List of works - Mark A. Lemmon

A New Twist in the Transmembrane Signaling Tool-Kit

A dimerization motif for transmembrane α–helices

scientific article published on 01 March 1994

A possible effector role for the pleckstrin homology (PH) domain of dynamin

scientific article published on 03 August 2009

A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein

scientific article published on 16 October 1995

A structure-based model for ligand binding and dimerization of EGF receptors

scholarly article

ALK mutations confer differential oncogenic activation and sensitivity to ALK inhibition therapy in neuroblastoma

scientific article

Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

scientific article published in January 1998

Ala-insertion scanning mutagenesis of the glycophorin A transmembrane helix: a rapid way to map helix-helix interactions in integral membrane proteins

scientific article published on July 1996

All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate.

scientific article

An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors

scientific article (publication date: September 2003)

Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma

scientific article published on 23 January 2012

Argos inhibits epidermal growth factor receptor signalling by ligand sequestration

scientific article

Argos mutants define an affinity threshold for spitz inhibition in vivo

scientific article published on 26 July 2006

Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family

scientific article

Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations

Biochemistry. KSR plays CRAF-ty

scientific article (publication date: 27 May 2011)

Cell signaling by receptor tyrosine kinases

scientific article

Comparison of Saccharomyces cerevisiae F-BAR domain structures reveals a conserved inositol phosphate binding site

scientific article

Comparison of tyrosine kinase domain properties for the neurotrophin receptors TrkA and TrkB

scientific article published on 12 October 2020

Complex relationship between ligand binding and dimerization in the epidermal growth factor receptor

scientific article

Computational algorithms for in silico profiling of activating mutations in cancer

scientific article published on 13 April 2019

Computational analysis of EGFR inhibition by Argos

scientific article published in August 2005

Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation

scientific article published in 2021

Conditional peripheral membrane proteins: facing up to limited specificity

scientific article published on 21 December 2011

Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin

scientific article

Deletion Mutations Keep Kinase Inhibitors in the Loop

scientific article published on April 2016

Determining selectivity of phosphoinositide-binding domains

scientific article published on June 2006

Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma.

scientific article

Dimerization of Tie2 mediated by its membrane-proximal FNIII domains

scientific article

Dimerization of glycophorin A transmembrane helices: mutagenesis and modeling.

scientific article

Dimerization of the p185neu transmembrane domain is necessary but not sufficient for transformation

scientific article published on February 1997

Dominant-negative inhibition of receptor-mediated endocytosis by a dynamin-1 mutant with a defective pleckstrin homology domain

scientific article

Drug sensitivity and allele-specificity of first-line osimertinib resistance EGFR mutations

scientific article published on 19 March 2020

Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers

scientific article published in 2021

Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients

scientific article

EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization

scientific article

EGF-independent activation of cell-surface EGF receptors harboring mutations found in gefitinib-sensitive lung cancer

scientific article published on 4 September 2006

EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics

scientific article

EGFR mutations cause a lethal syndrome of epithelial dysfunction with progeroid features

scientific article published on 4 June 2015

Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface

scientific article

ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor

scientific article

ErbB3/HER3 does not homodimerize upon neuregulin binding at the cell surface

scientific article published on July 2004

ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation

scientific article

Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain

scientific article

Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4.

scientific article

Extracellular domains drive homo- but not hetero-dimerization of erbB receptors

scientific article

Finding the missing links in EGFR.

scientific article

Flipping ATP to AMPlify Kinase Functions

scientific article published on 01 October 2018

Functional selectivity of EGF family peptide growth factors: implications for cancer

scientific article published on 16 December 2008

Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains

scientific article

Genome-wide analysis of signaling domain function

scientific article

Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias

scientific article published in February 2022

Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices

scientific article

Helix-helix interactions inside lipid bilayers

scholarly article

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

scientific article published on 01 December 1994

High-affinity binding of a FYVE domain to phosphatidylinositol 3-phosphate requires intact phospholipid but not FYVE domain oligomerization

scientific article published in July 2001

Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

scientific article

Identification of the Binding Site for Acidic Phospholipids on the PH Domain of Dynamin: Implications for Stimulation of GTPase Activity

Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

scientific article

Inhibition of nuclear import and cell-cycle progression by mutated forms of the dynamin-like GTPase MxB

scientific article

Insulin and EGF receptor family members share parallel activation mechanisms

scientific article published on 16 April 2020

Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids

scientific article

Kinetics of receptor tyrosine kinase activation define ERK signaling dynamics

scientific article published on 18 August 2020

Kit receptor dimerization is driven by bivalent binding of stem cell factor

scientific journal article

Ligand regulation of a constitutively dimeric EGF receptor

scientific article published on 10 June 2015

Ligand-induced ErbB receptor dimerization

scientific article published on 31 October 2008

Ligand-induced structural transitions in ErbB receptor extracellular domains

scientific article published on August 2007

Live cell imaging with protein domains capable of recognizing phosphatidylinositol 4,5-bisphosphate; a comparative study

scientific article

Looking lively: emerging principles of pseudokinase signaling

scientific article published in 2022

Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting

scientific journal article

Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis

scientific journal article

Mechanism for activation of mutated epidermal growth factor receptors in lung cancer

scientific article

Mechanism of activation and inhibition of the HER4/ErbB4 kinase

scientific article

Membrane activity of the phospholipase C-delta1 pleckstrin homology (PH) domain

scientific journal article

Modulation of cardiac PIP2 by cardioactive hormones and other physiologically relevant interventions

scientific article

Molecular determinants in pleckstrin homology domains that allow specific recognition of phosphoinositides

scientific article

Molecular determinants of KA1 domain-mediated autoinhibition and phospholipid activation of MARK1 kinase

scientific article

Molecular dynamics analysis of conserved hydrophobic and hydrophilic bond-interaction networks in ErbB family kinases

scientific article published on June 2011

Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenic

scientific article

N-terminal domains elicit formation of functional Pmel17 amyloid fibrils

scientific article published on December 2009

Neuregulin Signaling Is a Mechanism of Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma

scientific article published on 06 August 2019

Non-acylated Wnts Can Promote Signaling

scientific article published on 01 January 2019

Normalization of nomenclature for peptide motifs as ligands of modular protein domains

scientific article

Nuclear signaling by receptor tyrosine kinases: the first robin of spring

scientific article published on October 2006

Occupy EGFR.

scientific article published on May 2012

On the nature of low- and high-affinity EGF receptors on living cells

scholarly article

Overcoming resistance to HER2 inhibitors through state-specific kinase binding

scientific article published on 05 September 2016

PH Domains

PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface

scientific article published on May 1996

Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion

scientific article published on February 2006

Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions

scientific article

Phosphatidylinositol-4,5-bisphosphate is required for endocytic coated vesicle formation

scientific article

Phosphatidylserine binding directly regulates TIM-3 function

scientific article published in 2021

Phosphoinositide binding by the pleckstrin homology domains of Ipl and Tih1

scientific article (publication date: 20 December 2002)

Phosphoinositide recognition domains

scientific article

Pleckstrin Homology (PH) Domains

Pleckstrin homology (PH) domains and phosphoinositides

scientific article published on January 2007

Pleckstrin homology domains and the cytoskeleton

scientific article

Pleckstrin homology domains.

scientific article published on January 1998

Pleckstrin homology domains: not just for phosphoinositides

scientific article published in November 2004

Pleckstrin homology domains: two halves make a hole?

scientific article

Protein kinase C regulation: C1 meets C-tail

scientific article

Putting together structures of epidermal growth factor receptors

scientific article published on 24 October 2014

Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins

scientific article published in Journal of Biological Chemistry

ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes

Receptor tyrosine kinases with intracellular pseudokinase domains

scientific article

Regulation of Kinase Activity in the Caenorhabditis elegans EGF Receptor, LET-23.

scientific article published on 17 January 2018

Regulation of growth factor activation by proteoglycans: what is the role of the low affinity receptors?

scientific article published on November 1995

Regulation of signal transduction and signal diversity by receptor oligomerization

scientific article published on November 1994

Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae.

scientific article

SH2 and PTB domains in tyrosine kinase signaling

scientific article

Scratching the surface with the PH domain

scientific article

Sequence specificity in the dimerization of transmembrane alpha-helices

scientific article

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

scientific article

Signaling by the sea.

scientific article published in August 2004

Smoothening out the patches

scientific article

Solution structure of pleckstrin homology domain of dynamin by heteronuclear NMR spectroscopy

scientific article

Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain

scientific article

Specific role for the PH domain of dynamin-1 in the regulation of rapid endocytosis in adrenal chromaffin cells

scientific article published on April 1997

Specificity and promiscuity in membrane helix interactions

scientific article published on 01 June 1994

Specificity and promiscuity in membrane helix interactions

scientific article published on May 1994

Specificity of the myotubularin family of phosphatidylinositol-3-phosphatase is determined by the PH/GRAM domain

scientific article published on 16 August 2006

Stabilization of an active dimeric form of the epidermal growth factor receptor by introduction of an inter-receptor disulfide bond

scientific article published on April 1994

Structural Basis for MARK1 Kinase Autoinhibition by Its KA1 Domain

scientific article published on 28 June 2018

Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor

scientific article

Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases

scientific article published on 24 June 2020

Structural basis for EGFR ligand sequestration by Argos

scientific article

Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains

scientific article

Structural basis for high-affinity phosphoinositide binding by pleckstrin homology domains

scientific article

Structural basis for ligand reception by anaplastic lymphoma kinase

Structural organization of the pentameric transmembrane alpha-helices of phospholamban, a cardiac ion channel

scientific article published on October 1994

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

scientific article

Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling

scientific article published on 17 January 2018

Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors

scientific article

TIPE3 is the transfer protein of lipid second messengers that promote cancer

scientific journal article

The ALK/ROS1 Inhibitor PF-06463922 Overcomes Primary Resistance to Crizotinib in ALK-Driven Neuroblastoma

scientific article

The Dark Side of Cell Signaling: Positive Roles for Negative Regulators

scientific article published on March 2016

The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity

scientific article published on December 2006

The EGF receptor family as therapeutic targets in breast cancer.

scientific article

The EGFR Exon 19 Mutant L747-A750>P Exhibits Distinct Sensitivity to Tyrosine Kinase Inhibitors in Lung Adenocarcinoma

scientific article published on 10 June 2019

The EGFR family: not so prototypical receptor tyrosine kinases

scientific article published on April 2014

The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain

scientific article

The Pleckstrin Homology Domains of Dynamin Isoforms Require Oligomerization for High Affinity Phosphoinositide Binding

scientific article published in Journal of Biological Chemistry

The glycophorin A transmembrane domain dimer: Sequence-specific propensity for a right-handed supercoil of helixes

scientific article published on 01 December 1992

The p21-activated protein kinase-related kinase Cla4 is a coincidence detector of signaling by Cdc42 and phosphatidylinositol 4-phosphate

scientific article

The role of the pleckstrin homology domain in membrane targeting and activation of phospholipase Cbeta(1).

scientific article published on May 2000

The single transmembrane domains of ErbB receptors self-associate in cell membranes

scientific article published on 10 December 2001

The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function

scholarly article

Thermodynamic Studies of SHC Phosphotyrosine Interaction Domain Recognition of the NPXpY Motif

scientific article published in Journal of Biological Chemistry

Thermodynamic studies of tyrosyl-phosphopeptide binding to the SH2 domain of p56lck

scientific article

Transmembrane signaling by receptor oligomerization

scientific article published in January 1998

Two EGF molecules contribute additively to stabilization of the EGFR dimer

scientific article

[48] Analysis of phosphoinositide binding by Pleckstrin homology domain from dynamin

scientific article published on 01 January 2001

List of works by Mark A. Lemmon

A New Twist in the Transmembrane Signaling Tool-Kit

A dimerization motif for transmembrane α–helices

A possible effector role for the pleckstrin homology (PH) domain of dynamin

A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein

A structure-based model for ligand binding and dimerization of EGF receptors

ALK mutations confer differential oncogenic activation and sensitivity to ALK inhibition therapy in neuroblastoma

Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

Ala-insertion scanning mutagenesis of the glycophorin A transmembrane helix: a rapid way to map helix-helix interactions in integral membrane proteins

All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate.

An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors

Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma

Argos inhibits epidermal growth factor receptor signalling by ligand sequestration

Argos mutants define an affinity threshold for spitz inhibition in vivo

Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family

Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations

Biochemistry. KSR plays CRAF-ty

Cell signaling by receptor tyrosine kinases

Comparison of Saccharomyces cerevisiae F-BAR domain structures reveals a conserved inositol phosphate binding site

Comparison of tyrosine kinase domain properties for the neurotrophin receptors TrkA and TrkB

Complex relationship between ligand binding and dimerization in the epidermal growth factor receptor

Computational algorithms for in silico profiling of activating mutations in cancer

Computational analysis of EGFR inhibition by Argos

Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation

Conditional peripheral membrane proteins: facing up to limited specificity

Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin

Deletion Mutations Keep Kinase Inhibitors in the Loop

Determining selectivity of phosphoinositide-binding domains

Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma.

Dimerization of Tie2 mediated by its membrane-proximal FNIII domains

Dimerization of glycophorin A transmembrane helices: mutagenesis and modeling.

Dimerization of the p185neu transmembrane domain is necessary but not sufficient for transformation

Dominant-negative inhibition of receptor-mediated endocytosis by a dynamin-1 mutant with a defective pleckstrin homology domain

Drug sensitivity and allele-specificity of first-line osimertinib resistance EGFR mutations

Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers

Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients

EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization

EGF-independent activation of cell-surface EGF receptors harboring mutations found in gefitinib-sensitive lung cancer

EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics

EGFR mutations cause a lethal syndrome of epithelial dysfunction with progeroid features

Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface

ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor

ErbB3/HER3 does not homodimerize upon neuregulin binding at the cell surface

ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation

Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain

Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4.

Extracellular domains drive homo- but not hetero-dimerization of erbB receptors

Finding the missing links in EGFR.

Flipping ATP to AMPlify Kinase Functions

Functional selectivity of EGF family peptide growth factors: implications for cancer

Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains

Genome-wide analysis of signaling domain function

Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias

Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices

Helix-helix interactions inside lipid bilayers

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

High-affinity binding of a FYVE domain to phosphatidylinositol 3-phosphate requires intact phospholipid but not FYVE domain oligomerization

Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

Identification of the Binding Site for Acidic Phospholipids on the PH Domain of Dynamin: Implications for Stimulation of GTPase Activity

Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

Inhibition of nuclear import and cell-cycle progression by mutated forms of the dynamin-like GTPase MxB

Insulin and EGF receptor family members share parallel activation mechanisms

Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids

Kinetics of receptor tyrosine kinase activation define ERK signaling dynamics

Kit receptor dimerization is driven by bivalent binding of stem cell factor

Ligand regulation of a constitutively dimeric EGF receptor

Ligand-induced ErbB receptor dimerization

Ligand-induced structural transitions in ErbB receptor extracellular domains

Live cell imaging with protein domains capable of recognizing phosphatidylinositol 4,5-bisphosphate; a comparative study

Looking lively: emerging principles of pseudokinase signaling

Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting

Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis

Mechanism for activation of mutated epidermal growth factor receptors in lung cancer

Mechanism of activation and inhibition of the HER4/ErbB4 kinase

Membrane activity of the phospholipase C-delta1 pleckstrin homology (PH) domain

Modulation of cardiac PIP2 by cardioactive hormones and other physiologically relevant interventions

Molecular determinants in pleckstrin homology domains that allow specific recognition of phosphoinositides

Molecular determinants of KA1 domain-mediated autoinhibition and phospholipid activation of MARK1 kinase

Molecular dynamics analysis of conserved hydrophobic and hydrophilic bond-interaction networks in ErbB family kinases

Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenic