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List of works by Andres Merits

A Chikungunya virus trans-replicase system reveals the importance of delayed non-structural polyprotein processing for efficient replication complex formation in mosquito cells.

scientific article published on 25 April 2018

A Sensitive Method for Detecting Zika Virus Antigen in Patients' Whole-Blood Specimens as an Alternative Diagnostic Approach

scientific article published on 06 June 2017

A Systems Approach to Study Immuno- and Neuro-Modulatory Properties of Antiviral Agents

scientific article published on 12 August 2018

A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs

scientific article published on 12 May 2016

A pathogenic role for CD4+ T cells during Chikungunya virus infection in mice

scientific article

ADP-ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication

article published in the Proceedings of the National Academy of Sciences of the United States of America

Antibacterial activity of the nitrovinylfuran G1 (Furvina) and its conversion products.

scientific article

Antigenic Variation of East/Central/South African and Asian Chikungunya Virus Genotypes in Neutralization by Immune Sera

scientific article

Antiviral RNA interference responses induced by Semliki Forest virus infection of mosquito cells: characterization, origin, and frequency-dependent functions of virus-derived small interfering RNAs

scientific article published on 29 December 2010

Antiviral activity of silymarin against chikungunya virus

scientific article published on 16 June 2015

Attenuated and vectored vaccines protect nonhuman primates against Chikungunya virus

scientific article published on 23 March 2017

Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss induced by chikungunya virus infection

scientific article

Biochemical and Genetic Evidence for Interactions between Potato A Potyvirus-Encoded Proteins P1 and P3 and Proteins of the Putative Replication Complex

article

Biological, Serological, and Molecular Differences Among Isolates of Potato A Potyvirus

article by M Rajamäki et al published April 1998 in Phytopathology

Cell-to-Cell Spread of the RNA Interference Response Suppresses Semliki Forest Virus (SFV) Infection of Mosquito Cell Cultures and Cannot Be Antagonized by SFV

scientific article (publication date: June 2009)

Characterization of Aedes aegypti innate-immune pathways that limit Chikungunya virus replication

scientific article

Characterization of the Zika virus induced small RNA response in Aedes aegypti cells ⬇️

scientific article published on 17 October 2017

Characterization of β-d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus

scientific article

Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease's active site cysteine residue.

scientific article published on 15 November 2016

Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo.

scientific article published on 31 December 2013

Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen

scientific article

Cis-acting sequences and secondary structures in untranslated regions of duck Tembusu virus RNA are important for cap-independent translation and viral proliferation

scientific article published on 10 June 2020

Comparison of the complete sequences of five different isolates of Potato virus A (PVA), genus Potyvirus.

scientific article published in January 1999

Comparison of the nucleotide sequences of the 3'-terminal regions of one aphid and two non-aphid transmissible isolates of potato A potyvirus

scientific article published in January 1996

Complex formation between hepatitis C virus NS2 and NS3 proteins

scientific article published on December 2005

Construction, properties, and potential application of infectious plasmids containing Semliki Forest virus full-length cDNA with an inserted intron

scientific article published on 3 December 2007

Control of the rescue and replication of Semliki Forest virus recombinants by the insertion of miRNA target sequences

scientific article

Correction for Utt et al., Mutations Conferring a Noncytotoxic Phenotype on Chikungunya Virus Replicons Compromise Enzymatic Properties of Nonstructural Protein 2.

scientific article published on 12 August 2016

Cross-utilisation of template RNAs by alphavirus replicases

scientific article published on 04 September 2020

Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold

scientific article published on 01 January 2022

DNA-launched RNA replicon vaccines induce potent anti-Ebolavirus immune responses that can be further improved by a recombinant MVA boost

scientific article published in Scientific Reports

Deciphering the potential of baicalin as an antiviral agent for Chikungunya virus infection

scientific article published on 18 December 2017

Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAs

scientific article published on 21 August 2018

Design and Use of Chikungunya Virus Replication Templates Utilizing Mammalian and Mosquito RNA Polymerase I-Mediated Transcription

scientific article published on 28 August 2019

Design and Validation of Novel Chikungunya Virus Protease Inhibitors

scientific article published on 10 October 2016

Design, discovery, modelling, synthesis, and biological evaluation of novel and small, low toxicity s-triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors.

scientific article published on 8 April 2016

Detection of Persistent Chikungunya Virus RNA but not Infectious Virus in Experimental Vertical Transmission in Aedes aegypti from Malaysia

scientific article

Development of a luciferase-based system for the detection of ZnT8 autoantibodies

scientific article published on 22 January 2014

Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses

scientific article published on 19 October 2017

Evaluation of a range of mammalian and mosquito cell lines for use in Chikungunya virus research ⬇️

scientific article published on 7 November 2017

Expanding the activity spectrum of antiviral agents

scientific article published on 10 April 2019

Fingolimod treatment abrogates chikungunya virus–induced arthralgia

scientific article

Functional cross-talk between distant domains of chikungunya virus non-structural protein 2 is decisive for its RNA-modulating activity

scientific article

Glycosylation of phytepsin and expression of dad1 , dad2 and ost1 during onset of cell death in germinating barley scutella

scientific article published on 01 May 2000

ICTV Virus Taxonomy Profile: Togaviridae.

scientific article

Identification of Alphavirus Inhibitors by Using Virus-Based Assays and a Chikungunya Replicon Cell Line

scientific article published in 2011

Identification of Natural Molecular Determinants of Ross River Virus Type I Interferon Modulation

scientific article published on 31 March 2020

Identification of a Novel Function of theAlphavirusCapping Apparatus

scientific article published in Journal of Biological Chemistry

Identification of mutations causing temperature-sensitive defects in Semliki Forest virus RNA synthesis

scientific article published on March 2006

Identification of the genome-linked protein in virions of Potato virus A, with comparison to other members in genus Potyvirus.

scientific article published in March 2001

Imipramine Inhibits Chikungunya Virus Replication in Human Skin Fibroblasts through Interference with Intracellular Cholesterol Trafficking

scientific article published on 09 June 2017

Inactivation of the type I interferon pathway reveals long double-stranded RNA-mediated RNA interference in mammalian cells.

scientific article

Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays

scientific article

Insertion of EGFP into the replicase gene of Semliki Forest virus results in a novel, genetically stable marker virus

scientific article published on April 2007

Inter-domain Flexibility of Chikungunya Virus nsP2 Helicase-Protease Differentially Influences Viral RNA Replication and Infectivity

scientific article published on 16 December 2020

Kinetic and phenotypic analysis of CD8+ T cell responses after priming with alphavirus replicons and homologous or heterologous booster immunizations

scientific article

Low Temperature and Low UV Indexes Correlated with Peaks of Influenza Virus Activity in Northern Europe during 2010⁻2018

scientific article published on 01 March 2019

Macromolecular assembly-driven processing of the 2/3 cleavage site in the alphavirus replicase polyprotein

scientific article

Magnetic fractionation and proteomic dissection of cellular organelles occupied by the late replication complexes of Semliki Forest virus

scientific article published on 17 July 2013

Modulation of Aire regulates the expression of tissue-restricted antigens

scientific journal article

Molecular defects caused by temperature-sensitive mutations in Semliki Forest virus nsP1.

scientific article

Molecular determinants of substrate specificity for Semliki Forest virus nonstructural protease

scientific article published on June 2006

Mouse macrophage innate immune response to Chikungunya virus infection

scientific article published on 19 December 2012

Mutating chikungunya virus non-structural protein produces potent live-attenuated vaccine candidate.

scientific article published in June 2019

Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus

scientific article published on 27 April 2018

Mutation of the N-Terminal Region of Chikungunya Virus Capsid Protein: Implications for Vaccine Design

scientific article (publication date: 21 February 2017)

Mutations at the palmitoylation site of non-structural protein nsP1 of Semliki Forest virus attenuate virus replication and cause accumulation of compensatory mutations

scientific article published on July 2007

Mutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2

scientific article

Mutations in the nuclear localization signal of nsP2 influencing RNA synthesis, protein expression and cytotoxicity of Semliki Forest virus

scientific article published on March 2008

Neurons and oligodendrocytes in the mouse brain differ in their ability to replicate Semliki Forest virus

scientific article published on 24 December 2008

Novel activities of safe-in-human broad-spectrum antiviral agents

scientific article published on 23 April 2018

Novel attenuated Chikungunya vaccine candidates elicit protective immunity in C57BL/6 mice

scientific article

Novel functions of the alphavirus nonstructural protein nsP3 C-terminal region

scientific article

Novel vectors expressing anti-apoptotic protein Bcl-2 to study cell death in Semliki Forest virus-infected cells

scientific article

Novel viral vectors utilizing intron splice-switching to activate genome rescue, expression and replication in targeted cells

scientific article

Obatoclax Inhibits Alphavirus Membrane Fusion by Neutralizing the Acidic Environment of Endocytic Compartments

scientific article published on 19 December 2016

Palmitoylated cysteines in Chikungunya virus nsP1 are critical for targeting to cholesterol-rich plasma membrane microdomains with functional consequences for viral genome replication

scientific article published on 04 March 2020

Partially Uncleaved Alphavirus Replicase Forms Spherule Structures in the Presence and Absence of RNA Template

scientific article published on 12 July 2017

Persistent Replication of a Chikungunya Virus Replicon in Human Cells Is Associated with Presence of Stable Cytoplasmic Granules Containing Nonstructural Protein 3 ⬇️

scientific article published on 31 July 2018

Phenoloxidase activity acts as a mosquito innate immune response against infection with Semliki Forest virus

scientific article

Poly(A) Addition Site Mapping and Polyadenylation Signal Analysis in a Plant Circovirus Replication-Related Gene

scientific article published on 01 August 1995

Polypurine (A)-rich sequences promote cross-kingdom conservation of internal ribosome entry

scientific article

Presentation overrides specificity: probing the plasticity of alphaviral proteolytic activity through mutational analysis

scientific article published on 17 July 2013

Prime-boost immunization strategies against Chikungunya virus

scientific article

Properly folded nonstructural polyprotein directs the semliki forest virus replication complex to the endosomal compartment

scientific article

Properties and use of novel replication-competent vectors based on Semliki Forest virus

scientific article

Properties of non-structural protein 1 of Semliki Forest virus and its interference with virus replication

scientific article published on June 2008

RIG-I and MDA-5 detection of viral RNA-dependent RNA polymerase activity restricts positive-strand RNA virus replication

scientific article

RNA Interference-Guided Targeting of Hepatitis C Virus Replication with Antisense Locked Nucleic Acid-Based Oligonucleotides Containing 8-oxo-dG Modifications

scientific article published on 3 June 2015

Regulation of -1 ribosomal frameshifting directed by cocksfoot mottle sobemovirus genome

scientific article published on June 2000

Regulation of the sequential processing of Semliki Forest virus replicase polyprotein

scientific article published on 12 August 2003

Reverse genetic system, genetically stable reporter viruses and packaged subgenomic replicon based on a Brazilian Zika virus isolate

scientific article published on 12 October 2017

Role of the Amphipathic Peptide of Semliki Forest Virus Replicase Protein nsP1 in Membrane Association and Virus Replication

scientific article

SAMHD1 Enhances Chikungunya and Zika Virus Replication in Human Skin Fibroblasts ⬇️

scientific article published on 05 April 2019

SNAP-tagged Chikungunya Virus Replicons Improve Visualisation of Non-Structural Protein 3 by Fluorescence Microscopy ⬇️

scientific article

Safe and Effective Treatment of Experimental Neuroblastoma and Glioblastoma Using Systemically Delivered Triple MicroRNA-Detargeted Oncolytic Semliki Forest Virus

scientific article

Semliki Forest Virus Chimeras with Functional Replicase Modules from Related Alphaviruses Survive by Adaptive Mutations in Functionally Important Hot Spots

scientific article published on 28 July 2021

Semliki Forest virus strongly reduces mosquito host defence signaling

scientific article

Semliki forest virus-induced endoplasmic reticulum stress accelerates apoptotic death of mammalian cells

scientific article published on 28 April 2010

Sensitivity of Alphaviruses to G3BP Deletion Correlates with Efficiency of Replicase Polyprotein Processing

scientific article published on 17 March 2020

Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection

scientific article published on 19 October 2012

Spindle-E Acts Antivirally Against Alphaviruses in Mosquito Cells

scientific article published on 18 February 2018

Stress granule components G3BP1 and G3BP2 play a proviral role early in Chikungunya virus replication

scientific article published on 4 February 2015

Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase

scientific article published on 18 April 2019

Synthesis and biological activity of bimorpholine and its carbanucleoside

scientific article published in November 2011

Synthesis of novel acyclic nucleoside analogues with anti-retroviral activity

scientific article published on September 2010

The Antiviral Alkaloid Berberine Reduces Chikungunya Virus-Induced Mitogen-Activated Protein Kinase Signaling

scientific article published on 17 August 2016

The Dimeric Peptide (KKYRYHLKPF)2K Shows Broad-Spectrum Antiviral Activity by Inhibiting Different Steps of Chikungunya and Zika Virus Infection

scientific article published in 2023

The first nonmammalian pegivirus demonstrates efficient in vitro replication and high lymphotropism

scientific article published on 05 August 2020

The host DHX9 DExH Box helicase is recruited to Chikungunya virus replication complexes for optimal genomic RNA translation

scientific article published on 05 February 2019

The host nonsense-mediated mRNA decay pathway restricts Mammalian RNA virus replication

scientific article published on September 2014

The infection of mammalian and insect cells with SFV bearing nsP1 palmitoylation mutations

scientific article published on 27 August 2010

The structure of GFRalpha1 domain 3 reveals new insights into GDNF binding and RET activation

scientific article published on 25 March 2004

The type I interferon system protects mice from Semliki Forest virus by preventing widespread virus dissemination in extraneural tissues, but does not mediate the restricted replication of avirulent virus in central nervous system neurons

scientific article published in December 2007

Therapeutics and vaccines against chikungunya virus

scientific article published on April 2015

Timeliness of proteolytic events is prerequisite for efficient functioning of the alphaviral replicase.

scientific article published on 25 April 2018

Transfection of infectious RNA and DNA/RNA layered vectors of semliki forest virus by the cell-penetrating peptide based reagent PepFect6.

scientific article

Trisubstituted Thieno[3,2-b]pyrrole 5-Carboxamides as Potent Inhibitors of Alphaviruses

scientific article published on 5 November 2015

Unique epitopes recognized by antibodies induced in Chikungunya virus-infected non-human primates: implications for the study of immunopathology and vaccine development

scientific article

Versatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein

scientific article

Viperin restricts chikungunya virus replication and pathology

scientific article

Viral Polymerase-Helicase Complexes Regulate Replication Fidelity To Overcome Intracellular Nucleotide Depletion

scientific article

Virus replicon particle based Chikungunya virus neutralization assay using Gaussia luciferase as readout

scientific article published on 15 July 2013

Virus-Specific mRNA Capping Enzyme Encoded by Hepatitis E Virus

Virus-specific mRNA capping enzyme encoded by hepatitis E virus

scientific article

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