Search filters

List of works by Antony Giuseppe Galione

'Click cyclic ADP-ribose': a neutral second messenger mimic

scientific article

2'-deoxy cyclic adenosine 5'-diphosphate ribose derivatives: importance of the 2'-hydroxyl motif for the antagonistic activity of 8-substituted cADPR derivatives

scientific article

7-Deaza cyclic adenosine 5'-diphosphate ribose: first example of a Ca(2+)-mobilizing partial agonist related to cyclic adenosine 5'-diphosphate ribose

scientific article published in January 1997

7-Deaza-8-bromo-cyclic ADP-ribose, the First Membrane-permeant, Hydrolysis-resistant Cyclic ADP-ribose Antagonist

scientific article published in Journal of Biological Chemistry

A cADP-ribose antagonist does not inhibit secretagogue-, caffeine- and nitric oxide-induced Ca2+ responses in rat pancreatic beta-cells

scientific article published on 01 November 1995

A multiscale analysis in CD38-/- mice unveils major prefrontal cortex dysfunctions

scientific article published on 07 March 2019

A pivotal role for cADPR-mediated Ca2+ signaling: regulation of endothelin-induced contraction in peritubular smooth muscle cells

scientific article published in May 2002

A primer of NAADP-mediated Ca(2+) signalling: From sea urchin eggs to mammalian cells

scientific article

A specific cyclic ADP-ribose antagonist inhibits cardiac excitation-contraction coupling

scientific article published on 01 August 1996

ADP-ribose gates the fertilization channel in ascidian oocytes.

scientific article published in November 1998

AMP-activated protein kinase couples mitochondrial inhibition by hypoxia to cell-specific Ca2+ signalling mechanisms in oxygen-sensing cells.

scientific article

Acidic NAADP-sensitive calcium stores in the endothelium: agonist-specific recruitment and role in regulating blood pressure

scientific article

Activation of Ca(2+)-dependent currents in cultured rat dorsal root ganglion neurones by a sperm factor and cyclic ADP-ribose ⬇️

scientific article published on December 1, 1992

Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice

scientific article published on 09 April 2021

Adp-ribosyl cyclase and cyclic ADP-ribose hydrolase act as a redox sensor. a primary role for cyclic ADP-ribose in hypoxic pulmonary vasoconstriction

scientific article

Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization from Acidic Stores in Pancreatic α-Cells.

scientific article published on 21 March 2018

Altered distribution and function of natural killer cells in murine and human Niemann-Pick disease type C1.

scientific article

An N-terminal dileucine motif directs two-pore channels to the tonoplast of plant cells

scientific article

An antagonist of cADP-ribose inhibits arrhythmogenic oscillations of intracellular Ca2+ in heart cells

scientific article published on 01 June 1999

An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell

scientific article published on September 2010

Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor

scientific article published on 13 October 2009

Anti-Ig-induced calcium influx in rat B lymphocytes mediated by cGMP through a dihydropyridine-sensitive channel

scientific article published on 01 March 1996

Aplysia californica mediated cyclisation of novel 3'-modified NAD+ analogues: a role for hydrogen bonding in the recognition of cyclic adenosine 5'-diphosphate ribose

scientific article

Bidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organelles

scientific article

Ca(2+) signaling occurs via second messenger release from intraorganelle synthesis sites

scientific article published on October 2008

Ca(2+)-induced Ca2+ release and its modulation by cyclic ADP-ribose

scientific article published on 01 August 1992

Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor

scientific article

Ca2+ release induced by cyclic ADP ribose in mice lacking type 3 ryanodine receptor

scientific article published in November 2001

Ca2+ release induced by cyclic ADP-ribose

scientific article published on 01 December 1994

Ca2+ release via two-pore channel type 2 (TPC2) is required for slow muscle cell myofibrillogenesis and myotomal patterning in intact zebrafish embryos.

scientific article published on 5 April 2017

Calcium signaling via two-pore channels: local or global, that is the question

scientific article

Calcium signalling by nicotinic acid adenine dinucleotide phosphate (NAADP).

scientific article

Calcium store depletion potentiates a phosphodiesterase inhibitor- and dibutyryl cGMP-evoked calcium influx in rat pituitary GH3 cells.

scientific article published on May 1996

Calmodulin dissociation mediates desensitization of the cADPR-induced Ca2+ release mechanism

scientific article published in December 2002

Carvedilol inhibits cADPR- and IP3-induced Ca2+ release.

scientific article published on June 2016

Cell-permeant NAADP: a novel chemical tool enabling the study of Ca2+ signalling in intact cells

scientific article

Cell-permeant small-molecule modulators of NAADP-mediated Ca2+ release

scientific article published on 01 June 2006

Characterization of ADP-ribosyl cyclase 1-like (ARC1-like) activity and NAADP signaling during slow muscle cell development in zebrafish embryos

scientific article published on 14 November 2018

Chemical synthesis of the novel Ca2+ messenger NAADP

scientific article published on 01 January 2005

Chemical synthesis of the second messenger nicotinic acid adenine dinucleotide phosphate by total synthesis of nicotinamide adenine dinucleotide phosphate

scientific article published on 01 September 2004

Chemo-enzymatic synthesis and biological evaluation of photolabile nicotinic acid adenine dinuclotide phosphate (NAADP+).

scientific article published on 11 December 2006

Convergent synthesis and unexpected Ca(2+)-mobilizing activity of 8-substituted analogues of cyclic ADP-carbocyclic-ribose, a stable mimic of the Ca(2+)-mobilizing second messenger cyclic ADP-ribose

scientific article published in October 2003

Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells

scientific article (publication date: 4 March 1999)

Cyclic ADP-ribose and the regulation of calcium-induced calcium release in eggs and cardiac myocytes.

scientific article published on January 1998

Cyclic ADP-ribose: a new way to control calcium.

scientific article

Cyclic ADP-ribose: metabolism and calcium mobilizing function

scientific article published on 01 January 1994

Cyclic aristeromycin diphosphate ribose: a potent and poorly hydrolysable Ca(2+)-mobilising mimic of cyclic adenosine diphosphate ribose

scientific article published on 01 February 1996

Cytolytic granules supply Ca(2+) for their own exocytosis via NAADP and resident two-pore channels

scientific article

Development of inositol-based antagonists for thed-myo-inositol 1,4,5-trisphosphate receptor

scientific article published in 2011

Diabetes mellitus as a predictor for radial artery vasoreactivity in patients undergoing coronary artery bypass grafting

scientific article published on 24 August 2007

Differential regulation of nicotinic acid-adenine dinucleotide phosphate and cADP-ribose production by cAMP and cGMP

scientific article

Distinct pharmacology of 2-hydroxycarbazole-induced Ca2+ release in the sea urchin egg.

scientific article published in August 2001

Dual effects of cyclic ADP-ribose on sarcoplasmic reticulum Ca2+ release and storage in cardiac myocytes isolated from guinea-pig and rat ventricle

scientific article published on 5 December 2006

Ebolavirus Glycoprotein Directs Fusion through NPC1+ Endolysosomes

scientific article

Effects of glyburide-cyclosporin A interaction on interleukin-2 production in rats

scientific article published on 01 August 1999

Effects of photoreleased cADP-ribose on calcium transients and calcium sparks in myocytes isolated from guinea-pig and rat ventricle

scientific article published in September 1999

Endogenously bound calmodulin is essential for the function of the inositol 1,4,5-trisphosphate receptor

scientific article published on 12 January 2006

Evidence of a role for cyclic ADP-ribose in long-term synaptic depression in hippocampus

scientific journal article

Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells

scientific article

Fertilization and nicotinic acid adenine dinucleotide phosphate induce pH changes in acidic Ca(2+) stores in sea urchin eggs

scientific article

Flipping the switch: how a sperm activates the egg at fertilization

scientific article

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation

scientific article

Hax-1 identified as a two-pore channel (TPC)-binding protein

scientific article

High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart

scientific article

Hippocampal mGluR1-dependent long-term potentiation requires NAADP-mediated acidic store Ca2+ signaling

scientific article published on 27 November 2018

Identification of a chemical probe for NAADP by virtual screening

scientific article

Identification of a novel gene for diabetic traits in rats, mice, and humans

scientific article

Imaging approaches to measuring lysosomal calcium

scientific article published on 19 January 2015

Increased lipoprotein (a) levels in subjects with chronic renal failure on hemodialysis

scientific article published on 01 January 1992

Induction of hippocampal LTD requires nitric-oxide-stimulated PKG activity and Ca2+ release from cyclic ADP-ribose-sensitive stores

scientific article

Influence of haemodialysis on lipase activity

scientific article published on 01 March 1997

Inhibition of cADPR-Hydrolase by ADP-ribose potentiates cADPR synthesis from beta-NAD+

scientific article published on 01 June 1996

Interactions between calcium release pathways: multiple messengers and multiple stores.

scientific article

Intracellular sphingosine releases calcium from lysosomes

scientific article published on 27 November 2015

Investigating cADPR and NAADP in intact and broken cell preparations

scientific article published on 11 October 2008

Ionophore-Induced Calcium Waves Activate Unfertilized Zebrafish (Dank rerio) Eggs

scientific article published in October 1996

Kinetic properties of nicotinic acid adenine dinucleotide phosphate-induced Ca2+ release

scientific article published on 01 March 1997

Lipoprotein (a) levels in end-stage renal failure and renal transplantation

scientific article published on 01 January 1993

Lithium-induced decrease in spontaneous Ca2+ oscillations in single GH3 rat pituitary cells

scientific article published on June 1994

Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes

scientific article published on 18 October 2011

Lysosomal agents inhibit store-operated Ca<sup>2+</sup> entry

scientific article published on 16 December 2020

Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling

scientific article

Lysosome-sarcoplasmic reticulum junctions. A trigger zone for calcium signaling by nicotinic acid adenine dinucleotide phosphate and endothelin-1.

scientific article

Measurement of luminal pH of acidic stores as a readout for NAADP action

scientific article published on 01 October 2014

Mechanically Induced Calcium Release From Xenopus Cell Cycle Extracts

scientific article published on 01 October 1993

Mechanistic convergence and shared therapeutic targets in Niemann-Pick disease

scientific article published on 09 November 2019

Metabolism of the novel Ca2+-mobilizing messenger nicotinic acid-adenine dinucleotide phosphate via a 2'-specific Ca2+-dependent phosphatase

scientific article

Modulation of Xenopus embryo mesoderm-specific gene expression and dorsoanterior patterning by receptors that activate the phosphatidylinositol cycle signal transduction pathway.

scientific article published in July 1996

Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease

scientific article

NAADP Receptors

scientific article published on 01 November 2019

NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing

scientific article published on 21 November 2012

NAADP as a second messenger: neither CD38 nor base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cells

scientific article

NAADP as an intracellular messenger regulating lysosomal calcium-release channels

scientific article published on 01 December 2010

NAADP controls cross-talk between distinct Ca2+ stores in the heart

scientific article published on 26 March 2007

NAADP induces Ca2+ oscillations via a two-pool mechanism by priming IP3- and cADPR-sensitive Ca2+ stores

scientific article published in June 2001

NAADP induces pH changes in the lumen of acidic Ca2+ stores

scientific article

NAADP influences excitation-contraction coupling by releasing calcium from lysosomes in atrial myocytes

scientific article published on 8 September 2011

NAADP links histamine H1 receptors to secretion of von Willebrand factor in human endothelial cells

scientific article published on March 2011

NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs

scientific article (publication date: 27 November 2002)

NAADP mobilizes calcium from acidic organelles through two-pore channels

scientific article

NAADP receptors

scientific article

NAADP receptors

scientific article published on 01 September 2005

NAADP-induced calcium release in sea urchin eggs

scientific article

NAADP-mediated channel 'chatter' in neurons of the rat medulla oblongata

scientific article

NAADP-regulated two-pore channels drive phagocytosis through endo-lysosomal Ca2+ nanodomains, calcineurin and dynamin

scientific article published on 08 June 2020

NAADP: a new second messenger for glucose-induced Ca2+ responses in clonal pancreatic beta cells

scientific article published on February 2003

Nicotinamide inhibits cyclic ADP-ribose-mediated calcium signalling in sea urchin eggs.

scientific article published on October 1996

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.

scientific article

Nicotinic acid adenine dinucleotide phosphate mediates Ca2+ signals and contraction in arterial smooth muscle via a two-pool mechanism

scientific article published in December 2002

Nicotinic acid adenine dinucleotide phosphate regulates skeletal muscle differentiation via action at two-pore channels

scientific article

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

scientific article

Nitric oxide gates fertilization channels in ascidian oocytes through nicotinamide nucleotide metabolism.

scientific article published in October 1997

Nitric oxide induces intracellular Ca2+ mobilization and increases secretion of incorporated 5-hydroxytryptamine in rat pancreatic beta-cells

scientific article published on 01 September 1995

Nitric oxide-induced mobilization of intracellular calcium via the cyclic ADP-ribose signaling pathway

scientific article published on 01 February 1996

Optogenetic Control of Heart Rhythm by Selective Stimulation of Cardiomyocytes Derived from Pnmt+ Cells in Murine Heart

scientific article

Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells

scientific article published on 2 December 2003

Pancreatic enzymes in chronic renal failure and transplant patients

scientific article published on 01 December 1992

Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway

scientific article

Pharmacological characterization of the putative cADP-ribose receptor

scientific article

Pharmacological properties of the Ca2+-release mechanism sensitive to NAADP in the sea urchin egg

scientific article

Phospholipase C-dependent Ca2+ release by worm and mammal sperm factors

scientific article published in July 2003

Photoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin egg

scientific article

Physiological roles of NAADP-mediated Ca2+ signaling

scientific article published on 24 July 2011

Potentiation of cADPR-induced Ca(2+)-release by methylxanthine analogues

scientific article published on 01 July 1999

Preferential Coupling of the NAADP Pathway to Exocytosis in T-Cells.

scientific article published on June 2015

Preparation and use of sea urchin egg homogenates

scientific article published on 01 January 2014

Preparation and use of sea urchin egg homogenates for studying NAADP-mediated Ca²⁺ release

scientific article published on 02 September 2014

Psammechinus miliaris egg homogenate as a model to investigate Ca2+-release mechanisms

article by Armando A. Genazzani et al published April 1999 in Journal of the Marine Biological Association of the United Kingdom

Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking

scientific article

Pyridine nucleotide metabolites and calcium release from intracellular stores

scientific article published on January 2012

Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+

scientific article (publication date: 20 May 2014)

Redundant mechanisms of calcium-induced calcium release underlying calcium waves during fertilization of sea urchin eggs

scientific article published on 01 July 1993

Refinement of a radioreceptor binding assay for nicotinic acid adenine dinucleotide phosphate

scientific article published on September 2007

Regenerative and non-regenerative calcium transients in hamster eggs triggered by inositol 1,4,5-trisphosphate

scientific article published on 01 November 1994

Reply to "TPC1 Knockout Knocks Out TPC1"

scientific article published on May 2015

Response

scientific article published on 01 October 1993

Revealing the secrets of secretion

Rifampicin reduces nephrotoxicity of cyclosporine A in rats: studies of renal enzyme excretion

scientific article published on 01 April 1988

Role of NAADP and cADPR in the induction and maintenance of agonist-evoked Ca2+ spiking in mouse pancreatic acinar cells

scientific article

Roles for adenosine ribose hydroxyl groups in cyclic adenosine 5'-diphosphate ribose-mediated Ca2+ release

scientific article published on 01 August 1997

Serum apolipoprotein profile of hypertriglyceridemic patients with chronic renal failure on hemodialysis: a comparison with type IV hyperlipoproteinemic patients

scientific article published on 01 July 1989

Solubilization of receptors for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate

scientific article

Spatial control of Ca2+ signaling by nicotinic acid adenine dinucleotide phosphate diffusion and gradients

scientific article (publication date: 8 December 2000)

Sperm deliver a new second messenger: NAADP

scientific article (publication date: 21 January 2003)

Sperm express a Ca2+-regulated NAADP synthase

scientific article

Synthesis of NAADP-AM as a membrane-permeant NAADP analog

scientific article published on 01 October 2014

Synthesis of [³²P]NAADP for the radioreceptor binding assay

scientific article published on 02 September 2014

Synthesis of caged NAADP

scientific article published on 01 October 2014

Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor

scientific article published on 25 October 2010

Synthesis of the Ca2+-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling

scientific article published on 24 May 2017

TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2.

scientific article

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+

scientific article

TPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)- and agonist-evoked contractions of smooth muscle

scientific journal article

TPC2-mediated Ca2+ signaling is required for the establishment of synchronized activity in developing zebrafish primary motor neurons

scientific article published on 22 March 2018

TPC: the NAADP discovery channel?

scientific article

TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP

scientific article

The NAADP receptor: new receptors or new regulation?

scientific article

The NO pathway acts late during the fertilization response in sea urchin eggs

scientific article published on 22 January 2003

The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels

scientific article published on 28 May 2009

The calcium-mobilizing messenger nicotinic acid adenine dinucleotide phosphate participates in sperm activation by mediating the acrosome reaction

scientific article

The ecto-enzyme CD38 is a nicotinic acid adenine dinucleotide phosphate (NAADP) synthase that couples receptor activation to Ca2+ mobilization from lysosomes in pancreatic acinar cells

scientific article

The endoplasmic reticulum and junctional membrane communication during calcium signaling.

scientific article published on 13 June 2013

The luminal Ca(2+) chelator, TPEN, inhibits NAADP-induced Ca(2+) release

scientific article published on 23 October 2012

The relative order of IP3 sensitivity of types 1 and 3 IP3 receptors is pH dependent.

scientific article published on July 1999

The role of calcium and nicotinic acid adenine dinucleotide phosphate (NAADP) in human osteoclast formation and resorption

scientific article published on 30 November 2014

The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca²⁺ dynamics and insulin secretion

scientific article published on 23 December 2015

Transformation of local Ca2+ spikes to global Ca2+ transients: the combinatorial roles of multiple Ca2+ releasing messengers

scientific article published on March 2002

Two neuropeptides recruit different messenger pathways to evoke Ca2+ signals in the same cell

scientific article published on 01 August 2000

Two-Pore Channel 2 activity is required for slow muscle cell-generated Ca(2+) signaling during myogenesis in intact zebrafish.

scientific article published in January 2015

Two-Pore Channels: Lessons from Mutant Mouse Models

scientific article

Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart

scientific article published on 5 October 2015

Two-pore channels (TPCs): current controversies

scientific article

Two-pore channels for integrative Ca signaling.

scientific article

Two-pore channels form homo- and heterodimers

scientific article

Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance

scientific article published on 27 February 2020

Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance

Unique inactivation properties of NAADP-sensitive Ca2+ release

scientific article

Unveiling (-)-Englerin A as a Modulator of L-Type Calcium Channels

scientific article published on 8 July 2016

VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling

scientific article

Vasodilation by the calcium-mobilizing messenger cyclic ADP-ribose

scientific article

Widespread distribution of binding sites for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate, in the brain

scientific article published on 01 November 2000

[The action of cyclosporin A (CSA) on glycogen synthesis processes in rats in vivo]

scientific article published in May 1989

[The prevalence of anti-HCV antibodies in a population of Sicilian hemodialysis patients]

scientific article published on 01 September 1994

cGMP mobilizes intracellular Ca2+ in sea urchin eggs by stimulating cyclic ADP-ribose synthesis

scientific article published in Nature

ß-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart

scientific article published on 18 September 2012

Paulina is supported by:

About Paulina

Help