List of works by Leif Østergaard

A MRI-compatible stereotaxic localizer box enables high-precision stereotaxic procedures in pigs.

scientific article published in October 2004

A multicenter, randomized, double-blind, placebo-controlled trial to test efficacy and safety of magnetic resonance imaging-based thrombolysis in wake-up stroke (WAKE-UP).

scientific article published on 12 March 2013

Abnormal Intravoxel Cerebral Blood Flow Heterogeneity in Human Ischemic Stroke Determined by Dynamic Susceptibility Contrast Magnetic Resonance Imaging

scientific article published on 02 December 2004

Absolute cerebral blood flow and blood volume measured by magnetic resonance imaging bolus tracking: comparison with positron emission tomography values

scientific article

Accessing the mental space-Spatial working memory processes for language and vision overlap in precuneus

scientific article

Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors

scientific article

Accuracy and reliability assessment of CT and MR perfusion analysis software using a digital phantom

scientific article

Active surface approach for extraction of the human cerebral cortex from MRI

scientific article published on 01 January 2006

Acute stroke imaging research roadmap

scientific article

Acute stroke: automatic perfusion lesion outlining using level sets

scientific article published on 17 May 2013

An evaluation of the time dependence of the anisotropy of the water diffusion tensor in acute human ischemia.

scientific article

Analysis of partial volume effects on arterial input functions using gradient echo: A simulation study

scientific article published on 01 June 2009

Applying instance-based techniques to prediction of final outcome in acute stroke

scientific article

Assessing response to stroke thrombolysis: validation of 24-hour multimodal magnetic resonance imaging

scientific article

Assessing the outcome of stroke: a comparison between MRI and clinical stroke scales

scientific article published on 01 February 2006

Assessment of baseline hemodynamic parameters within infarct progression areas in acute stroke patients using perfusion-weighted MRI

scientific article published on 27 November 2010

Assessment of ischemic penumbra in patients with hyperacute stroke using amide proton transfer (APT) chemical exchange saturation transfer (CEST) MRI.

scientific article

Assessment of tumor oxygenation and its impact on treatment response in bevacizumab-treated recurrent glioblastoma

scientific article published on 9 February 2016

August Krogh's theory of muscle microvascular control and oxygen delivery: a paradigm shift based on new data

scientific article published on 12 September 2020

August Krogh: Physiology genius and compassionate humanitarian

scientific article published on 27 August 2020

Automated decision-support system for prediction of treatment responders in acute ischemic stroke

scientific article published on 26 September 2013

Automated estimation of salvageable tissue: Comparison with expert readers

scientific article

Automatic selection of arterial input function using cluster analysis.

scientific article published in March 2006

Bayesian estimation of cerebral perfusion using a physiological model of microvasculature

scientific article published on 12 September 2006

Bayesian modeling of Dynamic Contrast Enhanced MRI data in cerebral glioma patients improves the diagnostic quality of hemodynamic parameter maps

scientific article published in PLoS ONE

Bayesian regularization of diffusion tensor images

scientific article

Better Diffusion Segmentation in Acute Ischemic Stroke Through Automatic Tree Learning Anomaly Segmentation.

scientific article

Biased visualization of hypoperfused tissue by computed tomography due to short imaging duration: improved classification by image down-sampling and vascular models

scientific article published on 17 April 2015

CAPILLARY TRANSIT TIME HETEROGENEITY IN THE CEREBRUM CORRELATE WITH COGNITIVE DECLINE IN AD

CT and MR perfusion can discriminate severe cerebral hypoperfusion from perfusion absence: evaluation of different commercial software packages by using digital phantoms

scientific article

Capillary Transit Time Heterogeneity Is Associated with Modified Rankin Scale Score at Discharge in Patients with Bilateral High Grade Internal Carotid Artery Stenosis

scientific article

Capillary dysfunction and impaired tissue oxygenation in complex regional pain syndrome: a hypothesis

scientific article

Capillary dysfunction is associated with symptom severity and neurodegeneration in Alzheimer's disease

scientific article published on 23 March 2017

Capillary dysfunction: its detection and causative role in dementias and stroke

scientific article published on June 2015

Capillary transit time heterogeneity and flow-metabolism coupling after traumatic brain injury

scientific article

Carbogen inhalation increases oxygen transport to hypoperfused brain tissue in patients with occlusive carotid artery disease: increased oxygen transport to hypoperfused brain

scientific article published on 25 September 2009

Cerebral Hemodynamics in a Healthy Population Measured by Dynamic Susceptibility Contrast Mr Imaging

Cerebral blood flow and blood volume measured by magnetic resonance imaging bolus tracking after acute stroke in pigs: comparison with [(15)O]H(2)O positron emission tomography

scientific article published in August 2000

Cerebral blood flow in volunteers measured by PET and Xe CT/CBF. A comparison

scientific article published in February 2000

Cerebral blood flow measurements by magnetic resonance imaging bolus tracking: comparison with [(15)O]H2O positron emission tomography in humans

scientific article

Cerebral blood flow, blood volume, and mean transit time responses to propofol and indomethacin in peritumor and contralateral brain regions: perioperative perfusion-weighted magnetic resonance imaging in patients with brain tumors

scientific article published in January 2010

Cerebral blood flow, blood volume, and oxygen metabolism dynamics in human visual and motor cortex as measured by whole-brain multi-modal magnetic resonance imaging

scientific article published on 5 August 2009

Cerebral hemodynamics in a healthy population measured by dynamic susceptibility contrast MR imaging

scientific article

Cerebral metabolic response to low blood flow: possible role of cytochrome oxidase inhibition

scientific article published in September 2005

Cerebral perfusion imaging by bolus tracking

scientific article

Changes in regional brain volume three months after stroke

scientific article published in August 2012

Characterizing physiological heterogeneity of infarction risk in acute human ischaemic stroke using MRI.

scientific article published on 3 August 2006

Combretastatin A-4 phosphate affects tumor vessel volume and size distribution as assessed using MRI-based vessel size imaging

scientific article

Comparing anesthesia with isoflurane and fentanyl/fluanisone/midazolam in a rat model of cardiac arrest

scientific article

Comparison of 10 perfusion MRI parameters in 97 sub-6-hour stroke patients using voxel-based receiver operating characteristics analysis

scientific article published on 9 April 2009

Comparison of gradient- and spin-echo imaging: CBF, CBV, and MTT measurements by bolus tracking

scientific article published in September 2000

Concrete spatial language: see what I mean?

scientific article published on March 2005

Contrast agents in functional MR imaging

scientific article published on January 1997

Correlation between Diffusion- and Perfusion-Weighted MRI and Neurological Deficit Measured by the Scandinavian Stroke Scale and Barthel Index in Hyperacute Subcortical Stroke (≤6 Hours)

scientific article published on 01 January 2001

Correlations between Stroop task performance and white matter lesion measures in late-onset major depression

scientific article published on May 2012

Cortical capillary dysfunction in patients suspected of Alzheimer’s disease

Cortical spreading depolarizations in the postresuscitation period in a cardiac arrest male rat model

scientific article published on 15 February 2017

Depression severity is correlated to the integrity of white matter fiber tracts in late-onset major depression

scientific article published on 15 September 2010

Diffusion MRI findings in patients with extensive and minimal post-concussion symptoms after mTBI and healthy controls: a cross sectional study

scientific article

Diffusion and perfusion MR imaging in acute ischemic stroke: a comparison to SPECT.

scientific article published in July 2001

Distinct neural responses to chord violations: a multiple source analysis study

scientific article

Disturbances in the control of capillary flow in an aged APPswe/PS1ΔE9 model of Alzheimer's disease

scientific article published on 16 October 2017

Do indomethacin and propofol cause cerebral ischemic damage? Diffusion-weighted magnetic resonance imaging in patients undergoing craniotomy for brain tumors

scientific article published in October 2004

Dynamic changes in corticospinal tracts after stroke detected by fibretracking

scientific article

Dynamic changes of CBF, CMRO2, OEF, CMRglc, CBV and ADC during neuronal suppression due to hypothermia

Early changes measured by magnetic resonance imaging in cerebral blood flow, blood volume, and blood-brain barrier permeability following dexamethasone treatment in patients with brain tumors

scientific article

Effect of electrical forepaw stimulation on capillary transit-time heterogeneity (CTH).

scientific article published on 8 February 2016

Effect of hypnotic pain modulation on brain activity in patients with temporomandibular disorder pain.

scientific article published on 8 October 2010

Effect of impermeable boundaries on diffusion-attenuated MR signal

scientific article published on 10 January 2006

Effect of impermeable interfaces on apparent diffusion coefficient in heterogeneous media

Effects of tracer arrival time on flow estimates in MR perfusion-weighted imaging

scientific article published in October 2003

Elevated T2-values in MRI of stroke patients shortly after symptom onset do not predict irreversible tissue infarction

scientific article

Evaluation of four postprocessing methods for determination of cerebral blood volume and mean transit time by dynamic susceptibility contrast imaging

scientific article published on 01 May 2002

FDOPA metabolism in the adult porcine brain: influence of tracer circulation time and VOI selection on estimates of striatal DOPA decarboxylation

scientific article

Feasibility and logistics of MRI before thrombolytic treatment

scientific article published on 01 September 2009

Final infarct size after acute stroke: prediction with flow heterogeneity

scientific article published in October 2002

GABA levels are decreased after stroke and GABA changes during rehabilitation correlate with motor improvement

scientific article

High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part I: Mathematical approach and statistical analysis

scientific article

High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part II: Experimental comparison and preliminary results

scientific article

Hippocampal Atrophy Following Subarachnoid Hemorrhage Correlates with Disruption of Astrocyte Morphology and Capillary Coverage by AQP4.

scientific article published on 31 January 2018

How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET.

scientific article published on 7 February 2008

Improvement of brain tissue oxygenation by inhalation of carbogen

scientific article

In vivo estimation of cerebral blood flow, oxygen consumption and glucose metabolism in the pig by [15O]water injection, [15O]oxygen inhalation and dual injections of [18F]fluorodeoxyglucose.

scientific article

Increased cortical capillary transit time heterogeneity in Alzheimer's disease: a DSC-MRI perfusion study

scientific article published on 19 November 2016

Increased oxygen extraction capacity in the basal ganglia and thalamus of people with Alzheimer's disease

Infarct prediction and treatment assessment with MRI-based algorithms in experimental stroke models

scientific article

Infarction of ‘non-core–non-penumbral’ tissue after stroke: multivariate modelling of clinical impact

scientific article published on 01 June 2011

Inferring origin of vascular supply from tracer arrival timing patterns using bolus tracking MRI.

scientific article

Influence of stroke infarct location on functional outcome measured by the modified rankin scale

scientific article published on 29 April 2014

Interrater agreement for final infarct MRI lesion delineation

scientific article published on 24 September 2009

Intravascular contrast agent-enhanced MRI measuring contrast clearance and tumor blood volume and the effects of vascular modifiers in an experimental tumor

scientific article

Ischemic injury detected by diffusion imaging 11 minutes after stroke

scientific article published in September 2005

It don't mean a thing... Keeping the rhythm during polyrhythmic tension, activates language areas (BA47)

scientific article

Letter to the Editor: A rejoinder to Grool et al. (2010).

scientific article published on 24 August 2010

Localization of white-matter lesions and effect of vascular risk factors in late-onset major depression.

scientific article published on 9 November 2009

MR perfusion studies with T1-weighted echo planar imaging.

scientific article

MRI Assessment of Ischemic Lesion Evolution within White and Gray Matter

scientific article published on 12 February 2016

MRI detection of early blood-brain barrier disruption: parenchymal enhancement predicts focal hemorrhagic transformation after thrombolysis

scientific article published on 7 February 2008

Magnetic resonance imaging criteria for thrombolysis in acute cerebral infarct.

scientific article

Making sense: Dopamine activates conscious self-monitoring through medial prefrontal cortex

scientific article published on 27 January 2015

Microstructural changes in ischemic cortical gray matter predicted by a model of diffusion-weighted MRI.

scientific article

Microstructural changes in the thalamus after mild traumatic brain injury: A longitudinal diffusion and mean kurtosis tensor MRI study

scientific article published on 5 January 2017

Model-based inference from microvascular measurements: Combining experimental measurements and model predictions using a Bayesian probabilistic approach

scientific article published on 17 December 2016

Modeling dendrite density from magnetic resonance diffusion measurements.

scientific article

Motion verb sentences activate left posterior middle temporal cortex despite static context

scientific article published on April 2005

NC100150-enhanced 3D-SPGR MR angiography of the common carotid artery in a pig vascular stenosis model. Quantification of stenosis and dose optimization

scientific article published on May 1999

Neurite density from magnetic resonance diffusion measurements at ultrahigh field: comparison with light microscopy and electron microscopy

scientific article

Neuroplasticity in Constraint-Induced Movement Therapy

Neurovascular coupling during cortical spreading depolarization and -depression

scientific article published on 16 April 2015

Non-invasive imaging of combretastatin activity in two tumor models: Association with invasive estimates

scientific article published on October 2010

Noninvasive Characterization of Tumor Angiogenesis and Oxygenation in Bevacizumab-treated Recurrent Glioblastoma by Using Dynamic Susceptibility MRI: Secondary Analysis of the European Organization for Research and Treatment of Cancer 26101 Trial

scientific article published on 28 July 2020

Noninvasive assessment of isocitrate dehydrogenase mutation status in cerebral gliomas by magnetic resonance spectroscopy in a clinical setting

scientific article published on 3 March 2017

Perfusion MRI derived indices of microvascular shunting and flow control correlate with tumor grade and outcome in patients with cerebral glioma

scientific article

Perfusion magnetic resonance imaging: a comprehensive update on principles and techniques

scientific article

Perfusion-Weighted MRI in Human Acute Ischemic Stroke

scientific article published on 01 May 2002

Preclinical studies to predict efficacy of vascular changes induced by combretastatin a-4 disodium phosphate in patients

scientific article published on 31 December 2007

Predicting infarction within the diffusion-weighted imaging lesion: does the mean transit time have added value?

scientific article published on 21 April 2011

Predicting tissue outcome from acute stroke magnetic resonance imaging: improving model performance by optimal sampling of training data

scientific article

Predicting tissue outcome in acute human cerebral ischemia using combined diffusion- and perfusion-weighted MR imaging

scientific article published in April 2001

Predicting tissue outcome in stroke: new approaches

scientific article published on February 2009

Prediction of tissue survival after middle cerebral artery occlusion based on changes in the apparent diffusion of water

scientific article

Prediction of tissue survival after stroke based on changes in the apparent diffusion of water (cytotoxic edema).

scientific article

Predictive coding of music--brain responses to rhythmic incongruity.

scientific article

Preserved Cerebral Microcirculation After Cardiac Arrest in a Rat Model

scientific article

Presymptomatic cerebral blood flow changes in CHMP2B mutation carriers of familial frontotemporal dementia (FTD-3), measured with MRI.

scientific article published on 15 March 2012

Presymptomatic generalized brain atrophy in frontotemporal dementia caused by CHMP2B mutation

scientific article published on 7 February 2009

Principles of cerebral perfusion imaging by bolus tracking

scientific article published in December 2005

Pulmonary function affects the quantification of rCBF by non-invasive xenon methods.

scientific article published in February 2000

Quantitative cerebral perfusion using the PRESTO acquisition scheme

scientific article published on 01 December 2004

Quantitative measurements of cerebral blood flow in patients with unilateral carotid artery occlusion: a PET and MR study

scientific article

Quantitative perfusion imaging in carotid artery stenosis using dynamic susceptibility contrast-enhanced magnetic resonance imaging

scientific article published on 01 January 2000

Quantitative t2 values predict time from symptom onset in acute stroke patients

scientific article

Radiation administered as a large single dose or in a fractionated schedule: Role of the tumour vasculature as a target for influencing response.

scientific article published in January 2006

Recurrent activity in higher order, modality non-specific brain regions: a Granger causality analysis of autobiographic memory retrieval

scientific article

Reduced cerebral cortical thickness in Non-cirrhotic patients with hepatitis C.

scientific article published on 3 November 2015

Regional Cerebral Blood Flow Distributions in Normal Volunteers: Dynamic Susceptibility Contrast MRI Compared with 99mTc-HMPAO SPECT

scientific article published on 01 July 2000

Relationship between residual cerebral blood flow and oxygen metabolism as predictive of ischemic tissue viability: sequential multitracer positron emission tomography scanning of middle cerebral artery occlusion during the critical first 6 hours aft

scientific article published on 01 October 2000

Reliable estimation of capillary transit time distributions using DSC-MRI

scientific article

Reliable estimation of microvascular flow patterns in patients with disrupted blood-brain barrier using dynamic susceptibility contrast MRI.

scientific article published on 30 November 2016

Remote ischemic perconditioning as an adjunct therapy to thrombolysis in patients with acute ischemic stroke: a randomized trial

scientific article

Remote ischemic perconditioning in thrombolysed stroke patients: randomized study of activating endogenous neuroprotection - design and MRI measurements.

scientific article published on 30 March 2012

Reperfusion within 6 hours outperforms recanalization in predicting penumbra salvage, lesion growth, final infarct, and clinical outcome

scientific article published on 23 April 2015

Safety and efficacy of MRI-based selection for recombinant tissue plasminogen activator treatment: responder analysis of outcome in the 3-hour time window.

scientific article

Schwann cell interactions with axons and microvessels in diabetic neuropathy

scientific article

Segmentation of dynamic contrast enhanced magnetic resonance imaging data

scientific article

Size-Dependent Accumulation of PEGylated Silane-Coated Magnetic Iron Oxide Nanoparticles in Murine Tumors

scientific article published on 2 July 2009

Spatial distribution of malignant tissue in gliomas: correlations of 11C-L-methionine positron emission tomography and perfusion- and diffusion-weighted magnetic resonance imaging

scientific article published on 30 September 2014

Spatially regularized mixture model for lesion segmentation with application to stroke patients

scientific article

Statistical mapping of effects of middle cerebral artery occlusion (MCAO) on blood flow and oxygen consumption in porcine brain

scientific article published on 28 November 2006

Stroke infarct volume estimation in fixed tissue: Comparison of diffusion kurtosis imaging to diffusion weighted imaging and histology in a rodent MCAO model.

scientific article published on 26 April 2018

Superior analgesic effect of an active distraction versus pleasant unfamiliar sounds and music: the influence of emotion and cognitive style

scientific article

Susceptibility of Tmax to tracer delay on perfusion analysis: quantitative evaluation of various deconvolution algorithms using digital phantoms

scientific article

Tapping polyrhythms in music activates language areas

scientific article

Technical aspects of perfusion-weighted imaging

scientific article

The Effects of Capillary Transit Time Heterogeneity (CTH) on the Cerebral Uptake of Glucose and Glucose Analogs: Application to FDG and Comparison to Oxygen Uptake

scientific article published on 13 October 2016

The capillary dysfunction hypothesis of Alzheimer's disease

scientific article published on 18 October 2012

The effect of impermeable boundaries of arbitrary geometry on the apparent diffusion coefficient

scientific article

The effects of capillary dysfunction on oxygen and glucose extraction in diabetic neuropathy

scientific article

The effects of capillary transit time heterogeneity (CTH) on brain oxygenation

scientific article published on 11 February 2015

The effects of hypercapnia on cortical capillary transit time heterogeneity (CTH) in anesthetized mice

scientific article

The effects of transit time heterogeneity on brain oxygenation during rest and functional activation

scientific article

The impact of susceptibility gradients on cartesian and spiral EPI for BOLD fMRI.

scientific article published on 6 July 2006

The physiological significance of the time-to-maximum (Tmax) parameter in perfusion MRI.

scientific article published on 22 April 2010

The relationship between tumor blood flow, angiogenesis, tumor hypoxia, and aerobic glycolysis

scientific article published on 13 June 2013

The role of capillary transit time heterogeneity in myocardial oxygenation and ischemic heart disease

scientific article

The role of the cerebral capillaries in acute ischemic stroke: the extended penumbra model

scientific article published on 27 February 2013

The role of the microcirculation in delayed cerebral ischemia and chronic degenerative changes after subarachnoid hemorrhage.

scientific article published on 25 September 2013

The roles of cerebral blood flow, capillary transit time heterogeneity, and oxygen tension in brain oxygenation and metabolism

scientific article published on 2 November 2011

Theophylline as an add-on to thrombolytic therapy in acute ischaemic stroke (TEA-Stroke): A randomized, double-blinded, placebo-controlled, two-centre phase II study

scientific article published on 14 October 2016

Theoretical model of intravascular paramagnetic tracers effect on tissue relaxation

scientific article published in July 2006

Theory of susceptibility-induced transverse relaxation in the capillary network in the diffusion narrowing regime

scientific article published in March 2005

Time evolution of cerebral perfusion and apparent diffusion coefficient measured by magnetic resonance imaging in a porcine stroke model

scientific article published on 01 February 2002

Tissue viability assessed by MRI

To musicians, the message is in the meter pre-attentive neuronal responses to incongruent rhythm are left-lateralized in musicians.

scientific article

Total mismatch: negative diffusion-weighted imaging but extensive perfusion defect in acute stroke.

scientific article published on 20 August 2009

Tracer arrival timing-insensitive technique for estimating flow in MR perfusion-weighted imaging using singular value decomposition with a block-circulant deconvolution matrix

scientific article published in July 2003

Ultra-high field 1H magnetic resonance imaging approaches for acute hypoxia.

scientific article published on 30 August 2013

Upgraded acute stroke care including thrombolysis is associated with reduced length of hospital stay among non-stroke patients.

scientific article

Validity of shape as a predictive biomarker of final infarct volume in acute ischemic stroke

scientific article

Very Low Cerebral Blood Volume Predicts Parenchymal Hematoma in Acute Ischemic Stroke

scientific article published on 30 May 2013

Visualization of altered neurovascular coupling in chronic stroke patients using multimodal functional MRI.

scientific article

White matter biomarkers from fast protocols using axially symmetric diffusion kurtosis imaging

scientific article published on 22 May 2017

Xenon CT cerebral blood flow in patients with head injury: influence of pulmonary trauma on the input function

scientific article published in March 2000

[14C]Serotonin uptake and [O-methyl-11C]venlafaxine kinetics in porcine brain

scientific article

[24-hour nonstop research training course].

scientific article published in October 2008

[Imaging of the pathophysiology in acute stroke].

scientific article

[Thrombolysis of apoplexy patients. A year's experience and results in Aarhus Hospital].

scientific article published in June 2006

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