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List of works by Joan Seoane

Active CREB1 promotes a malignant TGFβ2 autocrine loop in glioblastoma.

scientific article

An antisense oligonucleotide targeting TGF-β2 inhibits lung metastasis and induces CD86 expression in tumor-associated macrophages.

scientific article

Blockade of the SNARE protein syntaxin 1 inhibits glioblastoma tumor growth.

scientific article

Brain metastasis: new opportunities to tackle therapeutic resistance

scientific article

Bridging the gap between glucose phosphorylation and glycogen synthesis in the liver

scientific article published on February 1997

Cancer: Division hierarchy leads to cell heterogeneity

scientific article published on 30 August 2017

Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle

scientific article published on 01 November 2018

Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle.

scientific article published on 09 July 2014

Cerebrospinal fluid cell-free tumour DNA as a liquid biopsy for primary brain tumours and central nervous system metastases

scientific article published on 01 February 2019

Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma.

scientific article

Circulating tumour DNA from the cerebrospinal fluid allows the characterisation and monitoring of medulloblastoma

scientific article published on 27 October 2020

Circulating tumour cells and cell-free DNA as tools for managing breast cancer

scientific article published on 28 May 2013

Circulating tumour cells in early breast cancer

Clinical response to a lapatinib-based therapy for a Li-Fraumeni syndrome patient with a novel HER2V659E mutation.

scientific article

Crystal Structure of a Phosphorylated Smad2

article

Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures

scientific article published on 15 December 2020

Early evolutionary divergence between papillary and anaplastic thyroid cancers.

scientific article

Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program

scientific article published on 19 August 2019

Escaping out of the brain

scientific article published in November 2014

Establishing the origin of metastatic deposits in the setting of multiple primary malignancies: the role of massively parallel sequencing

scientific article published on 31 October 2013

Genetic heterogeneity and actionable mutations in HER2-positive primary breast cancers and their brain metastases.

scientific article

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets

scientific article published on 26 September 2015

Glioblastoma multiforme: a look inside its heterogeneous nature

scientific article published on 27 January 2014

Glucokinase overexpression restores glucose utilization and storage in cultured hepatocytes from male Zucker diabetic fatty rats.

scientific article

Gremlins sabotage the mechanisms of cancer stem cell differentiation.

scientific article

High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene

scientific article published in February 2007

How liquid biopsies can change clinical practice in oncology

scientific article published on 01 October 2019

Identification of multipotent mesenchymal stromal cells in the reactive stroma of a prostate cancer xenograft by side population analysis

scientific article

Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment

scientific article published on 08 March 2021

Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

scientific journal article

Interrogating open issues in cancer precision medicine with patient-derived xenografts.

scientific article published on 20 January 2017

LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy

scientific article published on 11 June 2019

Metabolic Impact of Adenovirus-mediated Overexpression of the Glucose-6-phosphatase Catalytic Subunit in Hepatocytes ⬇️

scientific article published on October 24, 1997

MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients

scientific article published on 7 October 2015

Molecular Diagnosis of Diffuse Gliomas through Sequencing of Cell-Free Circulating Tumor DNA from Cerebrospinal Fluid.

scientific article

Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway.

scientific article

Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis.

scientific article

Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

scientific article published in Nature

NO Signals from the Cancer Stem Cell Niche.

scientific article published in February 2010

New approach to cancer therapy based on a molecularly defined cancer classification.

scientific article

Noncyclam tetraamines inhibit CXC chemokine receptor type 4 and target glioma-initiating cells

scientific article published on 29 August 2012

Patient-derived xenograft models: an emerging platform for translational cancer research

scientific article

Pharmacokinetic, pharmacodynamic and biomarker evaluation of transforming growth factor-β receptor I kinase inhibitor, galunisertib, in phase 1 study in patients with advanced cancer

scientific article

Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235.

scientific article published on November 2008

Relative bioavailability of three formulations of galunisertib administered as monotherapy in patients with advanced or metastatic cancer.

scientific article published on 02 December 2016

Relevance of IGFBP2 proteolysis in glioma and contribution of the extracellular protease ADAMTS1

scientific article

Repression of p15INK4b expression by Myc through association with Miz-1

scientific article (publication date: April 2001)

TET2 controls chemoresistant slow-cycling cancer cell survival and tumor recurrence

scientific article published on 06 August 2018

TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma

scientific article published in April 2009

TGF-β Family Signaling in Tumor Suppression and Cancer Progression.

scientific article published on 28 February 2017

TGF-β Receptor Inhibitors Target the CD44high/Id1high Glioma-Initiating Cell Population in Human Glioblastoma ⬇️

scientific article published on December 14, 2010

TGF-β signalling-related markers in cancer patients with bone metastasis

scientific article published on 01 March 2008

TGFbeta and cancer initiating cells

scientific article

TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

scientific article published in April 2001

The European Society for Medical Oncology (ESMO) Precision Medicine Glossary

scientific article published on 13 November 2017

The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer.

scientific article

The TGFBeta pathway as a therapeutic target in cancer.

scientific article published on January 2008

The Taming of the TAMs

scientific article published on 6 July 2016

The challenge of intratumour heterogeneity in precision medicine

scientific article published on July 2014

The right compound for the right target: tackling RET

scientific article published on 01 August 2018

USP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination.

scientific article

USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

scientific article

p21(WAF1/CIP1) at the switch between the anti-oncogenic and oncogenic faces of TGFbeta

scientific article published in February 2004

p95HER2-T cell bispecific antibody for breast cancer treatment

scientific article published on 01 October 2018

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