List of works by David A. Hafler

A High-Density Admixture Map for Disease Gene Discovery in African Americans

scientific article

A high-density screen for linkage in multiple sclerosis

scientific article

A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC.

scientific article published on 24 September 2006

A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility.

scientific article published on 24 February 2011

A local antigen-driven humoral response is present in the inflammatory myopathies

scientific article

A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.

scientific article

A model for harmonizing flow cytometry in clinical trials

scientific article

A non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosis

scientific article

A randomized controlled double-masked trial of albuterol add-on therapy in patients with multiple sclerosis.

scientific article

A review of T-cell receptors in multiple sclerosis: clonal expansion and persistence of human T-cells specific for an immunodominant myelin basic protein peptide

scientific article published on July 1995

A second major histocompatibility complex susceptibility locus for multiple sclerosis

scientific article published on March 2007

A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis

scientific article

A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility

scientific article published on 25 September 2005

AKT isoforms modulate Th1-like Treg generation and function in human autoimmune disease

scientific article published on 16 June 2016

AKT isoforms modulate Th1-like Treg generation and function in human autoimmune disease

scientific article published on 01 August 2019

Abnormal Tr1 differentiation in multiple sclerosis

scientific article published on 22 October 2007

Activated CD8+ T cells in secondary progressive MS secrete lymphotoxin

scientific article published on 01 February 2003

Activated β-catenin in Foxp3 regulatory T cells links inflammatory environments to autoimmunity

scientific article published on 29 October 2018

Activation of human T cell lymphotropic virus type I-infected T cells is independent of B7 costimulation

scientific article published in October 1996

Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice

scientific article published on 11 March 2019

Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis

scientific article published on 17 August 2009

Allelic variant in CTLA4 alters T cell phosphorylation patterns

scholarly article

Allelic variation of MHC structure alters peptide ligands to induce atypical partial agonistic CD8+ T cell function

scientific article

Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis

scientific article

Altered blood T-cell subsets in patients with multiple sclerosis ⬇️

scientific article published on 01 April 1984

An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity

scientific article

An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells

scientific journal article

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

scientific article published on 29 September 2013

Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human anti-mouse responses.

scientific article published in July 1988

Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human antimouse responses

scientific article published on 01 January 1988

Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein

scientific article published in August 2005

Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid

scientific article

Antigen reactive memory T cells are defined by Ta1.

scientific article published in July 1986

Antigen specific therapies for the treatment of autoimmune diseases.

scientific article published on January 1995

Antigen-specific TGF-beta1 secretion with bovine myelin oral tolerization in multiple sclerosis

scientific article published on February 1996

Antigen-specific immunosuppression: oral tolerance for the treatment of autoimmune disease.

scientific article published on January 1995

Antigen-specific therapies for the treatment of autoimmune diseases

scientific article published on January 1995

Antigen-specific therapy for autoimmune disease

scientific article

Applying a new generation of genetic maps to understand human inflammatory disease

scientific article

Author Correction: Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity

scientific article published on 01 July 2019

Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity

scientific article published on 01 March 2019

Autoantigen recognition by human CD8 T cell clones: enhanced agonist response induced by altered peptide ligands

scientific article

Autoimmunity following viral infection: demonstration of monoclonal antibodies against normal tissue following infection of mice with reovirus and demonstration of shared antigenicity between virus and lymphocytes ⬇️

scientific article published on June 1, 1984

Autoimmunity risk alleles in costimulation pathways

scientific article published on May 2009

Automated high-dimensional flow cytometric data analysis

scientific article

Autoreactive T Cells in Multiple Sclerosis ⬇️

scientific article published on January 1, 1992

B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes

scientific article

B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors.

scientific article published on March 1997

Biological activity of recombinant human myelin basic protein.

scientific article published in May 1993

Biomarkers in multiple sclerosis

scientific article

CBM-04PD-1 EXPRESSION IDENTIFIES EXHAUSTED TUMOR INFILTRATING REGULATORY T CELLS IN GLIOBLASTOMA.

scientific article

CBM-05FUNCTIONAL DIFFERENCES BETWEEN PD-1+ AND PD-1– CD4+ T EFFECTOR CELLS IN HEALTHY DONORS AND PATIENTS WITH GLIOBLASTOMA.

scientific article

CBM-06IMMUNE BIOMARKER RESULTS FROM A TRIAL OF NIVOLUMAB ± IPILIMUMAB IN PATIENTS WITH RECURRENT GLIOBLASTOMA: CHECKMATE-143.

scientific article

CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis

scientific article published on 7 February 2011

CD4 + CD25 + Regulatory Cells from Human Peripheral Blood Express Very High Levels of CD25 Ex Vivo ⬇️

scientific article published on 01 January 2003

CD4+CD25high regulatory cells in human peripheral blood

scientific article published on 01 August 2001

CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis

scientific article

CNS demyelination and enhanced myelin-reactive responses after ipilimumab treatment

scientific article published on 16 March 2016

CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production ⬇️

scientific article published on December 15, 1992

CTLA-4 dysregulation in the activation of myelin basic protein reactive T cells may distinguish patients with multiple sclerosis from healthy controls

scientific article published on 01 February 2003

CTLA4 is associated with susceptibility to multiple sclerosis

CTLA4Ig treatment in patients with multiple sclerosis: an open-label, phase 1 clinical trial.

scientific article published in September 2008

CXCR3+ T cells in multiple sclerosis correlate with reduced diversity of the gut microbiome

scientific article published on 20 December 2019

Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells

scientific article published on 24 June 2009

Cell-mediated immunity to myelin-associated glycoprotein, proteolipid protein, and myelin basic protein in multiple sclerosis

scientific article published on 01 November 1986

Changes in cytokine secretion induced by altered peptide ligands of myelin basic protein peptide 85-99 ⬇️

scientific article published on 01 September 1997

Characterization of HTLV-I in vivo infected T cell clones. IL-2-independent growth of nontransformed T cells.

scientific article published in May 1992

Characterization of in vivo expanded OspA-specific human T-cell clones

scientific article

Class II HLA interactions modulate genetic risk for multiple sclerosis

scientific article published on 07 September 2015

Class II MHC self-antigen presentation in human B and T lymphocytes

scientific article

Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus

scientific article published on 30 October 2013

Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide

scientific article published on June 1994

Co-inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma

scientific article published on March 2017

Common T-cell receptor V beta usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis

scientific article published on January 1991

Common genetic factors among autoimmune diseases

scientific article published on 04 May 2023

Common genetic variants modulate pathogen-sensing responses in human dendritic cells

scientific article

Complementary mutations in an antigenic peptide allow for crossreactivity of autoreactive T-cell clones

scientific article published on December 1996

Comprehensive phenotyping in multiple sclerosis: discovery based proteomics and the current understanding of putative biomarkers

scientific article published on January 2006

Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies

scientific article

Conserved CDR3 regions in T-cell receptor (TCR) CD8(+) T cells that recognize the Tax11-19/HLA-A*0201 complex in a subject infected with human T-cell leukemia virus type 1: relationship of T-cell fine specificity and major histocompatibility complex

scientific article

Constitutive expression of costimulatory molecules by human microglia and its relevance to CNS autoimmunity

scientific article published in June 1997

Correction: Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting

scientific article published on 13 November 2018

Corrigendum to "Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo" [Yjaut 96C (2019) 40-49]

scientific article published on 18 May 2019

Corrigendum: multiple sclerosis-a quiet revolution

scientific article published on 24 March 2015

Cross-reactive TCR responses to self antigens presented by different MHC class II molecules

scientific article published on August 2004

Cross-reactivity of T-cell clones specific for altered peptide ligands of myelin basic protein

scientific article published on April 1999

Cumulative experience with high-dose intravenous cyclophosphamide and ACTH therapy in chronic progressive multiple sclerosis

scientific article published on January 1988

Cutting Edge: Distinct B Cell Repertoires Characterize Patients with Mild and Severe COVID-19

scientific article published on 28 May 2021

Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells

scientific article published on 21 June 2008

Cytotoxic gamma delta I lymphocytes associated with an Epstein-Barr virus-induced posttransplantation lymphoproliferative disorder

scientific article published in September 1996

De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot

scientific article published on 13 July 2009

Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells

scientific article

Decreased autologous mixed lymphocyte reaction in multiple sclerosis

scientific article published on 01 October 1985

Degeneracy, as opposed to specificity, in immunotherapy

scientific article

Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand

scientific article

Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells

scientific article

Differential expression of the T-cell inhibitor TIGIT in glioblastoma and MS

scientific article published on 08 April 2020

Direct analysis of viral-specific CD8+ T cells with soluble HLA-A2/Tax11-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy.

scientific article

Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers

scientific article

Direct ex vivo analysis of activated, Fas-sensitive autoreactive T cells in human autoimmune disease

scientific article

Disease-related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis

scientific article published in July 2004

Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain

scientific article published on 08 March 2022

Distinct molecular forms of human T cell receptor gamma/delta detected on viable T cells by a monoclonal antibody

scientific article

Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple Sclerosis ⬇️

scientific article published on February 26, 1993

Downregulation of IL-10 secretion and enhanced antigen-presenting abilities following HTLV-I infection of T cells.

scientific article published in September 1996

Droplet-based microfluidic platforms for single T cell secretion analysis of IL-10 cytokine

scientific article published on 15 September 2010

Dysregulated T cell expression of TIM3 in multiple sclerosis

scientific article (published 2006-06-12)

Early signaling defects in human T cells anergized by T cell presentation of autoantigen ⬇️

scientific article published on July 1, 1992

Editorial: T cell regulation by the environment

scientific article published on 13 May 2015

Effects of oral administration of type II collagen on rheumatoid arthritis

scientific article published on 01 September 1993

Embarrassment as the aura of a complex partial seizure

scientific article

Engineered interleukin-2 antagonists for the inhibition of regulatory T cells

scientific article published on November 2009

Enhanced B7 costimulatory molecule expression in inflammatory human sural nerve biopsies

scientific article published in September 2000

Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis

scientific article published in Nature Communications

Enhanced suppressor function of TIM-3+ FoxP3+ regulatory T cells

scientific article

Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping

article

Epigenetic fine-mapping: identification of causal mechanisms for autoimmunity

scientific article published on 22 September 2020

Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain

scientific article

Erratum: Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes

scientific article published in Nature

Evaluating the intrinsic cysteine redox-dependent states of the A-chain of human insulin using NMR spectroscopy, quantum chemical calculations, and mass spectrometry

scientific article

Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis

scientific article published in March 2006

Evaluation of KIR4.1 as an Immune Target in Multiple Sclerosis

scientific article published on April 2016

Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals

scientific article

Examination of CD8+ T cell function in humans using MHC class I tetramers: similar cytotoxicity but variable proliferation and cytokine production among different clonal CD8+ T cells specific to a single viral epitope

scientific article

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

scientific article published in Nature

Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation

scientific article published on 01 February 1998

Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4.

scientific article

Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions

scientific article

Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes.

scientific article published in January 1998

FOXP3+ regulatory T cells in the human immune system

scientific article (publication date: 18 June 2010)

FcR-mediated crosslinking of Ta1 (CDw26) induces human T lymphocyte activation.

scientific article

Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects

scientific article published in November 2013

Fingolimod for multiple sclerosis

scientific article

Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo

scientific article published on 16 August 2018

Frequency analysis of CD4+CD8+ T cells cloned with IL-4.

scientific article published in February 1990

From Big Data to Precision Medicine

Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+ CD25+ T cells

scientific article

Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+CD25+ T cells

scientific article published on 01 November 2005

Functional differences between PD-1+ and PD-1- CD4+ effector T cells in healthy donors and patients with glioblastoma multiforme.

scientific article published on 7 September 2017

Functional gamma chain-associated T cell receptors on cerebrospinal fluid-derived natural killer-like T cell clones

scientific article

Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis

scientific article published on May 2015

Functional three-domain single-chain T-cell receptors

scientific article

Functionally defective germline variants of sialic acid acetylesterase in autoimmunity

scientific article

GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes

scientific article

GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes

Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions ⬇️

scientific article published on May 15, 1992

Gene expression profiling in MS: what is the clinical relevance?

scientific article published on 01 May 2004

Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines

scientific article

Genetic analysis of multiple sclerosis

Genetic and epigenetic fine mapping of causal autoimmune disease variants

scientific article

Genetic basis of autoimmunity

scientific article published in June 2015

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

scientific article

Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli

scientific article

Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility

scientific article

Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery

scientific article

Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene

scientific article

Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci

scientific article

Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis

scientific article published in April 2000

HLA B*44: protective effects in MS susceptibility and MRI outcome measures

scientific article

HTLV-I-induced T-cell activation

scientific article

HTLV-I-infected T cells evade the antiproliferative action of IFN-beta

scientific article published on May 1999

Heterophile antibodies indicate progression of autoimmunity in human type 1 diabetes mellitus before clinical onset

scientific article published on January 2001

Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes

scientific article

High Incidence of Spontaneous Disease in an HLA-DR15 and TCR Transgenic Multiple Sclerosis Model

article

Human CD4+CD25+ regulatory T cells

scientific article published on April 2004

Human T cell lymphotropic virus type I-induced T cell activation. Resistance to TGF-beta 1-induced suppression.

scientific article published in July 1994

Human and murine CD4 T cell reactivity to a complex antigen: recognition of the synthetic random polypeptide glatiramer acetate

scientific article

Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells

scientific article

Human regulatory T cells and autoimmunity

scientific article published on April 2008

Human regulatory T cells and their role in autoimmune disease

scientific article published on August 2006

Human regulatory T cells in autoimmune diseases ⬇️

scientific article published on September 24, 2010

IL-12 induces human T cells secreting IL-10 with IFN-gamma

scientific article published on 01 August 1996

IL-17-producing human peripheral regulatory T cells retain suppressive function

scientific article published on 26 January 2009

IL-21 and TGF-beta are required for differentiation of human T(H)17 cells

scientific article published on 11 May 2008

IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production

scientific article

IMCT-03SAFETY AND ACTIVITY OF NIVOLUMAB MONOTHERAPY AND NIVOLUMAB IN COMBINATION WITH IPILIMUMAB IN RECURRENT GLIOBLASTOMA: UPDATED RESULTS FROM CHECKMATE-143.

scientific article

Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease ⬇️

scientific article published on 3 May 2011

Identification of a T cell subset capable of both IFN-gamma and IL-10 secretion in patients with chronic Borrelia burgdorferi infection.

scientific article

Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: Increased interleukin-4 production and associated eosinophilia

article

Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children

scientific article published on 11 May 2021

Immune tolerance and the nervous system

scientific article

Immune-mediated disease genetics: the shared basis of pathogenesis

scientific article

Immunohistochemical analysis of suppressor-inducer and helper-inducer T cells in multiple sclerosis brain tissue

scientific article

Immunologic Mechanisms and Therapy in Multiple Sclerosis ⬇️

scientific article published on April 1, 1995

Immunologic effects of cyclophosphamide/ACTH in patients with chronic progressive multiple sclerosis

scientific article published in May 1991

Immunologic responses of progressive multiple sclerosis patients treated with an anti-T-cell monoclonal antibody, anti-T12.

scientific article

Immunological memory: contribution of memory B cells expressing costimulatory molecules in the resting state.

scientific article published in November 2001

Immunology. An innate role for IL-17

scientific article published on 01 April 2011

Immunoregulation in multiple sclerosis

scientific article published on February 1989

Immunosuppression in progressive multiple sclerosis with high dose intravenous cyclophosphamide and monoclonal antibodies

scientific article published on 01 March 1987

Immunosuppression with high-dose i.v. cyclophosphamide and ACTH in progressive multiple sclerosis: cumulative 6-year experience in 164 patients

scientific article published on 01 July 1988

Immunosuppression with monoclonal antibodies in multiple sclerosis

scientific article published in July 1988

Immunotherapy in autoimmune diseases

scientific article published on 01 December 1991

Immunotherapy of multiple sclerosis

scientific article published on March 1988

In vitro evidence that immunuaffinity-purified MOG contains immunogenic quantities of contaminating mouse IgG; techniques for producing Ig-free MOG.

scientific article

In vitro evidence that subcutaneous administration of glatiramer acetate induces hyporesponsive T cells in patients with multiple sclerosis ⬇️

scientific article published on March 1, 2003

In vivo activated T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis

scientific article

In vivo labeling of blood T cells: rapid traffic into cerebrospinal fluid in multiple sclerosis

scientific article published on 01 July 1987

Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis

scientific article published on March 2008

Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis

scientific article

Increased frequency of gamma delta T cells in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis. Reactivity, cytotoxicity, and T cell receptor V gene rearrangements.

scientific article

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis

scientific article

Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand

scientific article

Increased protein kinase C activity in human memory T cells.

scientific article published in June 1993

Induction and molecular signature of pathogenic TH17 cells

scientific article

Induction of anergy in CD8 T cells by B cell presentation of antigen

scientific article published on December 1996

Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients

scientific article published on July 1996

Infection-triggered familial or recurrent cases of acute necrotizing encephalopathy caused by mutations in a component of the nuclear pore, RANBP2.

scientific article published on January 2009

Inflammatory cerebrospinal fluid T cells have activation requirements characteristic of CD4+CD45RA- T cells

scientific article published on 01 October 1989

Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis

scientific article

Inhibition of human CD4(+)CD25(+high) regulatory T cell function

scientific article

Innate immunity in multiple sclerosis: myeloid dendritic cells in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response

scientific article published on 01 September 2006

Insulin auto-antigenicity in type 1 diabetes (Reply)

scientific article published in Nature

Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple sclerosis

scientific article published on 13 February 2008

Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score

scientific article

Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferonβ therapy in multiple sclerosis

scientific article published on 07 April 2011

Interleukin-1 corrects the defective autologous mixed lymphocyte response in multiple sclerosis ⬇️

scientific article published on January 1, 1991

Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis: final report of the Northeast Cooperative Multiple Sclerosis Treatment Group

scientific article published on 01 May 1993

Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex

scientific article

Investigating the Antigen Specificity of Multiple Sclerosis Central Nervous System-Derived Immunoglobulins

scientific article

Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases

scientific article published in November 1985

Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis

scholarly article by Duojia Cao et al published January 2003 in European Journal of Immunology

Joint modeling and registration of cell populations in cohorts of high-dimensional flow cytometric data

scientific article

Lack of TIM-3 immunoregulation in multiple sclerosis

scientific article

Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis

scientific article published on June 2010

Latent autoimmunity across disease-specific boundaries in at-risk first-degree relatives of SLE and RA patients

Linking Genotype to Clinical Phenotype in Multiple Sclerosis: In Search of the Holy Grail

scientific article published on 31 May 2016

Loss of IL-4 secretion from human type 1a diabetic pancreatic draining lymph node NKT cells

scientific article published on 01 October 2005

Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis

scientific article

Loss of functional suppression is linked to decreases in circulating suppressor inducer (CD4+ 2H4+) T cells in multiple sclerosis

scientific article published on 01 August 1988

Loss of functional suppression is linked to decreases in circulating suppressor-inducer (CD4+ 2H4+) T cells in multiple sclerosis

scientific article published on 01 January 1988

Low frequency and rare coding variation contributes to multiple sclerosis risk

Lymphokine regulation of CD45R expression on human T cell clones

scientific article

Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation

scientific journal article

MHC class II expression identifies functionally distinct human regulatory T cells

scientific article published on 01 April 2006

MHC-Restricted Depletion of Human Myelin Basic Protein-Reactive T Cells by T Cell Vaccination ⬇️

scientific article published on September 10, 1993

MS: a CNS and systemic autoimmune disease

scientific article published on March 1989

Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases

scientific article published on 21 October 2009

Mechanisms of immune memory. T cell activation and CD3 phosphorylation correlates with Ta1 (CDw26) expression.

scientific article published in April 1989

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

scientific article

Methods for high-density admixture mapping of disease genes

scientific article

Microbial Reprogramming Inhibits Western Diet-Associated Obesity

Microbial reprogramming inhibits Western diet-associated obesity

scientific article

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization

scientific article published in January 2017

Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data

scientific article

Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data

scientific article

Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand

scientific article published on April 1995

Molecular mimicry in Lyme arthritis demonstrated at the single cell level: LFA-1 alpha L is a partial agonist for outer surface protein A-reactive T cells.

scientific article

Molecular pathogenesis of multiple sclerosis

scientific article

Monoallelic expression of the human FOXP2 speech gene

scientific article published on 24 November 2014

Monoclonal gammopathy and neuropathy: myelin-associated glycoprotein reactivity and clinical characteristics

scientific article published in January 1986

Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells

scientific article published on 11 September 2009

Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving

scientific article

Multiple differences in gene expression in regulatory Valpha 24Jalpha Q T cells from identical twins discordant for type I diabetes

scientific article

Multiple sclerosis

scientific article published on 01 March 2004

Multiple sclerosis

scientific article published on 01 April 2005

Multiple sclerosis

scientific article published on 02 April 2012

Multiple sclerosis

scientific article published on 01 January 2018

Multiple sclerosis

Multiple sclerosis and regulatory T cells

scientific article published on 02 September 2008

Multiple sclerosis enters a grey area

scientific article published on 01 February 2019

Multiple sclerosis-a quiet revolution

scientific article

Multiple sclerosis: genetics, biomarkers, treatments

scientific article published on 7 April 2016

Multispecific responses by T cells expanded by endogenous self-peptide/MHC complexes

scientific article published on March 2007

Myelin basic protein and proteolipid protein reactivity of brain- and cerebrospinal fluid-derived T cell clones in multiple sclerosis and postinfectious encephalomyelitis

scientific article published on 01 July 1987

Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions

scientific article published on 01 March 2003

National Heart, Lung, and Blood Institute Working Group Report on Salt in Human Health and Sickness: Building on the Current Scientific Evidence

scientific article published on 20 June 2016

Natural killer activating receptors trigger interferon gamma secretion from T cells and natural killer cells

scientific article published on March 1998

New therapeutic approaches for multiple sclerosis

scientific article published on January 2007

OR.102. The CD58 Pathway is Implicated in MS Susceptibility

OR.80. Identifying Regulators of Cytokine Production in Primary Human T-Cells Using a Lentiviral RNAi Library

Oleic acid restores suppressive defects in tissue-resident FOXP3 regulatory T cells from patients with multiple sclerosis

scientific article published on 10 November 2020

Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis

scientific article

On-chip activation and subsequent detection of individual antigen-specific T cells

scientific article

Oral administration of myelin induces antigen-specific TGF-beta 1 secreting T cells in patients with multiple sclerosis

scientific article published in December 1997

Oral administration of myelin induces antigen-specific TGF-beta 1-secreting T cells in multiple sclerosis patients

scientific article published on April 1997

Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens

scientific article published on January 1994

PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells.

scientific article published in August 2004

PD-1 marks dysfunctional regulatory T cells in malignant gliomas

scientific article published on April 2016

Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population

article

Pathology of an islet transplant 2 years after transplantation: evidence for a nonimmunological loss

scientific article published on 01 July 2008

Perspective: Deconstructing a disease

journal article; published in Nature on 2012-04-11

Pervasive sharing of genetic effects in autoimmune disease

scientific article

PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis

scientific article

Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study

scientific article published in 2022

Phenotypic and functional analysis of T cells cloned directly from the blood and cerebrospinal fluid of patients with multiple sclerosis

scientific article published in October 1985

Phosphorylation of CD4 and CD8 molecules following T cell triggering

scientific article published in December 1987

Pilot study of oral tolerance to keyhole limpet hemocyanin in humans: down-regulation of KLH-reactive precursor-cell frequency

scientific article published on 01 February 1996

Podoplanin is a negative regulator of Th17 inflammation

scientific article published on 7 September 2017

Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes

scientific article published on May 2014

Polyfunctional responses by human T cells result from sequential release of cytokines

scientific article

Polyspecificity of T cell and B cell receptor recognition

scientific article

Population genetics meets single-cell sequencing

scientific article published on 8 April 2022

Population structure and HLA DRB1 1501 in the response of subjects with multiple sclerosis to first-line treatments

scientific article published on 27 November 2010

Post-infectious inflammatory disease in MIS-C features elevated cytotoxicity signatures and autoreactivity that correlates with severity

scientific article published on 04 December 2020

Power estimation for non-standardized multisite studies

scientific article

Presentation of autoantigen by human T cells ⬇️

scientific article published on August 1, 1991

Production of Proinflammatory Cytokines by Monocytes in Liver-Transplanted Recipients with De Novo Autoimmune Hepatitis Is Enhanced and Induces TH1-like Regulatory T Cells

scientific article published on 18 April 2016

Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults

scientific article

Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells

scientific journal article

Prospects of immune checkpoint modulators in the treatment of glioblastoma

scientific article

Prostaglandin E2 affects T cell responses through modulation of CD46 expression

scientific article published on 27 April 2012

Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination

scientific article published on 13 June 2007

Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis

scientific article published on 06 August 2013

Pulse cyclophosphamide plus methylprednisolone induces myelin-antigen-specific IL-4-secreting T cells in multiple sclerosis patients

scientific article published on July 1998

RNA interference screen in primary human T cells reveals FLT3 as a modulator of IL-10 levels

scientific article

Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity

scientific article

Re: GAMES issue study: Are international genetic consortia functional?

scientific article published in August 2004

Reactivity of normal T-cell lines to MBP isolated from normal and multiple sclerosis white matter

scientific article published on 01 February 1995

Regional specificity of HTLV-I proviral integration in the human genome

scientific article published on June 1994

Regulation of T cell clone function via CD4 and CD8 molecules. Anti-CD4 can mediate two distinct inhibitory activities

scientific article published in January 1988

Regulatory T Cells: From Discovery to Autoimmunity

scientific article published on 8 January 2018

Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis

scientific article

Regulatory T cells in autoimmune disease

scientific article published on 20 June 2018

Regulatory T cells in autoimmune neuroinflammation

scientific article

Regulatory T cells in the central nervous system

scientific article published on July 2012

Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis

scientific article

Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin

scientific article

Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor

scientific article published on 18 March 2009

Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitment

scientific article published on 20 March 2017

Restricted T cell expression of IL-2/IFN-gamma mRNA in human inflammatory disease

scientific article

Review of immunology

scientific article published on January 1990

Risk alleles for multiple sclerosis identified by a genomewide study

scientific article (publication date: 30 August 2007)

Role of "Western diet" in inflammatory autoimmune diseases

scientific article

Role of Th1 and Th2 cells in neurologic disorders.

scientific article published on January 1996

Secondary immune amplification following live poliovirus immunization in humans

scientific article

Selective loss of the suppressor-inducer T-cell subset in progressive multiple sclerosis. Analysis with anti-2H4 monoclonal antibody

scientific article published on 01 January 1987

Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein

scientific article

Seminars in medicine of the Beth Israel Hospital, Boston. Pathogenesis of diseases induced by human lymphotropic virus type I infection

scientific article published on April 1993

Sequestration of virus-specific T cells in the cerebrospinal fluid of a patient with varicella zoster viral meningoencephalitis

scientific article published in March 1989

Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing-remitting multiple sclerosis

scientific article published on 23 April 2013

Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein

scientific article

Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV

article

Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19

scientific article published on 21 January 2022

Siponimod Chips Away at Progressive MS

scientific article published on 12 December 2019

Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms

scientific article

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

scientific article

Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells.

scientific article

Sodium-activated macrophages: the salt mine expands

scientific article published on 28 July 2015

Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses

scientific article published on February 2009

Solving Immunology?

scientific article published on 13 December 2016

Specific peripheral B cell tolerance defects in patients with multiple sclerosis

scientific article published on 15 May 2013

Spinal subarachnoid hematoma: a hazard of lumbar puncture resulting in reversible paraplegia

scientific article published on 01 April 1981

Strength of prior stimuli determines the magnitude of secondary responsiveness in CD8+ T cells

scientific article published on May 2002

Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones

scientific article

Structure of human T-cell receptors specific for an immunodominant myelin basic protein peptide: positioning of T-cell receptors on HLA-DR2/peptide complexes

scientific article

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin antigens: IV. Suppression of chronic relapsing disease in the lewis rat and strain 13 guinea pig ⬇️

scientific article published on June 1, 1991

Suppressor T cells in human diseases

scientific article published on 26 July 2004

Systems immunology reveals markers of susceptibility to West Nile virus infection

scientific article

T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis

scientific article

T Cell Subsets in Patients with Multiple Sclerosis: An Overview ⬇️

scientific article published on January 1, 1984

T cell autoreactivity to proinsulin epitopes in diabetic patients and healthy subjects

scientific article published on June 1999

T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice

scientific article

T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions ⬇️

scientific article published on April 1, 1992

T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans.

scientific article published on July 1995

T cell vaccination in multiple sclerosis: a preliminary report

scientific article published on 01 March 1992

T cells in multiple sclerosis and inflammatory central nervous system diseases

scientific article

T-T cell interactions are mediated by adhesion molecules

scientific article published on 01 October 1990

T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones ⬇️

scientific article published on March 15, 1992

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis ⬇️

scientific article published on July 12, 1990

T-cell recognition of myelin basic protein ⬇️

scientific article published on August 1, 1991

T-cells in multiple sclerosis

scientific article published on January 2010

TCR usage in human and experimental demyelinating disease

scientific article published on April 1996

TGF-beta induces IL-9 production from human Th17 cells.

scientific article

TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage

scientific article

TIGIT signaling restores suppressor function of Th1 Tregs

scholarly article by Liliana E Lucca et al published 7 February 2019 in JCI insight

TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines

scientific article

TIM-4 expressed on APCs induces T cell expansion and survival

scientific article

TIMs: central regulators of immune responses

scientific article published on 17 November 2008

TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells

scientific article published on 16 April 2014

TLR7 induces anergy in human CD4(+) T cells

scientific article published on 17 November 2014

The 2H4 (CD45R) antigen is selectively decreased in multiple sclerosis lesions

scientific article published in April 1988

The B7-CD28/CTLA-4 costimulatory pathways in autoimmune disease of the central nervous system

scientific article

The CD226/CD155 interaction regulates the proinflammatory (Th1/Th17)/anti-inflammatory (Th2) balance in humans.

scientific article published on 26 August 2013

The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation

scientific article

The Human Functional Genomics Project: Understanding Generation of Diversity

scientific article published on 01 November 2016

The Link Between CD6 and Autoimmunity: Genetic and Cellular Associations

scientific article published on 31 January 2016

The Multiple Sclerosis Genomic Map: Role of peripheral immune cells and resident microglia in susceptibility

scholarly article published 13 July 2017

The Potential of Restricted T Cell Recognition of Myelin Basic Protein Epitopes in the Therapy of Multiple Sclerosis ⬇️

scientific article published on December 30, 1991

The TIGIT/CD226 axis regulates human T cell function

scientific article published on 16 March 2012

The Use of Cyclophosphamide in the Treatment of Multiple Sclerosis ⬇️

scientific article published on 01 January 1984

The coexpression of CD45RA and CD45RO isoforms on T cells during the S/G2/M stages of cell cycle.

scientific article published in November 1991

The developing mosaic of autoimmune disease risk

scientific article published on 01 February 2008

The development of antigen specific therapies for autoimmune diseases; investigations in multiple sclerosis as a paradigm for rheumatoid arthritis

scientific article published on 01 March 1993

The distinction blurs between an autoimmune versus microbial hypothesis in multiple sclerosis

scientific article published on September 1999

The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis

scientific article

The plasticity of human Treg and Th17 cells and its role in autoimmunity

scientific article

The purification and functional analysis of human CD4+CD25high regulatory T cells

scientific article published on 01 May 2006

The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus

article

The role of the CD58 locus in multiple sclerosis

scientific article

The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases

article

Therapy for multiple sclerosis.

scientific article published on February 1995

Three-year open protocol continuation study of oral tolerization with myelin antigens in multiple sclerosis and design of a phase III pivotal trial

scientific article published in February 1996

Thymic selection: to thine own self be true.

scientific article published in May 2015

Tolerance and suppressor mechanisms in experimental autoimmune encephalomyelitis: implications for immunotherapy of human autoimmune diseases.

scientific article published on August 1991

Transcriptomic and clonal characterization of T cells in the human central nervous system

scientific article published on 01 September 2020

Treatment of Uveitis by Oral Administration of Retinal Antigens: Results of a Phase I/II Randomized Masked Trial

article

Treatment of progressive multiple sclerosis with pulse cyclophosphamide/methylprednisolone: response to therapy is linked to the duration of progressive disease

scientific article published on December 1999

Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses

scientific article

Tropical spastic paraparesis on the Caribbean coast of Colombia

scientific article published on February 1995

Two genetic variants explain the association of European ancestry with multiple sclerosis risk in African-Americans

scientific article published on 09 October 2020

Two independent alleles at 6q23 associated with risk of rheumatoid arthritis

scientific article

Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells

scientific article published on 31 October 2020

Ubiquitous pathogens: links between infection and autoimmunity in MS?

scientific article published in July 2000

Uncoupling p70(s6) kinase activation and proliferation: rapamycin-resistant proliferation of human CD8(+) T lymphocytes

scientific article

Unraveling the autoimmune translational research process layer by layer

scientific article

Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting

scientific article published on 01 August 2018

Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS.

scientific article published on 16 February 2009

Variable immortalizing potential and frequent virus latency in blood-derived T-cell clones infected with human T-cell leukemia virus type I.

scientific article published on May 1997

Variation within DNA repair pathway genes and risk of multiple sclerosis

scientific article published on 3 June 2010

Weak peptide agonists reveal functional differences in B7-1 and B7-2 costimulation of human T cell clones ⬇️

scientific article published on August 15, 1997

What is the pathogenesis of human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis?

scientific article published in February 1995

pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires

scientific article

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