List of works by Thomas Jentsch

A bicarbonate-dependent process inhibitable by disulfonic stilbenes and a Na+/H+ exchange mediate 22Na+ uptake into cultured bovine corneal endothelium

scientific article published in Journal of Biological Chemistry

A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly

scientific article

A cation counterflux supports lysosomal acidification

scientific article published on 21 June 2010

A family of putative chloride channels from Arabidopsis and functional complementation of a yeast strain with a CLC gene disruption

scientific article published in December 1996

A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism

scientific article

A missense mutation accelerating the gating of the lysosomal Cl-/H+-exchanger ClC-7/Ostm1 causes osteopetrosis with gingival hamartomas in cattle

scientific article published on 23 October 2013

A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule

scientific article

Additional disruption of the ClC-2 Cl(-) channel does not exacerbate the cystic fibrosis phenotype of cystic fibrosis transmembrane conductance regulator mouse models

scientific article published on 7 March 2004

Alteration of GABAA receptor function following gene transfer of the CLC-2 chloride channel

scientific article published in September 1996

An internalization signal in ClC-5, an endosomal Cl-channel mutated in dent's disease.

scientific article published on 14 December 2000

Analysis of CLCN2 as candidate gene for megalencephalic leukoencephalopathy with subcortical cysts

scientific article published in April 2010

Analysis of a protein region involved in permeation and gating of the voltage-gated Torpedo chloride channel ClC-0

article

Anion dependence of electrical effects of bicarbonate and sodium on cultured bovine corneal endothelial cells

scientific article published on 01 February 1985

CLC Chloride Channels and Transporters: From Genes to Protein Structure, Pathology and Physiology

article

CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease

scientific article published on 01 July 2018

CLC chloride channels and transporters

scientific article

CLC chloride channels in Caenorhabditis elegans

scientific article

CLC chloride channels: correlating structure with function

scientific article

CLCN7 and TCIRG1 mutations differentially affect bone matrix mineralization in osteopetrotic individuals

scientific article published in April 2014

Ca-activated Cl currents in the murine vomeronasal organ enhance neuronal spiking but are dispensable for male-male aggression

scientific article published in Journal of Biological Chemistry

Ca2+-activated Cl− currents are dispensable for olfaction

scientific journal article

Cell biology and physiology of CLC chloride channels and transporters

scientific article published on July 2012

Cellular basis of ClC-2 Cl- channel-related brain and testis pathologies

scientific article published on 13 November 2020

Channelopathies of transepithelial transport and vesicular function

scientific article published on January 2008

Characterisation of renal chloride channel, CLCN5, mutations in hypercalciuric nephrolithiasis (kidney stones) disorders.

scientific article

Characterization of renal chloride channel (CLCN5) mutations in Dent's disease

scientific article (publication date: August 2000)

Characterization of the hyperpolarization-activated chloride current in dissociated rat sympathetic neurons

scientific article published in February 1998

Chloride and the endosomal-lysosomal pathway: emerging roles of CLC chloride transporters.

scientific article published on 16 November 2006

Chloride channel 2 gene (Clc2) maps to chromosome 16 of the mouse, extending a region of conserved synteny with human chromosome 3q

article

Chloride channel diseases resulting from impaired transepithelial transport or vesicular function

scientific article

Chloride channelopathies

scientific article

Chloride channels

scientific article published on June 1993

Chloride channels are different

scientific article published in Nature

Chloride channels: a molecular perspective

scientific article published on June 1996

Chloride dependence of hyperpolarization-activated chloride channel gates

scientific article published in March 1999

Chloride in vesicular trafficking and function

scientific article published on 17 October 2012

Chloride transport in the kidney: lessons from human disease and knockout mice.

scientific article

ClC-1 chloride channel mutations in myotonia congenita: variable penetrance of mutations shifting the voltage dependence

scientific article published in October 1998

ClC-3—A Granular Anion Transporter Involved in Insulin Secretion?

scientific article published on 01 October 2010

ClC-5 Cl- -channel disruption impairs endocytosis in a mouse model for Dent's disease.

scientific article published in November 2000

ClC-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells

scientific article

ClC-7 expression levels critically regulate bone turnover, but not gastric acid secretion.

scientific article published on 5 October 2013

ClC-7 is a slowly voltage-gated 2Cl(-)/1H(+)-exchanger and requires Ostm1 for transport activity

scientific article published on 28 April 2011

ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function

scientific journal article

Common gating of both CLC transporter subunits underlies voltage-dependent activation of the 2Cl-/1H+ exchanger ClC-7/Ostm1.

scientific article published on 27 August 2013

Completely functional double-barreled chloride channel expressed from a single Torpedo cDNA ⬇️

scientific article published on December 15, 1991

Concentration and pH dependence of skeletal muscle chloride channel ClC-1.

scientific article published in December 1996

Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1.

scientific article published in April 2003

Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation

scientific article published on 15 May 2020

De novo and inherited mutations in the X-linked gene CLCN4 are associated with syndromic intellectual disability and behavior and seizure disorders in males and females.

scientific article published on 23 August 2016

Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4.

scientific article

Departure gate of acidic Ca²⁺ confirmed

scientific article published on 28 May 2015

Detection and differentiation of sensorineural hearing loss in mice using auditory steady-state responses and transient auditory brainstem responses

scientific article published on 10 August 2007

Determinants of anion-proton coupling in mammalian endosomal CLC proteins

scientific article published on 6 December 2007

Determinants of slow gating in ClC-0, the voltage-gated chloride channel of Torpedo marmorata.

scientific article published in April 1998

Discovery of CLC transport proteins: cloning, structure, function and pathophysiology

scientific article

Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction

scientific article published on 19 March 2014

Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition

scientific journal article

Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination

scientific article

Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice

scientific article published on 17 May 2007

Disruption of the K+ channel beta-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport

scientific article

Distinct neuropathologic phenotypes after disrupting the chloride transport proteins ClC-6 or ClC-7/Ostm1.

scientific article published in December 2010

Effect of bicarbonate, pH, methazolamide and stibenes on the intracellular potentials of cultured bovine corneal endothelial cells

scientific article published on 01 January 1984

Electrogenic sodium-bicarbonate symport in cultured corneal endothelial cells.

scientific article

Endocochlear potential depends on Cl- channels: mechanism underlying deafness in Bartter syndrome IV.

scientific article

Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis

scientific article published on 29 April 2010

Enhanced Synaptic Activity and Epileptiform Events in the Embryonic KCC2 Deficient Hippocampus

scientific article

Evidence for coupled transport of bicarbonate and sodium in cultured bovine corneal endothelial cells

article

Exome sequencing reveals new causal mutations in children with epileptic encephalopathies

scientific article

Expression of the KCl cotransporter KCC2 parallels neuronal maturation and the emergence of low intracellular chloride

scientific article

From mice to man: chloride transport in leukoencephalopathy

scientific article

Functional and structural analysis of ClC-K chloride channels involved in renal disease

scientific article published in August 2000

Functional and structural conservation of CBS domains from CLC chloride channels.

scientific article

Functional characterization of renal chloride channel, CLCN5, mutations associated with Dent'sJapan disease

scientific article published in December 1998

Gating choreography and mechanism of the human proton-activated chloride channel ASOR

scientific article published on 02 February 2022

Gating of the voltage-dependent chloride channel CIC-0 by the permeant anion

scientific article

Generation and analyses of R8L barttin knockin mouse

scientific article published on 18 May 2011

Genomic organization of the human muscle chloride channel CIC-1 and analysis of novel mutations leading to Becker-type myotonia.

scientific article

GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(-) channel auxiliary subunit

scientific article published in March 2012

Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC

scientific article

Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels

scientific article published on 18 July 2019

In Vivo Evidence for Lysosome Depletion and Impaired Autophagic Clearance in Hereditary Spastic Paraplegia Type SPG11

scientific journal article

Inactivation and Anion Selectivity of Volume-regulated Anion Channels (VRACs) Depend on C-terminal Residues of the First Extracellular Loop.

scientific article published on 20 June 2016

Independent gating of single pores in CLC-0 chloride channels

scientific article published on August 1997

Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors

scientific article

Interactions of pH and K+ conductance in cultured bovine retinal pigment epithelial cells.

scientific article published in January 1986

Intestinal electrolyte and fluid secretion: A model in trouble?

scientific article published on 16 April 2018

Inward rectification in ClC-0 chloride channels caused by mutations in several protein regions

scientific article published on August 1997

Ion channel diseases

scientific article

Ion channels: function unravelled by dysfunction

scientific article

Ion transport mechanisms in cultured bovine corneal endothelial cells

scientific article published on April 1985

K2P TASK-2 and KCNQ1-KCNE3 K+ channels are major players contributing to intestinal anion and fluid secretion.

scientific article published on 16 November 2017

KCNQ Potassium Channels Modulate Sensitivity of Skin Down-hair (D-hair) Mechanoreceptors

scientific article

KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man.

scientific article published on 20 November 2011

KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway.

scientific article published on April 2000

KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness

scientific article

KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations

scientific article published on 4 February 2015

KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents

scientific article (publication date: 4 August 2000)

Kidney-specific upregulation of vitamin D3 target genes in ClC-5 KO mice.

scientific article published on 3 May 2006

Kinetic properties of the sodium bicarbonate (carbonate) symport in monkey kidney epithelial cells (BSC-1). Interactions between Na+, HCO-3, and pH.

scientific article published in August 1986

Kv7 channels: interaction with dopaminergic and serotonergic neurotransmission in the CNS.

scientific article published on 03 January 2008

LRRC8 N termini influence pore properties and gating of volume-regulated anion channels (VRACs)

scientific article published in Journal of Biological Chemistry

LRRC8/VRAC anion channels are required for late stages of spermatid development in mice

scientific article published in Journal of Biological Chemistry

LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion.

scientific article published on 17 May 2018

Leukoencephalopathy upon disruption of the chloride channel ClC-2.

scientific article published in June 2007

Localization and induction by dehydration of ClC-K chloride channels in the rat kidney.

scientific article published on May 1997

Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold

scientific article

Loss of the Na+/H+ exchanger NHE8 causes male infertility in mice by disrupting acrosome formation

scientific article published on 5 May 2017

Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration

scientific article published on 10 February 2005

Lysosomal degradation of endocytosed proteins depends on the chloride transport protein ClC-7.

scientific article published on 6 August 2009

Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation

scientific article

Lysosomal storage disease upon disruption of the neuronal chloride transport protein ClC-6.

scientific article

Mice with a targeted disruption of the Cl-/HCO3- exchanger AE3 display a reduced seizure threshold

scientific article

Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness

scientific article

Molecular basis of epithelial Cl channels.

scientific article

Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.

scientific article published in May 2005

Molecular dissection of gating in the ClC-2 chloride channel

scientific article

Molecular physiology of anion channels

scientific article published on August 1994

Molecular physiology of renal chloride channels

scientific article published on 01 September 1998

Molecular physiology of voltage-gated chloride channels

scientific article published on October 1994

Molecular structure and physiological function of chloride channels

scientific article

Multimeric structure of ClC-1 chloride channel revealed by mutations in dominant myotonia congenita (Thomsen)

scientific article

Mutational analysis demonstrates that ClC-4 and ClC-5 directly mediate plasma membrane currents.

scientific article published on January 1999

Mutations in CAV3 cause mechanical hyperirritability of skeletal muscle in rippling muscle disease

scientific article (publication date: July 2001)

Myotonias due to CLC-1 chloride channel mutations

scientific article

NKCC1-dependent GABAergic excitation drives synaptic network maturation during early hippocampal development

scientific article

Neurogenic mechanisms contribute to hypertension in mice with disruption of the K-Cl cotransporter KCC3.

scientific article published on 19 January 2006

Neuronal KCNQ potassium channels: physiology and role in disease.

scientific article

No evidence for a role of CLCN2 variants in idiopathic generalized epilepsy

article

Nonsense and missense mutations in the muscular chloride channel gene Clc-1 of myotonic mice.

scientific article published in February 1994

Novel muscle chloride channel (CLCN1) mutations in myotonia congenita with various modes of inheritance including incomplete dominance and penetrance

scientific article published on 01 April 1998

Optogenetic acidification of synaptic vesicles and lysosomes

scientific article published on 9 November 2015

Pathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism

scientific article published on 15 October 2019

Pathophysiological mechanisms of dominant and recessive KVLQT1 K+ channel mutations found in inherited cardiac arrhythmias

scientific article published in October 1997

Pathophysiology of KCNQ Channels: Neonatal Epilepsy and Progressive Deafness

scientific article published on 01 August 2000

Permeation and block of the skeletal muscle chloride channel, ClC-1, by foreign anions

scientific article published on May 1998

Physiological functions of CLC Cl- channels gleaned from human genetic disease and mouse models

scientific article

Physiological roles of CLC Cl(-)/H (+) exchangers in renal proximal tubules

scientific article published on 14 October 2008

Planned law could put German research at risk

scientific article published in Nature

Plasmodium induces swelling-activated ClC-2 anion channels in the host erythrocyte

scientific article

Pores Formed by Single Subunits in Mixed Dimers of Different CLC Chloride Channels

scientific article published in Journal of Biological Chemistry

Potassium ion movement in the inner ear: insights from genetic disease and mouse models

scientific article

Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes

scientific article published in December 1990

Primary structure of a novel 4-acetamido-4'-isothiocyanostilbene-2,2'-disulphonic acid (SITS)-binding membrane protein highly expressed in Torpedo californica electroplax

scientific article published on July 1989

Properties of voltage-gated chloride channels of the ClC gene family

scientific article published on January 1995

Raising cytosolic Cl- in cerebellar granule cells affects their excitability and vestibulo-ocular learning

scientific article

Reconstitution of Functional Voltage-gated Chloride Channels from Complementary Fragments of CLC-1 ⬇️

scientific article published on August 15, 1997

Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume

scientific article published on December 1992

Regulation of cytoplasmic pH of cultured bovine corneal endothelial cells in the absence and presence of bicarbonate.

scientific article published in July 1988

Regulation of intracellular pH in cultured bovine retinal pigment epithelial cells

scientific article published on January 1988

Residues important for nitrate/proton coupling in plant and mammalian CLC transporters

scientific article published on 4 March 2009

Response of the intracellular potentials of cultured bovine lens cells to ions and inhibitors

Role of ClC-5 in renal endocytosis is unique among ClC exchangers and does not require PY-motif-dependent ubiquitylation

scientific article

Role of innervation, excitability, and myogenic factors in the expression of the muscular chloride channel ClC-1. A study on normal and myotonic muscle

scientific article published in November 1994

Role of the vesicular chloride transporter ClC-3 in neuroendocrine tissue.

scientific article published in October 2008

Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels

scientific article

Sorting Motifs of the Endosomal/Lysosomal CLC Chloride Transporters ⬇️

scientific article published on September 3, 2010

Stretch-activation of angiotensin II type 1a receptors contributes to the myogenic response of mouse mesenteric and renal arteries.

scientific article published on 16 May 2014

Structural determinants of M-type KCNQ (Kv7) K+ channel assembly.

scientific article published in April 2006

Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs

scientific article

Surface expression and single channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy

scientific article (publication date: 5 May 2000)

The ClC family of voltage-gated chloride channels: structure and function

scientific article published on December 1993

The ClC-5 chloride channel knock-out mouse - an animal model for Dent's disease.

scientific article

The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron.

scientific article published on 22 June 2016

The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus

scientific article

The calcium antagonist nisoldipine stimulates the electrolyte transport of the isolated frog skin

scientific article published on 01 September 1984

The late endosomal ClC-6 mediates proton/chloride countertransport in heterologous plasma membrane expression

scientific article published on 13 May 2010

The regulation of intracellular pH in monkey kidney epithelial cells (BSC-1). Roles of Na+/H+ antiport, Na+-HCO3(-)-(NaCO3-) symport, and Cl-/HCO3- exchange.

scientific article published in September 1986

The skeletal muscle chloride channel in dominant and recessive human myotonia

scientific article published on August 7, 1992

Transport activity and presence of ClC-7/Ostm1 complex account for different cellular functions.

scientific article published on 12 May 2014

Trinity of cation channels

scientific article published in Nature

Two highly homologous members of the ClC chloride channel family in both rat and human kidney

scientific article

Two physically distinct pores in the dimeric ClC-0 chloride channel.

scientific article

Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration

scientific article published on 02 March 2020

Unique structure and function of chloride transporting CLC proteins

scientific article

VRAC: molecular identification as LRRC8 heteromers with differential functions

scientific article published on 03 December 2015

VRACs and other ion channels and transporters in the regulation of cell volume and beyond

scientific article

Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models

scientific article published on 13 February 2013

Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins

scientific article published on July 2005

X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes

scientific journal article

[37] Cell culture of bovine corneal endothelial cells and its application to transport studies

article

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