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List of works by Don W. Cleveland

16 Peptide mapping in one dimension by limited proteolysis of sodium dodecyl sulfate-solubilized proteins

scientific article published on January 1, 1983

A Structural Scaffolding of Intermediate Filaments in Health and Disease ⬇️

scientific article published on January 23, 1998

A cellular structure: the cytoskeleton

scientific article published on 01 September 1986

A chemical tool box defines mitotic and interphase roles for Mps1 kinase.

scientific article published on July 2010

A combination of RNase H and S1 nuclease circumvents an artefact inherent to conventional S1 analysis of RNA splicing.

scientific article published on March 1987

A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly.

scientific article published in November 1996

A dispersed multigene family encoding tubulin in Drosophila melanogaster

scientific article published on 01 December 1980

A divergent testis-specific alpha-tubulin isotype that does not contain a coded C-terminal tyrosine.

scientific article published on January 1987

A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease

scientific journal article

A standardized kinesin nomenclature

scientific article

A survey of the alpha-tubulin gene family in chicken: unexpected sequence heterogeneity in the polypeptides encoded by five expressed genes.

scientific article published on April 1988

A two-step mechanism for epigenetic specification of centromere identity and function

scientific article

ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.

scientific article

ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP.

scientific article

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

scientific article

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

scientific article published in February 1997

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.

scientific article

ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import.

scientific article

ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS

scientific article published on 18 October 2018

Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A.

scientific article

Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant ⬇️

scientific article published on August 4, 1998

Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1.

scientific article published in July 2003

Advanced glycation endproduct-modified superoxide dismutase-1 (SOD1)-positive inclusions are common to familial amyotrophic lateral sclerosis patients with SOD1 gene mutations and transgenic mice expressing human SOD1 with a G85R mutation

scientific article published on 01 November 2000

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

scientific article

Altered axonal architecture by removal of the heavily phosphorylated neurofilament tail domains strongly slows superoxide dismutase 1 mutant-mediated ALS.

scientific article

Amyotrophic lateral sclerosis and gene therapy.

scientific article published on September 2006

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

scientific article published in June 1995

An amino-terminal tetrapeptide specifies cotranslational degradation of beta-tubulin but not alpha-tubulin mRNAs.

scientific article published on June 1994

An epigenetic mark generated by the incorporation of CENP-A into centromeric nucleosomes

scholarly article

An expansion in ALS genetics

scientific article published in Nature

Analysis of anticentromere autoantibodies using cloned autoantigen CENP-B.

scientific article

Aneuploidy acts both oncogenically and as a tumor suppressor

scientific article

Aneuploidy: instigator and inhibitor of tumorigenesis

scientific article

Antisense Oligonucleotide Therapies for Neurodegenerative Diseases

scientific article published on 01 July 2019

Antisense oligonucleotide therapy for neurodegenerative disease.

scientific article

Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E.

scientific article

Autoregulated control of tubulin synthesis in animal cells

scientific article published on 01 February 1989

Autoregulated instability of β-tubulin mRNAs by recognition of the nascent amino terminus of βtubulin

scientific article published in Nature

Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs

scientific article published on 01 October 1987

Autoregulatory control of beta-tubulin mRNA stability is linked to translation elongation

scientific article

Autoregulatory control of expression of alpha and beta tubulin

scientific article published on 01 January 1983

Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice.

scientific article published in July 1998

Bidirectional Transcriptional Inhibition as Therapy for ALS/FTD Caused by Repeat Expansion in C9orf72.

scientific article published in December 2016

Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling

scientific article

Biological Spectrum of Amyotrophic Lateral Sclerosis Prions.

scientific article published on 6 January 2017

Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

scientific article published on 03 March 2014

BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules

scientific article published on 14 June 2019

C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice.

scientific article published on 29 October 2013

C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation.

scientific article published on 4 January 2018

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

scientific article published on 21 March 2016

CELL BIOLOGY. Disrupted nuclear import-export in neurodegeneration.

scientific article published on January 2016

CENP-A Is Dispensable for Mitotic Centromere Function after Initial Centromere/Kinetochore Assembly

scientific article

CENP-A Modifications on Ser68 and Lys124 Are Dispensable for Establishment, Maintenance, and Long-Term Function of Human Centromeres

scientific article published on January 2017

CENP-A and the CENP nomenclature: response to Talbert and Henikoff

scientific article

CENP-A-containing nucleosomes: easier disassembly versus exclusive centromeric localization.

scientific article published on 3 May 2007

CENP-E Is a Plus End–Directed Kinetochore Motor Required for Metaphase Chromosome Alignment ⬇️

scientific article published on October 31, 1997

CENP-E as an essential component of the mitotic checkpoint in vitro.

scientific article published in September 2000

CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tether

scientific article published on 28 April 2008

CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint

scientific article published on August 2000

CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase

scientific article

Cancer. Aneuploidy drives a mutator phenotype in cancer.

scientific article published on August 2011

Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase.

scientific article

Catalytic assembly of the mitotic checkpoint inhibitor BubR1-Cdc20 by a Mad2-induced functional switch in Cdc20.

scientific article published on 20 June 2013

Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F.

scientific article

Centriole duplication: A lesson in self-control

scientific article

Centromere identity, function, and epigenetic propagation across cell divisions.

scientific article

Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss

scientific article

Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP.

scientific article

Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling

scientific article (publication date: 21 February 2003)

Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition

scientific article

Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals

scientific article

Centrosomes, chromosome instability (CIN) and aneuploidy

scientific article

Cep152 interacts with Plk4 and is required for centriole duplication.

scientific article

Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers

scientific article

Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants ⬇️

scientific article published on May 26, 1998

Chemically Modified Cpf1-CRISPR RNAs Mediate Efficient Genome Editing in Mammalian Cells

scientific article published on 6 March 2018

Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements

scientific article published on 7 November 2012

Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes

scientific article (publication date: 2008)

Chromosomal instability drives metastasis through a cytosolic DNA response

scientific article published on 17 January 2018

Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors.

scientific article

Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements

scientific article published on 04 March 2019

Chronic centrosome amplification without tumorigenesis

scientific article

Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint".

scientific article

Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis.

scholarly article

Conservation of microtubule associated proteins. Isolation and characterization of tau and the high molecular weight microtubule associated protein from chicken brain and from mouse fibroblasts and comparison to the corresponding mammalian brain pro ⬇️

scientific article published on December 25, 1979

Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis

scientific article

Cyclin-like accumulation and loss of the putative kinetochore motor CENP-E results from coupling continuous synthesis with specific degradation at the end of mitosis.

scientific article published on June 1994

Cytoplasmic O-GlcNAc modification of the head domain and the KSP repeat motif of the neurofilament protein neurofilament-H

scientific article

Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death

scientific article published on 07 March 2019

Cytoskeletal linkers: new MAPs for old destinations.

scientific article

DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function

scientific article published on May 2015

DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres

scientific article published on 03 June 2019

Decoding ALS: from genes to mechanism.

scientific article published on 9 November 2016

Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death.

scientific article

Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis.

scientific article published on 31 March 2013

Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism

scientific article published on 06 January 2016

Determinants of rapid disease progression in ALS

scientific article published on 01 December 2005

Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS

scientific article published on 30 December 2013

Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

scientific article published on 30 September 2012

Does aneuploidy cause cancer?

scientific article

Double-strand DNA breaks recruit the centromeric histone CENP-A.

scientific article

Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein ⬇️

scientific article published on December 1, 1991

Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing

scientific article

Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS

scientific article

Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superox

scientific article published on July 1997

Elevation of tubulin levels by microinjection suppresses new tubulin synthesis

scientific article published in Nature

Epidermal development, growth control, and homeostasis in the face of centrosome amplification

scientific article

Epigenetic centromere propagation and the nature of CENP-a nucleosomes.

scientific article

Error-prone mammalian female meiosis from silencing the spindle assembly checkpoint without normal interkinetochore tension.

scientific article

Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis.

scientific article published on 19 May 2016

Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex

scientific article published on October 1, 1992

Evidence of discontinuous transcription in the trypanosomatid Crithidia fasciculata.

scientific article published in November 1987

Expedition Inspiration Fund for Breast Cancer Research Meeting 2003.

scientific article

Ferritin synthesis is controlled by iron-dependent translational derepression and by changes in synthesis/transport of nuclear ferritin RNAs.

scientific article

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS).

scientific article

Forensic DNA typing

Formation of advanced glycation end-product-modified superoxide dismutase-1 (SOD1) is one of the mechanisms responsible for inclusions common to familial amyotrophic lateral sclerosis patients with SOD1 gene mutation, and transgenic mice expressing

scientific article published on 01 March 2001

Formation of spindle poles by dynein/dynactin-dependent transport of NuMA

scientific article

Four unique genes required for beta tubulin expression in vertebrates

scientific article published on 01 March 1983

From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS

scientific article (publication date: November 2001)

From Charcot to SOD1: mechanisms of selective motor neuron death in ALS.

scientific article

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

scientific article published on 19 April 2016

Gamma-tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation

scientific article published on March 5, 1992

Gene regulation through messenger RNA stability.

scientific article published on December 1989

Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport.

scientific article

Gene therapy for ALS delivers

scientific article published on May 2004

Gene therapy: Gene-editing therapy for neurological disease.

scientific article published on 16 December 2016

Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis

scholarly article

Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease

scientific article

Glyceraldehyde 3-phosphate dehydrogenase protein and mRNA are both differentially expressed in adult chickens but not chick embryos.

scientific article published on May 1983

Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M

scientific article

Going new places using an old MAP: tau, microtubules and human neurodegenerative disease.

scientific article

Going public

scientific article published on 01 July 1991

HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells

scientific article published on 17 December 2020

Has gene therapy for ALS arrived?

scientific article published in October 2003

High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment.

scientific article published on July 1984

High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal

scientific article published on 3 December 2001

How to survive aneuploidy

scientific article published on October 2010

Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling

scientific article

Human centromeric CENP-A chromatin is a homotypic, octameric nucleosome at all cell cycle points

scientific article published on 24 February 2017

Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation.

scientific article

Human neural stem cell replacement therapy for amyotrophic lateral sclerosis by spinal transplantation

scientific article

Hypoxia and Lou Gehrig

scientific article published on 01 June 2001

Immunoflourescent staining of cytoplasmic and spindle microtubules in mouse fibroblasts with antibody to tau protein ⬇️

scientific article published on June 1, 1977

In vivo coassembly of a divergent beta-tubulin subunit (c beta 6) into microtubules of different function

scientific article

In vivo discrimination among beta-tubulin isotypes: selective degradation of a type IV beta-tubulin isotype following overexpression in cultured animal cells

scientific article published on 01 January 1990

In vivo quantitative studies of dynamic intracellular processes using fluorescence correlation spectroscopy

scientific article

Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease

scientific article published on 01 April 1993

Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons.

scientific article

Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells

scientific article

Intercellular miscommunication in polyglutamine pathogenesis

scientific article published on 01 October 2006

Intermediate filaments and their associated proteins: multiple dynamic personalities.

scientific article published on February 1998

Interrogating cell division errors using random and chromosome-specific missegregation approaches

scientific article published on 26 June 2017

Intracellular localization of the high molecular weight microtubule accessory protein by indirect immunofluorescence ⬇️

scientific article published on March 1, 1978

Involvement of neurofilaments in motor neuron disease

scientific article published on 01 January 1993

Involvement of neurofilaments in the radial growth of axons ⬇️

scientific article published on January 1, 1991

Isolation of separate mRNAs for alpha- and beta-tubulin and characterization of the corresponding in vitro translation products

scientific article

Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips

scientific article

Kinetochore-microtubule attachment throughout mitosis potentiated by the elongated stalk of the kinetochore kinesin CENP-E.

scientific article

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

scientific article

Local control of neurofilament accumulation during radial growth of myelinating axons in vivo. Selective role of site-specific phosphorylation

scientific article

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.

scientific article

Losing balance: the origin and impact of aneuploidy in cancer

scientific article

MYC Is a Major Determinant of Mitotic Cell Fate

scientific article published in July 2015

Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1.

scientific article

Mechanisms of selective motor neuron death in transgenic mouse models of motor neuron disease.

scientific article published on October 1996

Medicine. Treating neurodegenerative diseases with antibiotics.

scientific article published in January 2005

Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment

scientific article published on 21 May 2019

Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS

scientific article

Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling

scientific article

Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset.

scientific article

Misfolded SOD1 is not a primary component of sporadic ALS.

scientific article published on 28 February 2017

Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS

scientific article

Misregulated RNA processing in amyotrophic lateral sclerosis ⬇️

scientific article published on 03 March 2012

Mitochondrial Isolation and Purification from Mouse Spinal Cord.

scientific article published on November 2013

Modest loss of peripheral axons, muscle atrophy and formation of brain inclusions in mice with targeted deletion of gigaxonin exon 1

scientific article published on 31 July 2008

Molecular biology and genetics of tubulin.

scientific article

Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations.

scientific article published in September 2002

Motor neurone disease and animal models ⬇️

scientific article published on November 1, 1994

Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint.

scientific article published in July 2001

Multiclassifier proteomics to define complexes yields new chromosomal proteins.

scientific article published on September 2010

Multiple alpha and beta tubulin genes represent unlinked and dispersed gene families

scientific article published on 01 March 1981

Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy

scientific article

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

scientific article

Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading

scientific article published on 01 April 2002

Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice.

scholarly article

Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis

scientific article

Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism

scientific article

NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growth

scientific article

Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases.

scientific article published in July 2006

Neurodegenerative diseases and model systems.

scientific article published on January 1996

Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: induction of a specific beta-tubulin isotype

scientific article

Neurofilament function and dysfunction: involvement in axonal growth and neuronal disease

scientific article published in February 1994

Neurofilament-dependent Radial Growth of Motor Axons and Axonal Organization of Neurofilaments Does Not Require the Neurofilament Heavy Subunit (NF-H) or Its Phosphorylation ⬇️

scientific article published on October 5, 1998

Neurofilaments, radial growth of axons, and mechanisms of motor neuron disease

scientific article published on January 1, 1996

Neuronal and glial cytoskeletons.

scientific article published on October 1991

Neuronal growth and death: order and disorder in the axoplasm.

scientific article published on March 1996

New consensus research on neuropathological aspects of familial amyotrophic lateral sclerosis with superoxide dismutase 1 (SOD1) gene mutations: inclusions containing SOD1 in neurons and astrocytes.

scientific article

Novel clinical associations with specific C9ORF72 transcripts in patients with repeat expansions in C9ORF72.

scientific article

Novel missense mutation in ALS2 gene results in infantile ascending hereditary spastic paralysis.

scientific article

NuMA after 30 years: the matrix revisited.

scientific article

NuMA is required for the proper completion of mitosis.

scientific article

NuMA, a nuclear protein involved in mitosis and nuclear reformation.

scientific article published on June 1994

Nucleotide and corresponding amino acid sequences encoded by alpha and beta tubulin mRNAs.

scientific article published in February 1981

On the road to cancer: aneuploidy and the mitotic checkpoint

scientific article (publication date: October 2005)

Onset and progression in inherited ALS determined by motor neurons and microglia

scientific article (publication date: 2 June 2006)

Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

article

Oxidation versus aggregation - how do SOD1 mutants cause ALS?

scientific article

Oxidative stress and iron are implicated in fragmenting vacuoles of Saccharomyces cerevisiae lacking Cu,Zn-superoxide dismutase

scientific article published on 01 September 1999

Pathogenesis of two axonopathies does not require axonal neurofilaments.

scientific article published in February 1998

Pathways of Spindle Pole Formation: Different Mechanisms; Conserved Components ⬇️

scientific article published on September 8, 1997

Phosphorylation of CENP-A on serine 7 does not control centromere function

scientific article published in Nature Communications

Phosphorylation of highly conserved neurofilament medium KSP repeats is not required for myelin-dependent radial axonal growth

scientific article published on February 2009

Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

scientific article

Physical evidence for cotranslational regulation of beta-tubulin mRNA degradation ⬇️

scientific article published on February 1, 1992

Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis

scientific article

Polo-like kinase 4 inhibition: a strategy for cancer therapy?

scientific article

Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability

scientific article

Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport

scientific article published in April 2017

Post-transcriptional processes.

scientific article

Potent spinal parenchymal AAV9-mediated gene delivery by subpial injection in adult rats and pigs

scientific article published on 13 July 2016

Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration

scientific article published on 14 January 2019

Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors

scientific article published on 25 March 2015

Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis ⬇️

scientific article published on March 1, 1992

Prion-like spread of protein aggregates in neurodegeneration

scientific article

Probing Mitotic CENP-E Kinesin with the Tethered Cargo Motion Assay and Laser Tweezers

Programmed expression of beta-tubulin genes during development and differentiation of the chicken

scientific article

Propagation of centromeric chromatin requires exit from mitosis.

scientific article

Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase ⬇️

scientific article published on August 4, 1998

Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin

scientific article

RCADiA: simple automation platform for comparative multidimensional protein identification technology

scientific article

Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis.

scientific article published on 9 September 2017

Reconstruction of tubulin gene regulation in cultured mammalian cells.

scientific article

Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72

scientific article published on 13 April 2020

Regional modulation of neurofilament organization by myelination in normal axons

scientific article published on 01 November 1994

Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells

scientific article

Replicating centromeric chromatin: spatial and temporal control of CENP-A assembly.

scientific article published on 27 April 2012

Reply to Woodruff et al.: C1q and C3-dependent complement pathway activation does not contribute to disease in SOD1 mutant ALS mice

scientific article published on January 2014

Requirements for NuMA in maintenance and establishment of mammalian spindle poles.

scientific article published on 02 March 2009

Rethinking Unconventional Translation in Neurodegeneration

scientific article published in November 2017

Reversing a model of Parkinson's disease with in situ converted nigral neurons

scientific article published on 24 June 2020

Revisiting oxidative damage in ALS: microglia, Nox, and mutant SOD1

scientific article

Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice.

scholarly article

Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining. ⬇️

scientific article published on 05 December 2016

Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria.

scholarly article

Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients

scientific article published on 03 May 2018

Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis.

scientific article

Sequence and expression of the chicken beta 3 tubulin gene. A vertebrate testis beta-tubulin isotype.

scientific article published in October 1986

Sequence and expression of the chicken beta 5- and beta 4-tubulin genes define a pair of divergent beta-tubulins with complementary patterns of expression

scientific article published on December 1986

Sequences that confer beta-tubulin autoregulation through modulated mRNA stability reside within exon 1 of a beta-tubulin mRNA.

scientific article

Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression.

scientific article

Slow axonal transport models come full circle: evidence that microtubule sliding mediates axon elongation and tubulin transport

scientific article published on November 1991

Slow axonal transport: fast motors in the slow lane.

scientific article

Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons

scientific article published on January 1999

Special Issue on amyotrophic lateral sclerosis.

scientific article

Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS

scientific article published on 23 December 2019

Structural determinants for generating centromeric chromatin

scientific article

Subunit composition of neurofilaments specifies axonal diameter.

scientific article published on June 1996

Superoxide dismutase 1 subunits with mutations linked to familial amyotrophic lateral sclerosis do not affect wild-type subunit function.

scientific article published on February 1995

Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis.

scientific article

Synthetic CRISPR RNA-Cas9-guided genome editing in human cells

scientific article

TDP-43 and HSP70 phase separate into anisotropic, intranuclear liquid spherical annuli

scientific article published on 29 March 2020

TDP-43 toxicity and the usefulness of junk

scientific article published on December 2012

TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC

scientific article published in Nature Communications

The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding

scientific article published on 28 June 2017

The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

scholarly article by Shan Lu published in January 2021

The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle

scientific article

The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle

scientific article published in January 2013

The curious incident of the translational dog that didn't bark

scientific article published in April 2015

The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation.

scientific article published on 26 November 2012

The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation.

scientific article published in February 2013

The human CENP-A centromeric nucleosome-associated complex

scientific article (publication date: May 2006)

The kinesin-like protein CENP-E is kinetochore-associated throughout poleward chromosome segregation during anaphase-A

scientific article published on 01 May 1996

The microtubule-dependent motor centromere-associated protein E (CENP-E) is an integral component of kinetochore corona fibers that link centromeres to spindle microtubules.

scientific article published in October 1997

The quantitative architecture of centromeric chromatin

scientific article

The role of NuMA in the interphase nucleus ⬇️

scientific article published on January 1, 1998

The role of aneuploidy in promoting and suppressing tumors

scientific article

The tubulins: from DNA to RNA to protein and back again.

scientific article

Therapeutic AAV9-mediated suppression of mutant SOD1 slows disease progression and extends survival in models of inherited ALS

scientific article published on 06 September 2013

Toxic mutants in Charcot's sclerosis

scientific article published in Nature

Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons

scientific article

Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria.

scientific article

Transient genomic instability drives tumorigenesis through accelerated clonal evolution

scientific article published on 15 July 2021

Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS.

scientific article published on 30 November 2015

Treadmilling of tubulin and actin

scientific article published on April 1982

Tubulin requires tau for growth onto microtubule initiating sites ⬇️

scientific article published on November 1, 1976

Tubulin site interpretation

scientific article published in Nature

Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1

scientific article published on 01 September 2018

Two distinct classes of keratin genes and their evolutionary significance.

scientific article

Understanding the role of TDP-43 and FUS/TLS in ALS and beyond.

scientific article published on 2 August 2011

Unpolymerized tubulin modulates the level of tubulin mRNAs

scientific article published on 01 August 1981

Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E

scientific journal article

Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F.

scientific article

Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease

scientific article

Use of molecular cloning methods to map the distribution of epitopes on topoisomerase I (Scl-70) recognized by sera of scleroderma patients

scientific article published on 01 October 1990

VEGF: multitasking in ALS

scientific article published on 01 January 2005

Variation in the biochemical/biophysical properties of mutant superoxide dismutase 1 enzymes and the rate of disease progression in familial amyotrophic lateral sclerosis kindreds.

scientific article

Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis

scientific article

Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS.

scientific article

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice ⬇️

scientific article published on October 3, 2003

ZW10 links mitotic checkpoint signaling to the structural kinetochore.

scientific article

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