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List of works by Holger Lode

2017 GPOH Guidelines for Diagnosis and Treatment of Patients with Neuroblastic Tumors

scientific article published on 30 May 2017

A dual-function DNA vaccine encoding carcinoembryonic antigen and CD40 ligand trimer induces T cell-mediated protective immunity against colon cancer in carcinoembryonic antigen-transgenic mice.

scientific article published on October 2001

A new development of triterpene acid-containing extracts from Viscum album L. displays synergistic induction of apoptosis in acute lymphoblastic leukaemia

scientific article published on 3 January 2012

A novel 2'-(N-methylpyridinium acetate) prodrug of paclitaxel induces superior antitumor responses in preclinical cancer models

scientific article published in September 2002

A rationally designed tyrosine hydroxylase DNA vaccine induces specific antineuroblastoma immunity

scientific article

AACR Special Conference in cancer research: ubiquitination in normal and cancer cells ⬇️

scientific article published on February 1, 2003

Amplification of T cell-mediated immune responses by antibody-cytokine fusion proteins

scientific article published on 01 May 2000

Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient-derived GBM tumor cells

scientific article published on 03 February 2017

Anti-neuroblastoma effect of ch14.18 antibody produced in CHO cells is mediated by NK-cells in mice.

scientific article published on 7 April 2005

Ascorbic acid induces lipid peroxidation on neuroectodermal SK-N-LO cells with high endogenous ferritin content and loaded with MAb-ferritin immunoconjugates

scientific article published on 01 September 1994

Ascorbic acid stimulates DOPA synthesis and tyrosine hydroxylase gene expression in the human neuroblastoma cell line SK-N-SH.

scientific article published on March 1998

Ascorbic-acid-mediated iron release from cellular ferritin and its relation to the formation of DNA strand breaks in neuroblastoma cells.

scientific article published on January 1994

Bioactivation of self-immolative dendritic prodrugs by catalytic antibody 38C2.

scientific article published on February 2004

Call for a European Paediatric Association/Union of National European Paediatric Societies and Associations Survey on National Child Health Care Services for European Children with Malignancies.

scientific article published on 11 July 2017

Ch14.18 antibody produced in CHO cells in relapsed or refractory Stage 4 neuroblastoma patients: a SIOPEN Phase 1 study.

scientific article published on 31 May 2013

Characterization of GD2 peptide mimotope DNA vaccines effective against spontaneous neuroblastoma metastases.

scientific article published on November 2006

Chronic diseases in pregnant women: prevalence and birth outcomes based on the SNiP-study

scientific article (publication date: 19 February 2014)

Co-expression of IL-15 enhances anti-neuroblastoma effectivity of a tyrosine hydroxylase-directed DNA vaccination in mice

scientific article published in PLoS ONE

DNA minigene vaccination for adjuvant neuroblastoma therapy.

scientific article

DNA vaccination: using the patient's immune system to overcome cancer

scientific article published on 16 December 2010

Determination of ascorbic acid by isotachophoresis with regard to its potential in neuroblastoma therapy

scientific article published on 01 May 1993

Development of immunomonitoring of antibody‑dependent cellular cytotoxicity against neuroblastoma cells using whole blood.

scientific article published on June 2014

Disialoganglioside-specific human natural killer cells are effective against drug-resistant neuroblastoma.

scientific article

Elimination of established murine colon carcinoma metastases by antibody-interleukin 2 fusion protein therapy.

scientific article published in November 1997

Eradication of CD19+ leukemia by targeted calicheamicin θ.

scientific article

Febrile ulceronecrotic Mucha-Habermann disease following suspected hemorrhagic chickenpox infection in a 20-month-old boy.

scientific article published on 28 January 2015

Fenretinide sensitizes multidrug-resistant human neuroblastoma cells to antibody-independent and ch14.18-mediated NK cell cytotoxicity.

scientific article

Fractalkine (CX3CL1)- and interleukin-2-enriched neuroblastoma microenvironment induces eradication of metastases mediated by T cells and natural killer cells.

scientific article published on March 2007

Functional bioassays for immune monitoring of high-risk neuroblastoma patients treated with ch14.18/CHO anti-GD2 antibody

scientific article

GD2 targeting by dinutuximab beta is a promising immunotherapeutic approach against malignant glioma

scientific article published on 03 April 2020

GM-CSF as successful salvage therapy of metamizole (dipyrone)-induced agranulocytosis with Fournier's gangrene and severe septic shock in an adolescent.

scientific article published on 20 July 2016

Gastric teratoma in a 6-month-old boy

scientific article published on 01 January 2012

Gene therapy with a single chain interleukin 12 fusion protein induces T cell-dependent protective immunity in a syngeneic model of murine neuroblastoma.

scientific article published in March 1998

Generation and Characterization of a Human/Mouse Chimeric GD2-Mimicking Anti-Idiotype Antibody Ganglidiximab for Active Immunotherapy against Neuroblastoma

scientific article

Haploidentical Stem Cell Transplantation for Refractory/Relapsed Neuroblastoma.

scientific article published on 4 January 2018

Hydrolytically activated etoposide prodrugs inhibit MDR-1 function and eradicate established MDR-1 multidrug-resistant T-cell leukemia.

scientific article published on 6 March 2003

IFN-gamma-inducible protein-10 is essential for the generation of a protective tumor-specific CD8 T cell response induced by single-chain IL-12 gene therapy.

scientific article published in June 2001

Immunocytokines: a promising approach to cancer immunotherapy

scientific article published on 01 December 1998

Immunotherapy with a posttranscriptionally modified DNA vaccine induces complete protection against metastatic neuroblastoma.

scientific article published on 12 September 2002

Impact of HACA on Immunomodulation and Treatment Toxicity Following ch14.18/CHO Long-Term Infusion with Interleukin-2: Results from a SIOPEN Phase 2 Trial

article

Impact of magnetic resonance urography and ultrasonography on diagnosis and management of hydronephrosis and megaureter in paediatric patients.

scientific article published in May 2012

In vivo activity in a catalytic antibody-prodrug system: Antibody catalyzed etoposide prodrug activation for selective chemotherapy

scientific article published on 12 June 2001

Incidence and duration of therapy of pathological hip findings in U2 and U3 examinations (SNiP study)

scientific article published in February 2014

Individualized risk assessment in neuroblastoma: does the tumoral metabolic activity on 123I-MIBG SPECT predict the outcome?

scientific article published on 14 August 2017

Induction of IgG antibodies against the GD2 carbohydrate tumor antigen by vaccination with peptide mimotopes.

scientific article

Inflammatory response and treatment tolerance of long-term infusion of the anti-GD2 antibody ch14.18/CHO in combination with interleukin-2 in patients with high-risk neuroblastoma.

scientific article

Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles

scientific article (publication date: 2012)

Interleukin 2 with anti-GD2 antibody ch14.18/CHO (dinutuximab beta) in patients with high-risk neuroblastoma (HR-NBL1/SIOPEN): a multicentre, randomised, phase 3 trial

scientific article published on 12 November 2018

Long-term continuous infusion of anti-GD2 antibody CH14.18/CHO in relapsed/refractory neuroblastoma patients.

scientific article published on 7 November 2013

Low CD4⁺/CD25⁺/CD127⁻ regulatory T cell- and high INF-γ levels are associated with improved survival of neuroblastoma patients treated with long-term infusion of ch14.18/CHO combined with interleukin-2

scientific article published on 08 September 2019

MYCN-targeting vaccines and immunotherapeutics

scientific article published on 20 April 2016

Molecular mechanisms of mistletoe plant extract-induced apoptosis in acute lymphoblastic leukemia in vivo and in vitro.

scientific article

Mucoepidermoid carcinoma of the lung in a 6-year-old boy.

scientific article published in May 2012

Mutational dynamics between primary and relapse neuroblastomas.

scientific article

NK cells engineered to express a GD2 -specific antigen receptor display built-in ADCC-like activity against tumour cells of neuroectodermal origin.

scientific article published on March 2012

NXS2 murine neuroblastomas express increased levels of MHC class I antigens upon recurrence following NK-dependent immunotherapy.

scientific article published on 18 September 2003

Natural killer cell-mediated eradication of neuroblastoma metastases to bone marrow by targeted interleukin-2 therapy

scientific article published on 01 March 1998

Neuroblastoma directed therapy by a rational prodrug design of etoposide as a substrate for tyrosine hydroxylase.

scientific article published in July 2003

Neuroblastoma patients with high-affinity FCGR2A, -3A and stimulatory KIR 2DS2 treated by long-term infusion of anti-GD2 antibody ch14.18/CHO show higher ADCC levels and improved event-free survival

scientific article published on 26 September 2016

Neuroblastoma triggers an immunoevasive program involving galectin-1-dependent modulation of T cell and dendritic cell compartments

scientific article published on 05 December 2011

Nutrient mixture including vitamin C, L-lysine, L-proline, and epigallocatechin is ineffective against tumor growth and metastasis in a syngeneic neuroblastoma model.

scientific article published in February 2008

P01.33. A new development of Triterpene Acids-containing extracts from Viscum album L. displays synergistic induction of apoptosis in childhood leukemia.

scientific article published on 12 June 2012

PD-1 blockade augments anti-neuroblastoma immune response induced by anti-GD2 antibody ch14.18/CHO.

scientific article published on 5 July 2017

Pharmacokinetics and pharmacodynamics of ch14.18/CHO in relapsed/refractory high-risk neuroblastoma patients treated by long-term infusion in combination with IL-2

scientific article published on 19 January 2016

Protective immunity against human carcinoembryonic antigen (CEA) induced by an oral DNA vaccine in CEA-transgenic mice.

scientific article published in March 2001

Pulmonary hypertension in a case of Hb-Mainz hemolytic anemia

scientific article published on March 2007

Radiolabeled metaiodobenzylguanidine (mibg) in diagnosis and therapy of neuroblastoma - results from basic research (review).

scientific article published on March 1995

Randomized controlled trial of taurolidine citrate versus heparin as catheter lock solution in paediatric patients with haematological malignancies.

scientific article published on 18 February 2012

Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of monoamine transporters in neuroblastoma cell lines: correlations to meta-iodobenzylguanidine (MIBG) uptake and tyrosine hydroxylase gene expression

scientific article published on 01 January 1995

Salmonella SL7207 application is the most effective DNA vaccine delivery method for successful tumor eradication in a murine model for neuroblastoma

scientific article published on 18 January 2013

Smac mimetic LBW242 sensitizes XIAP-overexpressing neuroblastoma cells for TNF-α-independent apoptosis

scientific article

Supporting the hypothesis of pregnancy as a tumor: survivin is upregulated in normal pregnant mice and participates in human trophoblast proliferation

scientific article published on January 2008

Suppression of human prostate carcinoma metastases in severe combined immunodeficient mice by interleukin 2 immunocytokine therapy.

scientific article

Survivin minigene DNA vaccination is effective against neuroblastoma

scientific article published on July 2009

Synergy between an antiangiogenic integrin alphav antagonist and an antibody-cytokine fusion protein eradicates spontaneous tumor metastases.

scientific article

Synthesis and characterization of a catalytic antibody-HPMA copolymer-Conjugate as a tool for tumor selective prodrug activation

scientific article

Synthesis and preclinical characterization of a paclitaxel prodrug with improved antitumor activity and water solubility.

scientific article

Systematic amino acid substitutions improved efficiency of GD2-peptide mimotope vaccination against neuroblastoma

scientific article published on 18 August 2009

Targeted cytokines for cancer immunotherapy.

scientific article published in January 2000

Targeting of MYCN by means of DNA vaccination is effective against neuroblastoma in mice.

scientific article published on 16 June 2015

Targeting of heme oxygenase-1 as a novel immune regulator of neuroblastoma

scientific article published on 23 November 2015

The impact of socioeconomic factors on the efficiency of voluntary toxoplasmosis screening during pregnancy: a population-based study.

scientific article

Tolerability, response and outcome of high-risk neuroblastoma patients treated with long-term infusion of anti-GD2 antibody ch14.18/CHO.

scientific article

Tumor-targeted IL-2 amplifies T cell-mediated immune response induced by gene therapy with single-chain IL-12.

scientific article published on July 1999

Using droplet digital PCR to analyze MYCN and ALK copy number in plasma from patients with neuroblastoma.

scientific article published on 7 July 2017

Vaccination with minigenes encoding for novel 'self' antigens are effective in DNA-vaccination against neuroblastoma.

scientific article published in July 2003

Validated detection of anti-GD2 antibody ch14.18/CHO in serum of neuroblastoma patients using anti-idiotype antibody ganglidiomab

scientific article

Validated detection of human anti-chimeric immune responses in serum of neuroblastoma patients treated with ch14.18/CHO

scientific article published on 12 April 2014

Xenogeneic immunization with human tyrosine hydroxylase DNA vaccines suppresses growth of established neuroblastoma.

scientific article published on 11 August 2009

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