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List of works by Maree Smith

A novel fully validated LC–MS/MS method for quantification of pyridoxal-5′-phosphate concentrations in samples of human whole blood

scientific article published on 17 July 2015

A randomized, controlled trial of oxycodone versus placebo in patients with postherpetic neuralgia and painful diabetic neuropathy treated with pregabalin

scientific article published on 3 December 2009

A small molecule angiotensin II type 2 receptor (AT₂R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 mitogen-activated protein kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia.

scientific article published on 6 June 2013

ASAP ECMO: Antibiotic, Sedative and Analgesic Pharmacokinetics during Extracorporeal Membrane Oxygenation: a multi-centre study to optimise drug therapy during ECMO.

scientific article

Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern?

article

Analgesic efficacy and mode of action of a selective small molecule angiotensin II type 2 receptor antagonist in a rat model of prostate cancer-induced bone pain.

scientific article published on 30 October 2013

Analgesic efficacy of small-molecule angiotensin II type 2 receptor antagonists in a rat model of antiretroviral toxic polyneuropathy

scientific article published on April 2014

Angiotensin II type 2-receptor: new clinically validated target in the treatment of neuropathic pain

scientific article published on 20 December 2014

Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain

scientific article

Antinociception versus serum concentration relationships following acute administration of intravenous morphine in male and female Sprague-Dawley rats: differences between the tail flick and hot plate nociceptive tests

scientific article published on 29 July 2008

Assessment of the anti-allodynic efficacy of a glycine transporter 2 inhibitor relative to pregabalin and duloxetine in a rat model of prostate cancer-induced bone pain

scientific article published on 26 July 2020

Assessment of the anti-hyperalgesic efficacy of J-2156, relative to clinically available analgesic/adjuvant agents in a rat model of mild to moderate chronic mechanical low back pain (LBP)

scientific article published on 19 July 2020

Bioavailability and pharmacokinetics of phenytoin during pregnancy

scientific article published on 01 January 1984

Cerebrospinal fluid and plasma concentrations of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in patients before and after initiation of intracerebroventricular morphine for cancer pain management.

scientific article

Characterisation of a rat model of mechanical low back pain at an advanced stage using immunohistochemical methods

scientific article published on 05 September 2020

Characterization of non-conventional opioid binding sites in rat and human lung

scientific article

Chronic propranolol administration during pregnancy

scientific article published on 01 January 1983

Co-administration of oxycodone and morphine and analgesic synergy re-examined

scientific article published on April 2005

Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats

scientific article

Comment on "protective arms of the renin-angiotensin system in neurological disease".

scientific article

Comments on Goucke et al., PAIN, 56 (1994) 145-149.

scientific article

Comparative analgesic efficacy of pregabalin administered according to either a prevention protocol or an intervention protocol in rats with cisplatin-induced peripheral neuropathy

scientific article published on 28 June 2018

Comparative oxycodone pharmacokinetics in humans after intravenous, oral, and rectal administration

scientific article published in December 1992

Comparative studies of the neuro-excitatory behavioural effects of morphine-3-glucuronide and dynorphin A(2-17) following spinal and supraspinal routes of administration

scientific article

Comparative studies using the Morris water maze to assess spatial memory deficits in two transgenic mouse models of Alzheimer's disease

scientific article published in October 2014

Comparison of Burrowing and Stimuli-Evoked Pain Behaviors as End-Points in Rat Models of Inflammatory Pain and Peripheral Neuropathic Pain.

scientific article published on 10 May 2016

Comparison of the pharmacokinetics of oxycodone and noroxycodone in male dark agouti and Sprague--Dawley rats: influence of streptozotocin-induced diabetes

scientific article published on 29 July 2005

Correlations between in vitro dissolution, in vivo bioavailability and hypoglycaemic effect of oral glibenclamide

scientific article published on 01 January 1986

Corrigendum: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere

scientific article published on 01 July 2018

Countering opioid-induced respiratory depression by non-opioids that are respiratory stimulants

scientific article published on 07 February 2020

Current developments in MRI for assessing rodent models of multiple sclerosis

Cyclooctatetraene: A Bioactive Cubane Paradigm Complement

scientific article published on 25 January 2019

Deletion of guanine nucleotide binding protein alpha z subunit in mice induces a gene dose dependent tolerance to morphine.

scientific article published in May 2004

Determination of the Serum Protein Binding of Oxycodone and Morphine Using Ultrafiltration

scientific article published on 01 October 1993

Development and validation of a sensitive solid-phase-extraction (SPE) method using high-performance liquid chromatography/tandem mass spectrometry (LC–MS/MS) for determination of risedronate concentrations in human plasma

article

Differences between and combinations of opioids re-visited

scientific article

Effects of morphine-3-glucuronide and morphine on the K+-evoked release of [3H]-glutamic acid and [14C]-gamma-aminobutyric acid from rat brain synaptosomes

scientific article published on 01 January 1996

Endomorphin analogues with mixed μ-opioid (MOP) receptor agonism/δ-opioid (DOP) receptor antagonism and lacking β-arrestin2 recruitment activity

scientific article

Establishment and characterisation of a stavudine (d4T)-induced rat model of antiretroviral toxic neuropathy (ATN) using behavioural and pharmacological methods

scientific article published on 01 January 2019

Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods

scientific article published on 16 September 2014

Evaluation of a High-Throughput Peptide Reactivity Format Assay for Assessment of the Skin Sensitization Potential of Chemicals

scientific article

Formulation of Bioerodible Ketamine Microparticles as an Analgesic Adjuvant Treatment Produced by Supercritical Fluid Polymer Encapsulation

scholarly article by Felicity Y Han et al published 6 December 2018 in Pharmaceutics

Fully validated LC–MS/MS method for quantification of homocysteine concentrations in samples of human serum: A new approach

scientific article published on 02 October 2014

High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS.

scientific article

Hydromorphone-3-glucuronide: a more potent neuro-excitant than its structural analogue, morphine-3-glucuronide.

scientific article published in June 2001

Hydromorphone-3-glucuronide: biochemical synthesis and preliminary pharmacological evaluation

scientific article published in January 1998

Improved One-Step Solid-Phase Extraction Method for Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide From Plasma and Quantitation Using High-Performance Liquid Chromatography With Electrochemical Detection

scientific article published on 01 April 1998

In vitro methods for hazard assessment of industrial chemicals - opportunities and challenges

scientific article

In vivo high angular resolution diffusion-weighted imaging of mouse brain at 16.4 Tesla

scientific article published on 25 June 2015

In vivo profiling of four centrally administered opioids for antinociception, constipation and respiratory depression: Between-colony differences in Sprague Dawley rats

scientific article published on 25 June 2018

In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile

scientific article published on July 2014

Insulin implants prevent the temporal development of mechanical allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic Wistar rats

scientific article published on 11 April 2011

Intraarticular and periarticular opioid binding in inflamed tissue in experimental canine arthritis

scientific article published in August 1999

Investigation of the antinociceptive efficacy and relative potency of extended duration injectable 3-acylmorphine-6-sulfate prodrugs in rats

Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation

scientific article

Longitudinal Study of Painful Diabetic Neuropathy in the Zucker Diabetic Fatty Rat Model of Type 2 Diabetes: Impaired Basal G-Protein Activity Appears to Underpin Marked Morphine Hyposensitivity at 6 Months

article

Low-level quantitation of oxycodone and its oxidative metabolites, noroxycodone, and oxymorphone, in rat plasma by high-performance liquid chromatography–electrospray ionization–tandem mass spectrometry

scientific article published on 13 November 2006

Measurement of intracellular Ca2+ in cultured rat embryonic hippocampal neurons using a fluorescence microplate reader: potential application to biomolecular screening

scientific article published in March 2004

Metabolism of propranolol in the human maternal-placental-foetal unit

article

Morphine has a dual concentration-dependent effect on K(+)-evoked substance P release from rat peripheral airways

scientific article

Morphine hyposensitivity in streptozotocin-diabetic rats: Reversal by dietary l-arginine treatment

scientific article published on 19 September 2017

Morphine-3-glucuronide's neuro-excitatory effects are mediated via indirect activation of N-methyl-D-aspartic acid receptors: mechanistic studies in embryonic cultured hippocampal neurones

scientific article published on August 2003

Morphine-3-glucuronide--a potent antagonist of morphine analgesia

scientific article published in January 1990

Morphine-3-glucuronide: evidence to support its putative role in the development of tolerance to the antinociceptive effects of morphine in the rat

article

Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models

scientific article published on February 2014

Neurotrophins and Neuropathic Pain: Role in Pathobiology

scientific article

Nitric oxide modulates μ-opioid receptor function in vitro

scientific article published on 14 April 2019

Novel Source of Ubiquitous Phthalates as Analytical Contaminant ⬇️

scientific article published on 01 March 1981

Novel polymeric bioerodable microparticles for prolonged-release intrathecal delivery of analgesic agents for relief of intractable cancer-related pain

scientific article published on 19 May 2015

Optimization and characterization of a rat model of prostate cancer-induced bone pain using behavioral, pharmacological, radiological, histological and immunohistochemical methods.

scientific article published on 13 March 2013

Optimization and pharmacological characterization of a refined cisplatin-induced rat model of peripheral neuropathic pain

article

Oxycodone and morphine have distinctly different pharmacological profiles: radioligand binding and behavioural studies in two rat models of neuropathic pain

scientific article

Oxycodone has a distinctly different pharmacology from morphine

scholarly article by Maree Smith et al published December 2001 in European Journal of Pain

Oxycodone???s Mechanism of Action and Potency Differences after Spinal and Systemic Routes of Administration

scientific article published on 01 May 2007

PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

scientific article

Pain, analgesia and genetics ⬇️

scientific article published on August 19, 2011

Pathobiology and management of prostate cancer-induced bone pain: recent insights and future treatments ⬇️

scientific article published on 06 August 2013

Pathobiology of cancer chemotherapy-induced peripheral neuropathy (CIPN).

scientific article published on 18 December 2013

Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation

scientific article published on 31 January 2013

Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation

scientific article published on 18 April 2012

Pharmacokinetics and pharmacodynamics of oxycodone when given intravenously and rectally to adult patients with cancer pain

scientific article

Pharmacokinetics of midazolam in the aged

scientific article published in January 1984

Pharmacokinetics of prazepam in man.

scientific article published on September 1979

Pregabalin for the treatment of fibromyalgia

scientific article published on July 2012

Pregabalin in severe burn injury pain: A double-blind, randomised placebo-controlled trial

scientific article published on 12 March 2011

Preliminary study of the plasma and cerebrospinal fluid concentrations of IL-6 and IL-10 in patients with chronic pain receiving intrathecal opioid infusions by chronically implanted pump for pain management

scientific article published in March 2010

Propranolol in Pregnancy Three Year Prospective Study

scientific article published on 01 January 1983

Quantitation of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide in Plasma and Cerebrospinal Fluid Using Solid-Phase Extraction and High-Performance Liquid Chromatography with Electrochemical Detection

scientific article published on 01 April 1994

Quantitation of Oxycodone in Human Plasma Using High-Performance Liquid Chromatography with Electrochemical Detection

scientific article published on 01 March 1991

Quantitative autoradiography of peripheral opioid binding sites in rat lung

scientific article

Selective small molecule angiotensin II type 2 receptor antagonists for neuropathic pain: preclinical and clinical studies

scientific article

Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation

scientific article published on 15 October 2012

Sex differences in the pharmacokinetics, oxidative metabolism and oral bioavailability of oxycodone in the Sprague-Dawley rat.

scientific article published on 31 October 2007

Simultaneous determination of morphine, oxycodone, morphine-3-glucuronide, and noroxycodone concentrations in rat serum by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry

scientific article published in January 2005

Small molecule angiotensin II type 2 receptor (AT₂R) antagonists as novel analgesics for neuropathic pain: comparative pharmacokinetics, radioligand binding, and efficacy in rats

scientific article published on 14 March 2013

Solid-phase extraction method with high-performance liquid chromatography and electrochemical detection for the quantitative analysis of oxycodone in human plasma

scientific article published on 01 August 1998

Studies with ketamine and alfentanil following Freund's complete adjuvant-induced inflammation in rats.

scientific article published in May 2007

Study Protocol for a Pilot, Open-Label, Prospective, and Observational Study to Evaluate the Pharmacokinetics of Drugs Administered to Patients during Extracorporeal Circulation; Potential of In Vivo Cytochrome P450 Phenotyping to Optimise Pharmacot

scientific article published on 13 May 2019

Synthesis and biological evaluation of an orally active glycosylated endomorphin-1.

scientific article

Targeting angiotensin II type 2 receptor pathways to treat neuropathic pain and inflammatory pain.

scientific article

The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation

scientific article

The antinociceptive potencies of oxycodone, noroxycodone and morphine after intracerebroventricular administration to rats

scientific article published on 01 January 1994

The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement

scientific article published on 01 July 2019

The excitatory effects of morphine-3-glucuronide are attenuated by LY274614, a competitive NMDA receptor antagonist, and by midazolam, an agonist at the benzodiazepine site on the GABAA receptor complex

scientific article published in January 1994

The furoxan nitric oxide donor, PRG150, evokes dose-dependent analgesia in a rat model of painful diabetic neuropathy

article

The intrinsic antinociceptive effects of oxycodone appear to be κ -opioid receptor mediated ⬇️

scientific article published on November 1, 1997

The neuroexcitatory morphine metabolite, morphine-3-glucuronide (M3G), is not neurotoxic in primary cultures of either hippocampal or cerebellar granule neurones

scientific article published in October 2003

The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices

scientific article

The pharmacokinetics of midazolam in man.

scientific article published in March 1981

The role of morphine-6-glucuronide (M6G) in pain control

The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes

scientific article

Theoretical and practical applications of the intracerebroventricular route for CSF sampling and drug administration in CNS drug discovery research: a mini review

scientific article

Topical application of a novel oxycodone gel formulation (tocopheryl phosphate mixture) in a rat model of peripheral inflammatory pain produces localized pain relief without significant systemic exposure

scientific article published on 20 May 2015

Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere.

scientific article

Ventilatory responses of healthy subjects to intravenous combinations of morphine and oxycodone under imposed hypercapnic and hypoxaemic conditions

scientific article published on May 2005

chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain

scientific article published in November 2009

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