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List of works by Ira Tabas

A New Activator of Hepatocyte CaMKII in Fasting and Type 2 Diabetes

scientific article published on 01 September 2018

A Therapeutic Silencing RNA Targeting Hepatocyte TAZ Prevents and Reverses Fibrosis in Nonalcoholic Steatohepatitis in Mice

scientific article published on 23 July 2019

A reporter for tracking the UPR in vivo reveals patterns of temporal and cellular stress during atherosclerotic progression

scientific article

ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis

scientific article

ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activity

scientific article

ACAT inhibition reduces the progression of preexisting, advanced atherosclerotic mouse lesions without plaque or systemic toxicity

scientific article

Accelerating the pace of atherosclerosis research

scientific article published on January 2015

Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice.

scientific article published on 2 April 2012

Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling.

scientific article

Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling

scientific article

An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1

scientific article published on 01 December 2018

An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo.

scientific article published on 10 February 2014

An apolipoprotein(a) peptide delays chylomicron remnant clearance and increases plasma remnant lipoproteins and atherosclerosis in vivo

scientific article published on 19 May 2005

An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

scientific article published on 23 September 2016

Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities ⬇️

scientific article published on January 11, 2013

Association of plasma sphingomyelin levels and incident coronary heart disease events in an adult population: Multi-Ethnic Study of Atherosclerosis

scientific article

Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress

scientific article

Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2.

scientific article

Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase

scientific article published on June 2011

Boosting Inflammation Resolution in Atherosclerosis: The Next Frontier for Therapy

scientific article published on June 2017

Brief report: increased apoptosis in advanced atherosclerotic lesions of Apoe-/- mice lacking macrophage Bcl-2.

scientific article

C/EBP-Homologous Protein (CHOP) in Vascular Smooth Muscle Cells Regulates Their Proliferation in Aortic Explants and Atherosclerotic Lesions

scientific article

CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis.

scientific article published on 3 October 2017

CD11c(+) dendritic cells maintain antigen processing, presentation capabilities, and CD4(+) T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosis

scientific article published on 2 October 2008

CaMKII in cardiometabolic disease

scientific article published on June 2014

Calcium Signaling through CaMKII Regulates Hepatic Glucose Production in Fasting and Obesity ⬇️

scientific article published on April 12, 2012

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways.

scientific article published on 08 September 2009

Cholesterol Distribution in Living Cells: Fluorescence Imaging Using Dehydroergosterol as a Fluorescent Cholesterol Analog ⬇️

scientific article published on October 1, 1998

Cholesterol-induced apoptotic macrophages elicit an inflammatory response in phagocytes, which is partially attenuated by the Mer receptor

scientific article published on 27 December 2005

Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages.

scholarly article

Common therapeutic targets in cardiometabolic disease

scientific article

Dachshund Depletion Disrupts Mammary Gland Development and Diverts the Composition of the Mammary Gland Progenitor Pool

article

Decreased lipid efflux and increased susceptibility to cholesterol-induced apoptosis in macrophages lacking phosphatidylcholine transfer protein

scientific article

Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet.

scientific article published on 15 October 2009

Deficiency of AXL in Bone Marrow-Derived Cells Does Not Affect Advanced Atherosclerotic Lesion Progression

scientific article published on 13 December 2016

Dendritic cells in atherosclerosis

scientific article

Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles ⬇️

scientific article published on March 26, 2013

Differential effects of pioglitazone on advanced atherosclerotic lesions

scientific article published on 6 August 2009

Effect and Cellular Site of Action of Cysteine Protease Inhibitors on the Cholesterol Esterification Pathway in Macrophages and Chinese Hamster Ovary Cells ⬇️

scientific article published on August 22, 1995

Efferocytosis in health and disease

scientific article published on 10 December 2019

Emerging roles of mitochondria ROS in atherosclerotic lesions: causation or association?

scientific article

Eradicating the Burden of Atherosclerotic Cardiovascular Disease by Lowering Apolipoprotein B Lipoproteins Earlier in Life

scientific article published in October 2018

Evidence for Prolonged Cell-Surface Contact of Acetyl-LDL Before Entry Into Macrophages ⬇️

scientific article published on 01 July 1997

Extracellular Nampt promotes macrophage survival via a nonenzymatic interleukin-6/STAT3 signaling mechanism.

scientific article published on 21 October 2008

Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress

scientific article published on 26 August 2008

FoxOs Integrate Pleiotropic Actions of Insulin in Vascular Endothelium to Protect Mice from Atherosclerosis ⬇️

scientific article published on March 7, 2012

Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

scientific article

HMGB1-C1q complexes regulate macrophage function by switching between leukotriene and specialized proresolving mediator biosynthesis

scientific article published on 30 September 2019

Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance

scientific article published on 26 May 2016

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis

scientific article published on 01 November 2018

Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis

scientific article published on 27 October 2016

Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance

scientific article published on 21 March 2018

Homozygosity for an Allele Encoding Deacetylated FoxO1 Protects Macrophages From Cholesterol-Induced Inflammation Without Increasing Apoptosis ⬇️

scientific article published on September 22, 2011

How an artery heals

scientific article

Human chondroitin 6-sulfotransferase: cloning, gene structure, and chromosomal localization ⬇️

scientific article published on July 1, 1998

Hypercholesterolemia induces T cell expansion in humanized immune mice

IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA.

scientific article

Identification of a non-growth factor role for GM-CSF in advanced atherosclerosis: promotion of macrophage apoptosis and plaque necrosis through IL-23 signaling

scientific article

Impaired MEK Signaling and SERCA Expression Promote ER Stress and Apoptosis in Insulin-Resistant Macrophages and Are Reversed by Exenatide Treatment ⬇️

scientific article published on June 29, 2012

Increased CD36 protein as a response to defective insulin signaling in macrophages

scientific article published on March 2004

Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase ⬇️

scientific article published on February 15, 1998

Induction of ER stress in macrophages of tuberculosis granulomas

scientific article

Inflammation and its resolution as determinants of acute coronary syndromes

scientific article

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes ⬇️

scientific article published on April 8, 2012

Insulin Resistance, Hyperglycemia, and Atherosclerosis ⬇️

scientific article published on November 2, 2011

Interacting hepatic PAI-1/tPA gene regulatory pathways influence impaired fibrinolysis severity in obesity

scientific article published on 13 July 2020

Interference with ER Stress and Restoration of Efferocytosis in the Treatment of Advanced Atherosclerosis

Interleukin-3/granulocyte macrophage colony-stimulating factor receptor promotes stem cell expansion, monocytosis, and atheroma macrophage burden in mice with hematopoietic ApoE deficiency

scientific article

Intracellular and Intercellular Aspects of Macrophage Immunometabolism in Atherosclerosis

scientific article published on 23 April 2020

Intracellular tPA–PAI-1 interaction determines VLDL assembly in hepatocytes

scientific article published on 31 August 2023

LXR Suppresses Inflammatory Gene Expression and Neutrophil Migration through cis-Repression and Cholesterol Efflux

scientific article published on 01 December 2018

Lack of association between adiponectin levels and atherosclerosis in mice

scientific article

Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice

scientific article published on 23 October 2008

Loss of subcellular lipid transport due to ARV1 deficiency disrupts organelle homeostasis and activates the unfolded protein response

scientific article

Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2 V617F Mice

scientific article published on 01 November 2018

Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury

scientific article published on 30 January 2020

Macrophage Phenotype and Function in Different Stages of Atherosclerosis

scientific article published on February 2016

Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis: JACC Macrophage in CVD Series (Part 2)

scientific article published on 01 October 2018

Macrophage apoptosis in advanced atherosclerosis

scientific article published on September 2009

Macrophage autophagy plays a protective role in advanced atherosclerosis

scientific article published on 22 March 2012

Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions.

scientific article

Macrophage mitochondrial oxidative stress promotes atherosclerosis and nuclear factor-κB-mediated inflammation in macrophages.

scientific article published on 02 December 2013

Macrophages in the Pathogenesis of Atherosclerosis ⬇️

scientific article (publication date: 29 April 2011)

Making Things Stick in the Fight Against Atherosclerosis ⬇️

scientific article published on April 12, 2013

Maladaptive regeneration - the reawakening of developmental pathways in NASH and fibrosis

scientific article published on 13 October 2020

Mechanisms and consequences of efferocytosis in advanced atherosclerosis

scientific article published on 04 May 2009

Mechanisms and consequences of macrophage apoptosis in atherosclerosis

scientific article published on 25 October 2008

Mechanisms of ER Stress-Induced Apoptosis in Atherosclerosis ⬇️

scientific article published on December 1, 2011

MerTK Cleavage on Resident Cardiac Macrophages Compromises Repair after Myocardial Ischemia Reperfusion Injury

scientific article published on 29 August 2017

MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation

scientific article published on 19 May 2016

MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis.

scientific article published on 9 January 2017

MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity

scientific article published on 25 September 2018

Mertk receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation and plaque necrosis in atherosclerotic lesions of apoe-/- mice

scientific article published on May 2008

Minimally oxidized LDL offsets the apoptotic effects of extensively oxidized LDL and free cholesterol in macrophages.

scientific article

Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages

scientific article

Mitochondrial Oxidative Stress Promotes Atherosclerosis and Neutrophil Extracellular Traps in Aged Mice

scientific article published on 8 June 2017

Monocyte-Macrophages and T Cells in Atherosclerosis

scientific article

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

scientific article

Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis

scientific article published on 15 August 2003

ODC (Ornithine Decarboxylase)-Dependent Putrescine Synthesis Maintains MerTK (MER Tyrosine-Protein Kinase) Expression to Drive Resolution

scientific article published on 06 January 2021

PPARγ Deacetylation Confers the Anti-Atherogenic Effect and Improves Endothelial Function in Diabetes Treatment

scientific article published on 14 May 2020

Phospholipid metabolism in cholesterol-loaded macrophages ⬇️

scientific article published on October 1, 1997

Pioglitazone increases macrophage apoptosis and plaque necrosis in advanced atherosclerotic lesions of nondiabetic low-density lipoprotein receptor-null mice

scientific article published on 22 October 2007

Pivotal Advance: Macrophages become resistant to cholesterol-induced death after phagocytosis of apoptotic cells

scientific article published on 18 June 2007

Pivotal role of calcium/calmodulin-dependent protein kinase II in ER stress-induced apoptosis

scientific article

Plasma sphingomyelin and subclinical atherosclerosis: findings from the multi-ethnic study of atherosclerosis

scientific article published on 12 April 2006

Pulling down the plug on atherosclerosis: Finding the culprit in your heart ⬇️

scientific article published on July 7, 2011

Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP.

scientific article

Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution

scientific article published on 02 October 2018

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway.

scientific article

Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis

scientific journal article

Role of endoplasmic reticulum stress in metabolic disease and other disorders.

scientific article published on January 2012

Shedding of the Mer tyrosine kinase receptor is mediated by ADAM17 protein through a pathway involving reactive oxygen species, protein kinase Cδ, and p38 mitogen-activated protein kinase (MAPK).

scientific article

Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo.

scientific article

Sitosterol-containing lipoproteins trigger free sterol-induced caspase-independent death in ACAT-competent macrophages

scientific article published on 24 August 2006

Sphingomyelinase Treatment Induces ATP-independent Endocytosis ⬇️

scientific article published on January 12, 1998

Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications

scientific article

Suppression of Adaptive Immune Cell Activation Does Not Alter Innate Immune Adipose Inflammation or Insulin Resistance in Obesity

scientific article published on 28 August 2015

TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells

scholarly article

Targeting soluble DPP-4 for insulin resistance: Origin matters

scientific article published on 04 December 2020

The Cellular Trafficking and Zinc Dependence of Secretory and Lysosomal Sphingomyelinase, Two Products of the Acid Sphingomyelinase Gene ⬇️

scientific article published on July 17, 1998

The LPS2 mutation in TRIF is atheroprotective in hyperlipidemic low density lipoprotein receptor knockout mice ⬇️

scientific article published on May 25, 2012

The Role of Endoplasmic Reticulum Stress in the Progression of Atherosclerosis ⬇️

scientific article published on October 1, 2010

The UPR in atherosclerosis ⬇️

scientific article published on 04 April 2013

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

scientific article published on 10 August 2003

The impact of insulin resistance on macrophage death pathways in advanced atherosclerosis

scientific article published on January 2007

The impact of macrophage insulin resistance on advanced atherosclerotic plaque progression

scientific article

The inflammatory cytokine response of cholesterol-enriched macrophages is dampened by stimulated pinocytosis

scientific article published on 24 October 2006

The role of macrophages and dendritic cells in the clearance of apoptotic cells in advanced atherosclerosis.

scientific article published on September 2011

The role of non-resolving inflammation in atherosclerosis

scientific article published on 02 July 2018

Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B.

scientific article

Treatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity

scientific article

Treg-mediated suppression of atherosclerosis requires MYD88 signaling in DCs ⬇️

scientific article published on December 21, 2012

microRNA-33 Regulates Macrophage Autophagy in Atherosclerosis

scientific article published on 20 April 2017

siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice

scientific article published on 01 July 2020

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