List of works by Titia de Lange

53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair

scientific article

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

scientific article published on 19 October 2008

53BP1 regulates DSB repair using Rif1 to control 5' end resection

scientific article

53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in

scientific article published in Nature

53BP1: a DSB escort

scientific article published on 01 January 2020

53BP1: pro choice in DNA repair

scientific article

<i>TINF2</i> is a haploinsufficient tumor suppressor that limits telomere length

scientific article published on 01 December 2020

A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus

scientific article

A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion

scientific article

A TIN2 dyskeratosis congenita mutation causes telomerase-independent telomere shortening in mice

scientific article published on January 2014

A TRF1-controlled common fragile site containing interstitial telomeric sequences

scientific article published on 13 July 2012

A human telomeric protein

scientific article

A loopy view of telomere evolution

scientific article published on 20 October 2015

A mammalian factor that binds telomeric TTAGGG repeats in vitro

scientific article

A map of the distal region of the long arm of human chromosome 21 constructed by radiation hybrid mapping and pulsed-field gel electrophoresis

scientific article published on January 1991

A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins

scientific article

APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis

scientific article published on 27 July 2020

ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres

scientific journal article

ATR blocks telomerase from converting DNA breaks into telomeres

scientific article published on 15 February 2024

ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity

scientific article published on 02 January 2020

An analysis of cosmid clones of nuclear DNA from Trypanosoma brucei shows that the genes for variant surface glycoproteins are clustered in the genome.

scientific article published on October 1982

Apollo contributes to G overhang maintenance and protects leading-end telomeres

scientific journal article

Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase

scientific article

Author Correction: Telomeres in cancer: tumour suppression and genome instability

scientific article published on 01 April 2019

Binding of TPP1 protein to TIN2 protein is required for POT1a,b protein-mediated telomere protection

scientific article

Break-induced replication promotes fragile telomere formation

scientific article published on 03 September 2020

CELL BIOLOGY: Enhanced: Telomere Capping--One Strand Fits All

scientific article published in Science

CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability

scientific article

Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2

scientific article published on May 2008

Cell cycle dependent localization of the telomeric PARP, tankyrase, to nuclear pore complexes and centrosomes

scientific article (publication date: November 1999)

Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2

scientific article published on 10 August 2009

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

scientific article published in July 2000

Characterization of t-loop formation by TRF2

scientific article published on 21 June 2020

Chromosomal mapping of the tankyrase gene in human and mouse

scientific article (publication date: 15 April 1999)

Chromothripsis and Kataegis Induced by Telomere Crisis

scientific article published in December 2015

Coincident multiple activations of the same surface antigen gene in Trypanosoma brucei

scientific article

Comparison of the genes coding for the common 5' terminal sequence of messenger RNAs in three trypanosome species

scientific article

Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression and conserved protein domains

scientific article

Control of human telomere length by TRF1 and TRF2

scientific article

Control of telomere length by the human telomeric protein TRF1

scientific article

DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites

scientific article (publication date: 26 March 2004)

DNA damage foci at dysfunctional telomeres

scientific article (publication date: 2 September 2003)

DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2

scientific journal article

DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

scientific journal article

Definition of regions in human c-myc that are involved in transformation and nuclear localization

scientific article published on May 1987

Different telomere damage signaling pathways in human and mouse cells

scientific article published on August 2002

Discontinuous synthesis of mRNA in trypanosomes ⬇️

scientific article published on October 1, 1984

Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs

scientific article published on 01 October 2020

ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

scientific article

Ending up with the right partner

scientific article published in Nature

Energy requirement for maintenance of the transmembrane potassium gradient in Klebsiella aerogenes NCTC 418: a continuous culture study

scientific article published on November 1979

Engineered telomere degradation models dyskeratosis congenita

scientific article published on 11 June 2008

Erratum: Corrigendum: Telomere protection by mammalian Pot1 requires interaction with Tpp1

scholarly article published in Nature Structural & Molecular Biology

Erratum: T-loops and the origin of telomeres

scholarly article by Titia de Lange published in June 2004

For better or worse? Telomerase inhibition and cancer

scientific article (publication date: 6 August 1999)

Functional dissection of human and mouse POT1 proteins

scientific article

Genomic environment of the expression-linked extra copies of genes for surface antigens of Trypanosoma brucei resembles the end of a chromosome

scientific article published in Nature

Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication

scientific article

Homologous recombination generates T-loop-sized deletions at human telomeres

scientific journal article

How shelterin protects mammalian telomeres

scientific article (publication date: 2008)

How shelterin solves the telomere end-protection problem

scientific article published in January 2010

How telomeres solve the end-protection problem

scientific article

Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint

scientific article

Human telomerase caught in the act.

scientific article

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

scientific article

Identification of human Rap1: implications for telomere evolution

scientific article

In search of vertebrate telomeric proteins

In vivo stoichiometry of shelterin components

scientific article

Ku binds telomeric DNA in vitro

scientific article

Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination

Lasker Laurels for telomerase

scientific article published on September 2006

Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway

scientific article

Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal

scientific journal article

MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres

scientific article

Mammalian Rif1 contributes to replication stress survival and homology-directed repair

scientific article

Mammalian meiotic telomeres: protein composition and redistribution in relation to nuclear pores

scientific article

Mammalian telomeres end in a large duplex loop

scientific article

Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication

scientific article published on July 2009

Many trypanosome messenger RNAs share a common 5' terminal sequence.

scientific article published on May 1984

Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages

scientific journal article

NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domains

scientific article

No overt nucleosome eviction at deprotected telomeres

scientific article

Nuclear envelope rupture is enhanced by loss of p53 or Rb.

scientific article published on 15 August 2017

PHF11 promotes DSB resection, ATR signaling, and HR.

scientific article

POT1 as a terminal transducer of TRF1 telomere length control

scientific article

POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end

scientific article

POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex

scientific article

Persistent telomere damage induces bypass of mitosis and tetraploidy

scientific article

Protection of telomeres 1 proteins POT1a and POT1b can repress ATR signaling by RPA exclusion, but binding to CST limits ATR repression by POT1b

scientific article published on 06 August 2018

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.

scientific article

RNA splicing is required to make the messenger RNA for a variant surface antigen in trypanosomes.

scientific article published on June 1982

Rap1 affects the length and heterogeneity of human telomeres

scientific article

Rap1-independent telomere attachment and bouquet formation in mammalian meiosis

scientific article

Rapid change of the repertoire of variant surface glycoprotein genes in trypanosomes by gene duplication and deletion

scientific article published in July 1986

Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres

scientific article

Regulation of telomerase by telomeric proteins

scientific article (publication date: 2004)

Removal of shelterin reveals the telomere end-protection problem

scientific article

Role of 53BP1 oligomerization in regulating double-strand break repair

scientific article published on 23 January 2013

Senescence Induced by Altered Telomere State, Not Telomere Loss

scientific article

Shelterin

article from 2016

Shelterin-Mediated Telomere Protection

scientific article published on 12 September 2018

Shelterin: the protein complex that shapes and safeguards human telomeres

scientific article

Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence

scholarly article

Stringent sequence requirements for the formation of human telomeres

scientific article published on September 1994

Structural variant evolution after telomere crisis

scientific article published on 07 April 2021

Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2

scientific article

Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation

scientific journal article

T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang

scientific article

T-loops and the origin of telomeres

scientific article published on April 2004

TALEN gene knockouts reveal no requirement for the conserved human shelterin protein Rap1 in telomere protection and length regulation

scientific article published on 6 November 2014

TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres

scientific article

TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex

scientific article

TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres

scientific article published on 12 January 2016

TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres

scholarly article by Tatsuya Kibe published in April 2017

TRF1 binds a bipartite telomeric site with extreme spatial flexibility

scientific article

TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling

scientific article

TRF1 promotes parallel pairing of telomeric tracts in vitro

TRF1, a mammalian telomeric protein

scientific article

TRF2 Protects Human Telomeres from End-to-End Fusions

scientific journal article

TRF2 binds branched DNA to safeguard telomere integrity.

scientific article published on 14 August 2017

TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1.

scientific article published on 27 January 2014

Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions

scientific article published on 10 October 2010

Tandem repetition of the 5' mini-exon of variant surface glycoprotein genes: a multiple promoter for VSG gene transcription?

scientific article published in October 1983

Tankyrase promotes telomere elongation in human cells

article published in 2000

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

scientific article

Targeted deletion reveals an essential function for the telomere length regulator Trf1.

scientific article published in September 2003

Tel2 regulates the stability of PI3K-related protein kinases

scientific article

Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes

scientific article

Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation

scientific article published on July 1996

Telomerase activity in normal and malignant hematopoietic cells

scientific article

Telomerase regulation at the telomere: a binary switch

scientific article published in April 2004

Telomere Protection by TPP1/POT1 Requires Tethering to TIN2

scholarly article by Kaori K. Takai published in July 2017

Telomere Recognition and Assembly Mechanism of Mammalian Shelterin

scientific article published on January 2017

Telomere biology and DNA repair: enemies with benefits.

scientific article

Telomere conversion in trypanosomes

scientific article

Telomere protection by TPP1 is mediated by POT1a and POT1b

scientific article

Telomere protection by TPP1/POT1 requires tethering to TIN2

scientific article

Telomere protection by mammalian Pot1 requires interaction with Tpp1

scientific article

Telomere-Internal Double-Strand Breaks Are Repaired by Homologous Recombination and PARP1/Lig3-Dependent End-Joining

scientific article published in November 2016

Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells

scientific article

Telomere-related genome instability in cancer.

scientific article published on January 2005

Telomeres and senescence: ending the debate

scientific article

Telomeres in cancer: tumour suppression and genome instability

scientific article published on 18 January 2017

Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.

scientific article published on 28 June 2012

Telomeric structure in cells with chromosome end associations

scientific article published on 01 January 1993

The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction

scientific article

The causes and consequences of polyploidy in normal development and cancer

scientific article published on 21 July 2011

The control of variant surface antigen synthesis in trypanosomes

scientific article published on December 1983

The evolution of metazoan shelterin

scientific article published on 11 November 2021

The role of double-strand break repair pathways at functional and dysfunctional telomeres

scientific article

The role of ferritin in developing primary bean leaves under various light conditions

scientific article published in December 1981

The role of the poly(ADP-ribose) polymerase tankyrase1 in telomere length control by the TRF1 component of the shelterin complex

scientific article

The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response

scientific article

Tubulin mRNAs of Trypanosoma brucei

scientific article published on 01 April 1986

Two modes of activation of a single surface antigen gene of Trypanosoma brucei

scientific article published in January 1984

Unlimited mileage from telomerase?

scientific article

Unusual chromatin in human telomeres

scientific article published on September 1994

What I got wrong about shelterin.

scientific article published on 24 May 2018

p16INK4a as a second effector of the telomere damage pathway

scientific article

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

scientific article

t-loops at trypanosome telomeres.

scientific article

β-Globin gene inactivation by DNA translocation in γβ-thalassaemi

scientific article published in Nature

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