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells

scientific article published on 13 July 2020

Novel behavioural characteristics of the superoxide dismutase 1 G93A (SOD1G93A ) mouse model of amyotrophic lateral sclerosis include sex-dependent phenotypes

scientific article published on 10 September 2019

Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons

scientific article published on 25 June 2018

P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1G93A amyotrophic lateral sclerosis mice.

scientific article published on March 2017

P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microglia

scientific article

P2X7 receptor antagonism in amyotrophic lateral sclerosis.

scientific article

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy

scientific article published on 29 August 2017

Potential roles of abundant extracellular chaperones in the control of amyloid formation and toxicity.

scientific article

Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

scientific article published on 01 November 2019

Protease activation of alpha2-macroglobulin modulates a chaperone-like action with broad specificity

scientific article published on 03 January 2008

Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms

scientific article

Protein aggregates stimulate macropinocytosis facilitating their propagation

scientific article published on 10 March 2016

Proteome Homeostasis Dysfunction: A Unifying Principle in ALS Pathogenesis

scientific article published on 14 April 2020

Quality control of protein folding in extracellular space

scientific article

Rapid flow cytometric measurement of protein inclusions and nuclear trafficking.

scientific article

Roles of Extracellular Chaperones in Amyloidosis ⬇️

scientific article published on January 10, 2012

SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation

scientific article

SOD1A4Vaggregation alters ubiquitin homeostasis in a cell model of ALS

scientific article published on 12 June 2018

Selenium-based compounds: Emerging players in the ever-unfolding story of SOD1 in amyotrophic lateral sclerosis

scientific article published on 03 September 2020

SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation

scientific article published on 17 June 2015

Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS.

scientific article

Strategies to promote the maturation of ALS-associated SOD1 mutants: small molecules return to the fold

scientific article published on 01 September 2019

Structural characterization of clusterin-chaperone client protein complexes

scientific article published on 17 June 2009

Susceptibility of Mutant SOD1 to Form a Destabilized Monomer Predicts Cellular Aggregation and Toxicity but Not In vitro Aggregation Propensity.

scientific article published on 4 November 2016

The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1G93A mice

scientific article published on 13 March 2020

The Trajectory Taken by Dimeric Cu/Zn Superoxide Dismutase Through the Protein Unfolding and Dissociation Landscape Is Modulated by Salt-Bridge Formation

The Ubiquitin Proteasome System Is a Key Regulator of Pluripotent Stem Cell Survival and Motor Neuron Differentiation

scientific article published on 13 June 2019

The acute phase protein haptoglobin is a mammalian extracellular chaperone with an action similar to clusterin

scientific article published on 01 August 2005

The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation.

scientific article published on 27 April 2018

The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures

scientific article

The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species

scientific article published on 07 March 2007

The heat shock response in neurons and astroglia and its role in neurodegenerative diseases.

scientific article published on 18 September 2017

The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS

scientific article published on 03 April 2019

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

scientific article published on 09 October 2019

The pivotal role of Ubiquitin-activating enzyme E1 (UBA1) in neuronal health and neurodegeneration

scientific article published on 18 April 2020

The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis

scientific article

The role of macropinocytosis in the propagation of protein aggregation associated with neurodegenerative diseases

scientific article

The small heat shock proteins αB-crystallin and Hsp27 suppress SOD1 aggregation in vitro

scientific article published on 21 September 2012

Trajectory Taken by Dimeric Cu/Zn Superoxide Dismutase through the Protein Unfolding and Dissociation Landscape Is Modulated by Salt Bridge Formation

scientific article published on 03 January 2020

Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells

scientific article published in Scientific Reports

Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

scientific article published on 30 January 2020

Ubiquitin Homeostasis Is Disrupted in TDP-43 and FUS Cell Models of ALS

scientific article published on 20 October 2020

Using Tetracysteine-Tagged TDP-43 with a Biarsenical Dye To Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral Sclerosis

scientific article published on 18 September 2019

Walking the tightrope: proteostasis and neurodegenerative disease

scientific article published on 12 February 2016

alpha2-Macroglobulin and haptoglobin suppress amyloid formation by interacting with prefibrillar protein species

scientific article published on 11 December 2008

p62 overexpression induces TDP-43 cytoplasmic mislocalisation, aggregation and cleavage and neuronal death

scientific article published on 01 June 2021

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