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List of works by Kristian Helin

A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2

scientific article published on 01 November 2019

A New Role for the Polycomb Group Protein Ezh1 in Promoting Transcription

scientific article published on 01 January 2012

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

scientific article (publication date: 24 July 1992)

A conserved TATA-less proximal promoter drives basal transcription from the urokinase-type plasminogen activator receptor gene.

scientific article published on July 1995

A dual program for translation regulation in cellular proliferation and differentiation

scientific article published on September 2014

A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation

scientific article

A model for transmission of the H3K27me3 epigenetic mark

scientific article published on 19 October 2008

A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation

scientific article published on 25 January 2016

A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner

scientific article

A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1

scientific journal article

A role for the transcription factor HEY1 in glioblastoma

scientific article

A screen identifies the oncogenic micro-RNA miR-378a-5p as a negative regulator of oncogene-induced senescence

scientific article

A single amino acid substitution is sufficient to modify the mitogenic properties of the epidermal growth factor receptor to resemble that of gp185erbB-2

scientific article

APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death.

scientific article

ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors

scientific article published on 20 October 2009

Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2.

scientific article published on 26 February 2018

Adenovirus E4 open reading frame 4-induced dephosphorylation inhibits E1A activation of the E2 promoter and E2F-1-mediated transactivation independently of the retinoblastoma tumor suppressor protein

scientific article

Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity

scientific article published on 10 December 2018

Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity

scientific article published on July 2004

Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line

scientific article published on January 1995

An inverted repeat motif stabilizes binding of E2F and enhances transcription of the dihydrofolate reductase gene

scientific article published on April 1995

Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1

scientific article

Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus

scientific article

Apaf-1 is a transcriptional target for E2F and p53

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

scientific article

Attenuation of the beta-catenin/TCF4 complex in colorectal cancer cells induces several growth-suppressive microRNAs that target cancer promoting genes

scientific article

BLUEPRINT to decode the epigenetic signature written in blood.

scientific article

BTK inhibitors synergise with 5-FU to treat drug-resistant TP53-null colon cancers

scientific article published on 02 December 2019

Bricks & Mortar

scientific article published in Nature

Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus

scientific article

CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase

scientific article

CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression

scientific article

Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site

scientific article

Cell cycle, differentiation and disease

scientific article published on 16 October 2013

Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1

scientific article

Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F.

scientific article

Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription

scientific article

Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes

scientific article

Chromatin proteins and modifications as drug targets

scientific article

Chromatin regulated interchange between polycomb repressive complex 2 (PRC2)-Ezh2 and PRC2-Ezh1 complexes controls myogenin activation in skeletal muscle cells

scientific article

Chromatin repressive complexes in stem cells, development, and cancer

scientific article

Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis

scientific article published on 02 March 2021

Concurrent neutral endopeptidase and ACE inhibition in experimental heart failure: renal and hormonal effects

scientific article published on 01 December 1993

Conditional E2F1 activation in transgenic mice causes testicular atrophy and dysplasia mimicking human CIS.

scientific article

Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development ⬇️

scientific article published on 06 June 2016

Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2

scientific article

Cyclin E-induced S phase without activation of the pRb/E2F pathway.

scientific article published in June 1997

DAPK2 is a novel E2F1/KLF6 target gene involved in their proapoptotic function

scientific article published on 2 June 2008

DNA methylation: TET proteins-guardians of CpG islands?

scientific article published on 23 December 2011

DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice

scientific article published on 15 February 2016

DcE2F, a functional plant E2F-like transcriptional activator from Daucus carota

scientific article published in June 2000

Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland

scientific article

Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression

scientific article published on March 1996

E2F Family Members Are Differentially Regulated by Reversible Acetylation

scientific article published in Journal of Biological Chemistry

E2F activates late-G1 events but cannot replace E1A in inducing S phase in terminally differentiated skeletal muscle cells

scientific article published on September 1999

E2F target genes: unraveling the biology

scientific article published in August 2004

E2F-1-induced p53-independent apoptosis in transgenic mice.

scientific article

E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription

scientific article

E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer

scientific article

E2F-Rb complexes assemble and inhibit cdc25A transcription in cervical carcinoma cells following repression of human papillomavirus oncogene expression

scientific article

E2F-dependent induction of p14ARF during cell cycle re-entry in human T cells

scientific article

E2F1 is crucial for E2F-dependent apoptosis

scientific article published in July 2005

E2F1-mediated transcriptional inhibition of the plasminogen activator inhibitor type 1 gene

scientific article

E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes

scientific article

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.

scientific article published on February 2001

EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in Mice

scientific article published on 10 July 2017

EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas

scientific article published on 27 February 2017

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

scientific article

Epigenetic Regulation of Angiogenesis by JARID1B-Induced Repression of HOXA5.

scientific article published on 28 May 2015

Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation

scientific article published on 12 April 2018

Epigenetic control of embryonic stem cell fate

scientific article

Epigenetic inheritance through self-recruitment of the polycomb repressive complex 2.

scientific article published on 18 April 2009

Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2.

scientific article published on 14 April 2015

Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation

scientific article published on 7 February 2013

FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS

scientific article published on 16 February 2014

Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer

scientific article

G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter.

scientific article published in January 1994

Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication

scientific article published on 08 July 2013

Geminin: a major DNA replication safeguard in higher eukaryotes

scientific article published on 25 August 2004

Gene silencing triggers polycomb repressive complex 2 recruitment to CpG islands genome wide

scientific article published on 3 July 2014

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions

scientific article (publication date: May 2006)

Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma

scientific article published on 05 July 2013

H3K23me2 is a new heterochromatic mark in Caenorhabditis elegans

scientific article published on 17 October 2015

H3K9 dimethylation safeguards cancer cells against activation of the interferon pathway

scientific article published on 18 March 2022

HER2-positive breast-cancer cell lines are sensitive to KDM5 inhibition: definition of a gene-expression model for the selection of sensitive cases

scientific article published on 11 December 2018

HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity

scientific article

Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein

scientific article published on August 1994

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation

scientific article

Histone acetyltransferase PCAF is required for Hedgehog-Gli-dependent transcription and cancer cell proliferation

scientific article published on 13 August 2013

Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders

scientific article published on 01 December 2019

Histone demethylases in development and disease ⬇️

scientific article published on September 20, 2010

Histone lysine demethylases as targets for anticancer therapy

scientific article

Histone methyltransferases in cancer

scientific article (publication date: April 2010)

Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase

scientific article

Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F

scientific article

Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis

scientific article

Hypermethylated in cancer 1 (HIC1) recruits polycomb repressive complex 2 (PRC2) to a subset of its target genes through interaction with human polycomb-like (hPCL) proteins

scientific article published on 7 February 2012

Identification of catechols as histone-lysine demethylase inhibitors

scientific article

Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary

scientific article published on 02 January 2020

Identification of target genes of the p16INK4A-pRB-E2F pathway.

scientific article

Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes

scientific article published on December 1993

Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

scientific article published on July 1997

Induction of S-Phase Entry by E2F Transcription Factors Depends on Their Nuclear Localization ⬇️

scientific article published on September 1, 1997

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein

scientific article published on October 1993

Inhibition of GSK3B bypass drug resistance of p53-null colon carcinomas by enabling necroptosis in response to chemotherapy

scientific article

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein

scientific article (publication date: July 1993)

Inhibition of demethylases by GSK-J1/J4.

scientific article published on October 2014

Inhibition of in vitro myogenic differentiation by cellular transcription factor E2F1.

scientific article

Inhibitors of histone demethylases

scientific article published on February 2011

Isolation and characterization of DUSP11, a novel p53 target gene

scientific article published in August 2009

JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

scientific article

Jarid1b targets genes regulating development and is involved in neural differentiation

scientific article published on November 2011

Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome

scientific article published on 01 January 2014

Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2.

scientific article

Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells

scientific article published on 02 June 2016

KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes

scientific article published on 30 March 2020

Loss of Geminin induces rereplication in the presence of functional p53

scientific article

Loss of MYC confers resistance to doxorubicin-induced apoptosis by preventing the activation of multiple serine protease- and caspase-mediated pathways

scientific article published on 27 February 2004

Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

scientific article published on 17 April 2015

Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma

scientific article

MMSET Is Highly Expressed and Associated with Aggressiveness in Neuroblastoma

scientific article published on 28 April 2011

Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint

scientific article

Maintaining cell identity: PRC2-mediated regulation of transcription and cancer

scientific article published on 23 September 2016

Maternal expression of the histone demethylase Kdm4a is crucial for pre-implantation development

scientific article

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

scientific article

Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms

scientific article published on March 2005

Middle-down hybrid chromatography/tandem mass spectrometry workflow for characterization of combinatorial post-translational modifications in histones

scientific article

Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation

scientific article published on 01 April 2019

Molecular mechanisms and potential functions of histone demethylases

scientific article published on 04 April 2012

Molecular mechanisms and potential functions of histone demethylases

Molecular mechanisms in gliomagenesis

scientific article

Multiple autophosphorylation sites of the epidermal growth factor receptor are essential for receptor kinase activity and internalization. Contrasting significance of tyrosine 992 in the native and truncated receptors ⬇️

scientific article published in Journal of Biological Chemistry

Mutant FOXL2C134W highjacks SMAD4 and SMAD2/3 to drive adult granulosa cell tumors

scientific article published on 08 July 2020

NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint

scientific article

NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling

scientific article

NPAT expression is regulated by E2F and is essential for cell cycle progression

scientific article

Naturally death-resistant precursor cells revealed as the origin of retinoblastoma

scientific article published on June 2004

Non-core Subunits of the PRC2 Complex Are Collectively Required for Its Target-Site Specificity

scientific article published on 11 September 2019

Nucleocytoplasmic shuttling of transcription factors

scientific article

Nucleophosmin is required for DNA integrity and p19Arf protein stability

scientific journal article

OVCA1: emerging as a bona fide tumor suppressor

scientific article published in February 2004

Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression

scientific article published on 28 June 2016

PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells

scientific article published on 23 January 2019

PR-DUB maintains expression of critical genes through FOXK1/2 and ASXL1/2/3-dependent recruitment to chromatin and H2AK119ub1 deubiquitination

scientific article published on 03 August 2020

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies

scientific article published on 13 August 2014

PRMT5 inhibition modulates E2F1 methylation and gene regulatory networks leading to therapeutic efficacy in JAK2V617F mutant MPN

scientific article published on 15 July 2020

PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia

scientific article published on 14 October 2019

PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation

scientific article published on January 2013

Phosphorylation of a specific cdk site in E2F-1 affects its electrophoretic mobility and promotes pRB-binding in vitro

scientific article published on January 1995

Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization

scientific article

Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation.

scientific article published on 17 March 2013

Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor.

scientific article published on 2 June 2008

Polycomb complexes act redundantly to repress genomic repeats and genes

scientific article

Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation

scientific article published on September 2010

Polycomb group protein-mediated repression of transcription

scientific article

Polycomb group proteins in cell cycle progression and cancer.

scientific article published in April 2004

Polycomb group proteins: navigators of lineage pathways led astray in cancer

scientific article

Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication

scientific article published on 14 April 2014

Positive and negative regulation of cell proliferation by E2F-1: influence of protein level and human papillomavirus oncoproteins

scientific article published on December 1994

Precision mapping of coexisting modifications in histone H3 tails from embryonic stem cells by ETD-MS/MS.

scientific article published on 16 August 2013

Profiling cancer

scientific article

Quantification of Differential Transcription Factor Activity and Multiomics-Based Classification into Activators and Repressors: diffTF

scientific article published on 01 December 2019

Quantification of differential transcription factor activity and multiomics-based classification into activators and repressors: diffTF

Quantitative mass spectrometry of histones H3.2 and H3.3 in Suz12-deficient mouse embryonic stem cells reveals distinct, dynamic post-translational modifications at Lys-27 and Lys-36

scientific article

RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3

scientific article

RSV-Induced H3K4 Demethylase KDM5B Leads to Regulation of Dendritic Cell-Derived Innate Cytokines and Exacerbates Pathogenesis In Vivo

scientific article (publication date: June 2015)

Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas

scientific article

Reduced hepatic tumor incidence in cyclin G1-deficient mice

scientific article published in April 2003

Regional tumour glutamine supply affects chromatin and cell identity

scientific article

Regulation of cell proliferation by the E2F transcription factors ⬇️

scientific article published on February 1, 1998

Regulation of stem cell differentiation by histone methyltransferases and demethylases

scientific article

Revolution in the Polycomb hierarchy

scientific article published on 01 July 2014

Role of TET enzymes in DNA methylation, development, and cancer

scientific article

Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer

scientific article

Role of the polycomb repressive complex 2 in acute promyelocytic leukemia

scientific article

SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation ⬇️

scientific article

SWI/SNF Subunits SMARCA4, SMARCD2 and DPF2 Collaborate in MLL-Rearranged Leukaemia Maintenance

scientific article published on 16 November 2015

Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor

scientific article

Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry

scientific article published on 06 May 2002

Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity

scientific article

Systems Level Analysis of Histone H3 Post-translational Modifications (PTMs) Reveals Features of PTM Crosstalk in Chromatin Regulation

scientific article published on 14 June 2016

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

scientific journal article

TET1: an epigenetic guardian of lymphomagenesis

scientific article published in June 2015

TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells

TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells

scientific article published on 22 February 2019

TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells.

scientific article published on August 2014

TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis

scientific article published on 18 October 2021

Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells

scientific article

Tet2 facilitates the derepression of myeloid target genes during CEBPα-induced transdifferentiation of pre-B cells

scientific article published on 13 September 2012

The E2F family: specific functions and overlapping interests

scientific article

The E2F transcription factors: key regulators of cell proliferation

scientific article

The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence

scientific article (publication date: 15 May 2009)

The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and over-expressed in Hodgkin's Lymphoma

scientific article published on 17 January 2011

The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance

scientific article published on 21 August 2019

The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis

scientific article published on 28 July 2019

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

scientific article

The SETDB1-TRIM28 Complex Suppresses Antitumor Immunity

scientific article published on 01 December 2021

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation

article

The biological activity of the human epidermal growth factor receptor is positively regulated by its C-terminal tyrosines

scientific article published on May 1991

The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells

scientific article published on 27 March 2019

The demethylase JMJD2C localizes to H3K4me3-positive transcription start sites and is dispensable for embryonic development

scientific article published on 06 January 2014

The emerging functions of histone demethylases

scientific article published on 20 February 2008

The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3

scientific article published in April 2013

The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal in mice

scientific article published on 5 February 2015

The histone demethylase Jarid1b mediates angiotensin II-induced endothelial dysfunction by controlling the 3'UTR of soluble epoxide hydrolase

scientific article published on 25 August 2018

The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia

scientific article

The histone lysine demethylase JMJD3/KDM6B is recruited to p53 bound promoters and enhancer elements in a p53 dependent manner

scientific article

The histone methyltransferase SET8 is required for S-phase progression

scientific article published on December 2007

The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors

scientific article published on 8 March 2011

The lncRNA MIR31HG regulates p16(INK4A) expression to modulate senescence

scientific article published on 24 April 2015

The p53 tumour suppressor protein

scientific article

The polycomb group protein Suz12 is required for embryonic stem cell differentiation

scientific article published on 5 March 2007

The polycomb repressive complex 2 is a potential target of SUMO modifications

scientific article

The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein

scientific article

The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

scientific article (publication date: 20 July 2006)

The regulation of APAF1 expression during development and tumourigenesis

scientific article

The retinoblastoma protein as a transcriptional repressor

scientific article published on February 1993

The role of p53 and pRB in apoptosis and cancer

scientific article

The tumor suppressor gene hypermethylated in cancer 1 is transcriptionally regulated by E2F1.

scientific article

The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation

scientific article

Transcriptional regulation by Polycomb group proteins

scientific article published on October 2013

Translational control and differential RNA decay are key elements regulating postsegregational expression of the killer protein encoded by the parB locus of plasmid R1.

scientific article

Transmembrane signalling at the epidermal growth factor receptor. Positive regulation by the C-terminal phosphotyrosine residues

scientific article published on July 1991

Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals

scientific article

Tumor suppressors: from genes to function and possible therapies

article

UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

scientific article (publication date: 11 October 2007)

Utx is required for proper induction of ectoderm and mesoderm during differentiation of embryonic stem cells

scientific article

Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells

scientific article published on 12 June 2013

ZFP57 maintains the parent-of-origin-specific expression of the imprinted genes and differentially affects non-imprinted targets in mouse embryonic stem cells

scientific article published on June 2016

[Basic stem cell biology and cancer]

scientific article published on 01 September 2010

erbB-2 autophosphorylation is required for mitogenic action and high-affinity substrate coupling.

scientific article

p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression

scientific article published on January 1997

shRNA screening identifies JMJD1C as being required for leukemia maintenance

scientific article

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