List of works - Mark A. Lemmon

Cell signaling by receptor tyrosine kinases

scientific article

An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors

scientific article (publication date: September 2003)

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

scientific article

EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization

scientific article

Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain

scientific article

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

scientific article

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

scientific article published on 01 December 1994

Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

scientific article published in January 1998

PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface

scientific article published on May 1996

Phosphoinositide recognition domains

scientific article

Sequence specificity in the dimerization of transmembrane alpha-helices

scientific article

ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation

scientific article

Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains

scientific article

Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

scientific article

Regulation of signal transduction and signal diversity by receptor oligomerization

scientific article published on November 1994

Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors

scientific article

Regulation of growth factor activation by proteoglycans: what is the role of the low affinity receptors?

scientific article published on November 1995

A dimerization motif for transmembrane α–helices

scientific article published on 01 March 1994

Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains

scientific article

Two EGF molecules contribute additively to stabilization of the EGFR dimer

scientific article

The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain

scientific article

Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices

scientific article

Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin

scientific article

The single transmembrane domains of ErbB receptors self-associate in cell membranes

scientific article published on 10 December 2001

Identification of the Binding Site for Acidic Phospholipids on the PH Domain of Dynamin: Implications for Stimulation of GTPase Activity

Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface

scientific article

Phosphatidylinositol-4,5-bisphosphate is required for endocytic coated vesicle formation

scientific article

Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions

scientific article

ALK mutations confer differential oncogenic activation and sensitivity to ALK inhibition therapy in neuroblastoma

scientific article

The Pleckstrin Homology Domains of Dynamin Isoforms Require Oligomerization for High Affinity Phosphoinositide Binding

scientific article published in Journal of Biological Chemistry

A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein

scientific article published on 16 October 1995

Pleckstrin homology domains: not just for phosphoinositides

scientific article published in November 2004

All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate.

scientific article

Pleckstrin homology (PH) domains and phosphoinositides

scientific article published on January 2007

SH2 and PTB domains in tyrosine kinase signaling

scientific article

Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma.

scientific article

Pleckstrin homology domains and the cytoskeleton

scientific article

The EGFR family: not so prototypical receptor tyrosine kinases

scientific article published on April 2014

Ligand-induced ErbB receptor dimerization

scientific article published on 31 October 2008

Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

scientific article

Conditional peripheral membrane proteins: facing up to limited specificity

scientific article published on 21 December 2011

Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor

scientific article

Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids

scientific article

Specificity and promiscuity in membrane helix interactions

scientific article published on May 1994

Functional selectivity of EGF family peptide growth factors: implications for cancer

scientific article published on 16 December 2008

The glycophorin A transmembrane domain dimer: Sequence-specific propensity for a right-handed supercoil of helixes

scientific article published on 01 December 1992

Mechanism of activation and inhibition of the HER4/ErbB4 kinase

scientific article

ErbB3/HER3 does not homodimerize upon neuregulin binding at the cell surface

scientific article published on July 2004

Argos inhibits epidermal growth factor receptor signalling by ligand sequestration

scientific article

Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion

scientific article published on February 2006

List of works by Mark A. Lemmon

Cell signaling by receptor tyrosine kinases

An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization

Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface

Phosphoinositide recognition domains

Sequence specificity in the dimerization of transmembrane alpha-helices

ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation

Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains

Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

Regulation of signal transduction and signal diversity by receptor oligomerization

Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors

Regulation of growth factor activation by proteoglycans: what is the role of the low affinity receptors?

A dimerization motif for transmembrane α–helices

Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains

Two EGF molecules contribute additively to stabilization of the EGFR dimer

The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain

Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices

Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin

The single transmembrane domains of ErbB receptors self-associate in cell membranes

Identification of the Binding Site for Acidic Phospholipids on the PH Domain of Dynamin: Implications for Stimulation of GTPase Activity

Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface

Phosphatidylinositol-4,5-bisphosphate is required for endocytic coated vesicle formation

Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions

ALK mutations confer differential oncogenic activation and sensitivity to ALK inhibition therapy in neuroblastoma

The Pleckstrin Homology Domains of Dynamin Isoforms Require Oligomerization for High Affinity Phosphoinositide Binding

A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein

Pleckstrin homology domains: not just for phosphoinositides

All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate.

Pleckstrin homology (PH) domains and phosphoinositides

SH2 and PTB domains in tyrosine kinase signaling

Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma.

Pleckstrin homology domains and the cytoskeleton

The EGFR family: not so prototypical receptor tyrosine kinases

Ligand-induced ErbB receptor dimerization

Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

Conditional peripheral membrane proteins: facing up to limited specificity

Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor

Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids

Specificity and promiscuity in membrane helix interactions

Functional selectivity of EGF family peptide growth factors: implications for cancer

The glycophorin A transmembrane domain dimer: Sequence-specific propensity for a right-handed supercoil of helixes

Mechanism of activation and inhibition of the HER4/ErbB4 kinase

ErbB3/HER3 does not homodimerize upon neuregulin binding at the cell surface

Argos inhibits epidermal growth factor receptor signalling by ligand sequestration

Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion