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List of works by Richard P. Harvey

A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.

scientific article published in October 2017

A Universal and Robust Integrated Platform for the Scalable Production of Human Cardiomyocytes From Pluripotent Stem Cells

scientific article

A common Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node

scientific article published on 2 July 2015

A critical time for stem cell research in Australia.

scientific article

A gain-of-function TBX20 mutation causes congenital atrial septal defects, patent foramen ovale and cardiac valve defects

scientific article

A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels.

scientific article published on 17 February 2016

A rapid co-culture stamping device for studying intercellular communication

scientific article

A tyrosine-rich domain within homeodomain transcription factor Nkx2-5 is an essential element in the early cardiac transcriptional regulatory machinery

scientific journal article

Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene

scientific journal article

Advances in the Genetics of Congenital Heart Disease: A Clinician's Guide.

scientific article published on February 2017

Altered cytokine profile, pain sensitivity, and stress responsivity in mice with co-disruption of the developmental genes Neuregulin-1×DISC1.

scientific article published in December 2016

Altered motor activity, exploration and anxiety in heterozygous neuregulin 1 mutant mice: implications for understanding schizophrenia.

scientific article published on 13 February 2007

An endothelial contribution to coronary vessels

scientific article published on 01 November 2012

Analysis of cardiac stem cell self-renewal dynamics in serum-free medium by single cell lineage tracking

scientific article published on 8 February 2018

Analysis of steric effects in DamID profiling of transcription factor target genes

scientific article published on 8 February 2017

Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy.

scientific article published on 9 March 2015

Architectural defects in the spleens of Nkx2-3-deficient mice are intrinsic and associated with defects in both B cell maturation and T cell-dependent immune responses

scientific journal article

Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart.

scientific article published on 4 May 2007

Biased DNA Segregation and Cardiac Stem Cell Therapies ⬇️

scientific article published on September 14, 2012

Bioengineered FSTL1 Patches Restore Cardiac Function Following Myocardial Infarction

scientific article published on 17 November 2015

Cardiac Regeneration Therapies - Targeting Neuregulin 1 Signalling

scientific article published on 25 September 2015

Cardiac Repair With a Novel Population of Mesenchymal Stem Cells Resident in the Human Heart

scientific article published on 16 July 2015

Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart

scientific journal article

Cardiac deletion of Smyd2 is dispensable for mouse heart development

scientific journal article

Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome

scientific article

Cardiac looping — an uneasy deal with laterality ⬇️

scientific article published on February 1, 1998

Cardiac outflow tract development relies on the complex function of Sox4 and Sox11 in multiple cell types.

scientific article published on 6 December 2013

Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5

scientific article published on 01 November 2000

Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair

scientific article

Cardiomyocytes Replicate and their Numbers Increase in Young Hearts

scientific article

Cardiovascular regenerative medicine: digging in for the long haul

scientific article published on 01 December 2007

Chamber formation and morphogenesis in the developing mammalian heart

scientific journal article

Characterization of Pitx2c expression in the mouse heart using a reporter transgene.

scientific article

Chromatin remodelling complex dosage modulates transcription factor function in heart development

scientific article

Combined mutation screening of NKX2-5, GATA4, and TBX5 in congenital heart disease: multiple heterozygosity and novel mutations

scientific article published on 20 October 2011

CompGO: an R package for comparing and visualizing Gene Ontology enrichment differences between DNA binding experiments

scientific article published on 2 September 2015

Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5

scientific article

Comprehensive transcriptome and immunophenotype analysis of renal and cardiac MSC-like populations supports strong congruence with bone marrow MSC despite maintenance of distinct identities

article

Conditional (loxP-flanked) allele for the gene encoding the retinoic acid-synthesizing enzyme retinaldehyde dehydrogenase 2 (RALDH2).

scientific article published in March 2006

Conformational stability and DNA binding specificity of the cardiac T-box transcription factor Tbx20.

scientific article published on 3 May 2009

Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module

scientific article

Congenital heart disease: current knowledge about causes and inheritance ⬇️

scientific article published on August 6, 2012

DAN is a secreted glycoprotein related to Xenopus cerberus.

scientific article published in October 1998

Developmental origin and lineage plasticity of endogenous cardiac stem cells

scientific article

Developmental origins and lineage descendants of endogenous adult cardiac progenitor cells.

scientific article published on 02 October 2014

Differential binding of an SRF/NK-2/MEF2 transcription factor complex in normal versus neoplastic smooth muscle tissues

scientific article (publication date: 14 September 2001)

Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7

scholarly article

Disruption of thermal nociceptive behaviour in mice mutant for the schizophrenia-associated genes NRG1, COMT and DISC1.

scientific article published on 16 June 2010

ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation

scientific article published on 6 April 2015

Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 × DISC1.

scientific article published on 9 September 2016

Epithelial to mesenchymal transition as a portal to stem cell characters embedded in gene networks.

scientific article published on 18 September 2012

Erratum to: 'CompGO: an R package for comparing and visualizing Gene Ontology enrichment differences between DNA binding experiments'.

scientific article published on 25 April 2016

Essential role for the lymphostromal plasma membrane Ly-6 superfamily molecule thymic shared antigen 1 in development of the embryonic adrenal gland

scientific article

Expression of NK-2 class homeobox gene Nkx2–6 in foregut endoderm and heart ⬇️

scientific article published on April 1, 1998

Expression of Slit and Robo genes in the developing mouse heart.

scientific article

Expression of cardiac muscle markers in rat myocyte cell lines.

scientific article published on April 1996

Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium.

scientific article

Formation of the Venous Pole of the Heart From an Nkx2-5-Negative Precursor Population Requires Tbx18

scientific article published in June 2006

Functional characterization of a novel mutation in NKX2-5 associated with congenital heart disease and adult-onset cardiomyopathy.

scientific article published on 09 May 2013

GATA4 mutations in 357 unrelated patients with congenital heart malformation

scientific article

Gene-environment interaction demonstrates the vulnerability of the embryonic heart.

scientific article published on 18 March 2014

Genetic burden and associations with adverse neurodevelopment in neonates with congenital heart disease

scientific article published on 05 April 2018

Genetic networks governing heart development.

scientific article

Haemogenic endocardium contributes to transient definitive haematopoiesis.

scientific article

Heart field origin of great vessel precursors relies on nkx2.5-mediated vasculogenesis.

scientific article published on 27 October 2013

Heart redevelopment

scientific article published in Nature

High-resolution genetic analysis of a deletion on mouse Chromosome 17 extending over the Fused, tufted, and homeobox Nkx2-5 loci

scientific article published on 01 December 1994

Histone genes are clustered with a 15-kilobase repeat in the chicken genome

scientific article published on May 10, 1979

Hlx homeo box gene is essential for an inductive tissue interaction that drives expansion of embryonic liver and gut

scientific journal article

Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera

scientific journal article

Hop is an unusual homeobox gene that modulates cardiac development

scientific article (publication date: 20 September 2002)

Hypoplastic left heart syndrome: new genetic insights

scientific article published on 01 March 2009

Identification and cloning of localized maternal RNAs from Xenopus eggs

scientific article

Increasing the tolerance of DCD hearts to warm ischemia by pharmacological postconditioning

scientific article published on 01 August 2014

Independently evolving chicken histone H2B genes: identification of a ubiquitous H2B-specific 5' element.

scientific article

Inhibition of Notch2 by Numb/Numblike controls myocardial compaction in the heart

scientific article published on 03 August 2012

Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer.

scientific article

Introduction to the special issue on heart regeneration and rejuvenation

scientific article published on 12 October 2014

Investigation of association between PFO complicated by cryptogenic stroke and a common variant of the cardiac transcription factor GATA4.

scientific article

Irreversible triggers for hypertrophic cardiomyopathy are established in the early postnatal period.

scientific article published in February 2015

Isolation of a genomal clone containing chicken histone genes ⬇️

scientific article published on December 11, 1979

Lack of Genetic Interaction between Tbx20 and Tbx3 in Early Mouse Heart Development ⬇️

scientific article published on July 25, 2013

Landmarks and Lineages in the Developing Heart

scientific article published on 01 June 2009

Large-Scale Production of Cardiomyocytes from Human Pluripotent Stem Cells Using a Highly Reproducible Small Molecule-Based Differentiation Protocol

scientific article published on 25 July 2016

Links in the left/right axial pathway.

scientific article published in August 1998

Localized maternal mRNAs in Xenopus laevis eggs.

scientific article published in January 1985

Long noncoding RNAs in cardiac development and pathophysiology

scientific article published on October 2012

Loss of Cited2 causes congenital heart disease by perturbing left-right patterning of the body axis

scientific article published on 28 December 2010

Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.

scientific article published on 5 December 2016

Molecular analysis ofPRKAG2,LAMP2, andNKX2-5genes in a cohort of 125 patients with accessory atrioventricular connection

article

Molecular pathway for the localized formation of the sinoatrial node

scientific article

Molecular pathways in myocardial development: a stem cell perspective.

scientific article

Murine cerberus homologue Cer1 maps to chromosome 4

scientific article published on 01 April 1998

Muscle costameric protein, Chisel/Smpx, associates with focal adhesion complexes and modulates cell spreading in vitro via a Rac1/p38 pathway.

scientific article

Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy

scientific article

MyoD protein expression in Xenopus embryos closely follows a mesoderm induction-dependent amplification of MyoD transcription and is synchronous across the future somite axis

scientific article published on May 1, 1992

MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels

scientific article published on 17 August 2023

Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5

scientific journal article

NK-2 homeobox genes and heart development

scientific article

NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets

scientific article

NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network

scientific article published on 10 April 2018

Neuregulin 1 and susceptibility to schizophrenia

scientific article

Nkx2-5 mediates differential cardiac differentiation through interaction with Hoxa10.

scientific article published on 09 April 2013

Nkx2-5 represses Gata1 gene expression and modulates the cellular fate of cardiac progenitors during embryogenesis.

scientific article published on 4 April 2011

Nkx2-5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo.

scholarly article

Nkx2-5(+)islet1(+) mesenchymal precursors generate distinct spleen stromal cell subsets and participate in restoring stromal network integrity

scientific article published on April 2013

Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta.

scientific article

Normothermic ex vivo perfusion provides superior organ preservation and enables viability assessment of hearts from DCD donors.

scientific article published in February 2015

Pathophysiological Trends During Withdrawal of Life Support: Implications for Organ Donation After Circulatory Death

scientific article published in December 2016

Patterning the vertebrate heart

scientific article published on 01 July 2002

Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development.

scientific article

Phenotype of spontaneous orofacial dyskinesia in neuregulin-1 'knockout' mice.

scientific article published on 25 December 2008

Phenotypic effects of maternal immune activation and early postnatal milieu in mice mutant for the schizophrenia risk gene neuregulin-1.

scientific article published on 23 June 2014

Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene × environment interaction

scientific article

Platelet-derived growth factor (PDGF) signaling directs cardiomyocyte movement toward the midline during heart tube assembly.

scientific article published on 18 January 2017

Platelet-derived growth factor-AB improves scar mechanics and vascularity after myocardial infarction

scientific article published on 01 January 2020

Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling.

scientific article

Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitors

scientific article

Prediction and validation of protein-protein interactors from genome-wide DNA-binding data using a knowledge-based machine-learning approach

scientific article

Pressure Overload by Transverse Aortic Constriction Induces Maladaptive Hypertrophy in a Titin-Truncated Mouse Model

scientific article

QTL mapping of complex binary traits in an advanced intercross line.

scientific article published in July 2012

Quantifying intrinsic and extrinsic control of single-cell fates in cancer and stem/progenitor cell pedigrees with competing risks analysis

scientific article

Quantitative trait loci modifying cardiac atrial septal morphology and risk of patent foramen ovale in the mouse

scientific article published on 16 February 2006

RNA toxicity in myotonic muscular dystrophy induces NKX2-5 expression

scientific article

Selective Inhibition of Human Group IIA-secreted Phospholipase A2 (hGIIA) Signaling Reveals Arachidonic Acid Metabolism Is Associated with Colocalization of hGIIA to Vimentin in Rheumatoid Synoviocytes

scientific article

Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

article

Somatic mutations in NKX2–5, GATA4, and HAND1 are not a common cause of tetralogy of Fallot or hypoplastic left heart

scientific article published on 01 October 2011

Specialized Information Processing Deficits and Distinct Metabolomic Profiles Following TM-Domain Disruption of Nrg1.

scientific article published on 11 March 2017

Structural and functional characterization of the mouse Hlx homeobox gene.

scientific article published on October 2000

Targeted next-generation sequencing identifies pathogenic variants in familial congenital heart disease

scientific article published on December 2014

The Combinatorial Activities of Nkx2.5 and dHAND Are Essential for Cardiac Ventricle Formation ⬇️

scientific article published on November 15, 2001

The Hlx homeobox transcription factor is required early in enteric nervous system development

scientific journal article

The Ontogeny of Cardiac Regeneration ⬇️

scientific article published on May 27, 2011

The murine homeobox genes Nkx2.3 and Nkx2.6 are located on chromosomes 19 and 14, respectively

scientific article published on 01 August 1994

The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors.

scientific article published on June 1996

The promises and challenges of exome sequencing in familial, non-syndromic congenital heart disease

scientific article published on 13 December 2016

The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin-like growth factor 1-dependent manner

scientific journal article

Time to mend a broken heart

scientific article published on 17 September 2007

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis.

scientific article published in April 2017

Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1.

scientific article published on 18 September 2017

Vertebrate histone genes: nucleotide sequence of a chicken H2A gene and regulatory flanking sequences

scientific article published on July 1981

Widespread expression of MyoD genes in Xenopus embryos is amplified in presumptive muscle as a delayed response to mesoderm induction.

scientific article published on October 1991

Wnt inhibition promotes vascular specification of embryonic cardiac progenitors

scientific article published on 7 December 2017

XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: evidence for a conserved role in cardiac development.

scientific article published in March 1994

Zac1 is an essential transcription factor for cardiac morphogenesis.

scientific article published on 18 February 2010

c-Kit function is necessary for in vitro myogenic differentiation of bone marrow hematopoietic cells.

scientific article published in August 2009

epicardin: A novel basic helix-loop-helix transcription factor gene expressed in epicardium, branchial arch myoblasts, and mesenchyme of developing lung, gut, kidney, and gonads ⬇️

scientific article published on September 1, 1998

musculin: a murine basic helix-loop-helix transcription factor gene expressed in embryonic skeletal muscle ⬇️

scientific article published on August 1, 1998

α-cardiac myosin heavy chain (MYH6) mutations affecting myofibril formation are associated with congenital heart defects

scientific article

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