List of works - Ramanujan Shankar Hegde

A Calmodulin-Dependent Translocation Pathway for Small Secretory Proteins ⬇️

scientific article published on December 23, 2011

A Conserved Archaeal Pathway for Tail-Anchored Membrane Protein Insertion

scientific article

A flip turn for membrane protein insertion

scientific article

A multistep, ATP-dependent pathway for assembly of human immunodeficiency virus capsids in a cell-free system

scientific article

A ribosome-associating factor chaperones tail-anchored membrane proteins

scientific article

A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum

scientific article published in July 2005

A transmembrane form of the prion protein in neurodegenerative disease

scientific article

A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation

scientific article

An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR maturation by a Ufm1-independent mechanism

scientific article

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate

scientific article published on 04 February 2014

An intramembrane chaperone complex facilitates membrane protein biogenesis

scientific article published on 19 August 2020

Architecture of the Ribosome–Channel Complex Derived from Native Membranes

scientific article published on 01 April 2005

Arginine 383 is a crucial residue in ABCG2 biogenesis

scientific article

Asymmetric distribution of pause transfer sequences in apolipoprotein B-100.

scientific article published in June 1997

Combinatorial Control of Prion Protein Biogenesis by the Signal Sequence and Transmembrane Domain

scientific article published in Journal of Biological Chemistry

Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo

scientific article

Conformational control through translocational regulation: a new view of secretory and membrane protein folding.

scientific article

Coordinate control of translation and localization of Vg1 mRNA in Xenopus oocytes

scientific article

Cotranslational partitioning of nascent prion protein into multiple populations at the translocation channel

scientific article

Cytosolic aggregates perturb the degradation of nontranslocated secretory and membrane proteins

scientific article

Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6

scientific article

Cytotoxicity of Aberrant Proteins

Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes ⬇️

scientific article

Design principles of protein biosynthesis-coupled quality control

scientific article

Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER

scientific article

EMC Is Required to Initiate Accurate Membrane Protein Topogenesis

scientific article published on 08 November 2018

ER stress-induced clearance of misfolded GPI-anchored proteins via the secretory pathway

scientific article

Formation of stacked ER cisternae by low affinity protein interactions

scientific article

Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration

scientific article

How much do rural Hispanics know about the adverse health risks of smoking?

scientific article published in January 2001

IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses

scientific article published on 18 January 2017

Identification of a quality-control factor that monitors failures during proteasome assembly

scientific article published on 27 August 2021

Identification of a targeting factor for posttranslational membrane protein insertion into the ER

scientific article

In vitro dissection of protein translocation into the mammalian endoplasmic reticulum

scientific article

Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination

scientific journal article

Intracellular Ca(2+) release via the ER translocon activates store-operated calcium entry

scientific article published on 14 December 2006

Ionic effects on bumetanide binding to the activated Na/K/2Cl cotransporter: selectivity and kinetic properties of ion binding sites

scientific article published in February 1992

Lighting up the stressed ER.

scientific article

Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociation

scientific article (publication date: 6 June 2013)

Local synthesis and disposal

scientific article published in Science

Mechanism of ribosome stalling during translation of a poly(A) tail

scientific article published on 25 November 2019

Mechanistic basis for a molecular triage reaction

scientific article published on January 2017

Membrane Protein Insertion at the Endoplasmic Reticulum ⬇️

scientific article published on July 21, 2011

Membrane protein biogenesis: regulated complexity at the endoplasmic reticulum

scientific article published on November 1997

Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors

scientific article published on 16 May 2019

Monitoring chaperone engagement of substrates in the endoplasmic reticulum of live cells

scientific article

Msp1: patrolling mitochondria for lost proteins

scientific article published on 10 June 2014

Mutant PrPSc conformers induced by a synthetic peptide and several prion strains

scientific article published on February 2004

Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation

scientific article

Prion protein biosynthesis and its emerging role in neurodegeneration

scientific article

Prion protein trafficking and the development of neurodegeneration

scientific article

Prions and retroviruses: an endosomal rendezvous?

scientific article

Protection from cytosolic prion protein toxicity by modulation of protein translocation

scientific article

Protein targeting and degradation are coupled for elimination of mislocalized proteins

scientific article

Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo

scientific article published on March 2015

Quality Control of Orphaned Proteins

scientific article published on 01 August 2018

Quality and quantity control at the endoplasmic reticulum

scientific article

Rational design and evaluation of FRET experiments to measure protein proximities in cells

scientific article

Reconstitution of a minimal ribosome-associated ubiquitination pathway with purified factors

scientific article

Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration

scientific article

Regulation of basal cellular physiology by the homeostatic unfolded protein response

scientific article

Regulation of protein biogenesis at the endoplasmic reticulum membrane

scientific article

Regulation of protein compartmentalization expands the diversity of protein function

scientific article published on October 2005

Regulation of protein topology by trans-acting factors at the endoplasmic reticulum

scientific article published in July 1998

Relocalization of STIM1 for activation of store-operated Ca(2+) entry is determined by the depletion of subplasma membrane endoplasmic reticulum Ca(2+) store

scientific article published on 12 February 2007

Retrotranslocation of prion proteins from the endoplasmic reticulum by preventing GPI signal transamidation

scientific article published on 28 May 2008

Ribosome collisions trigger cis-acting feedback inhibition of translation initiation

scientific article published on 13 July 2020

Ribosome-associated protein quality control

scientific article

Secretory protein profiling reveals TNF-α inactivation by selective and promiscuous Sec61 modulators

scientific article published on September 2011

Selective processing and metabolism of disease-causing mutant prion proteins

scientific article

Sequence-specific alteration of the ribosome-membrane junction exposes nascent secretory proteins to the cytosol

scientific article published in April 1996

Short circuiting stress protein expression via a tyrosine kinase inhibitor, herbimycin A.

scientific article published in October 1995

Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein

scientific article

Signal sequences control gating of the protein translocation channel in a substrate-specific manner

scientific article published on February 2002

Single Copies of Sec61 and TRAP Associate with a Nontranslating Mammalian Ribosome

scientific article

Structural basis for stop codon recognition in eukaryotes

scientific article

Structure and assembly pathway of the ribosome quality control complex

scientific article

Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution

scientific article

Structure of the Sec61 channel opened by a signal sequence

scientific article

Structures of the scanning and engaged states of the mammalian SRP-ribosome complex

scientific article published on 9 July 2015

Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane

scientific article

Substrate-specific regulation of the ribosome- translocon junction by N-terminal signal sequences

scientific article published on 19 June 2001

Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway

scientific article

TRAM regulates the exposure of nascent secretory proteins to the cytosol during translocation into the endoplasmic reticulum.

scientific article

TTC5 mediates autoregulation of tubulin via mRNA degradation

scientific article

Tail-anchored membrane protein insertion into the endoplasmic reticulum

scientific article

Target Selection during Protein Quality Control

scientific article

Targeting and beyond: new roles for old signal sequences

scientific article published in October 2002

The ASC-1 Complex Disassembles Collided Ribosomes

scientific article published on 18 June 2020

The ER membrane protein complex is a transmembrane domain insertase

scientific article

The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis

scientific article published on 16 January 2019

The architecture of EMC reveals a path for membrane protein insertion

scientific article published on 27 May 2020

The concept of translocational regulation

scientific article

The efficiency of protein compartmentalization into the secretory pathway

scientific article

The life of proteins: the good, the mostly good and the ugly

scientific article published on 01 January 2011

The mechanism of membrane-associated steps in tail-anchored protein insertion

scientific article

The organization of engaged and quiescent translocons in the endoplasmic reticulum of mammalian cells

scientific article published in March 2004

The ribosome quality control pathway can access nascent polypeptides stalled at the Sec61 translocon

scientific article published on 15 April 2015

The role of p58IPK in protecting the stressed endoplasmic reticulum

scientific article

The structural basis of tail-anchored membrane protein recognition by Get3

scientific article published on 12 August 2009

The surprising complexity of signal sequences

scientific article published on 21 August 2006

Toward a structural understanding of co-translational protein translocation

scientific article published on 5 May 2016

Translation stress and collided ribosomes are co-activators of cGAS

scientific article published in July 2021

Translocational pausing of apolipoprotein B can be regulated by membrane lipid composition

scientific article published in June 1998

Transmembrane domain modulates sorting of membrane proteins in Toxoplasma gondii

scientific article published on 31 March 2004

Transmembrane topogenesis of a tail-anchored protein is modulated by membrane lipid composition

scientific article

Transmissible and genetic prion diseases share a common pathway of neurodegeneration

scientific article

UBE2O is a quality control factor for orphans of multiprotein complexes.

scientific article

Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation.

scientific article published on 21 June 2016

ZNF598 Is a Quality Control Sensor of Collided Ribosomes

scientific article published on 04 October 2018

List of works by Ramanujan Shankar Hegde

A Calmodulin-Dependent Translocation Pathway for Small Secretory Proteins ⬇️

A Conserved Archaeal Pathway for Tail-Anchored Membrane Protein Insertion

A flip turn for membrane protein insertion

A multistep, ATP-dependent pathway for assembly of human immunodeficiency virus capsids in a cell-free system

A ribosome-associating factor chaperones tail-anchored membrane proteins

A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum

A transmembrane form of the prion protein in neurodegenerative disease

A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation

An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR maturation by a Ufm1-independent mechanism

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate

An intramembrane chaperone complex facilitates membrane protein biogenesis

Architecture of the Ribosome–Channel Complex Derived from Native Membranes

Arginine 383 is a crucial residue in ABCG2 biogenesis

Asymmetric distribution of pause transfer sequences in apolipoprotein B-100.

Combinatorial Control of Prion Protein Biogenesis by the Signal Sequence and Transmembrane Domain

Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo

Conformational control through translocational regulation: a new view of secretory and membrane protein folding.

Coordinate control of translation and localization of Vg1 mRNA in Xenopus oocytes

Cotranslational partitioning of nascent prion protein into multiple populations at the translocation channel

Cytosolic aggregates perturb the degradation of nontranslocated secretory and membrane proteins

Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6

Cytotoxicity of Aberrant Proteins

Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes ⬇️

Design principles of protein biosynthesis-coupled quality control

Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER

EMC Is Required to Initiate Accurate Membrane Protein Topogenesis

ER stress-induced clearance of misfolded GPI-anchored proteins via the secretory pathway

Formation of stacked ER cisternae by low affinity protein interactions

Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration

How much do rural Hispanics know about the adverse health risks of smoking?

IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses

Identification of a quality-control factor that monitors failures during proteasome assembly

Identification of a targeting factor for posttranslational membrane protein insertion into the ER

In vitro dissection of protein translocation into the mammalian endoplasmic reticulum

Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination

Intracellular Ca(2+) release via the ER translocon activates store-operated calcium entry

Ionic effects on bumetanide binding to the activated Na/K/2Cl cotransporter: selectivity and kinetic properties of ion binding sites

Lighting up the stressed ER.

Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociation

Local synthesis and disposal

Mechanism of ribosome stalling during translation of a poly(A) tail

Mechanistic basis for a molecular triage reaction

Membrane Protein Insertion at the Endoplasmic Reticulum ⬇️

Membrane protein biogenesis: regulated complexity at the endoplasmic reticulum

Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors

Monitoring chaperone engagement of substrates in the endoplasmic reticulum of live cells

Msp1: patrolling mitochondria for lost proteins

Mutant PrPSc conformers induced by a synthetic peptide and several prion strains

Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation

Prion protein biosynthesis and its emerging role in neurodegeneration

Prion protein trafficking and the development of neurodegeneration

Prions and retroviruses: an endosomal rendezvous?

Protection from cytosolic prion protein toxicity by modulation of protein translocation

Protein targeting and degradation are coupled for elimination of mislocalized proteins

Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo

Quality Control of Orphaned Proteins

Quality and quantity control at the endoplasmic reticulum

Rational design and evaluation of FRET experiments to measure protein proximities in cells

Reconstitution of a minimal ribosome-associated ubiquitination pathway with purified factors

Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration

Regulation of basal cellular physiology by the homeostatic unfolded protein response

Regulation of protein biogenesis at the endoplasmic reticulum membrane

Regulation of protein compartmentalization expands the diversity of protein function

Regulation of protein topology by trans-acting factors at the endoplasmic reticulum

Relocalization of STIM1 for activation of store-operated Ca(2+) entry is determined by the depletion of subplasma membrane endoplasmic reticulum Ca(2+) store

Retrotranslocation of prion proteins from the endoplasmic reticulum by preventing GPI signal transamidation

Ribosome collisions trigger cis-acting feedback inhibition of translation initiation

Ribosome-associated protein quality control

Secretory protein profiling reveals TNF-α inactivation by selective and promiscuous Sec61 modulators

Selective processing and metabolism of disease-causing mutant prion proteins

Sequence-specific alteration of the ribosome-membrane junction exposes nascent secretory proteins to the cytosol

Short circuiting stress protein expression via a tyrosine kinase inhibitor, herbimycin A.

Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein

Signal sequences control gating of the protein translocation channel in a substrate-specific manner

Single Copies of Sec61 and TRAP Associate with a Nontranslating Mammalian Ribosome

Structural basis for stop codon recognition in eukaryotes

Structure and assembly pathway of the ribosome quality control complex

Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution

Structure of the Sec61 channel opened by a signal sequence