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List of works by Thomas Benzing

A disease-causing mutation illuminates the protein membrane topology of the kidney-expressed prohibitin homology (PHB) domain protein podocin

scientific article

A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes

scientific article published on June 2016

A functional variant in NEPH3 gene confers high risk of renal failure in primary hematuric glomerulopathies. Evidence for predisposition to microalbuminuria in the general population

scientific article

A mammalian microRNA expression atlas based on small RNA library sequencing

scientific article

A molecular mechanism explaining albuminuria in kidney disease

scientific article published on 11 May 2020

AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis

scientific article

AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue

scientific article published on March 2016

Altered lipid metabolism in the aging kidney identified by three layered omic analysis

scientific article

An approach to cystic kidney diseases: the clinician's view

scientific article published on 30 September 2014

Assessing renal changes after remote ischemic preconditioning (RIPC) of the upper extremity using BOLD imaging at 3T.

scientific article published on 23 October 2017

Breaking the chain at the membrane: paraoxonase 2 counteracts lipid peroxidation at the plasma membrane

article published in 2014

Burden of multimorbidity and outcome in ambulatory geriatric hemodialysis patients : Report from the QiN registry in Germany

scientific article published on 10 November 2016

Caenorhabditis elegans, a model organism for kidney research: from cilia to mechanosensation and longevity

scientific article published on July 2011

Challenges in establishing genotype-phenotype correlations in ARPKD: case report on a toddler with two severe PKHD1 mutations

scientific article published on 31 March 2017

Characterization of a short isoform of the kidney protein podocin in human kidney

scientific article

Characterization of a splice-site mutation in the tumor suppressor gene FLCN associated with renal cancer

scientific article

Cilia-associated cellular function of the AAA ATPases RUVBL1 and RUVBL2.

scientific article

Cilium-generated signaling: a cellular GPS?

scientific article

Clinical spectrum and pathogenesis of nephronophthisis ⬇️

scientific article published on May 1, 2012

Comparative analysis of Neph gene expression in mouse and chicken development

scientific article

Conditional loss of kidney microRNAs results in congenital anomalies of the kidney and urinary tract (CAKUT).

scientific article published on 24 January 2013

Construction of a viral T2A-peptide based knock-in mouse model for enhanced Cre recombinase activity and fluorescent labeling of podocytes

scientific article published on 7 February 2017

Cyclin I and p35 determine the subcellular distribution of Cdk5.

scientific article

Cysteine S-Glutathionylation Promotes Stability and Activation of the Hippo Downstream Effector Transcriptional Co-activator with PDZ-binding Motif (TAZ).

scientific article published on 05 April 2016

Cystic Kidney Diseases From the Adult Nephrologist's Point of View

scientific article published on 22 March 2018

DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage

scientific article published on 24 November 2014

Detection of multiple annexin autoantibodies in a patient with recurrent miscarriages, fulminant stroke and seronegative antiphospholipid syndrome

scientific article published on January 2016

Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1

scientific article published in 2009

Dyslipidemia treatment and cardiovascular disease in the renal patient

scientific article published on January 2011

Dysregulated autophagy contributes to podocyte damage in Fabry's disease

scientific article

Endothelial cilia protect against atherosclerosis

scientific article published on 14 January 2016

Exercised-induced coronary spasm in near normal coronary arteries

scientific article published on 17 June 2010

Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling

scientific article

Expression and function of C/EBP homology protein (GADD153) in podocytes

scientific article published on January 2006

Extracellular phosphorylation of collagen XVII by ecto-casein kinase 2 inhibits ectodomain shedding

scientific article

Genome-Wide Analysis of Wilms' Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory Mechanisms

scientific article

Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1

scientific article (publication date: April 2003)

Hypertension: Testing for pre-eclampsia: paving the way to early diagnosis.

scientific article

Immunoadsorption in Patients with Chronic Inflammatory Demyelinating Polyradiculoneuropathy with Unsatisfactory Response to First-Line Treatment

article

Indicators of acute and persistent renal damage in adult thrombotic microangiopathy

scientific article

Induction therapy with rabbit antithymocyte globulin versus basiliximab after kidney transplantation: a health economic analysis from a German perspective

scientific article published on 27 May 2017

Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure

scientific article

Insulin enhances the expression of the endothelial nitric oxide synthase in native endothelial cells: a dual role for Akt and AP-1.

scientific article

Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha

scientific article (publication date: 6 September 2002)

Intrinsic proinflammatory signaling in podocytes contributes to podocyte damage and prolonged proteinuria

scientific article published on 12 September 2012

Ischemic preconditioning for prevention of contrast medium-induced nephropathy: randomized pilot RenPro Trial (Renal Protection Trial).

scientific article published on 26 June 2012

Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression

scientific article published on 26 February 2016

KIBRA modulates directional migration of podocytes

scientific article

Label-free quantitative proteomic analysis of the YAP/TAZ interactome

scientific article published on 26 February 2014

Lipid-protein interactions along the slit diaphragm of podocytes

scientific article published on 25 February 2009

Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation

scientific article published on 14 April 2015

Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia

scientific article

Loss of the Birt-Hogg-Dubé gene product folliculin induces longevity in a hypoxia-inducible factor-dependent manner

scientific article published on 15 May 2013

Low-grade proteinuria is highly prevalent in HIV-positive patients on antiretroviral treatment

scientific article published in July 2014

Low-molecular weight heparin increases circulating sFlt-1 levels and enhances urinary elimination

scientific article

Magnetic resonance T2 mapping and diffusion-weighted imaging for early detection of cystogenesis and response to therapy in a mouse model of polycystic kidney disease

scientific article published on 26 July 2017

Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure

scientific article

Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains

scientific article published on 21 October 2003

Molecular genetics in nephrology. Genetic kidney diseases provide clues for understanding the pathogenesis of proteinuria ⬇️

scientific article published on 01 August 2003

Monoclonal gammopathy-associated pauci-immune extracapillary-proliferative glomerulonephritis successfully treated with bortezomib

scientific article published on June 2013

Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination

scientific article (publication date: August 2003)

Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics

scientific article

Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expression

scientific article

Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis

scientific article

NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases

scientific article

NOX2 interacts with podocyte TRPC6 channels and contributes to their activation by diacylglycerol: essential role of podocin in formation of this complex

scientific article

NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway

scientific article

Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity

scientific article

Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling

scientific journal article

Nephrin mutations can cause childhood-onset steroid-resistant nephrotic syndrome

scientific article published on 9 July 2008

Nephrocystin specifically localizes to the transition zone of renal and respiratory cilia and photoreceptor connecting cilia

scientific article

Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia

scientific article published on 28 February 2011

Neuronal expression and interaction with the synaptic protein CASK suggest a role for Neph1 and Neph2 in synaptogenesis

scientific journal article

New insights into mechanisms of glomerular injury and repair from the 10th International Podocyte Conference 2014.

scientific article published on 25 February 2015

Occurrence and management of hepatitis B virus reactivation following kidney transplantation

scientific article published on June 1, 1998

Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol

scientific article published on 8 May 2013

Oral Supplementation of Glucosamine Fails to Alleviate Acute Kidney Injury in Renal Ischemia-Reperfusion Damage

scientific article

PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome

scientific article

Par3A is dispensable for the function of the glomerular filtration barrier of the kidney.

scientific article

Paraneoplastic cerebellar degeneration in Hodgkin's disease ⬇️

scientific article published on April 17, 1998

Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier

scientific article

Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia

scientific article

Pilot study of extracorporeal removal of soluble fms-like tyrosine kinase 1 in preeclampsia.

scientific article

Pleiotropic signaling evoked by tumor necrosis factor in podocytes

scientific article published on 27 May 2015

Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels

scholarly article

Podocin organizes ion channel-lipid supercomplexes: implications for mechanosensation at the slit diaphragm.

scientific article

Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease

scientific article published on 05 September 2008

Polycystic kidney disease. HALTing PKD progression--revival of blood pressure control.

scientific article published on 16 December 2014

Polyhydramnios, Transient Antenatal Bartter's Syndrome, and MAGED2 Mutations

scientific journal article

Poor cell survival limits the beneficial impact of mesenchymal stem cell transplantation on acute kidney injury.

scientific article

Practical approach to hyponatremia ⬇️

scientific article published on August 29, 2011

Prevalence of anemia among elderly inpatients and its association with multidimensional loss of function

scientific article published on 29 May 2014

Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 14 to control channel activity through increased membrane expression

scientific article

Proteinuria in systemic sclerosis: reversal by ACE inhibition ⬇️

scientific article published on February 28, 2013

Proteomic analysis of the kidney filtration barrier--Problems and perspectives

scientific article published on 23 April 2015

Putting the brakes on p53-driven apoptosis

scientific article published on 14 September 2012

Quantitative deep mapping of the cultured podocyte proteome uncovers shifts in proteostatic mechanisms during differentiation

scientific article published on 29 June 2016

RNA-binding proteins and their role in kidney disease

scientific article published in 2021

Recommendations for the use of tolvaptan in autosomal dominant polycystic kidney disease: a position statement on behalf of the ERA-EDTA Working Groups on Inherited Kidney Disorders and European Renal Best Practice

scientific article

Removal of Soluble Fms-Like Tyrosine Kinase-1 by Dextran Sulfate Apheresis in Preeclampsia

scientific article published on 24 September 2015

Response to Letter Regarding Article, “Ischemic Preconditioning for Prevention of Contrast Medium–Induced Nephropathy: Randomized Pilot RenPro-Trial (Renal Protection Trial)” ⬇️

scientific article published on 01 April 2013

Rituximab treatment for adults with refractory nephrotic syndrome: a single-center experience and review of the literature.

scientific article published on 26 January 2012

Signaling at the slit diaphragm

scientific article published on June 2004

Stra13, a prostaglandin E2-induced gene, regulates the cellular redox state of podocytes

scientific article published on 19 February 2003

Survival and distribution of injected haematopoietic stem cells in acute kidney injury

scientific article published on 29 November 2012

Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus.

scientific article published on 28 June 2018

The BAR domain protein PICK1 regulates cell recognition and morphogenesis by interacting with Neph proteins

scientific article published on 20 June 2011

The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1

scientific article (publication date: 11 April 2003)

The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1

scientific article

The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate β-catenin signaling

scientific journal article

The ciliopathy disease protein NPHP9 promotes nuclear delivery and activation of the oncogenic transcriptional regulator TAZ.

scientific article published in October 2012

The grand challenge of nephrology

scientific article

The hallmarks of cancer: relevance to the pathogenesis of polycystic kidney disease

scientific article published on 14 April 2015

The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells

scientific article

The promise of angiogenic markers for the early diagnosis and prediction of preeclampsia

scientific article published on 19 March 2012

The role of the podocyte in albumin filtration

scientific article published on 23 April 2013

The slit diaphragm: a signaling platform to regulate podocyte function

scientific journal article

The von Hippel Lindau tumor suppressor limits longevity

scientific article published on 24 September 2009

The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth

scientific article

Three-layered proteomic characterization of a novel ACTN4 mutation unravels its pathogenic potential in FSGS.

scientific article published on 5 January 2016

Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation

scientific article

Transcriptional profiling reveals progeroid Ercc1(-/Δ) mice as a model system for glomerular aging

scientific article

Transition zone proteins and cilia dynamics ⬇️

scientific article published on July 27, 2011

Treating the symptoms in nephrotic syndrome: which therapeutic strategies are evidence based in the treatment of proteinuria? ⬇️

scientific article published on February 7, 2011

Treatment of visceral leishmaniasis with intravenous pentamidine and oral fluconazole in an HIV-positive patient with chronic renal failure--a case report and brief review of the literature

scientific article published on September 2009

Urine-derived cells: a promising diagnostic tool in Fabry disease patients

scientific article published in Scientific Reports

Vasopressin-2 receptor signaling and autosomal dominant polycystic kidney disease: from bench to bedside and back again

scientific article

Von hippel-lindau: a tumor suppressor links microtubules to ciliogenesis and cancer development

scientific article published on May 2007

WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals

scientific article

Wnt signaling in polycystic kidney disease

scientific article published on 11 April 2007

YAP-mediated mechanotransduction determines the podocyte's response to damage.

scientific article published on 11 April 2017

mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells

scientific article published on 13 June 2016

p35, the non-cyclin activator of Cdk5, protects podocytes against apoptosis in vitro and in vivo.

scientific article published on 3 February 2010

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