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List of works by Darwin Prockop

A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma.

scientific article published on 17 November 2005

A subset of human rapidly self-renewing marrow stromal cells preferentially engraft in mice

scientific article

Absence of Therapeutic Benefit of the Anti-Inflammatory Protein TSG-6 for Corneal Alkali Injury in a Rat Model

scientific article published on 02 April 2019

Action at a distance: systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF-α stimulated gene/protein 6

scientific article published on 01 October 2011

Adipogenic differentiation of human adult stem cells from bone marrow stroma (MSCs).

scientific article published on 16 December 2003

Adult bone marrow stem/progenitor cells (MSCs) are preconditioned by microenvironmental "niches" in culture: a two-stage hypothesis for regulation of MSC fate.

scientific article

Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential ⬇️

scientific article published on October 30, 2003

Adult stem cells from bone marrow stroma differentiate into airway epithelial cells: potential therapy for cystic fibrosis

scientific article

Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties

scientific article

An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction

scientific article published on June 2004

Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis

scientific article

Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury.

scientific article

Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages.

scientific article

Assays of MSCs with microarrays

scientific article published in January 2008

Bone marrow progenitor cells contribute to repair and remodeling of the lung and heart in a rat model of progressive pulmonary hypertension.

scientific article published on 21 November 2007

Cancer cells enter dormancy after cannibalizing mesenchymal stem/stromal cells (MSCs).

scientific article published on 03 October 2016

Clinical trials with adult stem/progenitor cells for tissue repair: let's not overlook some essential precautions

scientific article published on 14 December 2006

Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma

scientific article

Comparison of the anti-inflammatory effects of induced pluripotent stem cell-derived and bone marrow-derived mesenchymal stromal cells in a murine model of corneal injury.

scientific article published on 10 November 2016

Cross-talk between human mesenchymal stem/progenitor cells (MSCs) and rat hippocampal slices in LPS-stimulated cocultures: the MSCs are activated to secrete prostaglandin E2.

scientific article

Data against a Common Assumption: Xenogeneic Mouse Models Can Be Used to Assay Suppression of Immunity by Human MSCs

scientific article

Defining the risks of mesenchymal stromal cell therapy ⬇️

scientific article published on September 1, 2010

Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma

scholarly article

Dkk-1-derived synthetic peptides and lithium chloride for the control and recovery of adult stem cells from bone marrow.

scientific article

Drosha regulates hMSCs cell cycle progression through a miRNA independent mechanism.

scientific article

Dynamic compaction of human mesenchymal stem/precursor cells into spheres self-activates caspase-dependent IL1 signaling to enhance secretion of modulators of inflammation and immunity (PGE2, TSG6, and STC1) ⬇️

scientific article published on November 1, 2013

Engraftment of bone marrow progenitor cells in a rat model of asbestos-induced pulmonary fibrosis

scientific article

Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs).

scientific article

Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality

scientific article published in January 2002

Histamine receptor H1 and dermatopontin: new downstream targets of the vitamin D receptor.

scientific article

How Wnt signaling affects bone repair by mesenchymal stem cells from the bone marrow

scientific article

Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration

article published in the Proceedings of the National Academy of Sciences of the United States of America

Human mesenchymal stem/stromal cells cultured as spheroids are self-activated to produce prostaglandin E2 that directs stimulated macrophages into an anti-inflammatory phenotype.

scientific article published on October 2012

Human mesenchymal stromal cells (MSCs) reduce neointimal hyperplasia in a mouse model of flow-restriction by transient suppression of anti-inflammatory cytokines

scientific article published on 5 February 2011

Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor-α-induced protein 6

scientific article

Human multipotent stromal cells from bone marrow and microRNA: regulation of differentiation and leukemia inhibitory factor expression.

scholarly article

Human multipotent stromal cells undergo sharp transition from division to development in culture

scientific article published on 4 October 2007

Human stem/progenitor cells from bone marrow enhance glial differentiation of rat neural stem cells: a role for transforming growth factor β and Notch signaling

scientific article published on 14 September 2010

Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice

scientific article

Identification of the HSPB4/TLR2/NF-κB axis in macrophage as a therapeutic target for sterile inflammation of the cornea.

scientific article

In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis

scientific article

Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels

scientific article

Internalized antigens must be removed to prepare hypoimmunogenic mesenchymal stem cells for cell and gene therapy

scientific article published in May 2004

Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus.

scientific article

Intranasally Administered Human MSC-Derived Extracellular Vesicles Pervasively Incorporate into Neurons and Microglia in both Intact and Status Epilepticus Injured Forebrain

scientific article published on 26 December 2019

Intraperitoneally infused human mesenchymal stem cells form aggregates with mouse immune cells and attach to peritoneal organs.

scientific article

Intravenous Mesenchymal Stem Cells Prevented Rejection of Allogeneic Corneal Transplants by Aborting the Early Inflammatory Response ⬇️

scientific article published on August 28, 2012

In Vitro Macrophage Assay Predicts the In Vivo Anti-inflammatory Potential of Exosomes from Human Mesenchymal Stromal Cells

scientific article published on 15 December 2018

Isolation of a highly clonogenic and multipotential subfraction of adult stem cells from bone marrow stroma

scientific article

MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis

scientific article

Mesenchymal Stem/Stromal Cells (MSCs): Role as Guardians of Inflammation ⬇️

scientific article published on October 18, 2011

Mesenchymal Stromal Cells Inhibit Inflammatory Lymphangiogenesis in the Cornea by Suppressing Macrophage in a TSG-6-Dependent Manner

scientific article published on 5 October 2017

Mesenchymal Stromal Cells Protect Cancer Cells From ROS-induced Apoptosis and Enhance the Warburg Effect by Secreting STC1 ⬇️

scientific article published on December 6, 2011

Mesenchymal stem/stromal cells inhibit the NLRP3 inflammasome by decreasing mitochondrial reactive oxygen species

scientific article published on June 2014

Mesenchymal stem/stromal cells precondition lung monocytes/macrophages to produce tolerance against allo- and autoimmunity in the eye.

scientific article

Methods and protocols. Preface

scientific article published in January 2008

Mitochondrial transfer between cells can rescue aerobic respiration

scientific article

Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment

scientific article published on 17 January 2007

Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1.

scientific article published on March 2009

Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice.

scientific article

Non-hematopoietic bone marrow stem cells: molecular control of expansion and differentiation

scientific article

Novel object recognition in Apoe(-/-) mice improved by neonatal implantation of wild-type multipotential stromal cells

scientific article published on 30 June 2006

One strategy for cell and gene therapy: harnessing the power of adult stem cells to repair tissues.

scientific article

Pharmaceutical induction of ApoE secretion by multipotent mesenchymal stromal cells (MSCs).

scientific article

Phase-directed therapy: TSG-6 targeted to early inflammation improves bleomycin-injured lungs

scientific article

Preactivation of Human MSCs with TNF-α Enhances Tumor-Suppressive Activity ⬇️

scientific article published on November 8, 2012

Rapidly self-renewing human multipotent marrow stromal cells (hMSC) express sialyl Lewis X and actively adhere to arterial endothelium in a chick embryo model system

scientific article (publication date: 2014)

Rat adult stem cells (marrow stromal cells) engraft and differentiate in chick embryos without evidence of cell fusion

scholarly article

Reversible commitment to differentiation by human multipotent stromal cells in single-cell-derived colonies

scientific article published on 10 July 2008

Sarcoma derived from cultured mesenchymal stem cells

scientific article published on 12 October 2006

Scalable Production of a Multifunctional Protein (TSG-6) That Aggregates with Itself and the CHO Cells That Synthesize It.

scientific article published on 21 January 2016

Serum deprivation of human marrow stromal cells (hMSCs) selects for a subpopulation of early progenitor cells with enhanced expression of OCT-4 and other embryonic genes.

scientific article

Short-term exposure of multipotent stromal cells to low oxygen increases their expression of CX3CR1 and CXCR4 and their engraftment in vivo

scientific article

Small-molecule antagonist of macrophage migration inhibitory factor enhances migratory response of mesenchymal stem cells to bronchial epithelial cells

scientific article published in September 2009

Sox11 is expressed in early progenitor human multipotent stromal cells and decreases with extensive expansion of the cells

scientific article

Stanniocalcin-1 attenuates ischemic cardiac injury and response of differentiating monocytes/macrophages to inflammatory stimuli

scientific article published on 9 July 2016

Stanniocalcin-1 regulates extracellular ATP-induced calcium waves in human epithelial cancer cells by stimulating ATP release from bystander cells

scientific article (publication date: 2010)

Stanniocalcin-1 rescued photoreceptor degeneration in two rat models of inherited retinal degeneration

scientific article published on 31 January 2012

Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses

scholarly article

TSG-6 as a biomarker to predict efficacy of human mesenchymal stem/progenitor cells (hMSCs) in modulating sterile inflammation in vivo.

scientific article

The CD34-like protein PODXL and alpha6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice

scientific article published on 25 September 2008

The Wnt signaling inhibitor dickkopf-1 is required for reentry into the cell cycle of human adult stem cells from bone marrow

scientific article (publication date: 25 July 2003)

Unique characteristics of human mesenchymal stromal/progenitor cells pre-activated in 3-dimensional cultures under different conditions.

scientific article

Use of differentiating adult stem cells (marrow stromal cells) to identify new downstream target genes for transcription factors

scientific article published on 26 January 2006

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