List of works - Craig M. Crews

Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation

scientific article published on 28 November 2018

Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance

scientific article published on 02 August 2018

Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation.

scientific article published on 2 August 2017

Catalytic in vivo protein knockdown by small-molecule PROTACs.

scientific article

Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase

scientific article published in Nature Communications

Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion

scientific article published on 19 November 2018

Evolving Rules for Protein Degradation? Insights from the Zinc Finger Degrome

scientific article published on 25 January 2019

Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1.

scientific article

Inducing Protein Degradation as a Therapeutic Strategy

scientific article published on 22 November 2017

Lineage tracing of genome-edited alleles reveals high fidelity axolotl limb regeneration

scientific article published on 16 September 2017

MDM2-recruiting PROTAC Offers Superior, Synergistic Anti-proliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53

scientific article published on 01 November 2018

Multiplex CRISPR/Cas screen in regenerating haploid limbs of chimeric Axolotls

scientific article published on 28 January 2020

Pharmacological targeting of the pseudokinase Her3

scientific article

Protein targeting chimeric molecules specific for bromodomain and extra-terminal motif family proteins are active against pre-clinical models of multiple myeloma

scientific article published on 27 March 2018

Proteolysis-Targeting Chimeras: Induced Protein Degradation as a Therapeutic Strategy.

scientific article published on 6 March 2017

RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1

scientific article published on 25 April 2019

Small-Molecule Modulation of Protein Homeostasis.

scientific article published on 4 August 2017

Targeted protein degradation: expanding the toolbox

scientific article published on 30 October 2019

Targeted protein destabilization reveals an estrogen-mediated ER stress response

scientific article

Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation

scientific article published on 16 July 2019

Targeting nuclear β-catenin as therapy for post-myeloproliferative neoplasm secondary AML

scientific article published on 21 December 2018

Waste disposal-An attractive strategy for cancer therapy.

scientific article

List of works by Craig M. Crews

Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation

Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance

Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation.

Catalytic in vivo protein knockdown by small-molecule PROTACs.

Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase

Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion

Evolving Rules for Protein Degradation? Insights from the Zinc Finger Degrome

Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1.

Inducing Protein Degradation as a Therapeutic Strategy

Lineage tracing of genome-edited alleles reveals high fidelity axolotl limb regeneration

MDM2-recruiting PROTAC Offers Superior, Synergistic Anti-proliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53

Multiplex CRISPR/Cas screen in regenerating haploid limbs of chimeric Axolotls

Pharmacological targeting of the pseudokinase Her3

Protein targeting chimeric molecules specific for bromodomain and extra-terminal motif family proteins are active against pre-clinical models of multiple myeloma

Proteolysis-Targeting Chimeras: Induced Protein Degradation as a Therapeutic Strategy.

RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1

Small-Molecule Modulation of Protein Homeostasis.

Targeted protein degradation: expanding the toolbox

Targeted protein destabilization reveals an estrogen-mediated ER stress response

Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation

Targeting nuclear β-catenin as therapy for post-myeloproliferative neoplasm secondary AML

Waste disposal-An attractive strategy for cancer therapy.