List of works - Ron Milo

A Minimalistic Resource Allocation Model to Explain Ubiquitous Increase in Protein Expression with Growth Rate

scientific article

A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination

scientific article

A feeling for the numbers in biology

scientific article

A minimalistic resource allocation model to explain ubiquitous increase in protein expression with growth rate

A model for 'sustainable' US beef production

article

A note on the kinetics of enzyme action: a decomposition that highlights thermodynamic effects

scientific article published on 23 July 2013

A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions

scientific article published on 12 December 2006

A proof for loop-law constraints in stoichiometric metabolic networks.

scientific article

A survey of carbon fixation pathways through a quantitative lens

scientific article

Achieving diversity in the face of constraints: lessons from metabolism

scientific article

Adaptive cyclic exit strategies from lockdown to suppress COVID-19 and allow economic activity

scientific article published on 07 April 2020

An in vivo metabolic approach for deciphering the product specificity of glycerate kinase proves that both E. coli's glycerate kinases generate 2-phosphoglycerate

scientific article published on 30 March 2015

An integrated open framework for thermodynamics of reactions that combines accuracy and coverage.

scientific article

Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans

scientific article

Assessment of GFP Tag Position on Protein Localization and Growth Fitness in Yeast

scientific article published on 12 December 2018

BioNumbers--the database of key numbers in molecular and cell biology

scientific article

Cell biology by the numbers ⬇️

book by Ron Milo and Ron Phillips

Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy

scientific article

Central carbon metabolism as a minimal biochemical walk between precursors for biomass and energy

scientific article published on September 2010

Coarse-graining and self-dissimilarity of complex networks

scientific article published on 21 January 2005

Consistent estimation of Gibbs energy using component contributions

scientific article

Conversion of Escherichia coli to Generate All Biomass Carbon from CO2

scientific article published in November 2019

Cross-species analysis traces adaptation of Rubisco toward optimality in a low-dimensional landscape

scientific article

Design and analysis of metabolic pathways supporting formatotrophic growth for electricity-dependent cultivation of microbes

scientific article

Design and analysis of synthetic carbon fixation pathways

scientific article

Design principles of autocatalytic cycles constrain enzyme kinetics and force low substrate saturation at flux branch points

scientific article published on 7 February 2017

Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins

scientific article

Dynamic proteomics in mammalian cells: capabilities and challenges

scientific article published on 5 June 2007

Dynamic proteomics of human protein level and localization across the cell cycle

scientific article

Dynamic proteomics of individual cancer cells in response to a drug.

scientific article

Efficient sampling algorithm for estimating subgraph concentrations and detecting network motifs

scientific article

Engineering carbon fixation in E. coli: from heterologous RuBisCO expression to the Calvin-Benson-Bassham cycle

scientific article

Environmentally Optimal, Nutritionally Aware Beef Replacement Plant-Based Diets.

scientific article published on 7 July 2016

Evolution. Efficiency in evolutionary trade-offs.

scientific article published in June 2012

Functional reconstitution of a bacterial CO2 concentrating mechanism in E. coli

scientific article published on 21 October 2020

Generation of a fluorescently labeled endogenous protein library in living human cells

scientific article

Global characterization of in vivo enzyme catalytic rates and their correspondence to in vitro kcat measurements

scientific article published on 7 March 2016

Global human-made mass exceeds all living biomass

article published in 2020

Glycolytic strategy as a tradeoff between energy yield and protein cost

scientific article published on 29 April 2013

HSP90 affects the expression of genetic variation and developmental stability in quantitative traits

scholarly article

Highly active rubiscos discovered by systematic interrogation of natural sequence diversity

scientific article published on 05 June 2020

Hydrophobicity and charge shape cellular metabolite concentrations

scientific article

Input output robustness in simple bacterial signaling systems

scholarly article

Integrating Material Stock Dynamics Into Economy-Wide Material Flow Accounting: Concepts, Modelling, and Global Application for 1900–2050

scientific article published on 09 December 2020

Land, irrigation water, greenhouse gas, and reactive nitrogen burdens of meat, eggs, and dairy production in the United States

scientific article

Lessons on enzyme kinetics from quantitative proteomics

scientific article

Massively Parallel Interrogation of the Effects of Gene Expression Levels on Fitness

scientific article

Network motifs in integrated cellular networks of transcription-regulation and protein-protein interaction

scholarly article

Network motifs: simple building blocks of complex networks

scientific article (publication date: 25 October 2002)

Noise genetics: inferring protein function by correlating phenotype with protein levels and localization in individual human cells

scientific article

Noise in gene expression is coupled to growth rate

scientific article

Oscillations and variability in the p53 system

scientific article

Pathway thermodynamics highlights kinetic obstacles in central metabolism

scientific article

Point mutations in topoisomerase I alter the mutation spectrum in E. coli and impact the emergence of drug resistance genotypes

scientific article published on 01 January 2020

Prediction of microbial growth rate versus biomass yield by a metabolic network with kinetic parameters

scientific article

Promoters maintain their relative activity levels under different growth conditions

scientific article published on 29 October 2013

Protection following BNT162b2 booster in adolescents substantially exceeds that of a fresh 2-dose vaccine

scientific article published in 2022

Protein dynamics in individual human cells: experiment and theory

scientific article

Pyruvate Formate-Lyase Enables Efficient Growth of Escherichia coli on Acetate and Formate

scientific article published on 19 April 2016

Quantifying translational coupling in E. coli synthetic operons using RBS modulation and fluorescent reporters.

scientific article

Reconstructing a puzzle: existence of cyanophages containing both photosystem-I and photosystem-II gene suites inferred from oceanic metagenomic datasets

scientific article

Reply to Metson et al.: The importance of phosphorus perturbations

scientific article published on 10 November 2014

Reply to Tichenor: Proposed update to beef greenhouse gas footprint is numerically questionable and well within current uncertainty bounds.

scientific article published on 4 February 2015

Rethinking glycolysis: on the biochemical logic of metabolic pathways

scientific article published on 17 May 2012

Revised Estimates for the Number of Human and Bacteria Cells in the Body

scientific article

Revisiting Trade-offs between Rubisco Kinetic Parameters

scientific article published on 22 July 2019

Robust control of PEP formation rate in the carbon fixation pathway of C(4) plants by a bi-functional enzyme

scientific article published on 24 October 2011

SARS-CoV-2 (COVID-19) by the numbers

scientific article published on 31 March 2020

SnapShot: Timescales in Cell Biology

scientific article

SnapShot: key numbers in biology

scientific article

Spanning high-dimensional expression space using ribosome-binding site combinatorics

scientific article published on 6 March 2013

Steady-state metabolite concentrations reflect a balance between maximizing enzyme efficiency and minimizing total metabolite load

scientific article

Sugar Synthesis from CO2 in Escherichia coli

scientific article published on 21 June 2016

Superfamilies of evolved and designed networks.

scientific article

Systematic assessment of GFP tag position on protein localization and growth fitness in yeast

The Biomass Composition of the Oceans: A Blueprint of Our Blue Planet

scientific article published on 01 December 2019

The Moderately Efficient Enzyme: Futile Encounters and Enzyme Floppiness.

scientific article published on 28 July 2015

The Protein Cost of Metabolic Fluxes: Prediction from Enzymatic Rate Laws and Cost Minimization ⬇️

scientific article

The biomass distribution on Earth.

scientific article

The distribution of cellular turnover in the human body ⬇️

journal article from 'Nature Medicine' published in 2021

The genetic basis for the adaptation of E. coli to sugar synthesis from CO2.

scientific article published on 22 November 2017

The global mass and average rate of rubisco

scientific article published on 19 February 2019

The moderately efficient enzyme: evolutionary and physicochemical trends shaping enzyme parameters

scientific article

The quantified cell

scientific article

The relationship between evolutionary and physiological variation in hemoglobin

scholarly article

The total number and mass of SARS-CoV-2 virions in an infected person

scientific article published on 17 November 2020

The unmitigated profile of COVID-19 infectiousness

scientific article published in August 2022

Thermodynamic constraints shape the structure of carbon fixation pathways

scientific article published on 17 May 2012

Topological generalizations of network motifs

scientific article published on 23 September 2004

Towards a quantitative view of the global ubiquity of biofilms

scientific article published on 01 April 2019

Variability and memory of protein levels in human cells

scientific article published on 19 November 2006

Visual account of protein investment in cellular functions

scientific article

Weizmann Young PI forum: The power of peer support

scientific article published on December 2009

What governs the reaction center excitation wavelength of photosystems I and II?

scientific article published on 8 July 2009

What is the error rate in transcription and translation? ⬇️

section in Cell biology by the numbers

What is the total number of protein molecules per cell volume? A call to rethink some published values

scientific article

eQuilibrator--the biochemical thermodynamics calculator

scientific article

List of works by Ron Milo

A Minimalistic Resource Allocation Model to Explain Ubiquitous Increase in Protein Expression with Growth Rate

A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination

A feeling for the numbers in biology

A minimalistic resource allocation model to explain ubiquitous increase in protein expression with growth rate

A model for 'sustainable' US beef production

A note on the kinetics of enzyme action: a decomposition that highlights thermodynamic effects

A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions

A proof for loop-law constraints in stoichiometric metabolic networks.

A survey of carbon fixation pathways through a quantitative lens

Achieving diversity in the face of constraints: lessons from metabolism

Adaptive cyclic exit strategies from lockdown to suppress COVID-19 and allow economic activity

An in vivo metabolic approach for deciphering the product specificity of glycerate kinase proves that both E. coli's glycerate kinases generate 2-phosphoglycerate

An integrated open framework for thermodynamics of reactions that combines accuracy and coverage.

Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans

Assessment of GFP Tag Position on Protein Localization and Growth Fitness in Yeast

BioNumbers--the database of key numbers in molecular and cell biology

Cell biology by the numbers ⬇️

Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy

Central carbon metabolism as a minimal biochemical walk between precursors for biomass and energy

Coarse-graining and self-dissimilarity of complex networks

Consistent estimation of Gibbs energy using component contributions

Conversion of Escherichia coli to Generate All Biomass Carbon from CO2

Cross-species analysis traces adaptation of Rubisco toward optimality in a low-dimensional landscape

Design and analysis of metabolic pathways supporting formatotrophic growth for electricity-dependent cultivation of microbes

Design and analysis of synthetic carbon fixation pathways

Design principles of autocatalytic cycles constrain enzyme kinetics and force low substrate saturation at flux branch points

Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins

Dynamic proteomics in mammalian cells: capabilities and challenges

Dynamic proteomics of human protein level and localization across the cell cycle

Dynamic proteomics of individual cancer cells in response to a drug.

Efficient sampling algorithm for estimating subgraph concentrations and detecting network motifs

Engineering carbon fixation in E. coli: from heterologous RuBisCO expression to the Calvin-Benson-Bassham cycle

Environmentally Optimal, Nutritionally Aware Beef Replacement Plant-Based Diets.

Evolution. Efficiency in evolutionary trade-offs.

Functional reconstitution of a bacterial CO2 concentrating mechanism in E. coli

Generation of a fluorescently labeled endogenous protein library in living human cells

Global characterization of in vivo enzyme catalytic rates and their correspondence to in vitro kcat measurements

Global human-made mass exceeds all living biomass

Glycolytic strategy as a tradeoff between energy yield and protein cost

HSP90 affects the expression of genetic variation and developmental stability in quantitative traits

Highly active rubiscos discovered by systematic interrogation of natural sequence diversity

Hydrophobicity and charge shape cellular metabolite concentrations

Input output robustness in simple bacterial signaling systems

Integrating Material Stock Dynamics Into Economy-Wide Material Flow Accounting: Concepts, Modelling, and Global Application for 1900–2050

Land, irrigation water, greenhouse gas, and reactive nitrogen burdens of meat, eggs, and dairy production in the United States

Lessons on enzyme kinetics from quantitative proteomics

Massively Parallel Interrogation of the Effects of Gene Expression Levels on Fitness

Network motifs in integrated cellular networks of transcription-regulation and protein-protein interaction

Network motifs: simple building blocks of complex networks

Noise genetics: inferring protein function by correlating phenotype with protein levels and localization in individual human cells

Noise in gene expression is coupled to growth rate

Oscillations and variability in the p53 system

Pathway thermodynamics highlights kinetic obstacles in central metabolism

Point mutations in topoisomerase I alter the mutation spectrum in E. coli and impact the emergence of drug resistance genotypes

Prediction of microbial growth rate versus biomass yield by a metabolic network with kinetic parameters

Promoters maintain their relative activity levels under different growth conditions

Protection following BNT162b2 booster in adolescents substantially exceeds that of a fresh 2-dose vaccine

Protein dynamics in individual human cells: experiment and theory

Pyruvate Formate-Lyase Enables Efficient Growth of Escherichia coli on Acetate and Formate

Quantifying translational coupling in E. coli synthetic operons using RBS modulation and fluorescent reporters.

Reconstructing a puzzle: existence of cyanophages containing both photosystem-I and photosystem-II gene suites inferred from oceanic metagenomic datasets

Reply to Metson et al.: The importance of phosphorus perturbations

Reply to Tichenor: Proposed update to beef greenhouse gas footprint is numerically questionable and well within current uncertainty bounds.

Rethinking glycolysis: on the biochemical logic of metabolic pathways

Revised Estimates for the Number of Human and Bacteria Cells in the Body

Revisiting Trade-offs between Rubisco Kinetic Parameters

Robust control of PEP formation rate in the carbon fixation pathway of C(4) plants by a bi-functional enzyme

SARS-CoV-2 (COVID-19) by the numbers

SnapShot: Timescales in Cell Biology

SnapShot: key numbers in biology

Spanning high-dimensional expression space using ribosome-binding site combinatorics

Steady-state metabolite concentrations reflect a balance between maximizing enzyme efficiency and minimizing total metabolite load

Sugar Synthesis from CO2 in Escherichia coli

Superfamilies of evolved and designed networks.

Systematic assessment of GFP tag position on protein localization and growth fitness in yeast

The Biomass Composition of the Oceans: A Blueprint of Our Blue Planet

The Moderately Efficient Enzyme: Futile Encounters and Enzyme Floppiness.

The Protein Cost of Metabolic Fluxes: Prediction from Enzymatic Rate Laws and Cost Minimization ⬇️

The biomass distribution on Earth.