List of works - Jonathon Noe Joseph Pines

A PP1-PP2A phosphatase relay controls mitotic progression

scientific article published on 10 December 2014

A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex.

scientific article published on January 1992

A quantitative protocol for dynamic measurements of protein interactions by Forster resonance energy transfer-sensitized fluorescence emission

A red light in mitosis ⬇️

scientific article published on August 1, 2012

A single cyclin A gene and multiple cyclin B1-related sequences are dispersed in the mouse genome

scientific article published on June 1992

APC/C Cdh1 targets aurora kinase to control reorganization of the mitotic spindle at anaphase

scientific article published on 30 October 2008

APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment

scientific article

Activation of cyclin B1-Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosis

scientific article

Active cyclin B1-Cdk1 first appears on centrosomes in prophase

scientific article

Arresting developments in cell-cycle control

scientific article published on April 1994

Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A.

scientific article

Cdc25B and Cdc25C differ markedly in their properties as initiators of mitosis

scientific article

Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A.

scientific article published on June 1991

Cell cycle trials in Salamanca: workshop on G2/M progression and associated checkpoints

scientific article published on January 2002

Cell cycle. Confirmational change.

scientific article

Cell division, growth and death. Cell growth: live and let die.

scientific article published in December 2003

Centromere tension: a divisive issue

scientific article

Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin

scientific article

Checkpoint on the nuclear frontier

scientific article published in Nature

Chfr acts with the p38 stress kinases to block entry to mitosis in mammalian cells

scientific article

Clear as crystal?

scientific article

Co-activator independent differences in how the metaphase and anaphase APC/C recognise the same substrate.

scientific article published on 12 September 2014

Cubism and the cell cycle: the many faces of the APC/C ⬇️

scientific article published on June 2, 2011

Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

scientific article

Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm

scientific article published on March 2002

Cyclin B1 is essential for mitosis in mouse embryos, and its nuclear export sets the time for mitosis

scientific article

Cyclin synthesis, modification and destruction during meiotic maturation of the starfish oocyte

scientific article

Cyclin-dependent kinase inhibitors: the age of crystals

scientific article published on February 1997

Cyclin-dependent kinases: a new cell cycle motif?

scientific article published on November 1991

Cyclins and cancer

scientific article published on September 1991

Cyclins and cyclin-dependent kinases: take your partners

scientific article

Defining the role of Emi1 in the DNA replication-segregation cycle

scientific article published on 04 March 2008

Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C

scientific article

Escaping the firing squad: acetylation of BubR1 protects it from degradation in checkpoint cells

scientific article published on July 2009

Four-dimensional control of the cell cycle

scientific article

GFP in mammalian cells

scientific article published on August 1995

GFP tagging reveals human Polo-like kinase 1 at the kinetochore/centromere region of mitotic chromosomes

scientific article published on 01 December 1998

How APC/C-Cdc20 changes its substrate specificity in mitosis

scientific article published on 20 February 2011

How cyclin A destruction escapes the spindle assembly checkpoint

scientific article

Human Mob1 proteins are required for cytokinesis by controlling microtubule stability

scientific article published on 27 March 2012

Human cyclin A is required for mitosis until mid prophase

scientific article published on October 1999

Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1.

scientific article

Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.

scientific article published on 17 June 2002

Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2

scientific article

Localization of cell cycle regulators by immunofluorescence

scientific article published on 01 January 1997

MPF localization is controlled by nuclear export

scientific article

Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation

scientific article

Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex

scientific article

Meeting report: International Symposium on 'Ran and the Cell Cycle', October 2-5, 2005, Awaji Yumebutai, Japan.

scientific article

Mitosis: a matter of getting rid of the right protein at the right time

scientific article

Mitotic regulation of the human anaphase-promoting complex by phosphorylation

scientific article

New approaches to research on mitosis

Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells

scientific article

Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

scientific article

Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis

scientific article published on April 2010

Proteolysis: anytime, any place, anywhere?

scientific article published in August 2005

Quantitative proteomics reveals the basis for the biochemical specificity of the cell-cycle machinery

scientific article published in August 2011

Re-staging mitosis: a contemporary view of mitotic progression

scientific article

Requirement for p34cdc2 kinase is restricted to mitosis in the mammalian cdc2 mutant FT210

scientific article published on June 1992

Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle

scientific article

The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulators

scientific article

The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction

scientific article

The APC/C: a smörgåsbord for proteolysis

scientific article published in April 2009

The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.

scientific article published on 25 November 2016

The Renaissance or the cuckoo clock ⬇️

scientific article published on December 27, 2011

The anaphase promoting complex/cyclosome is recruited to centromeres by the spindle assembly checkpoint.

scientific article published on 22 August 2004

The anaphase-promoting complex/cyclosome: APC/C.

scientific article published on June 2006

The biochemistry of mitosis

scientific article

The centrosome opens the way to mitosis

scientific article

The localization of human cyclins B1 and B2 determines CDK1 substrate specificity and neither enzyme requires MEK to disassemble the Golgi apparatus

scientific journal article

The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C

scientific article published on 12 November 2014

The spindle assembly checkpoint works like a rheostat rather than a toggle switch

scientific article

Torin1-mediated TOR kinase inhibition reduces Wee1 levels and advances mitotic commitment in fission yeast and HeLa cells

scientific article published on 14 January 2014

Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal

scientific article (publication date: July 1999)

UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit

scientific article

UbcH10 has a rate-limiting role in G1 phase but might not act in the spindle checkpoint or as part of an autonomous oscillator.

scientific article

Use of Green Fluorescent Protein in mouse embryos

scientific article

c-mos proto-oncogene product is partly degraded after release from meiotic arrest and persists during interphase in mouse zygotes

scientific article published in November 1991

List of works by Jonathon Noe Joseph Pines

A PP1-PP2A phosphatase relay controls mitotic progression

A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex.

A quantitative protocol for dynamic measurements of protein interactions by Forster resonance energy transfer-sensitized fluorescence emission

A red light in mitosis ⬇️

A single cyclin A gene and multiple cyclin B1-related sequences are dispersed in the mouse genome

APC/C Cdh1 targets aurora kinase to control reorganization of the mitotic spindle at anaphase

APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment

Activation of cyclin B1-Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosis

Active cyclin B1-Cdk1 first appears on centrosomes in prophase

Arresting developments in cell-cycle control

Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A.

Cdc25B and Cdc25C differ markedly in their properties as initiators of mitosis

Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A.

Cell cycle trials in Salamanca: workshop on G2/M progression and associated checkpoints

Cell cycle. Confirmational change.

Cell division, growth and death. Cell growth: live and let die.

Centromere tension: a divisive issue

Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin

Checkpoint on the nuclear frontier

Chfr acts with the p38 stress kinases to block entry to mitosis in mammalian cells

Clear as crystal?

Co-activator independent differences in how the metaphase and anaphase APC/C recognise the same substrate.

Cubism and the cell cycle: the many faces of the APC/C ⬇️

Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm

Cyclin B1 is essential for mitosis in mouse embryos, and its nuclear export sets the time for mitosis

Cyclin synthesis, modification and destruction during meiotic maturation of the starfish oocyte

Cyclin-dependent kinase inhibitors: the age of crystals

Cyclin-dependent kinases: a new cell cycle motif?

Cyclins and cancer

Cyclins and cyclin-dependent kinases: take your partners

Defining the role of Emi1 in the DNA replication-segregation cycle

Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C

Escaping the firing squad: acetylation of BubR1 protects it from degradation in checkpoint cells

Four-dimensional control of the cell cycle

GFP in mammalian cells

GFP tagging reveals human Polo-like kinase 1 at the kinetochore/centromere region of mitotic chromosomes

How APC/C-Cdc20 changes its substrate specificity in mitosis

How cyclin A destruction escapes the spindle assembly checkpoint

Human Mob1 proteins are required for cytokinesis by controlling microtubule stability

Human cyclin A is required for mitosis until mid prophase

Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1.

Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.

Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2

Localization of cell cycle regulators by immunofluorescence

MPF localization is controlled by nuclear export

Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation

Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex

Meeting report: International Symposium on 'Ran and the Cell Cycle', October 2-5, 2005, Awaji Yumebutai, Japan.

Mitosis: a matter of getting rid of the right protein at the right time

Mitotic regulation of the human anaphase-promoting complex by phosphorylation

New approaches to research on mitosis

Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells

Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis

Proteolysis: anytime, any place, anywhere?

Quantitative proteomics reveals the basis for the biochemical specificity of the cell-cycle machinery

Re-staging mitosis: a contemporary view of mitotic progression

Requirement for p34cdc2 kinase is restricted to mitosis in the mammalian cdc2 mutant FT210

Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle

The ABBA motif binds APC/C activators and is shared by APC/C substrates and regulators

The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction

The APC/C: a smörgåsbord for proteolysis

The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.

The Renaissance or the cuckoo clock ⬇️

The anaphase promoting complex/cyclosome is recruited to centromeres by the spindle assembly checkpoint.

The anaphase-promoting complex/cyclosome: APC/C.

The biochemistry of mitosis

The centrosome opens the way to mitosis

The localization of human cyclins B1 and B2 determines CDK1 substrate specificity and neither enzyme requires MEK to disassemble the Golgi apparatus

The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C

The spindle assembly checkpoint works like a rheostat rather than a toggle switch

Torin1-mediated TOR kinase inhibition reduces Wee1 levels and advances mitotic commitment in fission yeast and HeLa cells

Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal

UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit

UbcH10 has a rate-limiting role in G1 phase but might not act in the spindle checkpoint or as part of an autonomous oscillator.

Use of Green Fluorescent Protein in mouse embryos

c-mos proto-oncogene product is partly degraded after release from meiotic arrest and persists during interphase in mouse zygotes